Document Document Title
US10227639B2 Compositions and methods for analyte detection
The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
US10227631B2 Composition, device, and method for biological air sampling
The present invention generally relates to air sampling of biological compounds. Specifically, the present invention relates to a device and method for sampling the ambient air for detecting microbial propagules, microbial propagules being any spore, vegetative cell, or virion of microbiological origin including all bacteria, fungi, viruses, protozoans, molds, slime molds, chlamydospores, hyphae, and cysts.
US10227625B2 Methods of modifying eukaryotic cells
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
US10227621B2 Method for preparing an aqueous acrylamide solution having a low acrylic acid concentration
The present invention relates to methods for preparing an aqueous acrylamide solution having a low acrylic acid concentration. In addition, the present invention relates to methods for reducing the acrylic acid concentration of an aqueous acrylamide solution. The methods involve a bioconversion of acrylonitrile to acrylamide in the presence of a biocatalyst, wherein during the bioconversion the content of acrylonitrile is maintained at 0.3 w/w % or more referred to the total weight of the composition in the reactor. Also provided is an aqueous acrylamide solution which is obtained by the methods of the present invention. Furthermore, the present invention is related to an acrylamide homopolymer or copolymer obtained by polymerizing the acrylamide of the aqueous solution.
US10227613B2 Processes for producing fermentation products
The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and optionally a thermostable protease, pullulanase and/or glucoamylase are present and/or added during liquefaction, wherein a cellulolytic composition is present and/or added during fermentation or simultaneous saccharification and fermentation. The invention also relates to a composition suitable for use in a process of the invention.
US10227612B2 Method and device for continuous dry methanation
A device for continuous dry methanation in a fermenter having a closed tank having at least one compartment to ferment the slurry comprising at least 17% dry matter. An injector to inject pressurized gas close to the bottom of the compartment via at least one chimney that descends through the compartment. The injected gas rising through the slurry creates a convective movement in the slurry around the chimney to stir the matter at the bottom of the compartment. The tank can include a first compartment into which the slurry is introduced and a second compartment into which the hydrolyzed slurry flows after hydrolysis and acidogenesis in the first compartment. Methanogenesis takes place in the second compartment.
US10227610B2 Methods and compositions for enhancing nuclease-mediated gene disruption
Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.
US10227608B2 Insecticidal proteins from plants and methods for their use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
US10227597B2 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
US10227595B2 Universal protein overexpression tag comprising ramp function, and application thereof
Provided is a ramp tag capable of solving instability in translation rate resulting from poor compatibility between codons in a foreign gene and a host when expressing a recombinant protein in E. coli. Unlike the conventional codon optimization or codon deoptimization method for solving the problem of rare codons, the present invention increases an expression efficiency of a target protein by merely having the ramp tag be fused with a target gene or independently expressed, without changing the original codon sequence, thereby allowing tRNA to be reused. Thus, the present invention provides a novel method for increasing recombinant protein expression which is capable of reducing costs and time in comparison to the codon optimization method that artificially synthesizes DNA sequences. Therefore, it is expected that the method of the present invention will be able to be used in production of high value-added pharmaceuticals or industrial enzymes.
US10227580B2 Method and device for plankton separation
Methods, devices and kits for the physical separation of plankton into its component parts utilizing phototactic behavior are described. The methods utilize positive phototactic behavior and negative contrast orientation of the zooplankton for maximal in situ separation of phytoplankton and zooplankton for use in further studies and evaluation of separation efficiency. The devices provide effective conditions for use in the separation of plankton into component parts.
US10227570B2 Lactobacillus brevis bacteriophage Lac-BRP-1 and use thereof for inhibiting Lactobacillus brevis proliferation
The present invention relates to a Siphoviridae bacteriophage Lac-BRP-1 that is isolated from the nature and can kill Lactobacillus brevis cells specifically, which has a genome represented by the nucleotide sequence of SEQ. ID. NO: 1 (Accession NO: KCTC 12659BP), and a method for preventing and treating the contaminations of Lactobacillus brevis by using the composition comprising the bacteriophage as an active ingredient.
US10227569B2 Respiratory syncytial virus expression vectors
In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial chromosome (BAC), and a nucleic acid sequence comprising a respiratory syncytial virus (RSV) gene in operable combination with a regulatory element and optionally a reporter gene.
US10227563B2 Method for culture of stem cell
The present invention enables efficient suspension culture of stem cells in a serum-free medium by comprising a step for quickly forming homogenous aggregates of stem cells, and provides a method of selectively inducing the differentiation of nerves from a stem cell, a method of forming a cerebral cortical nerve network in vitro, and a method of producing a steric structure of a brain tissue in vitro, as well as a method of producing hypothalamic neuron progenitor cells, comprising culturing pluripotent stem cells as suspended aggregates in a serum-free medium that substantially does not contain a Nodal signal promoter, a Wnt signal promoter, an FGF signal promoter, a BMP signal promoter, retinoic acid and an insulin, and isolating hypothalamic neuron progenitor cells from the culture.
US10227561B2 Methods and compositions for targeting progenitor cell lines
The invention provides methods, compositions and kits for the identification and enrichment of progenitor cell lines obtained from pluripotent stem cells.
US10227559B2 Compounded media powder formulation and method of preparation of liquid medium for cell culture
The present invention provides a compounded cell culture medium powder formulation comprising: a basal medium powder and a cell culture media supplement, wherein the cell culture media supplement comprises and one or more salts; one or more growth factors; one or more inorganic ions; an amino acid supplement comprising one or more of asparagine, glutamine, histidine, and serine; one or more buffers; and one or more anti-foaming agents. The invention further provides methods of making a compounded cell culture medium powder formulation methods of making a cell culture medium for growing mammalian cells and methods of producing a protein of interest by culturing cells in the cell culture medium and isolating the protein of interest.
US10227552B2 Agent for treating textiles, containing at least one anionic, aromatic polyester and at least one non-ionic, aromatic polyester
An agent is provided which is to be used in the treatment of textiles, containing: i) at least one anionic, aromatic polyester, containing at least one structural unit of formula (I), at least one structural unit of formula (II) and at least one structural unit of formula (III) as described herein, and ii) at least one non-ionic, aromatic polyester containing at least one structural unit of formula (IV) and at least one structural unit of formula (V) as described herein, and iii) at least one surfactant. The agent has an excellent primary washing force and can be, in particular, more storage stable than single doses in a multi-chamber bag.
US10227548B2 Composition comprising a quat, cationic polysaccharide, and a mixture of nonionic polysaccharides
Provided is a composition, notably a fabric conditioning composition, comprising (a) a quaternary ammonium compound; (b) a cationic polysaccharide; (c) a first non-ionic polysaccharide; and (d) a second non-ionic polysaccharide, wherein the second non-ionic polysaccharide is different from the first non-ionic polysaccharide and the second non-ionic polysaccharide has a Molar Substitution (MS) in the range of 0.2 to 1.8.
US10227546B2 Multifunctional molybdenum containing compounds, method of making and using, and lubricating oil compositions containing same
Disclosed is a lubricating oil composition comprising the reaction product of a nitrogen containing reactant wherein the nitrogen containing reactant comprises an alkyl di-alkanolamide, an alkyl di-alkanolamine, or mixtures thereof; an acidic molybdenum compound; and a salicylate compound.Also disclosed is a method for operating an internal combustion engine comprising said lubricating composition and a method for preparing a molybdenum containing friction modifier.
US10227540B2 Powder lubricant composition and method for manufacturing seamless steel pipe
A powder lubricant composition according to the present invention includes 65 parts by mass to 95 parts by mass of sodium borate, and 5 parts by mass to 35 parts by mass of cryolite. A method for manufacturing a seamless steel pipe according to the present invention includes adhering the above-described powder lubricant composition to a pipe inner surface of a work piece which is piercing rolled to have a tubular shape, and elongation rolling on the work piece after the adhering of the powder lubricant composition.
US10227539B2 Noble metal hydrogenation catalysts and aromatic saturation methods
Methods are provided for modifying hydrogenation catalysts having silica supports (or other non-alumina supports) with additional alumina, and using such catalysts to achieve unexpectedly superior hydrogenation of feedstocks. The modified hydrogenation catalysts can have a relatively low cracking activity while providing an increased activity for hydrogenation.
US10227538B2 Facilitated oxygenate separations and synthetic fuel production via reactive distillation
A method includes a step of reacting a hydrocarbon-containing gas with an oxygen-containing gas to form a first product blend in a reactor. The first product blend includes a blend of partially oxygenated compounds. The blend of partially oxygenated compounds is provided to one or more reactive distillation stations; and The blend of partially oxygenated compounds is converted to a second product blend at one or more reactive distillation stations. Characteristically, the second product blend includes a mixture comprising a at least two of components selected from acetals, ethers, alcohols, esters, and alkenes.
US10227533B2 Process to prepare paraffins and waxes
Paraffins and waxes are produced from a gaseous feed stream comprising hydrogen and carbon monoxide in a Fischer-Tropsch reactor using a fixed bed of reduced Fischer-Tropsch catalyst having cobalt as catalytically active metal. A nitrogen-containing compound is added to the gaseous feed stream in a concentration of up to 10 ppmV and the mixture if fed to the reactor to obtain paraffins having from 5 to 300 carbon atoms. The product is subjected to a hydrogenation step, to obtain a hydrogenated fraction comprising 5 to 300 carbon atoms. The hydrogenated product is separated into C5-C9, C10-C17, and C18-300 fractions. The C18-C300 fraction is separated to obtain one or more first light waxes having a congealing point in the range of 30 to 75° C. and a second heavy wax having a congealing point in the range of 75 to 120° C.
US10227525B2 Rare earth materials to enhance properties of ceramic particles
A method of improving the flow of a proppant pack or gravel pack comprises: introducing into a subterranean formation or a well a plurality of ceramic particles, the ceramic particles comprising about 0.1 wt. % to about 25 wt. % of a rare earth-containing compound, based on the total weight of the ceramic particles; and forming a proppant pack or gravel pack comprising the plurality of the ceramic particles; wherein the proppant pack or gravel pack improves fluid flow as compared with a reference proppant pack or gravel pack formed from otherwise identical ceramic particles except for being free of the rare earth-containing compound.
US10227522B2 Fluid efficiency for viscoelastic surfactant based fluids with nanoparticles
A method of treating a subterranean formation penetrated by a well comprises combining an aqueous base fluid, a viscoelastic surfactant gelling agent, two or more types of the following nanoparticles: an alkaline earth metal oxide; an alkaline earth metal hydroxide; a transition metal oxide; or a transition metal hydroxide to form a treatment fluid, and pumping the treatment fluid into the well, wherein the weight ratio of the two or more types of the nanoparticles is selected such that the treatment fluid has an improved fluid efficiency as compared to an otherwise identical reference fluid except for comprising only one type of the nanoparticles selected from an alkaline earth metal oxide; an alkaline earth metal hydroxide; a transition metal oxide; and a transition metal hydroxide.
US10227518B2 Polishing composition and method for producing same
Provided is a polishing composition with which surface defects can be efficiently reduced. This invention provides a polishing composition comprising a water-soluble polymer MC-end. The main chain of the water-soluble polymer MC-end is formed with a non-cationic region as its main structural part and a cationic region located at least at one end of the main chain. The cationic region has at least one cationic group.
US10227513B2 Adhesive composition, adhesive film prepared from the same and display member including the same
An adhesive composition including a monomer mixture including a hydroxyl group-containing (meth)acrylate and a comonomer; and organic particles, the organic particles having an average particle diameter of about 10 nm to about 400 nm.
US10227512B2 Multi-purpose adhesives and methods of making and using thereof
Described herein are adhesives that exhibit good cohesive and tack properties. In certain aspects, the adhesives can be applied to substrates using a low- or medium-pressure delivery system. The adhesives can be readily applied to any substrate such as, for example, a floor, wall, ceiling, countertop, and the like. The adhesives are particularly effective in adhering heavy materials such as, for example ceramic tiles and wall panels to walls.
US10227510B2 Optical adhesive film, method for manufacturing optical adhesive film and touch screen panel comprising same
The present invention relates to an optical adhesive film including plate-type inorganic nanoparticles and a curable resin. The optical adhesive film has improved barrier characteristics to moisture and gas, improved light-transmittance, and excellent durability and peel characteristics.
US10227508B2 Pressure-sensitive adhesive composition
Provided are a pressure-sensitive adhesive composition, a protective film, an optical device, and a display device. The pressure-sensitive adhesive composition may exhibit excellent storage stability, suitable low speed and high speed peel-off strengths after a crosslinking structure is formed, and have an excellent balance between them. Accordingly, the pressure-sensitive adhesive composition may exhibit an excellent protective effect when applied to a protective film, may be easily peeled in high speed peel-off and thus advantageous for a high speed process, and may exhibit an excellent antistatic property in the process.
US10227505B2 Active energy ray-curable composition
An active energy ray-curable composition includes (A) a condensate having a weight average molecular weight of 20,000 or less, and (B) a photoacid generator, with the condensate (A) being obtained by hydrolysis/condensation of: (I) a silane compound containing a hydrolyzable silyl group represented by formula (I): R1—(SiR2a(OR3)3-a. A ratio (Y/X) of Y to X is 0.2 or less, where X represents the number of moles of OR3 groups directly bonded to silicon atoms in the silane compound (I) which is a starting material of the condensate (A) and Y represents the number of moles of OR3 groups directly bonded to silicon atoms in the condensate (A).
US10227504B2 Crosslinkers for coating compounds
The present invention describes new crosslinkers for coating compositions, their preparation, and their use.
US10227502B2 Methods for preparing curable solid particulate compositions
The present invention relates to curable solid particulate compositions that include: (a) a first reactant having at least two cyclic carbonate groups; and (b) a second reactant having at least two active hydrogen groups that are reactive with the cyclic carbonate groups of the first reactant. With some embodiments, the first reactant is a polyol residue having at least two cyclic carbonate groups, such as bisphenol A that has been reacted with epichlorohydrin, and in which the oxirane groups thereof have been converted to cyclic carbonate groups. The active hydrogen groups of the second reactant, with some embodiments, are each independently selected from hydroxyl groups, thiol groups, and amine groups. The curable solid particulate compositions, with some embodiments, are in the form of curable powder coating compositions.
US10227496B2 Composite conductive particle, conductive resin composition containing same and conductive coated article
A composite conductive particle according to the present invention includes a first conductive particle having a particle diameter of greater than or equal to 0.1 μm and less than or equal to 50 μm; and a second conductive particle adhering to the surface of the first conductive particle and having a particle diameter of greater than or equal to 50 nm and less than or equal to 1000 nm, and the first conductive particle is composed of a first particle and a first metal coating covering the surface of the first particle, the second conductive particle is composed of a second particle and a second metal coating covering the surface of the second particle, a particle diameter of the first conductive particle is larger than a particle diameter of the second conductive particle, and an adhering rate of the second conductive particle.
US10227495B2 Biocidal biopolymer coatings
Disclosed herein are biopolymer-based biocidal coatings. The coatings have excellent antimicrobial and antifungal properties, and retain their activity over substantially prolonged periods of time.
US10227492B2 Modifications of the sol-gel films and production processes thereof
Color conversion films for a LCD (liquid crystal display) having RGB (red, green, blue) color filters, as well as such displays, formulations, precursors and methods are provided, which improve display performances with respect to color gamut, energy efficiency, materials and costs. The color conversion films absorb backlight illumination and convert the energy to green and/or red emission at high efficiency, specified wavelength ranges and narrow emission peaks. The color conversion films may comprise at least one of: polydimethylsiloxane hydroxy terminated, dendritic polyol or polyvinylpyrrolidone.
US10227491B2 Fluorescent reactive dyes, process for the production thereof and their use
The present invention is directed to fluorescent reactive dyes of general formula (I) a process for the production thereof and their use.
US10227490B2 Polymer composite comprising an interfacially modified fiber and particle
Embodiments herein relate to a composite material including about 10 to 80 wt. % of a polymer phase, the polymer phase comprising a thermoplastic polymer with a density of less than about 1.9 g-m−2; and about 20 to 90 wt. % of a dispersed mixed particulate phase, the dispersed mixed particulate phase comprising a mixed particulate and about 0.005 to 8 wt. % of a coating of at least one interfacial modifier. The mixed particulate including a portion of a reinforcing fiber and a portion of a particle. The composite material having a Young's modulus of greater than 700 MPa. In various embodiments, structural building components made from the composite are included as well as additive manufacturing components made from the composite.
US10227489B2 Thermoplastic resin composition and molded article using the same
Disclosed are a thermoplastic resin composition including (A) about 100 parts by weight of a base resin including (A-1) about 65 wt % to about 85 wt % of a polycarbonate resin, (A-2) about 5 wt % to about 15 wt % of a polybutylene terephthalate resin, (A-3) about 5 wt % to about 20 wt % of a methyl methacrylate-styrene-acrylonitrile copolymer, and (A-4) greater than about 0 wt % and less than or equal to about 10 wt % of an aromatic vinyl compound-vinyl cyanide compound copolymer; and (B) about 5 parts by weight to about 10 parts by weight of a methyl methacrylate-butadiene-styrene copolymer, and a molded article using the same.
US10227484B2 Fluorothermoplastic polymer compositions
Described herein is a composition comprising (i) a hydrofluorothermoplastic polymer, wherein the hydrofluorothermoplastic polymer is derived from: (a) 50-85 mol % tetrafluoroethene; (b) 2-15 mol % hexafluoropropene; (c) 10-35 mol % vinylidene fluoride; and (d) 0.1 to 5 mol % of a bromine-containing monomer; and (ii) a perhalogenated thermoplastic polymer. Such compositions can be used in multilayer constructions in, for example, fuel hose applications.
US10227472B2 Hydrophobic aerogel materials
The present disclosure provides an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties. Further provided is a method of improving the hydrophobicity, the liquid water uptake, the heat of combustion, or the onset of thermal decomposition temperature of an aerogel composition.
US10227470B2 Recycled composite materials and related methods
Methods of producing particles of fiber and resin from fiber-resin composite materials are disclosed. The particles may be combined with a resin system and optionally combined with fillers, binders or reinforcements to produce new cured solid composite products.
US10227466B2 Material for flexible thermal and acoustic insulation
The present invention relates to a material for thermal and/or acoustic insulation comprising an expanded elastomeric and/or thermoplastic elastomer blend based on styrenic organic polymer and chlorinated organic polymer, the process for the manufacturing of such material, and the use of such material.
US10227465B2 Conductive multilayer sheet for thermal forming applications
A method of making a multilayer sheet includes: forming a substrate including a substrate first surface and a substrate second surface; applying a conductive layer including a base and a conductive coating to the substrate first surface; and applying an ultraviolet cured coating layer to a surface of the conductive layer opposite that in contact with the substrate second surface, wherein the ultraviolet cured coating layer comprises a multifunctional acrylate oligomer and an acrylate monomer; pressing the substrate, conductive layer, and ultraviolet cured coating layer together to form a stack; heating the stack; activating the ultraviolet cured coating layer with an ultraviolet radiation source; and removing the base from the stack leaving a conductive multilayer sheet; wherein the ultraviolet cured coating layer remains adhered to the conductive layer.
US10227460B2 Lignocellulose composite products
Lignocellulose composite products that include a hydrophobizing agent. The lignocellulose composite product can include a plurality of lignocellulose substrates, an at least partially cured binder composition, and a hydrophobizing agent. In one example, the hydrophobizing agent can include about 30 wt % to about 98 wt % of a fatty acid compound, about 0.1 wt % to about 15 wt % of a rosin acid compound, and about 1 wt % to about 40 wt % of an unsaponifiable compound. In another example, the hydrophobizing agent can include a tall oil pitch and a fatty acid composition.
US10227458B2 Polymeric nanocomposites and methods for their preparation and use
Methods of forming a polymeric nanocomposite are provided. The methods include combining one or more monomers to form a mixture and adding a plurality of carbon fibers to the mixture prior to or concurrently with formation of a polymer from the monomers. The methods can also include polymerizing the monomers to form the polymer and adding a hydrophobic agent and a plasticizer to the mixture to form the polymer nanocomposite.
US10227456B2 High-recoverability resin particles of a crosslinked (meth)acrylic acid ester-based resin, and use thereof
A high-recoverability resin particles having a mean particle size of 1 to 100 μm containing a cross-linked (meth)acrylic acid ester-based resin, wherein the high-recoverability resin particles have a recovery rate of 22% or greater, and a 30% compression strength of 1.5 to 5.0 kgf/mm2.
US10227451B2 Method for producing polyamide
A method for producing a polyamide, comprising performing melt polycondensation of a diamine component comprising xylylenediamine in an amount of 70 mol % or more and a dicarboxylic acid component comprising a linear aliphatic dicarboxylic acid having 6 to 18 carbon atoms in an amount of 70 mol % or more in the presence of a phosphorus atom-containing compound (A), wherein the decomposition temperature of the phosphorus atom-containing compound (A) is not lower than the melting point of the polyamide, and an aqueous solution of the phosphorus atom-containing compound (A) and the diamine component are added to the dicarboxylic acid component being in a molten state to perform the melt polycondensation.
US10227450B2 Polymer for preparing resist underlayer film, resist underlayer film composition containing the polymer and method for manufacturing semiconductor device using the composition
Provided are a polymer used for a manufacturing process of a semiconductor and a display, a resist underlayer film composition containing the polymer for a manufacturing process of a semiconductor and a display, and a method for manufacturing semiconductor device using the composition, and more specifically, the polymer of the present disclosure simultaneously has optimized etching selectivity and planarization characteristics, such that the resist underlayer film composition containing the polymer is usable as a hard mask for a multilayer semiconductor lithography process.
US10227442B2 Optical resin composition and optical lens using same
The present invention provides an optical polymerizable composition, an optical composition, a large-area window, a polyisocyanate composition, and eyeglass lens and producing method thereof. The optical polymerizable composition is composed of a polythiol compound and a polyisocyanate compound, and a urethane-based optical lens obtained by reacting the compounds has a low specific gravity and thus is lightweight, and has excellent heat resistance, and particularly, problems of degradation in impact resistance which appear after hard-multi coating are solved. The lens produced using the composition has various excellent optical characteristics including workability such as formability and dyeability, transparency and the like.
US10227435B2 Polymerizable polysiloxanes with hydrophilic substituents
The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
US10227431B2 Binder compositions and methods for making and using same
Binder compositions and methods for making and using same are provided. In at least one specific embodiment, the binder composition can include at least one unsaturated compound having two or more unsaturated carbon-carbon bonds and at least one free radical precursor. At least one of the unsaturated carbon-carbon bonds can be a pi-bond that is not conjugated with an aromatic moiety and can be capable of free radical addition. The free radical precursor can be present in an amount of about 7 wt % to about 99 wt %, based on the weight of the one or more unsaturated compounds.
US10227427B2 Process for preparing propylene/1-butene copolymers
The present invention relates to an olefin polymerization process, wherein propylene and 1-butene and optionally ethylene are reacted in the presence of a Ziegler-Natta catalyst system so as to obtain a polypropylene, wherein the polypropylene comprises 1-butene-derived comonomer units in an amount of from 5 to 20 wt % and optionally ethylene-derived comonomer units in an amount of up to 3 wt %, and the Ziegler-Natta catalyst system comprises an external donor of the following formula (I): (R3)z(R2O)ySi(R1)x.
US10227424B2 Vinyl chloride polymer and preparation method thereof
The present invention relates to a method of preparing a vinyl chloride polymer having good thermal stability due to the restraint of dehydrochlorination by heat or ultraviolet rays, and a vinyl chloride polymer prepared thereby. In the preparation method through bulk polymerization, a modifier is introduced to a polymerization process to impart the vinyl chloride polymer with high thermal stability without inducing modification. Therefore, the preparation method via the bulk polymerization of the vinyl chloride polymer and the vinyl chloride polymer prepared thereby according to the present invention may be readily applied to industries requiring thereof such as industries concerning a vinyl chloride resin and the molded article thereof.
US10227423B2 (Ethylene, vinyl acetal) copolymers and their use in lithographic printing plate precursors
A copolymer includes (i) a plurality of ethylenic moieties A having a structure according to the formula: wherein R2 and R3 independently represent hydrogen, a halogen, an optionally substituted linear, branched, or cyclic alk(en)yl group, or an optionally substituted aromatic or heteroaromatic; (ii) a plurality of acetal moieties B having a structure according to the formula: wherein L1 represents a divalent linking group, x=0 or 1, and R1 represents an optionally substituted aromatic or heteroaromatic group including at least one hydroxyl group; and (iii) a plurality of acetal moieties C and/or moieties D which include a structural moiety including a chromophoric group having its main absorption in the infrared region.
US10227421B2 Chemically functionalized renewed rubber composition
The renewed rubber of this invention can be used in rubber formulations that are used in manufacturing a wide array of rubber products, including tires, power transmission belts, conveyor belts, hoses, and a wide array of other products. The present invention more specifically discloses a method for manufacturing an environmentally friendly, chemically functionalized, renewed rubber composition having a highly desirable combination of physical properties and which exhibits excellent processability comprising the steps of (1) blending a micronized rubber powder with a processing aid and a chemical functionalizing agent to produce a blended mixture; (2) processing the blended mixture under conditions of high shear and low temperature to produce a reacted mixture; (3) adding a stabilizer to the reacted mixture to produce the chemically functionalized renewed rubber composition.
US10227416B2 Methods and composition for secretion of heterologous polypeptides
The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
US10227411B2 Modulation of T cells with bispecific antibodies and FC fusions
The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
US10227402B2 Anti-NGF antibodies and anti-NGF antibody fragments
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
US10227398B2 Anti-complement factor C1q antibodies and uses thereof
The present invention provides anti-C1q antibodies and methods of using the same.
US10227392B2 ALK7:ActRIIB heteromultimers and uses thereof
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an extracellular domain of ActRIIB. In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to improve metabolic parameters in a patient in need thereof. In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to treat or prevent one or more kidney-associated disease or condition in a patient in need thereof.
US10227386B2 Recombinant polypeptides for membrane fusion and uses thereof
Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.
US10227385B2 Chimeric poly peptides and the therapeutic use thereof against a flaviviridae infection
The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
US10227384B2 Modified proteins and methods of use thereof
This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
US10227382B2 Method of designing a peptide and/or peptide derivative for modulating gamma-c-cytokine activity
The γc-family cytokines, Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), Interleukin-15 (IL-15), and Interleukin-21 (IL-21), are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (GvHD). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Peptide and/or peptide derivative antagonists based on the consensus γc-subunit binding site to inhibit γc-cytokine activity are described. Also described are peptide and/or peptide derivative antagonists exhibiting Simul-Block activity, and inhibiting the activity of multiple γc-cytokine family members.
US10227378B2 Method of loading a crystallization device
The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby prefilled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.
US10227376B2 Radiolabeled cationic steroid antimicrobials and diagnostic methods
The disclosure provides compounds, methods, and kits for diagnosis, detection, screening, and imaging of a disease condition (e.g., infection, cancer, tumor, neoplasia), in vitro, ex vivo, and/or in vivo. Certain embodiments include administering a cationic steroid antimicrobial (a “CSA” or “ceragenin”), the CSA including a steroidal backbone and a heterocyclic ring separated from the steroidal backbone by at least 4 atoms (and up to 24 atoms or more), to a subject having or at risk of having a disease condition in an amount effective to diagnose, detect, screen for or image the disease condition in the subject.
US10227374B2 Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
The present invention relates to a prodrug of 5-azacytidine or 2′-deoxy-5-azacytidine having remarkable stability against cytidine deaminase, a metabolic hydrolyzing enzyme in replacement of current injections (5-azacytidine or 2′-deoxy-5-azacytidine) which are clinically used as therapeutic agents for various myelomas including myelodysplastic syndrome. The present invention provides a compound represented by formula (1), or salt thereof, wherein, R is OR3 or a hydrogen atom, R1, R2, and R3 are each independently hydrogen atom or silyl group represented by formula (2): wherein, R4, R5, and R6 are each independently alkyl group which may have a substituent, aryl group which may have a substituent, or arylalkyl group which may have a substituent, with the provision that R1, R2, and R3 are not hydrogen atom simultaneously.
US10227372B2 Bola-amphiphilic compounds and their uses for biomedical applications
The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.
US10227370B2 Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.
US10227368B2 Generation of glucosamine from plant material
The invention relates to an efficient and reproducible process for generating glucosamine from plants which allows high glucosamine content to be obtained while reducing the content of residual ammonium or sulfate ions. The invention also concerns food compositions or cosmetic compositions which comprise the obtained glucosamine-enriched plant compositions.
US10227366B2 Bis-iridium-complexes for manufacturing of ECL-labels
The present invention relates to novel bis-iridium-based Ir(III) complexes, labels manufactured using these complexes and a method for producing such complexes.
US10227361B2 Fused imidazobenzothiazole compounds
The present invention relates to novel fused Imidazobenzothiazole derivatives, their pharmaceutically acceptable salts, and their isomers, stereoisomers, atropisomers, conformers, tautomers, polymorphs, hydrates, solvates and N-oxide. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.
US10227357B2 Compounds and methods for kinase modulation, and indications therefor
Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.
US10227355B2 Quinoline derivatives and preparation thereof
The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.
US10227353B2 Compositions and methods for making alkaloid morphinans
Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.
US10227350B2 Phosphatidylinositol 3-kinase inhibitors
The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, n, R1, R2, R3, R4, R5, and R6 are as described herein.
US10227349B2 Pyrazolo[1,5-a]pyrimidine compound
The disclosure provides pyrazolo[1,5-a]pyrimidine compounds, and pharmaceutically acceptable salts thereof, having protease-activated receptor 2 (PAR2) inhibitory action, pharmaceutical compositions containing the same, and methods of treatment using the same.
US10227348B2 Use of 10H-benzo[g]pteridine-2,4-dione derivatives
Use of 10H-benzo[g]pteridine-2,4-dione derivatives as photosensitizers in the inactivation of microorganisms.
US10227345B2 Compounds and methods for inhibiting fascin
Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in need thereof.
US10227344B2 CK2 inhibitors, compositions and methods thereof
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, R3, Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.
US10227341B2 Inhibiting agents for bruton's tyrosine kinase
Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
US10227340B2 Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.
US10227339B2 Salt form and crystal form of 1,2,5-thiadiazolidin-1,1-dioxide, preparation method thereof and intermediate
The present invention discloses a salt form, crystal form and intermediate of the compound 1, and preparation method thereof.
US10227338B2 Substituted benzenesulfonamides as sodium channel blockers
The invention relates to a compound represented by Chemical Formula 1, below, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compound or salt. The compound of the invention or pharmaceutically acceptable salts thereof can be used for the prevention or treatment of sodium channel blocker-related diseases. in Chemical Formula 1, R1 is hydrogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, halogen, or cyano, R2 and R3 are each independently hydrogen, or halogen, R4 is C5-10 heteroaryl containing one or two elements each independently selected from the group consisting of N, S and O, wherein the C5-10 heteroaryl is unsubstituted or substituted with C1-4 alkyl or halogen, R5 is —CH2CH2—N(R7)(R8), or —CH2CH2CH2—N(R7)(R8), R6 is hydrogen, or C1-4 alkyl; or R5 and R6 together form C3-5 alkylene, (C2-4 alkylene)-N(R9)—(C2-4 alkylene), or (C2-4 alkylene)-O—(C2-4 alkylene), wherein the C3-5 alkylene, or C2-4 alkylene is each independently unsubstituted or substituted with one or two R10, R7, R8, and R9 are each independently hydrogen, or C1-4 alkyl, R10 is C1-4 alkyl, C1-4 alkoxy, halogen, amino, NH(C1-4 alkyl), N(C1-4 alkyl)2, NHCO(C1-4 alkyl), or pyrrolidinyl, X1 is C—R′, or N, wherein R′ is hydrogen, or halogen, X2 is CH, or N, and X3 is N—R″, wherein R″ is hydrogen, or C1-4 alkyl.
US10227335B2 Preparation of sufentanil citrate and sufentanil base
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
US10227331B2 Metallo-β-lactamase inhibitors
The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and RB are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
US10227324B2 2-morpholin-4,6-disubstituted pyrimidine derivative, and preparation method and pharmaceutical use thereof
Disclosed is a 2-morpholin-4,6-disubstituted pyrimidine derivative as shown in formula (1) below, and a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof, and a pharmaceutical composition thereof and a use thereof, wherein the definition of each group is as shown in the description. The compound has a PI3K kinase inhibition activity, and has a relatively high inhibitive ability and a low cytotoxicity against PIK3CA mutant breast cancer cell strains T47D and MCF-7.
US10227323B2 Glucosylceramide synthase inhibitors for the treatment of diseases
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
US10227322B2 Production of meso-lactide, D-lactide and L-lactide by back biting of polylactide
Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i) Depolymerizing polylactide into its corresponding dimeric cyclic esters by heating the polylactide in the presence of a catalyst system comprising a catalyst and a co-catalyst in a reaction zone at temperature and pressure at which the polylactide is molten; (ii) Forming a vapor product stream from the reaction zone; (iii) Removing the vapor product stream and optionally condense it; (iv) Recovering, either together or separately meso-lactide, D-lactide and L-lactide.
US10227321B2 Soothing pro-pheromonal composition for mammals
The invention relates to a compound of general formula (I) (in configuration Z or E) and to pro-pheromonal compositions and formulations comprising said compound, in addition to the uses thereof for soothing purposes for non-human mammals such as sheep, pigs, sheep, cattle, felines, equines and canines.
US10227319B2 Catalytic converter arrangement with optimized surface for producing phthalic anhydride
A catalytic converter arrangement for producing phthalic anhydride by means of a gas phase oxidation of aromatic hydrocarbons, comprising a reactor with a gas inlet side for a reactant gas, a gas outlet side for a product gas, a first catalytic converter layer made of catalytic converter elements, and at least one second catalytic converter layer made of catalytic converter elements. The first catalytic converter layer is arranged on the gas inlet side, and the second catalytic converter layer is arranged downstream of the first catalytic converter layer in the gas flow direction. The catalytic converter elements have an outer layer of an active compound. The invention is characterized in that the active compound content in the first catalytic converter layer and/or in the second catalytic converter layer is below 7 wt. %, based on the total weight of the catalytic converter elements, and the ratio of the total surface of the active compound to the volume of the catalytic converter layer is preferably 10000 cm−1 to 20000 cm−1, in each catalytic converter layer.
US10227318B2 Method for producing gamma-valerolactone
Provided is a method for producing γ-valerolactone that is hard to elute metallic components and has high productivity. γ-Valerolactone is synthesized by bringing a levulinic acid compound represented by the formula (1) (where R represents a hydrogen atom, a linear alkyl group of 1 to 6 carbon atoms or a branched alkyl group of 3 to 6 carbon atoms) into contact with hydrogen in the presence of a catalyst in which two or more different kinds of metals of Group VIII to Group X metals in the periodic table are supported on a support.
US10227314B2 Cystathionine-gamma-lyase (CSE) inhibitors
Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.
US10227310B2 Ghrelin 0-acyl transferase inhibitors
The present invention provides novel GOAT inhibitors and their salts and pharmaceutical compositions thereof.
US10227307B2 PRMT1 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.
US10227303B2 Process for the preparation of halosubstituted trifluoromethylpyridines
The present invention provides a process for the preparation of halosubstituted-6-trifluoromethyl pyridine of Formula I wherein X is a halogen.
US10227302B2 Ionizable cationic lipid for RNA delivery
What is described is a compound wherein R1 and R2 are the same or different, each a linear or branched alkyl consisting of 1 to 20 carbons, or a linear or branched alkenyl or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a bond, a linear alkylene of 1-18 carbons, or a linear alkenylene consisting of 2 to 18 carbons; L3 is a bond or a linear or branched alkylene consisting of 1 to 6 carbons; L4 is a bond or a methylene; X is S or O, R3 is a linear or branched alkylene consisting of 1 to 6 carbons, and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
US10227300B2 Synthesis of triacetonediamine compounds by reductive amination proceeding from triacetonediamine and derivatives thereof
An N-substituted triacetonediamine compound is prepared by reacting 4-amino-2,2,6,6-tetramethylpiperidine or a derivative thereof with a carbonyl compound in a reductive amination, wherein reductive conditions are established by conducting the reaction in the presence of hydrogen and in the presence of a supported catalyst, wherein the supported catalyst includes at least one metal M, wherein the metal M is selected from the group consisting of V, Cr, Mo, Mn, Ni, Pd, Pt, Fe, Ru, Os, Co, Rh, Ir, and Cu.
US10227296B2 Bis(sulfonamide) derivatives and their use as mPGES inhibitors
The present invention relates to bis(sulfonamide) compounds and pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising these compounds and to their use as a medicament for the treatment and/or prevention of a disease, disorder or condition in which modulation of microsomal prostaglandin E synthase-1 activity is beneficial, such as pain, inflammation and cancer.
US10227295B2 Selective histone deactylase 6 inhibitors
Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
US10227293B2 Method for preparing citalopram diol intermediate
The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced.
US10227282B2 Anti-virulence compositions and methods
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
US10227280B1 Process for preparing spirogalbanone
A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalization reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.
US10227279B2 Dehydrogenation of LPG or NGL and flexible utilization of the olefins thus obtained
The object of the invention is to specify a process with which both C5 and C9 aldehydes can be produced economically. Here, the process should be able to to be supplied with the lowest possible dependence on raw material suppliers and also should be able to react flexibly to fluctuations in demand with respect to C5 and C9 aldehydes. The use of resources should also be optimized. The process proposed uses LPG or NGL as raw material. The process according to the invention essentially differs from known LPG-based processes in that the intermediate obtained, after dehydrogenation and removal of by-products, is divided into two portions. C9 aldehyde is produced from the first portion by oligomerization and hydroformylation while C5 aldehyde is obtained by hydroformylation of the second portion. This has the critical advantage that it is possible to divide the intermediate flexibly into the two portions so that either more C5 or more C9 aldehydes can be produced depending on the respective demand.
US10227278B2 Economical production of 2-propylheptanol
The production of 2-propylheptanol described here is effected via Rh-catalyzed hydroformylation of C4-olefin to afford C5-aldehyde, aldol condensation to afford the C10-aldehyde and hydrogenation to afford the C10-alcohol. The emphasis is on the hydroformylation and the ligand employed therein. The problem addressed by the invention is that of reducing the costs of 2PH production. This problem is solved when a cheaper catalyst system which simultaneously achieves a better regioselectivity is employed in the hydroformylation. This catalyst system contains rhodium as the central atom and is complexed with the ligand (1):
US10227274B2 Separations with ionic liquid solvents
Disclosed are systems and methods which provide a process stream comprising a gaseous component, capture the gaseous component from the process stream by an ionic liquid solvent of a separator, and recover a captured gaseous component from the ionic liquid solvent in a regenerator. A second gaseous component from the process stream may be captured by the ionic liquid solvent of the separator, and the second gaseous component may be recovered from the ionic liquid solvent in the regenerator. Alternatively, the second gaseous component from the process stream may be uncaptured by the ionic liquid solvent, and the uncaptured second gaseous component may be recovered from a membrane unit.
US10227272B2 Processes and apparatuses for recovery of ethylene from hydrocarbons
Embodiments of methods and apparatuses for recovery of ethylene from FCC absorber off-gas comprising a heavy cut comprising ethylene, ethane and heavier hydrocarbons and a light cut comprising hydrogen, nitrogen and methane. An exemplary method includes passing the FCC absorber off-gas to an adsorption zone containing an adsorbent selective for the adsorption of the light cut, the adsorption zone adsorbing at least a portion of the light cut and recovering an adsorption zone effluent stream comprising the heavy cut. The adsorption zone effluent is passed to a demethanizer column to provide an overhead stream comprising hydrogen, nitrogen, methane, ethylene and ethane and a net bottoms stream comprising ethylene, ethane and the heavier hydrocarbons.
US10227271B2 Integrated C3—C4 hydrocarbon dehydrogenation process
An integrated process, suitable for use in a new or retrofitted plant, produces an olefin or di-olefin via the dehydrogenation of an appropriate C3-C4 hydrocarbon feed includes (1) contacting the feed and a dehydrogenation catalyst having a Geldart A or Geldart B classification in a fluidized bed at a temperature from 550° C. to 760° C. and a pressure from about 41.4 to about 308.2 kPa (about 6.0 to about 44.7 psia) and a catalyst to feed ratio, w/w, from 5 to 100 to form a dehydrogenate product; separating the dehydrogenate product and unreacted starting feed mixture from a portion of the catalyst by means of a cyclonic separation system; reactivating the catalyst in a fluidized regenerator by combustion at 660° C. to 850° C., followed by contact with an oxygen-containing fluid at 660° C. or greater, and returning the catalyst to the dehydrogenation reactor; (2) compressing the product mixture to form a compressed product mixture; and (3) fractionating the compressed product mixture to form a product stream including at least the target olefin or di-olefin. The integrated process offers increased plant capacity, improved economics, and reduced environmental impact in comparison with other known and conventional processes.
US10227269B2 Cyclopropanation of substituted alkenes
Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.
US10227265B2 Granulation of urea products
Disclosed is a method of making a granulate of a urea product comprising urea and a salt, such as urea ammonium sulfate, having a high content of the salt. The high content is such as to provide an amount of the salt above the limit of solubility of the salt in urea. The granulate of the invention is characterized by having a smooth surface, which, e.g. in the event of urea ammonium sulfate, is not normally the case for granulate having the aforementioned high ammonium sulfate content. According to the invention this is realized by dividing the feed liquids to granulation. This division is based on non-final granulation liquids of a sufficiently high content of the salt, and a final granulation liquid (determining the surface) having a salt content of below the solubility limit of the salt, or no salt at all. E.g. in the event of urea ammonium sulfate, the non-final granulation liquids possibly are a slurry of urea and more than 20 wt. % of ammonium sulfate. The final granulation liquid then has 0-20 wt. % of ammonium sulfate, i.e. below the solubility limit.
US10227261B2 Oxide sintered compact, oxide sputtering target, and oxide thin film
A sintered compact essentially consisting of zinc (Zn), gallium (Ga), silicon (Si) and oxygen (O), wherein a Zn content expressed in terms of ZnO is 5 to 60 mol %, a Ga content expressed in terms of Ga2O3 is 8.5 to 90 mol %, and a Si content expressed in terms of SiO2 is 0 to 45 mol %, and the sintered compact satisfies a condition of A≤(B+2C) when the Zn content expressed in terms of ZnO is A (mol %), the Ga content expressed in terms of Ga2O3 is B (mol %), and the Si content expressed in terms of SiO2 is C (mol %), and has a relative density of 90% or higher. An object of this invention is to efficiently obtain an amorphous film having high transmissivity and a low refractive index without having to introduce oxygen into the atmosphere during film deposition by DC sputtering.
US10227260B2 Refractories and use thereof
A refractory has the form of a dry, mineral batch of fire-resistant mineral materials combined in such a way that refractories which are long-term resistant to fayalite-containing slags, sulfidic melts (mattes), sulfates and non-ferrous metal melts and are used for refractory linings in industrial non-ferrous metal melting furnaces can be manufactured. The refractory at least contains: —at least one coarse-grained magnesia raw material as the main component; —magnesia (MgO) meal; —at least one fire-resistant reagent which, during the melting process, acts (in situ) in a reducing manner on non-ferrous metal oxide melts and/or non-ferrous metal iron oxide melts and converts same into non-ferrous metal melts.
US10227257B2 Cement binder
The invention provides a binder composition comprising: (a) ground granulated blast furnace slag (GGBS), (b) basic oxygen slag (BOS), and (c) an alkaline inorganic waste material selected from by-pass dust (BPD), cement kiln dust (CKD), and mixtures thereof. The use of such a composition as a binder in a concrete mix, concrete mixes comprising such a composition, methods of manufacturing concrete articles, and concrete articles such as paving blocks are also provided.
US10227256B2 Machining of fusion-drawn glass laminate structures containing a photomachinable layer
Methods for machining glass structures may be performed on fusion-drawn glass laminates having a core layer interposed between a first cladding layer and a second cladding layer. The core layer may be formed from a core glass composition having a core photosensitivity, the first cladding layer may be formed from a glass composition having a photosensitivity different from the core photosensitivity, and the second cladding layer may be formed from a glass composition having a photosensitivity different from the core photosensitivity. At least one of the core layer, the first cladding layer, and the second cladding layer is a photomachinable layer. The methods may include exposing a selected region of a photomachinable layer in the fusion-drawn laminate to ultraviolet radiation; heating the glass structure until the selected region crystallizes; and removing the crystallized material selectively from the photomachinable layer.
US10227255B2 Lithium silicate glass ceramic and lithium silicate glass comprising a pentavalent metal oxide
Lithium silicate glass ceramics and glasses containing specific oxides of pentavalent elements are described which crystallize at low temperatures and are suitable in particular as dental materials.
US10227251B2 Method for redrawing of glass
A drawing method for glass is described. The method provides glass components that have a strongly increased ratio of width to thickness when compared to the preform, which makes the manufacturing of flat glass components more economical. The method purposefully controls the temperature distribution within the preform.
US10227248B2 Apparatus and method for treating slurries
An apparatus for treating slurries, in particular biogenic or industrial slurries, can include at least one treatment rotor which is arranged or can be arranged in the slurry and which rotates or is rotatable about an axis of rotation (R), with treatment elements which project outward, as seen from the axis of rotation (R), and between which interspaces are formed, at least some of the treatment elements having, at—at least one, preferably each—adjacent interspace, in each case at least one treatment edge, preferably at least two treatment edges spaced apart from one another, each of these treatment edges running from the inside outward, as seen from the axis of rotation. Methods for treating slurries are also disclosed, including methods using the apparatus for treating slurries.
US10227245B2 Advanced oxidation system and method in a UV reactor with electrode
A system and method for applying an advanced oxidation process to a UV fluid reactor. An L-shaped electrode is connected to a UV reactor hatch and inserted into the reactor upstream from a UV radiation source.
US10227240B2 Water reclamation system and method
A system may include a catch tray coupled with a flow distributor. A mesh screen and carriage may be positioned within the catch tray. A drive bar may be coupled with the carriage and a pitman arm. A gear box may be coupled with a motor and the pitman arm. A process may include distributing contaminated fluid onto the mesh screen. A screen plane of the mesh screen may be at a screen angle that is oblique relative to the direction of the force of gravity. The screen plane is defined by a top surface of the mesh screen. The process may include moving the carriage in a reciprocating linear motion by rotating the pitman arm, and spraying a liquid onto the mesh screen. Liquid may flow through the mesh screen forming clarified liquid, and contaminate may move along the top of the mesh screen to a contaminate outlet.
US10227237B2 Methods for processing fumed metallic oxides
Novel methods for processing fumed metallic oxides into globular metallic oxide agglomerates are provided. The methodology may allow for fumed metallic oxide particles, such as fumed silica and fumed alumina particles, to be processed into a globular morphology to improve handling while retaining a desirable surface area. The processes may include providing fumed metallic oxide particles, combining the particles with a liquid carrier to form a suspension, atomizing the solution of suspended particles, and subjecting the atomized droplets to a temperature range sufficient to remove the liquid carrier from the droplets, to produce metallic oxide-containing agglomerations.
US10227233B2 MEMS device formed by at least two bonded structural layers and manufacturing process thereof
A microelectromechanical device having a first substrate of semiconductor material and a second substrate of semiconductor material having a bonding recess delimited by projecting portions, monolithic therewith. The bonding recess forms a closed cavity with the first substrate. A bonding structure is arranged within the closed cavity and is bonded to the first and second substrates. A microelectromechanical structure is formed in a substrate chosen between the first and second substrates. The device is manufactured by forming the bonding recess in a first wafer; depositing a bonding mass in the bonding recess, the bonding mass having a greater depth than the bonding recess; and bonding the two wafers.
US10227231B2 Wafer-level package with enhanced performance
The present disclosure relates to a wafer-level package that includes a first thinned die, a multilayer redistribution structure, a first mold compound, and a second mold compound. The first thinned die resides over a top surface of the multilayer redistribution structure. The multilayer redistribution structure includes at least one support pad that is on a bottom surface of the multilayer redistribution structure and vertically aligned with the first thinned die. The first mold compound resides over the multilayer redistribution structure and around the first thinned die, and extends beyond a top surface of the first thinned die to define an opening within the first mold compound and over the first thinned die. The second mold compound fills the opening and is in contact with the top surface of the first thinned die.
US10227229B2 Method for manufacturing headrest, and headrest
A headrest in which a pad layer is integrally formed, including a portion with a narrow gap, between a mechanism having various types of incorporated functions and a skin member. A shock absorbing member that is an injection-passage-forming member having a foaming raw material injection passage formed so as to run substantially along a direction that is the vertical direction of the headrest in orientation of when a seat is attached, is set in the inside of a skin member, and a foaming raw material for forming the pad layer is injected through the foaming raw material injection passage. The configuration preferably causes the foaming raw material to spread by the foaming start time, as the foaming raw material spreads to the outer side of the headrest, that is, to the inner surface of the skin member, where the pad layer is required to be formed.
US10227227B2 Liner for a vessel
A beverage containment assembly may include a disposable liner assembly for dispensing fluids with a vessel. The liner assembly may comprise a flexible liner configured for the vessel, a flexible tube; and a cuff having an interlock surface. The cuff may be received in at least a portion of the tube thereby securing the liner and the tube. The interlock surface may be configured to provide a seal between at least the cuff and the liner. A method of manufacturing same is further provided.
US10227225B2 Liquid dispensing device and valve assembly for use therewith
A liquid dispensing device for use with a flexible bag containing a liquid and having a spigot connected thereto includes a housing, a valve assembly and a member. The housing includes an upper part having a receiver configured to receive the spigot. The valve assembly is housed within the receiver and includes a liquid channel and a valve. The liquid channel has an inner end configured to connect to the spigot, and an outer end opposite the inner end. The valve, which is positioned closer to the outer end than the inner end, includes a closed position, in which a flow of the liquid through the liquid channel is prevented, and an open position for dispensing the liquid through the liquid channel. The member is configured to keep the spigot in a permanent open position when the spigot is connected to the inner end of the liquid channel.
US10227223B2 Pedestrian truck steering
A pedestrian truck (50) steered with a tiller (56) is operable in a first mode where a controllable front wheel (64) is aligned generally parallel with a front-rear center line of the truck, or a second mode where the wheel is generally perpendicular to the front-rear center line. A steering controller can operate in either a normal steering mode to steer the rear steerable wheel (52) in the same sense (clockwise or anticlockwise) as the tiller is rotated and in an alternate steering mode to steer the rear steerable wheel in the opposite sense to the rotation of the tiller. A steering mode selector is provided which automatically engages the alternate steering mode when the truck is in the second mode of operation and either (i) the tiller is positioned on the same side of the center line as the controllable front wheel and the drive direction is such that the tiller leads the truck (FIGS. 12-14), or (ii) the tiller is positioned on the same side of the center line as the castor front wheel (58) and the drive direction is such that the tiller trails the truck (FIGS. 4, 5).
US10227222B2 Precast concrete pit
A pit for containing a vehicle lifting apparatus is constructed from a plurality of precast concrete pieces and assembled in a trench. Conduit, plumbing, heating elements, and the like are cast into the pieces to facilitate safe construction/assembly of the pit. A lift apparatus is assembled or positioned in and at least partly attached to the pit. One or more mounting features are cast into and/or attached to the pit wall to help fix the lifting apparatus relative to the pit and/or to help fix the pit relative to a surrounding building.
US10227220B2 Methods and apparatus for constructing glass furnace structures
Methods and apparatus for constructing refractory structures, e.g., glass furnace regenerator structures and/or glass furnace structures having walls formed of refractory block and buck stays externally supporting the walls are provided. Opposed pairs of supports are connected to at least a respective one of the vertically oriented buck stays with cross-support beams spanning the refractory structure between a respective pair of the supports. An overhead crane assembly is supported by the cross-support beams. In such a manner, refractory components of the refractory structure (e.g., refractory wall blocks and/or refractory checker bricks) may be installed using the overhead crane assembly.
US10227218B1 Universal slab removal device
A universal slab removal device for picking up and moving large slabs of cement, concrete or any other types of heavy solid material using any type of lifting machine. The universal slab removal device includes an anchor assembly including an elongated anchor member adapted to be fastened to a slab of heavy solid material such as cement, pavement, and stone and be lifted with a lifting apparatus such as a fork lift and the like.
US10227216B2 Tool lifting devices, oilfield flange lifting safety devices, and related methods of use
A tool lifting device has: arms connected to pivot relative to one another; and a load bearing pin secured to a first arm of the arms, the arms having a closed position where the load bearing pin is supported by, and spans a tool receiving gap defined between, the arms. A tool lifting device has: arms connected to pivot relative to one another; a load bearing pin supported by one or more of the arms, the arms having a closed position where the load bearing pin extends across a tool receiving gap defined between the arms; and a pivot lock for restricting the arms from pivoting relative to one another in the closed position.
US10227215B2 Passenger conveyor and method for monitoring vibrations in a passenger conveyor
A passenger conveyor (1) comprises at least one transport chain (6) connected to a plurality of transportation elements (4) which are configured for travelling in a closed loop along a pathway; at least one sensor (24), which is arranged in a non-straight portion of the pathway and which is configured for detecting a varying force (F′) exerted by the transport chain (6) and/or by the transportation elements (4) in a direction oriented transversely, in particular orthogonally, to a travelling direction of the transportation elements (4); and a calculation and alarm unit (26).
US10227213B2 Handrail used to open and close elevator car panels
An elevator car panel configured to open and methods of opening the same. The elevator car panel includes a handrail configured on a first side of the elevator car panel and a locking mechanism configured on a second side of the elevator car panel, the second side opposite the first side. The handrail is operably connected to the locking mechanism such that movement of the handrail from a first position to a second position operates the locking mechanism to transition from a locked position to an unlocked position and, when in the unlocked position, the elevator car panel is openable.
US10227212B2 Elevator arrangement and method
An elevator arrangement, includes an elevator hoistway, an elevator car, which is arranged to travel in the elevator hoistway, a counterweight, a movable supporting platform above the elevator car, suspension roping, which is connected to the elevator car and to the counterweight, and supports them while suspended from the supporting platform, and a hoisting machine, which includes a device configured to move the roping. The elevator arrangement also includes a hoisting machine and traction roping that are separate from the supporting platform, which hoisting machine is in power transmission connection via the traction roping with the elevator car and with the counterweight.
US10227208B2 Safety apparatus for an elevator
A safety apparatus for elevator apparatuses which can move a cab via a drive including a monitoring unit for monitoring at least one of the drive and/or the motor regulation system of the drive, a safety device having at least two sensors, which can be switched between at least two switching states depending on a state, in particular a closing state. In order to be able to reduce operating costs, at least one of the safety device and the monitoring unit includes a controller, which is designed to identify the respective switching states of the sensors, and to transmit at least one of data and monitoring signals to the monitoring unit.
US10227203B2 Rotary-type film folding machine
A rotary-type film folding machine comprises a feeding mechanism providing a tubular material for a folding mechanism in an axial direction, with a first driving mechanism driving the feeding mechanism to operate; a folding mechanism folding the tubular material delivered by the feeding mechanism, with a second driving mechanism driving the rotation of an outer sheath of the folding mechanism; a pressing mechanism pressing the tubular material folded by the folding mechanism, with a third driving mechanism driving the rotation of a first inner rotor for rotating the pressing mechanism and the folding mechanism; said pressing mechanism being driven by a fourth driving mechanism to move up and down; and the operations of the first, second, third and fourth driving mechanisms are controlled by a controller.
US10227202B2 Method and system for cutting and placing nose wires in a facemask manufacturing process
A method and associated system are provided for cutting and placing individual nose wires in a facemask production line. A continuous wire is supplied from a supply source to a cutting station in the facemask production line where the continuous wire is cut into individual nose wires having a defined length. A first web is conveyed to a vacuum conveyor, and the individual nose wires are deposited from the cutting station onto the vacuum conveyor such that the nose wires are drawn by vacuum against the first web at a defined spacing and orientation. With the vacuum conveyor, the first web and attached nose wires are conveyed to a folding station wherein the first web and nose wires are combined with a second web such that the nose wires are encapsulated between the first and second webs.
US10227201B2 Automated mail tray loading system and method
Presently disclosed embodiments are directed to a system and method for loading mail trays in a sorter without human intervention. Specifically, the disclosed embodiments utilize an automated mail tray having a bottom plate that is selectively moveable between an elevated position and a lowered position. The automated mail tray may be positioned on a shelf under a corresponding output pocket of a mail stacker, and the bottom plate may be elevated to receive mail product transferred from the output pocket to the automated mail tray. After receiving the mail product on the elevated bottom plate, the bottom plate of the mail tray may be lowered so that the mail product is transferred from the output pocket to a position fully situated in the automated mail tray. The mail tray filled with mail product may then be removed from the shelf and replaced with an empty automated mail tray.
US10227200B2 Medium discharge device and image reading apparatus
A medium discharge device includes a discharge roller pair that is provided with a discharge driving roller and a discharge driven roller which drivably rotates in contact with the discharge driving roller, and a medium receiving tray which receives the medium that is fed and discharged by the discharge roller pair, in which the medium receiving tray includes a guide member which guides such that a tip end of the medium which is discharged from the discharge roller pair enters the medium mounting surface at a predetermined angle, and the guide member is provided to be elastically displaceable in an advancing and retreating direction with respect to the medium mounting surface of the medium receiving tray and is displaced in a direction coming close to the medium mounting surface according to raising of a pressing load due to the medium that is discharged to the medium receiving tray.
US10227198B1 Device for producing both linerless labels and lined labels
A device for producing both linerless labels and lined labels includes a base frame; a hotmelt station arranged on the base frame; and a portal frame arranged on the base frame and extending over the hotmelt station. A number of guide rollers are arranged on the portal frame for guiding a web of material along a web path. The hotmelt station is rotatably arranged on the base frame around an axis parallel to the plane of the web path of the guide rollers between a first position and a reversed, second position. Both the first and second position the plane of the web path of the hotmelt station are parallel to the plane of the web path of the guide rollers on the portal frame.
US10227192B2 Image forming apparatus
An image forming apparatus including: a sheet feeding tray configured to support a sheet; and an apparatus main body configured to support the sheet feeding tray so as to be moveable in a direction parallel with a sheet feeding direction, the apparatus main body including a chute configured to guide the sheet that is fed from the sheet feeding tray, wherein the sheet feeding tray includes a guiding member configured to be displaced between an engaging position at which the guiding member engages with the chute and restrains movement of the sheet feeding tray and a separation position at which the guiding member separates from the chute and permits movement of the sheet feeding tray, and wherein the guiding member is configured to guide the sheet that is fed from the sheet feeding tray toward the chute when the guiding member is located at the engaging position.
US10227191B2 Sheet supporting apparatus and image forming apparatus
A sheet supporting apparatus includes a supporting portion to support a sheet, and a regulation unit to regulate a position of an edge of the supported sheet. The regulation unit includes a body portion, an engagement portion to move between an engagement position at which the engagement portion engages with the supporting portion and a separation position at which the engagement portion is separated away from the supporting portion, and an operation portion to move the engagement portion between the engagement position and the separation position. The operation portion is pivotably supported by the body portion and includes a pressing portion to press the engagement portion from the engagement position to the separation position by the operation portion being pivoted. In addition, a fixing component fixes the operation portion to be immovable with respect to the body portion so as to retain the engagement portion at the engagement position.
US10227186B2 Method of, a control system, a device, a sensor and a computer program product for controlling transport of fibrous material in a transport line of a pneumatic conveying system
A method of and control system for controlling transport of fibrous material travelling in dune or dune and layer flow mode conveyed by a pneumatic fluid flow through a transport line of a pneumatic conveying system, such as a cut tobacco conveying system in a device for feeding cut tobacco to a tobacco processing device. The transport velocity of a dune or layer and the velocity of pneumatic fluid passing the dune or layer in the transport line are determined. A difference between the determined dune or layer transport velocity and the determined passing fluid velocity is controlled by controlling the pneumatic fluid flow in the transport line. An optical sensor and a computer program product for use with the method and system are provided.
US10227182B2 Movement device
The invention relates to a device for moving objects, comprising a plurality of individually movable transport movers for transporting the objects, comprising a track system for the transport movers, said transport movers being movable in a transport direction along at least one specified track in said track system, and comprising a controller for controlling the movements of the transport movers in the track system. Each of the transport movers comprises at least one slide which interacts with the track system and at least one object support attached to the slide. The support is at least temporarily arranged in a protruding position in which at least an object receiving region of the support protrudes laterally.
US10227180B2 Robotic placement machine for optical bonding, system and method of use thereof
A robotic placement machine including a base operably connected to the Y axis actuator and the X axis actuator, a first Z axis actuator coupled to the first end of the base, the first Z axis actuator capable of moving up and down a first Z axis, a second Z axis actuator coupled to the second end of the base, the second Z axis actuator capable of moving up and down a second Z axis, and a pick and place plate operably connected to the first Z axis actuator and the second Z axis actuator, wherein the first Z axis actuator and the second Z axis actuator are each capable of moving independently of each other to tilt the pick and place plate is provided. Furthermore, a system comprising a first machine, second machine, and third machine to eliminate air bubbles when bonding two substrates is also provided. A method of optical bonding is further provided.
US10227178B2 Autonomous locker delivery
Various systems, apparatuses, and methods are provided herein that are useful for autonomously delivering lockers. In some embodiments, a system comprises a carrier vehicle, the carrier vehicle comprising a storage area, a docking station including a plurality of storage docks, each of the plurality of storage docks configured to secure at least one locker, wherein the docking station is located within the storage area, and a retrieval point, a plurality of lockers each configured to house at least one product, a delivery vehicle, the delivery vehicle comprising a delivery dock, wherein the delivery dock is configured to receive, at the retrieval point, at least one locker, and a propulsion mechanism, wherein the propulsion mechanism propels the delivery vehicle, and a control circuit, the control circuit configured to identify, from the plurality of lockers, a selected locker, and cause the selected locker to move to the retrieval point.
US10227177B2 Automated bot transfer arm drive system
An autonomous transport vehicle including a transfer arm including at least one finger and a movable finger support member, at least one sensor configured to detect movement of the at least one finger, the at least one sensor having a registration member and a detection member where one of the registration member and detection member is mounted to each of the at least one finger so as to be movable with a respective one of the at least one finger and the other one of the registration member and detection member is stationary relative to the at least one finger, and a controller in communication with the at least one sensor, the controller being configured to determine a position of the at least one finger along the second direction based on a proximity of the registration member relative to the detection member.
US10227176B2 Picking apparatus
According to one embodiment, a picking apparatus includes a carriage, a holding mechanism, and a movement mechanism. The holding mechanism includes an arm, a rotating shaft provided at one end of the arm and rotating the arm, and a holding part provided at the other end of the arm and able to hold at least one object. The movement mechanism is provided on the carriage, and includes a first movement part that moves the rotating shaft along a first direction toward the object, and a second movement part that moves the first movement part along a second direction intersecting with the first direction and approximately perpendicular to the carriage. The first movement part is positioned along a direction away from the object with respect to the second movement part.
US10227175B2 Reusable tie down storage case
Provided is a reusable tie down storage case including a housing having a tie down storage area and first and second strap storage areas, at least one tab in the tie down area for engaging a tie down, a first movable flap covering the first strap storage area to prevent removal of a first strap, and a second movable flap covering the second strap storage area to prevent removal of the second strap. The reusable case can be used as a retail package and as a reusable case after purchase to hold the tie downs in the case without an additional fastener.
US10227172B2 Microwave popcorn bag
A microwaveable popcorn container may be fashioned from glassine or similar materials to provide a susceptor-free, biodegradable, and/or compostable container for cooking microwave popcorn. The material of the container may be translucent in order to advantageously permit inspection of contents during cooking, as well as to permit evaluation of the completeness of kernel popping after microwaving.
US10227164B2 Rigid shell for a compressible tube
The invention relates to a rigid shell (10) for a flexible tube (12), which comprises: a body (20) having a longitudinal main orientation, which is made up of an upper wall (26), a lower wall (28) located opposite and separated from the upper longitudinal wall (26), and two side walls (30) connecting the upper wall (26) and the lower wall (28), a rigid head (22) located at a front longitudinal end of the body (20) which includes a central opening (32), the shell being made in a single piece from a rigid material, the rear longitudinal end of each side wall having a boss which projects towards the inside from the inner surface of the side wall.
US10227163B2 Audible slidable zipper bags
A plastic bag has a closure comprising first and second mutually interlocking profiles and a slider on the closure adapted to engage the interlocking profiles in locking relationship when the slider is moved across the profiles in a locking direction and to disengage the interlocking profiles when the slider is moved across the profiles in an opening direction opposite the locking direction. Topographical features are spaced periodically along the width of the closure. The topographical features are arranged for engagement with the slider as the slider moves across the profiles. Engagement between the topographical features and the slider produces a locking tactile and audible sensation upon closing the closure which is different from an opening tactile and audible sensation upon opening the closure.
US10227162B2 Stackable and collapsible crate
A stackable wooden crate that can be assembled and disassembled without tools, and stored flat is provided. The crate may include: two sides with box joint tabs, two sides with matching box joint recesses, a bottom, and a lid. The sides may come together at box joints held together with strap binding that stretches tight when the sides are folded 90 degrees to each other. A modified strap binding on one corner of the box is held tight via a tensioner buckle. The bottom is held captive by the four sides. The lid rests between four tabs that extend upward out of all four sides. When the lid is removed, multiple crates can be stacked, the upper crate held in place by the lower crate's four tabs which interface with recesses on the bottom of the upper crate.
US10227159B2 Nestable containers having nestable lid arrangements
A container (10) comprises a base (12), upstanding walls (14) on the base and a lid arrangement (16) pivotally attacked to at least one of the walls at a hinge (17). The lid arrangement is pivotally moveable about the hinge from an open position to a closed position. When the lid arrangement (16) is in the open position, the container (10) can be nested within a similar further container having a similar further lid arrangement, and the lid arrangement (16) can be received within the further lid arrangement in a nested condition of the lid arrangements.
US10227157B2 Egg carton with diagonal lid panel
A plastic egg carton having features that enable aligning and stacking of multiple cartons for transport, and providing easy-to-view print and labeling areas in multiple directions. In one embodiment, the egg carton has a unique lid including a flat diagonal stacking panel (also referred to as a diagonal lid panel) that extends between two opposing corners of the rectangular shaped carton. The top wall of the diagonal lid panel can receive labeling or printing. The diagonal lid panel also includes a sidewall extending downwardly from the top wall toward a bottom perimeter edge of the lid, the sidewall having at each of the two opposing corners at least one flat side panel that can also receive printing or labeling. In one embodiment, each of the opposing corners includes a rounded corner portion and two flat side panels disposed on either side of the rounded corner, thus providing a total of four side viewing areas (each in a different direction) for labeling or printing, enabling the consumer to view information such as egg size, date, nutritional information, retail information, or UPC labels.
US10227156B2 Laminated metal sheet for two-piece can and two-piece laminated can body
A laminated metal sheet for a two-piece can includes: a metal sheet; and first and second polyester resin layers formed on outer and inner face sides of the container, respectively. The first polyester resin layer contains polyethylene terephthalate or a copolymerized polyethylene terephthalate with a content of a copolymerized component of less than 6 mol % in a ratio of 30% to 60% by mass, polybutylene terephthalate or a copolymerized polybutylene terephthalate with a content of a copolymerized component of less than 5 mol % in a ratio of 40% to 70% by mass, and a polyolefinic wax in an amount of 0.01% to 3.0% in outer percentage, the second polyester resin layer is a copolymerized polyethylene terephthalate with a content of a copolymerized component of less than 22 mol %, and residual degrees of orientation of the first and the second polyester resin layers are less than 30%.
US10227155B2 Storage and shipping box
A storage and shipping box includes first closing flaps of the exterior of the box that extend from a pair of opposing sides of the upper face of the box and that are capable of being sealed, stapled or glued in order to carry out one or several shipments. The box further includes second closing flaps of the exterior of the box that extend from the other opposing sides of the upper face of the box. The second flaps include a closing element to open and close the box as many times as needed and are capable of being used for the storage of products or for preparing orders before or after carrying out a shipment.
US10227154B1 Movable loading support platform within a container
A moveable support platform within a container may reduce a distance that items fall into the container when stowed. The moveable support platform is lowered by a movement mechanism as items are placed into the container. The movement mechanism may be a bladder filled with air, a biasing device, a pneumatic device, or a mechanical device. The moveable support platform may form a bottom portion of the container during transport of the container. In some instances, the movement mechanism may lift items out of the container to empty the container at a destination.
US10227151B2 Functional trays for handling products in a materials handling facility
A conveyor system is provided including a conveyor and a plurality of functional trays that are removably attachable to the conveyor. Each tray includes a plate having first and second dimensions that are orthogonal to each other, and the plate includes a coupler configured to be removably attached to the conveyor with the second dimension of the plate being in parallel with a moving direction of the conveyor. The plurality of functional trays include one or more of an envelope-opening mechanism, an item-pushing mechanism, an envelope-closing mechanism, an item-wrapping mechanism, and a tray-height-adjustment mechanism. For example, the item-pushing mechanism includes a pusher slidably coupled to the plate, and a linear actuator configured to move the pusher relative to the plate along the first dimension so as to push an item off the functional tray.
US10227149B2 Strapping apparatus
In order, in the case of a strapping apparatus for strapping articles with a strapping band, having a base plate (4) which is provided for arranging on an article, having a tensioning device (6) with which a band tension can be applied to the strapping band, the tensioning device (6) being provided for this purpose with an actuable tensioning tool which can be brought into and out of contact with the band, having a sealing device with which, by contact with the band, two band layers can be permanently connected to each other by forming a seal between the two band layers, being provided with a clamping device which has at least one clamp with two interacting clamping elements for clamping the band between the clamping elements, and being provided with at least one actuating element with which a magnitude of a tensioning force which can be applied to the strapping band or a magnitude which is dependent on the tensioning force can be set, to improve the strength of friction-welded band strapping seals produced by the strapping apparatus, it is proposed that a cooling time period for the seal, during which the strapping apparatus does not release the strapping band after the end of a welding time, is variable depending on the variably adjustable tensioning force or a magnitude which is dependent thereon.
US10227146B2 Container sealing device
An apparatus for filling a plurality of containers with a fluid. The apparatus including a connector configured to removably couple the apparatus to a fluid source, a flow path providing fluid communication between the fluid source and a plurality of containers coupled to the apparatus, a sealing element disposed within each of the plurality of containers, the sealing element configured to couple the container to the apparatus and automatically seal the container when the container is decoupled from the apparatus, a mixing mechanism disposed in the flow path and configured to receive an additive and introduce the additive into the flow path, and a retaining mechanism including an adhesive disposed on each of the plurality of containers to position the sealing element in a neck of each of the plurality of containers.
US10227143B2 Lock actuation system for aircraft
Described herein is a system that includes an actuator with a movable input, a first summing mechanism with an input, a first output, and a second output. The input of the first summing mechanism is movably driven by the movable input of the actuator and the first output of the first summing mechanism is movably coupled to a first actuatable element. The system also includes an end mechanism with an input and a first output. The input of the end mechanism is movably driven by the second output and the first output of the end mechanism is movably coupled to a second actuatable element. The system further includes a sensor that senses a position of the rotational input of the actuator. A status of the first and second actuatable elements is based on a sensed position of the movable input of the actuator.
US10227135B1 Redundant clustered parachute apparatus
A redundant clustered parachute apparatus includes a harness and a plurality of lines operatively coupled to the harness. Each line has a length and a plurality of canopies coupled to and along the length. The plurality of canopies, across the plurality of lines, create an aggregated force of air resistance to slow a falling object in the harness. Loss of some of the canopies or some of the lines does not significantly affect the performance of the redundant clustered parachute apparatus to safely deliver the object to the ground.
US10227134B2 Using drones to lift personnel up cell towers
A method for transporting maintenance personnel at a cell tower includes, responsive to a requirement for a tower climb for one or more of a site survey, a site audit, maintenance, and installation at the cell tower, securing a person in a drone, wherein the drone includes flight components at a substantial length from the person allowing the flight components to fly over a top of the cell tower and to place the person directly adjacent to a desired location on the cell tower; flying the drone up the cell tower to locate the person directly adjacent to the desired location; and performing the one or more of a site survey, a site audit, maintenance, and installation at the cell tower.
US10227132B2 Rotorcraft rotor blade assembly
A rotorcraft rotor blade assembly includes an upper skin portion extending substantially a full span of the rotor blade assembly and a lower skin portion extending substantially the full span of the rotor blade assembly. Each of the upper skin portion and the lower skin portion is configured to carry at least substantially 30% of rotor blade assembly loads.
US10227130B2 Drive system for aircraft landing gear
A method of engaging a drive system with a rotating wheel of an aircraft landing gear is disclosed. A motor is operated to rotate a pinion which is moved from a neutral position to a contact position in which it contacts a rotating driven gear at an initial contact time, the rotating driven gear being mounted to a rotating wheel of an aircraft landing gear; then after the initial contact time moving the pinion further to a meshing position where the pinion meshes with the driven gear. A center-to-center distance between the pinion and the driven gear reduces as the pinion moves to the contact position and to the meshing position. The driven gear has Ngear teeth or rollers, the pinion has Npinion teeth or rollers which mesh with the teeth or rollers of the driven gear when the pinion is at the meshing position.
US10227129B2 Aircraft system for reduced observer visibility
An aircraft apparatus is disclosed that has a fuselage boom having proximal and distal ends, a wing coupled to a proximal end of the fuselage boom and at least one transparent stabilizer coupled to a distal end of the fuselage boom.
US10227126B2 Ceiling trim element for an interior trim arrangement of an aircraft cabin
A ceiling trim element for a passenger cabin of a vehicle, in particular for an aircraft cabin of an aircraft which has a planar panel element with a front side and a rear side, wherein the front side is provided to point towards the interior of the passenger cabin, and the rear side is provided to point away from the interior of the passenger cabin, wherein an image surface is provided in the panel element, wherein the image surface is assigned a varying pattern generator in order to illuminate the image surface with varying patterns, and having an illuminating ring generator to generate an illuminating ring which surrounds the image surface.
US10227125B2 Steering system for a marine vessel
A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.
US10227121B2 Propulsion system for aquatic vessels
A propulsion system (102) for an aquatic vessel (100) is provided. The propulsion system includes a plurality of Magnus-type rotors (108) and a drive arrangement (147) for rotating the plurality of Magnus-type rotors. The plurality of Magnus-type rotors are operable to rotate about corresponding substantially upright axes. The propulsion system also includes a control arrangement (150) for controlling the drive arrangement to vary rates of rotations of the plurality of Magnus-type rotors. Each of the plurality of Magnus-type rotors includes a hollow region (116) therein. Each of the Magnus-type rotors is rotationally supported onto a support arrangement (118) which extends into the hollow region. The drive arrangement includes at least one motor (148) disposed in the hollow region and located outside the support arrangement such that the at least one motor is accessible for maintenance. Furthermore, the at least one Magnus-type rotor includes a ventilation aperture arrangement (132) for enabling an upward movement of air to occur in operation within the at least one Magnus-type rotor for ventilating and cooling the drive arrangement and/or other internal components.
US10227120B2 Retrofittable watercraft propulsion device
A retrofittable watercraft propulsion device enables motorized propulsion and maneuvering of a watercraft occupied by a user. The retrofittable watercraft propulsion device includes an elongated shaft, an impeller pump, a handle, a control input device, a portable power source, a swivel bracket, and a microprocessor. The elongated shaft submerges the impeller pump below the waterline and provides support for the user while the watercraft is in motion. The impeller pump harnesses the water and generates thrust to propel and maneuver the watercraft. The control input device allows the user to throttle or brake the impeller pump. The portable power source supplies electrical energy to the microprocessor and the impeller pump. The swivel bracket swivels the elongated shaft and redirects the thrust of the impeller pump. Finally, the microprocessor controls the impeller pump based on how the user operates the control input device.
US10227118B2 Modular flotation system
A buoyant apparatus and method of use buoyancy to offset the weight of a load during immersion of the load in a fluid medium such as a payload manipulated by a cable and crane or by a remotely operated undersea vehicle. Buoyancy modules that can be of different size and shape have elongated supports that are attachable via complementary connection fixtures at the ends. The attached supports form a skeleton of the array. The connection fixtures are axially resiliently compressible and maintain the buoyancy modules in abutment notwithstanding shrinkage or expansion of the buoyant material due to hydrostatic pressure that increases with depth.
US10227117B2 Autonomous underwater vehicle for aiding a scuba diver
A system for use by a diver during an underwater dive. An autonomous underwater vehicle (one component of the system, AUV) comprises a component for detecting that the AUV has entered water, an AUV acoustic transceiver, a plurality of AUV sensors, a propulsion unit, a processor for determining dive information and diver information responsive to data from one or both of the AUV acoustic transceiver and the plurality of AUV sensors, and one or more cameras. Diver equipment carried by the diver comprises a plurality of diver sensors and a diver acoustic transceiver for receiving sensed information from the plurality of diver sensors and communicating the sensed information to the AUV, and for receiving information from the AUV acoustic transceiver.
US10227116B2 Transceiver devices and related communication and navigation methods
A system and a method, as well as a positioning and wearable devices for determining the distance and position of devices communicating with each other over a medium, the system, are disclosed. At least one remote device comprises first processing unit, at least one transmitter functionally connected to the first processing unit and adapted to transmit signals over a medium, and at least one receiver functionally connected to the first processing unit and adapted to receive signals over said medium. At least two wearable devices, each comprising a second processing unit and wireless communication means capable of receiving and sending data signals over said medium, are also provided. The remote device is adapted to determine the distance to at least two wearable devices, to determine the direction to said at least two wearable devices based on at least two different bearings taken from said at least one remote device to each wearable device, to calculate the position of said at least two wearable devices relative to the remote device, and to communicate the position of at least one first wearable device to a second wearable device. The wearable devices are adapted to process the position of a first wearable device in their processing unit and to present to the user of a second wearable device an indication of direction and distance to said first wearable device.
US10227115B2 Submersible vessel for dry docking a vessel
This invention relates to a submersible vessel for dry docking a vessel. The submersible vessel comprises a floating unit, a deck above the floating unit and a number of stabilizing towers arranged on the deck. The deck has a base, a sidewall along a perimeter of the base and a block provided within the sidewall and resting on the base, defining a cavity such that when the vessel is being docked onto the deck, a thruster of the vessel is above the cavity.
US10227114B1 Visual distress signal device
The present invention is directed to an electronic visual distress signal device. In one embodiment, the invention may comprise a waterproof housing comprising: a bulbous portion; a cylindrical portion; and a collar portion. An optical lens may be coupled to the collar portion, extend along a central lens axis, and comprise: an outer lens surface comprising a central outer flat surface located along the central lens axis and an outer convex surface radially outward of the central outer flat surface; and an inner lens surface comprising a central inner flat surface located along the central lens axis and an inner concave surface radially outward of the central inner flat surface. A light source may be positioned beneath the central inner flat surface so that light emitted from the light source passes through the optical lens. A power source may be located within the cylindrical portion.
US10227111B2 Lower bearing for mooring assembly for a vessel
A mooring assembly for a vessel comprises a moonpool having a casing, a turret mounted in a moonpool for a rotation by upper and lower bearing assemblies. The lower bearing assembly comprises a stiff inner bearing ring attached to a lower part of the turret, an outer bearing ring attached to a casing of the moonpool and a number of circumferentially spaced bearing blocks positioned between the inner and outer bearing rings. A mounting assembly maintains a substantially fixed position of the bearing blocks relative to the outer bearing ring but allows the bearing blocks to assume a position where the load transfer between the bearing blocks and outer bearing ring occurs with a minimum of stress concentrations within the outer bearing ring and wherein the larger part of the load transfer occurs directly between the bearing blocks and outer bearing ring without being directed through the mounting assembly.
US10227109B2 Watercraft securement device
A watercraft securement device including a boat attachment line configured for connection to a watercraft and a dock attachment line configured for connection to an anchoring structure. A tensioning apparatus is connected to the boat attachment line and the dock attachment line. The tensioning apparatus is configured to adjust the length of one of the boat attachment line or the dock attachment line. The tensioning apparatus further includes a pulley for engaging the adjustable length and a ratcheting mechanism. The ratcheting mechanism operates to permit rotation of the pulley in only one direction when engaged, and to permit free rotation of the pulley when released. The ratcheting mechanism maintains tension as the adjustable length is pulled through the pulley.
US10227108B2 Methods and apparatus to couple components to a fuel tank
Apparatus and methods to couple fuel components to a fuel tank are described. An example method includes coupling a carrier to a guide suspended in a cavity of a fuel tank, where the guide extends in a longitudinal direction between a first end of the guide adjacent a first side wall of the fuel tank and a second end of the guide adjacent a second side wall of the fuel tank opposite the first side wall, and moving the carrier along the guide between the first end of the guide and the second end of the guide.
US10227106B2 Bicycle controller and bicycle drive device
A bicycle controller and bicycle drive device that improves the stability of the behavior of a bicycle. The bicycle controller includes an electronic control unit that reduces the output of a motor, which is configured to assist in propulsion of the bicycle, in accordance with an angular acceleration of a rotary body. The rotary body is included in a human power transmission path extending from an input for human power to a coupling portion coupled to a drive wheel.
US10227103B2 Saddle-riding-type vehicle sensor unit attachment structure
In a saddle-riding-type vehicle sensor unit attachment structure, a brake caliper bracket that holds the brake caliper is attached to the rearward extension stay of the front fork, the wheel speed sensor is attached to a lower position than the rearward extension stay of the brake caliper bracket, and the sensor cable is arranged toward an upward direction at an inner side in a vehicle width direction of the rearward extension stay and is then drawn to an outer side in a vehicle width direction of the brake caliper bracket at an upper position than the rearward extension stay to be supported by the brake caliper bracket.
US10227099B2 Splined idler for scallop resistance
An idler wheel for use with a track chain of a vehicle that includes a plurality of track pins and bushings comprises a main body that includes a generally cylindrical configuration defining an axis of rotation, a circumferential direction and a radial direction, the main body including a central portion disposed along the axis of rotation defining an axial extremity of the radial portion, and at least a first outside portion disposed along the axis of rotation that includes an undulating circumferential perimeter.
US10227098B2 Control of a transporter based on attitude
A transporter for transporting a load over a surface. The transporter includes a support platform for supporting the load. The support platform is characterized by a fore-aft axis, a lateral axis, and an orientation with respect to the surface, the orientation referred to as an attitude. At least one ground-contacting element is flexibly coupled to the support platform in such a manner that the attitude of the support platform is capable of variation. One or more ground-contacting elements are driven by a motorized drive arrangement. A sensor module generates a signal characterizing the attitude of the support platform. Based on the attitude, a controller commands the motorized drive arrangement.
US10227095B2 Vehicle aerodynamic apparatus
A vehicle having one or more guide vanes each disposed at each of a respective front and/or rear quarter of the vehicle for guiding the airflow in the vicinity of an adjacent wheel of the vehicle.
US10227093B2 Sub-frame method and arrangement for releasing a front section of the subframe
A sub-frame and method in a sub-frame arrangement in a vehicle wherein said sub-frame arrangement comprises a sub-frame, a body member, and a first and second attachment socket. Each attachment socket is adapted to host a fastening means arranged in a through going apertures of each attachment socket and adapted to fasten said sub-frame to the body member. The fastening means are adapted to fasten a front section of said sub-frame, first and second attachment sockets each comprises a weakened portion arranged at an angle separated from the vehicle deformation direction during a front collision, and the weakened portions are adapted to give way releasing the sub-frame in the event of deformation of the vehicle.
US10227088B2 Detection method of a steering reversal by monitoring of the torque provided by a steering assist motor and application of said method for evaluating the friction
A method for managing a power steering system, including a step (a) of detecting a reversal in the steering direction which involves acquiring a signal, referred to as a “motor torque signal” (CMot), representative of the assistance force (Cassist) delivered by the power steering motor, then evaluating the time derivative (δCMot/δt) of the motor torque signal, then comparing the time derivative of the motor torque signal to a predefined variation threshold (Spic) in order to detect a derivative peak, greater than the variation threshold (Spic), that indicates a reversal in the steering direction. The method next includes a friction evaluation step (b) which involves evaluating the friction from the drop, during the reversal in the steering direction, in a so-called “actuation force signal” (Caction), which is representative of the total actuation force exerted together on the power steering by the driver and by the power steering motor.
US10227087B2 Steering control device and steering control method
A steering control device that can set and cancel an automatic driving mode includes a steering control unit, a cancellation instruction detection unit, a stop detection unit, and a steering angle reduction unit. The steering control unit controls a steering angle in the automatic driving mode so that a vehicle travels along an intended route. The cancellation instruction detection unit detects a cancellation instruction to cancel the automatic driving mode. The stop detection unit detects a stop of the vehicle. The steering angle reduction unit reduces the steering angle set by the steering control unit, if the cancellation instruction detection unit detects the cancellation instruction and the stop detection unit detects the stop of the vehicle.
US10227085B2 Rotary electric machine control apparatus and electric power steering apparatus using the same
A rotary electrical machine control apparatus is provided which controls drive of a rotary electrical machine having a plurality of winding sets. The apparatus includes inverters that are provided so as to respectively correspond to the winding sets, a temperature detection element that detects a base element that is used as a base for estimation of inverter temperatures, which are temperatures of the inverters, and a control section that has a temperature estimation section that estimates the inverter temperatures based on the base temperature and a temperature change amount generated due to current application to the inverters. On-resistance of the switching elements of the first inverter is smaller than on-resistance of the switching elements of the second inverter. The temperature detection element is disposed in an area, a distance between the area and the first inverter being shorter than a distance between the area and the second inverter.
US10227082B2 Power generation systems and methods for wheeled objects
A power generation system for wheeled objects comprises a generator mechanically coupled to one or more of the object's wheels to convert wheel rotational energy into electrical energy. The power generation system may comprise an electrical storage device configured to store the electrical power produced by the generator. Power from the generator and/or the electrical storage device can be used to provide power to other electrical systems in or on the object. In certain embodiments, the electrical storage device comprises a bank of high-capacity capacitors connected in series. Some embodiments use a control circuit, for example, to regulate the charging and discharging of the capacitor bank and to provide suitable voltages for other systems. The power generation system may be disposed within an object's wheel, such as a wheel of a shopping cart.
US10227078B2 Luggage cart assembly
A luggage cart assembly including multiple luggage containers which are vertically arranged, and one or more of the containers are pivotable such that the container can be accessed without having to move the other containers, where the container includes first and second attachment members to attach the container to the luggage cart. When the first attachment member is detached from the luggage cart and the second attachment member remains attached to the luggage cart, the container is pivotable relative to luggage cart and the container is supported by the second attachment member. The first and second containers may be vertically separated from one another in some embodiments.
US10227075B2 System delay estimation method for autonomous vehicle control
In one embodiment, a steering control delay is measured, where the steering delay represents the delay between the time of issuing a steering control command and the time of a response from one or more wheels of an autonomous vehicle. A speed control delay is measured between the time of issuing a speed control command and the time of a response from one or more wheels of the autonomous vehicle or the time of supplying pressure to the gas pedal or brake pedal. In response to a given route subsequently, an overall system delay is determined based on the steering control delay and the speed control delay using a predetermined algorithm. Planning and control data is generated in view of the system delay for operating the autonomous vehicle.
US10227072B2 Travel control device
A travel control device includes an acquisition section configured to acquire, as surroundings in formation while a vehicle itself is traveling, at least information regarding a first other vehicle ahead in a traveling direction and information regarding lane markings of a first lane in which the vehicle itself is traveling. The travel control unit further includes a travel control section ECU configured to compute from the information acquired by the acquisition section a separation between the first other vehicle and the lane markings, and to control travel of the vehicle itself based on the separation.
US10227068B2 Hybrid vehicle
A control process including the following steps is executed. The control process includes, at the time of switching from series-parallel mode to series mode, a step of reducing an engine torque, a step of releasing a clutch, a step of reducing a reaction torque of a first rotary electric machine and a step of increasing a torque of a second rotary electric machine, and, when synchronization is started and a step of increasing a positive torque of the first MG, a step of starting engagement of a clutch, and, when a rotation speed of the first rotary electric machine and a rotation speed of an engine are synchronous with each other, a step of engaging the clutch.
US10227065B2 Damping device
A damping device, for example for damping pressure pulses in a brake circuit of a slip-controllable hydraulic vehicle brake system, includes a damper chamber with a pressure medium volumetric capacity, which can be varied in a pressure-dependent manner, and a flow resistor connected downstream thereof. Disadvantageously, the pressure medium volumetric capacity of the damping device is not available for the brake pressure build-up when the brake pressure is generated by the driver, and the pedal travel on a brake master cylinder of a vehicle brake system is therefore lengthened. A mechanism limits the pressure medium volumetric capacity of the damping device in the case of a passive braking operation. In the case of partially active or fully active braking operations, in contrast, the mechanism has no effect and the full scope of the pressure medium volumetric capacity of the damping device is available for damping pressure pulses.
US10227064B2 Antilock braking systems, devices, and methods using sensorized brake pads
Various antilock braking systems, devices, and methods using sensorized brake pads are disclosed. In some embodiments, the present disclosure provides a method for improving the performance of an antilock braking (ABS) and anti-slip regulation (ASR) system of a vehicle. The method can include detecting the actual value of the coefficient of friction (e.g., between a tire and the ground), updating the coefficient of friction during braking using the braking torque data derived from at least one braking pad of each wheel, and adjusting brake force. For example, the brake force can be adjusted as a function of and/or to be approximately equal to the value of the actual tire-road friction during braking.
US10227063B2 Method and apparatus for biological evaluation
A medical device for monitoring biological parameters through an Abreu Brain Thermal Tunnel (ABTT) is provided. By monitoring and analyzing the temperature of the ABTT, it is possible to diagnosis changes in a patient or subject under a variety of conditions, including predicting the course of medical conditions. Furthermore, since the ABTT is predictive, analysis of the ABTT may be used to control mechanisms for safety when an impending medical condition makes such operation hazardous.
US10227060B2 Vehicle control device
A vehicle control device configured to perform transmission of a drive signal for driving an antenna and reception of a detection signal from a sensor detection unit configured to detect a user operation by common wire, and a controller configured to control the antenna driving unit to transmit the drive signal. The controller is configured to determine whether the determination process is being performed by the sensor detection signal determination unit each when the antenna driving unit transmits the drive signal. The controller is configured to cause the antenna driving unit to transmit the drive signal after the sensor detection signal determination unit finishes the determination process in a case where the controller determines that the determination process is being performed by the sensor detection signal determination unit.
US10227059B2 Process and system for secure access to a determined space by means of a wearable object
In the case of the process for secure access to a determined space, it is provided that after activation of the wearable object, a first coded signal is transmitted from the access or unlocking device, this first coded signal is received in the object and a coded response signal is transmitted with synchronization to the device after a defined time of transmission. A processing of the coded response signal converted in the processing unit of the device is conducted in order to check the defined time delay and the response code of the wearable object and to determine the flight times of the signals between the device and the wearable object. The distance separating the wearable object and the access or unlocking device is thus calculated to authorize access to the determined space if the calculated distance is below a determined threshold after recognition of the wearable object.
US10227056B2 Airbag testing apparatus
A test apparatus includes a linear-motion generator, an airbag, a plate, an anthropomorphic test device, a crushable member, and a guide bar. The linear-motion generator is deployable in a deployment direction. The airbag is spaced from the linear-motion generator and inflatable from an uninflated position to an inflated position. The plate and the anthropomorphic test device are movable together by the linear-motion generator. The crushable member is fixed relative to the airbag in the uninflated position and disposed in the deployment direction from the plate. The guide bar has an end fixed relative to the airbag in the uninflated position and is positioned to intersect the airbag in the inflated position. The test apparatus has a beltline bar that is elongated along an axis transverse to the deployment direction, adjacent the airbag in the uninflated position, and spaced farther from the linear-motion generator than the airbag in the inflated position.
US10227055B2 Locking device for an axle
A locking device for an axle includes a carrier for an axle, a cylinder for a fluid, having a cylinder wall, and a piston which is located inside the cylinder and is sealed against the cylinder wall at least in sections or at certain points, so that the interior of the cylinder is subdivided into a first volume and a second volume separated from the first volume by the piston, and also comprising a mechanical connection between the piston on one side and the carrier for the axle or the axle itself on the other, so that the position of the piston in the cylinder determines the orientation of the carrier for the axle or the orientation of the axle itself, and vice versa, wherein the first volume is connected to the second volume via a line system which has a line segment in which a valve is arranged.
US10227048B2 Adjustable load support
A load support for a vehicle load bar can include a base, a first arm coupled to the base and rotatable about a pivot axis, and a second arm coupled to the base and rotatable about the pivot axis. The first arm and the second arm can be configured to selectively move relative to each other. A locking device coupled with the first arm can be configured to selectively fix a position of the first arm and the second arm relative to each other in a locked configuration. The locking device can be configured to engage a notch in the second arm to prevent movement of the first arm and the second arm relative to each other and configured to disengage from the notch to allow movement of the first arm and the second arm relative to each other and separately about the pivot axis.
US10227047B2 Adjustable receptacle holder for a vehicle
An adjustable retainer for attaching a receptacle, such as a thermal cooler, to a vehicle includes a frame for securing to a vehicle, such as a truck bed. Opposing jaws are movable in guide slots in the frame. One jaw may be manually positioned in a guide slot having hooks, while the other jaw is movable by a linear actuator secured to the frame. The jaws allow optimum positioning of the receptacle and create a vice-like retaining mechanism.
US10227046B2 Sun visor and vanity mirror assembly for vehicle
A sun visor assembly for a vehicle includes a front transparent glass substrate having first and second surfaces and a rear transparent glass substrate having third and fourth surfaces, with an electro-optic medium sandwiched between the second surface of the front glass substrate and the third surface of the rear glass substrate. A vanity mirror including a mirror reflector is established at one of (i) the first surface of the front glass substrate and (ii) the second surface of the front glass substrate. When not electrically powered, the electro-optic medium is substantially transparent, and when electrically powered, the electro-optic medium is darkened so as to have reduced light transmission. When the electro-optic medium behind the mirror reflector is darkened, the mirror reflector is usable as a vanity mirror by a user of the sun visor.
US10227045B2 Inside mirror assembly of vehicle
An inside mirror assembly of a vehicle, the assembly having an improved structure capable of implementing reflective surfaces of a day mode and a night mode according to light reflectivity. The mirror assembly has a simplified mechanism for operating a tilting reflective plate by adopting two pivot shafts to it. The tilting reflective plate is prevented from vibrating, and play is prevented using the tensile force of a spring.
US10227044B2 Movement mechanism and wing mirror for a vehicle provided with such a movement mechanism
A movement mechanism comprising a substantially spherical holder and a substantially bowl-shaped ring, which are rotatable relative to each other about a first axis and a second axis enclosing an angle of approximately 90° to the first axis. Driving means are provided for enabling movement of the holder relative to the ring and comprise a first non-straight driving rod bearing-mounted in the holder, as well as means for activating the driving rod and a second non-straight driving rod bearing-mounted in the holder, as well as means for activating the driving rod. The first driving rod and the second driving rod are rotatable about a third and a fourth axis, respectively, which third and fourth axes are mutually parallel and lie in a plane equal or parallel to the top face of the holder and which third and fourth axes are parallel to or coincide with the first axis.
US10227037B2 Vehicle lamp device having adjustable light emitting surface
A lamp device for a vehicle includes a lamp housing and a light-emitting unit disposed therein. The light-emitting unit includes a light-emitting surface adjustable in at least one of a shape, an intensity of illumination, or a color of illumination. The lamp device further includes a bracket that supports the light-emitting unit to be mounted in the lamp housing, and that is configured to change the shape of the light-emitting surface of the light-emitting unit. The lamp device further includes a driving unit configured to apply a driving force to the bracket that changes the shape of the light-emitting surface of the light-emitting unit. The lamp device is configured to at least partially change, based on a plurality of lighting modes, at least one of the shape of the light-emitting surface, the intensity of illumination emitted from the light-emitting surface, or the color of illumination emitted from the light-emitting surface.
US10227035B2 Tail lamp assembly for a vehicle
A tail lamp assembly is provided to include a tail lamp and a tailgate lamp. The tail lamp assembly replaces the original taillights of a vehicle with the tail lamp, which is embedded in the rear side plate of the vehicle, whereas the tailgate lamp is attached to the tailgate of the vehicle. The tail lamp is directly controlled by the vehicle to selectively provide specific warning signals. The tailgate lamp is disposed on a surface of the tailgate, extending from the tail lamp at the position within a certain distance from the tail lamp. A light channel or electric channel is selectively established between the tail lamp and the tailgate lamp to link and synchronize the tailgate lamp with the tail lamp, so that the tailgate lamp provides specific warning signals accordingly.
US10227033B2 Lighting assembly for vehicle
The invention describes a lighting assembly (10, 10′, 20, 20′) for use in a lighting arrangement (2) of a vehicle (1), comprising a projection lens (11, 21) and an array (12, 22) of light sources (S11, . . . , S26), wherein the projection lens (11, 21) and the light source array (12, 22) are arranged according to an asymmetry displacement (Φi, Φ2, di, d2) of the optical axis (X1, X2) of the projection lens (11, 21), and wherein the light sources (S11, . . . , S26) of the light source array (12, 22) of the lighting assembly (10, 10′, 20, 20′) are individually controllable to adjust a swivel angle (σ1, σ2) of a light beam (BL, BH) generated by that lighting assembly (10, 10′, 20, 20′). The invention further describes a controller (3) for controlling the light sources (S11, . . . , S26) of such a lighting assembly (10, 10′, 20, 20′). The invention also describes a lighting arrangement (2) for a vehicle (1), comprising such a lighting assembly (10, 10′, 20, 20′) and such a controller (3) for controlling the light sources (S11, . . . , S26) of the lighting assembly (10, 10′, 20, 20′) to adjust the swivel angle (σ1 σ2) of the light beam (BL, BR). The invention also describes a method of generating a front beam (BL, BR) for a vehicle (1) comprising such a lighting assembly (10, 10′, 20, 20′).
US10227032B2 Vehicle headlamp alignment system and method
A vehicle headlamp alignment system is provided that includes a headlamp located on a vehicle, an adjuster module for adjusting aim of the headlamp, and a camera located on the vehicle. Sensors may determine distance and orientation of the vehicle relative to a wall. A controller processes images of a beam on the wall acquired by the camera and determines the aim of the headlamp based on the images. The controller controls the adjuster module to align the headlamp based on the determined aim.
US10227030B2 Ratchet configurations
An apparatus and system for improving rope, strap, tie downs, hooks, and nets is provided. Includes a new design whereby the apparatus has a thick walled body made of nylon, aluminum, or stainless steel with a spool and center hub and axle throughout the spool body frame and handle. The apparatus uses multiple coils to automatically retract strap or rope within the spool hub. It also contains a tangential rib opposing the face wheel. The apparatus may have gears on the radius of the wheel, spring loaded slidable pawl plates, or pivotally rotatable pawls or plates which allow the proper engagement of the wheel ratchet. It may also have rope, strap, or belt that is non-cuttable and corrosion, petrol, and chemical resistant used in tie downs and nets. The apparatus may have a lockable body frame, and/or hooks that are lockable to prevent theft.
US10227028B1 Side protection adjusting device for seat
A side protection adjusting device for a seat is disposed at a side protection portion of a seat. The side protection portion includes a side plate and a covering element covering the side plate. The device includes a limiting assembly disposed on the side plate and forming an operative space in between with the side plate, a fixing assembly for securing the limiting assembly on the side plate and including an axial portion, an air cushion arranged in the operative space and having an inflated state and a deflated state, and a rotating assembly axially disposed on the axial portion. Thus, the rotating assembly has a rotating state in which the covering element is driven to rotate while the air cushion is becoming the inflated state, and an initial state in which a position of the rotating assembly is restored while the air cushion is becoming the deflated state.
US10227019B2 Vehicle driving system and energy control methods
A vehicle propulsion system, comprising a DC-DC converter coupled to a DC link, a first and second energy storage devices coupled to the DC-DC converter, a DC-to-AC inverter coupled to the DC link, a motor coupled to the DC-to-AC inverter; and an energy management control system that generates a power split ratio between the first energy storage device and the second energy storage device based on operation conditions of the motor, a vehicle and a load.
US10227017B2 Camera-based vehicle position determination with known target
A vehicle control system capable of moving a vehicle to a target location is disclosed. According to a preferred embodiment, a camera captures one or more images of a known object corresponding to the target location. An on-board computer having stored thereon information about the known object can process the one or more images to determine vehicle location with respect to the known object. The system can use the vehicle's determined location and a feedback controller to move the vehicle to the target location.
US10227016B2 Ceiling mounted charging station and parking structure for charging electric vehicles
The present invention relates to a ceiling mounted charging station for charging the battery of an electric vehicle (210) parking on a parking space (200). The charging station comprises a charging arm (120) for connection with the electric vehicle (210). The first end of the charging arm (120) is mounted to a housing (140) of the charging station. A charging interface (180) for connection with a corresponding charging socket (220) of the electric vehicle (210) is located at a second end of the charging arm (120) opposite to the first end. The charging arm (120) is rotatable with respect to the housing (140) between a stored-position and a use-position. The distance of the second end of the charging arm (120) to the ground (250) of the parking space (200) is smaller in the use-position as in the store-position. The invention furthermore relates to a parking structure comprising a multiplicity of parking spaces (15) for vehicles and at least one charging station (22, 23) mounted to the ceiling of the parking structure. The inventive charging station and the inventive parking structure provide the possibility of an easy charging of electric vehicles, wherein installation costs are low.
US10227012B2 Brake control device of railcar
A brake control device of a railcar includes: a brake switching portion configured to perform switching from an operation of an electric brake device to an operation of a mechanical brake device when a switching monitoring speed obtained from a wheelset speed becomes less than a switching threshold; and an adhesion control portion configured to, when the brake switching portion performs the switching, control at least one of the electric brake device and the brake switching portion to cause a wheel to adhere to a rail.
US10227008B2 Operating device with character input and delete function
An operating device includes an input device that receives a character input of a user, a display device that displays input characters in an input field, and a delete device that deletes at least one character displayed in the input field in a deleting process. The delete device is configured, during the deleting process, in the input field, to move a delete element successively over in each case one of the displayed characters and in so doing in each case to delete the character or to mark it for a deletion to be carried out at the end of the deleting process. The delete device can also be configured to, during the deleting process, to detect a sliding movement of a user's finger on at least one touch-sensitive touch field and to control the movement of the delete element depending on the detected sliding movement.
US10227007B1 Seamlessly integrated instrument panel display
A composite instrument panel having both an electronic display and an opaque dial plate is provided with features that mimic a seamless electronic display. The instant panel includes an electronic display and an applique having a translucent or transparent window through which the electronic display is viewable, and an opaque area adjacent the window defining a dial plate upon which indicia can be printed, the transparent or translucent window having a peripheral border area that transitions from transparent or translucent at an inner edge of the border nearer a center of the window to opaque or nearly opaque at an outer edge of the border farther from the center of the window.
US10227005B2 Vehicular display device
A vehicular display device includes a plurality of monitors that include screens displaying vehicle information, a display board including a plurality transmission display portions each of which transmits and displays the screen of the respective monitors from a rear side and which are arranged side by side, a boundary portion that is positioned between the transmission display portions and an index display portion that forms an index row to display a vehicle state value, and an index light source that illuminates the index display portion. The index light source applies ultraviolet light for illuminating the index display portion to the index row from a front side of the display board, and the index row is formed in the display board in front of the transmission display portions over each of the transmission display portions interposing the boundary portion, and the index row is irradiated when receiving the ultraviolet light. Accordingly, the appearance of the display performed by the vehicular display device is improved.
US10227002B2 Vehicle display system and method of controlling vehicle display system
A vehicle display system includes a display device, a driver state determiner, and a display controller. The display device is configured to provide a display on a window in a rear portion of a vehicle. The driver state determiner is configured to determine whether a driver of the vehicle checks a rear area of the vehicle. The display controller is configured to control displaying of the display device to change the display provided by the display device in accordance with a determination result of the driver state determiner.
US10227000B1 Selectable four-wheel drive system
A drive system for a vehicle having a rear drive assembly having a first pair of axles drivingly engaged to a pair of rear wheels, a single front drive assembly in selective electrical communication with a power source and having a second pair of axles drivingly engaged to a pair of front wheels, a selector switch having a first position which prevents electrical communication between the front drive assembly and the power source and a second position which places the front drive assembly in electrical communication with the power source, where the rear drive assembly can power the vehicle when the selector switch is in the first position, and both the rear drive assembly and the front drive assembly can power the vehicle when the selector switch is in the second position.
US10226993B2 Hydraulic torque motor
An assembly (20) comprising a radial piston hydraulic motor (10), comprising a fixed housing (15), a shaft (14) that can be driven in rotation by the hydraulic motor (10), a wheel hub (30) comprising a hub barrel (31) that engages on the shaft (14), a bearing (40), a bearing support (41), in which the bearings (40) are housed between the hub barrel (31) and the bearing support (41) of the hydraulic motor (10), the bearing support (41) forming part of the housing (15), such that the bearing function is carried out by the housing (15), the shaft (14) supporting only the weight of same and having only a torque function.
US10226979B2 Damping force control device for vehicle
A damping force control device for controlling damping forces of shock absorbers by a control device, which is configured to to estimate first vertical speeds at the positions of wheels based on the vertical accelerations of a vehicle body at the positions of the wheels, to estimate second vertical speeds of the vehicle body caused by driver's driving operation based on driving operation amount of the driver, to calculate target damping forces by subtracting products of damping coefficients of the ride comfort control and second vertical speeds from the sums of products of the damping coefficients of the ride comfort control and first vertical speeds and products of damping coefficients for controlling posture change of the vehicle body and the second vertical speeds, and to control damping coefficients of the shock absorbers based on the target damping forces.
US10226978B2 Vehicle height adjustment device
A vehicle height adjustment device includes a changer, a detector, a vehicle height controller, and a malfunction detector. The changer is configured to change a relative position of a body of a vehicle relative to an axle of a wheel of the vehicle. The detector is configured to detect the relative position of the body of the vehicle relative to the axle of the wheel of the vehicle. The vehicle height controller is configured to control the changer based on a detection value detected by the detector to change the relative position to control a vehicle height, which is a height of the body. When the detection value detected by the detector changes by a predetermined amount or more in a predetermined period of time, the malfunction detector is configured to determine that there is a possibility of a malfunction occurring in the detector.
US10226976B2 Ball hitch cover
A ball hitch cover. The ball hitch cover includes a front tab and a pair of side tabs connected to a lower end of the front tab. Each side tab includes a first edge having a first width and a second edge having a second width, wherein the second edge width is greater than the first edge width. A pair of rear tabs are disposed opposing the front tab, such that each rear tab is disposed adjacent to the second edge of one of the side tabs of the pair of side tabs. A length of each rear tab of the pair of rear tabs is greater than a length of the front tab. The ball hitch cover is flexible and configured to conform to the shape of a ball hitch and is securable thereto via an adhesive disposed on an inner side of the ball hitch cover.
US10226974B2 Self-reinflating tire
A device for transport of air in the tire P or close to it consisting of a chamber K in the shape of a hollow compressible channel, placed along at least a part of the tire perimeter, characterized by the fact that a ring OK is placed at the inner side of the chamber K with the distance of its outer side from the tire axis of rotation equal to 1 to 1.1 multiple of the distance of the bottom side of the chamber K from the axis of rotation of the tire P.
US10226970B2 Sound-suppressor-equipped pneumatic tire, and sound suppressor for tires
The purpose of the present invention is to inhibit deterioration in the external appearance of a sound suppressor, even when used in cold areas. This sound-suppressor-equipped pneumatic tire includes: a pneumatic tire provided with a tread section; and a sponge-like sound suppressor which is affixed to a tire inner cavity-side surface of the tread section, and which extends in the peripheral direction of the tire. In the sound suppressor, a plurality of slits are formed in an exposed surface which faces the tire inner cavity.
US10226969B2 Heavy load tire with curved sidewall recess
A circumferential depressed portion extended along a tire circumferential direction is formed on an outer surface of a tire side portion of a pneumatic tire. On a tire cross-sectional plane, a rim-side outer surface formed in a range from a rim separation point to an inner-side end of the circumferential depressed portion along a tire radial direction is formed along a given circular-arc curved line. When a virtual circular-arc curved line drawn by extending the given circular-arc curved line is defined, a depth of the circumferential depressed portion with reference to the virtual circular-arc curved line is not smaller than 5 mm and not larger than 35 mm in a range of not smaller than 22% and not larger than 28% of a tire height from an bead end.
US10226965B1 Slider to frame construction
An agricultural machine such as a high clearance sprayer is provided with a frame capable of supporting wheels at a variable tread width. The frame includes a pair of cross members, both of which have slider receivers. The machine also includes a first axle slider for a first side and a second axle slider for a second side. The machine may also have a slider to frame connection arrangement that includes a reduced friction zone at the slider receivers that facilitate telescopic movement of the axle sliders. The slider to frame connection may also have at least one fixed slider wear pad in a fixed position within the reduced friction zone and at least one movable slider wear pad movably arranged within the reduced friction zone.
US10226963B2 Face seal with installation pilot for a wheel assembly of a work vehicle
A face seal for use within a wheel assembly may include an inner sealing ring and an outer sealing ring. The outer sealing ring may include a first flange, a second flange and an outer cylindrical portion extending between the first and second flanges. The outer cylindrical portion may include a first cylindrical section extending axially from the first flange and a second cylindrical section extending axially between the first cylindrical section and the second flange. The face seal may also include an inner elastomeric ring and an outer elastomeric ring having an axial portion extending radially outwardly from the second cylindrical section of the outer cylindrical portion. Additionally, the axial portion may be radially offset from the first cylindrical section of the outer cylindrical portion such that an outer surface of the first cylindrical section is spaced radially outwardly relative to an outer surface of the axial portion.
US10226962B2 Vehicle wheel including antirotation plate
A vehicle wheel includes a first annular component, a second annular component configured to be separable from the first annular component and mechanically connected to and aligned with the first annular component about an axis of rotation of the wheel, and a plate. In some examples, when the first and second annular components are mechanically connected, the first and second annular components are configured to receive a tire and define a recess along an annular surface of the first and second annular components, the recess being configured to receive the plate. In addition, in some examples, when the plate is received in the recess, the plate inhibits relative rotation between the first annular component and the second annular component about the axis of rotation of the wheel.
US10226961B2 Soundproof wheel for railway vehicle
This soundproof wheel includes a soundproofing device (3) which is mounted to an inner peripheral surface (6) of a rim section (5) of the wheel. The soundproofing device (3) is provided with: a fixing ring (10) which is fitted in and fixed to a groove (8) formed in the inner peripheral surface (6); a first elastic body section (11A) which is stuck to an outer peripheral surface (10a) of the fixing ring (10), is disposed within the groove (8), and has a plurality of first elastic body pieces; an additional mass section (12) which is stuck to a side of the first elastic body section (11A) opposite to the fixing ring (10), is disposed within the groove (8), and has a plurality of additional mass pieces; and a second elastic body section (11B) which is stuck to a side of the additional mass section (12) opposite to the first elastic body section (11A), is disposed within the groove (8), and has a plurality of second elastic body pieces. The soundproofing device (3) includes a plurality of dynamic vibration absorbers. Each of the dynamic vibration absorbers has first and second elastic body pieces and an additional mass piece. This soundproof wheel allows for significant reduction in wheel vibration noise and is highly durable.
US10226958B2 Clean edge business cards
A printable blank sheet includes a sheet with defined separation lines, a first layer with cuts running through the first layer along the defined separation lines, and a second layer attached to a bottom side of the first layer, with perforations running through the second layer along the defined separation lines. A method for creating custom print cards includes running a printable blank sheet through a printer to print on defined print areas, wherein the sheet includes slit-over-perforation lines defining a periphery of an object in the sheet, bending the sheet along the slit-over-perforation lines to weaken and separate the slit-over-perforation lines, and detaching the object from the sheet.
US10226957B2 Recording material and recording sheet
An object of the invention is to provide a recording material and recording sheet having excellent color-developing performance, storage stability, etc. A recording material having good color-developing performance and storage stability may be obtained by using a specific compound having a benzhydrol skeleton as an additive in a recording material employing color development through a reaction between a color former and a color-developing agent.
US10226951B1 System and method for pivoting a printhead in a direct-to-object printer during printing of an object
A direct-to-object printer includes a printhead pivoting subsystem. The printhead pivoting subsystem includes an actuator that rotates a frame in which a plurality of printheads is mounted. This rotation pivots the printheads about a pivot position to enable the printheads to change orientation with reference to a surface of an object being printed to accommodate contours of the object.
US10226949B2 Tape cassette
A tape cassette includes a box-like housing, a tape mounted within the housing, a hole and a first indicator portion. The housing includes a top wall having a top surface, a bottom wall having a bottom surface and opposing the top wall, and a front wall having a specified height and being formed along peripheries of the top wall and the bottom wall. The hole is provided in the front wall. The first indicator portion includes at least one first aperture and indicates a first element among a plurality of elements of a type of the tape. The first indicator portion is provided in a portion, spaced from the front wall, of the bottom wall. The hole and the one first aperture is located to intersect a virtual line orthogonal to the front wall when viewing along a vertical direction orthogonal to the top wall and the bottom wall.
US10226946B2 Post-processing device and recording apparatus
A post-processing device is provided with a post-processing unit which performs post-processing of a recording medium on which recording is performed, a transport path through which the recording medium is transported, or a deformation suppressing unit which suppresses deformation of the recording medium on a mounting unit on which the recording medium is mounted, in which the deformation suppressing unit is controlled based on a predetermined parameter related to recording processing with respect to the recording medium.
US10226944B2 Adaptable surface treatment repair system
A surface treatment repair assembly for applying a surface treatment to a contoured surface includes an attachment device configured to removably attach to the contoured surface and a robotic unit is coupled to the attachment device. Furthermore, a treating unit is operably mounted on the robotic unit and including a plurality of applicator heads forming a treatment array and each applicator head is configured to apply a surface repair treatment. At least one sensor is mounted on the treating unit and configured to identify a target area for the surface repair treatment and a controller is operably coupled to the robotic unit and the treating unit. The controller is programmed to control a movement of the robotic unit to position the treatment array adjacent to the target area and to selectively operate the treatment array to apply the surface repair treatment on the target area of the contoured surface.
US10226943B2 Printing apparatus
A printing apparatus includes: a main body; a cassette including a cassette case and a printing medium accommodated in the cassette case; an installing portion provided on the main body for installing the cassette detachably; a thermal head arranged on a substrate provided in the installing portion and having heating elements arranged along a predetermined arrangement direction; a conveyor which conveys the printing medium of the cassette installed in the installing portion along a conveyance path orthogonal to the arrangement direction; a first temperature sensor provided, in the installing portion, on a side of the thermal head with respect to the conveyance path; a second temperature sensor provided in the interior of the cassette case or the installing portion; and a processor which corrects an amount of applying energy to be applied to the heating elements, based on first and second temperatures detected by the first and second temperature sensors.
US10226942B2 Printer, method of controlling printer, and storage medium
A printer includes a processor; a thermal head driver circuit that drives a thermal head for printing on a printing medium; a motor driver circuit that drives a motor configured to convey the printing medium; and a power supply circuit that includes a capacitor and a first switching circuit to charge the capacitor, the power supply circuit supplying electrical power to the thermal head driver circuit and the motor driver circuit via the capacitor, wherein the processor, when stopping operation of the printer, performs a control process of discharging the capacitor via the motor driver circuit and the motor.
US10226940B2 Printer fluid circulation system including an air isolation chamber and a printer fluid pressure control valve
Systems and related methods are described for circulating and printing fluid onto a printer media. In one example, a system can include an air isolation chamber to pool printing fluid circulated within the system. The air isolation chamber can be fluidly connected to a printhead assembly to eject a portion of the printing fluid onto the printer media. The system can further include a pump to pump printing fluid from the air isolation chamber to the printhead assembly. The system can further include a pressure control valve along a return line between the air isolation chamber and the printhead assembly to regulate the flow of unejected printing fluid to the air isolation chamber to control printing fluid pressure over the printhead assembly.
US10226938B2 Identifying first and second reservoir statuses
An example device in accordance with an aspect of the present disclosure includes a first reservoir for a printable composition, a pump fluidically coupled to the first reservoir and a second reservoir, a sensor, and a controller. The controller is to identify first and second reservoir statuses based on the sensor.
US10226936B2 Liquid jetting apparatus
A liquid jetting apparatus includes: a liquid jetting unit which jets liquid; a casing including a tank storing part in which a tank containing the liquid to be supplied to the liquid jetting unit is stored, and having an opening which allows the tank storing part to communicate with an outside of the casing; and a cover pivotally attached to the casing and selectively positioned in a closed position where the opening is closed and an opened position where the opening is open. The casing includes an engaging part which engages with the cover in the closed position to prevent the pivoting of the cover. The liquid jetting apparatus further includes a movement mechanism which moves the cover relative to the casing between an engagement position where the engaging part is engaged with the cover and a release position where the pivoting of the cover is not prevented.
US10226935B2 Liquid cartridge
A liquid cartridge is configured to be inserted into a liquid consuming apparatus in a first direction along a horizontal direction against an urging force directed in a second direction opposite the first direction, and thereby to be mounted to the liquid consuming apparatus. The liquid cartridge is configured to pivot about a pivot center in the liquid consuming apparatus. The liquid cartridge includes a rear face, and the rear face includes a first portion and a second portion positioned further in an upward direction than the first portion. The first portion includes a portion positioned further in a downward direction than the pivot center, and the first portion is positioned further in the first direction than the second portion.
US10226934B2 Liquid storing tank having a first chamber and a second chamber below the first chamber
There is provided a tank including a liquid inlet port, an atmosphere open port, a liquid outflow port, a first liquid chamber having a first atmosphere communication channel, a second liquid chamber being in communication with the first liquid chamber and having a second atmosphere communication channel, and a liquid channel. The liquid inside the liquid channel is movable along with a liquid consumption of a liquid consuming device connected to the tank. With the tank in a usage posture, when the liquid is stored in the first liquid chamber and the second liquid chamber, the liquid level of the liquid stored in the first liquid chamber is formed independently from the liquid level of the liquid stored in the second liquid chamber.
US10226931B2 Printer
A printer includes a medium transporter configured to feed out a medium in a rolled shape and transport the medium in a first direction; a head provided movably in a second direction and configured to eject droplets for image-forming downward along a vertical direction toward the medium which is transported; a receiver provided below a region of the medium facing the head along the vertical direction, and configured to receive the droplets ejected onto the medium from the head and having passed through the medium downward along the vertical direction; and a support member configured switchably arranged at a supporting position arranged between the medium and the receiver along the vertical direction and a retracted position that is retracted from the supporting position, and configured capable of supporting the medium in a state of being arranged at the supporting position.
US10226930B2 Liquid ejecting apparatus
A detection unit that detects the presence of an object that can come into contact with a liquid ejecting unit with relative movement between a medium and the liquid ejecting unit is provided with a piezoelectric film sensor that outputs an electrical signal when the object comes into contact with the detection unit, where the detection unit has first, second, and third plate portions formed so as to be continuous, the first plate portion is fixed so that the second and third plate portions are cantilevered, and the second plate portion, in a state where the piezoelectric film sensor is mounted thereon, is continuous with the first plate portion and is disposed diagonally with respect to the vertical direction of the medium, and the third plate portion is bent from the second plate portion and faces the medium leaving a gap between the third plate portion and the medium.
US10226927B2 Method for manufacturing droplet-discharge head substrate and droplet-discharging head
An embodiment method for manufacturing a droplet-discharging head substrate may include a first step to perform a surface activation process on joint surfaces of first and second plates with an atom beam, ion beam or plasma; a second step to align and stack the first and second plates in such a manner that nozzle holes formed in the first plate communicate with through-holes formed in the second plate; and a third step to bond the joint surfaces of the stacked first and second plates by atomic bonding without covalent bonding caused by ion movement. The third step bonds the joint surfaces by bringing a load member into contact with the droplet-discharging surface of the first plate at a position away from the nozzle holes to apply pressure under an atmospheric pressure and by bringing the joint surfaces close to each other with an electrostatic attractive force.
US10226924B2 Printer and computer-implemented process for controlling a printer
A printer for printing on a print medium as said print medium advances through a print zone, the printer including a number of print heads extending over the print zone, each print head including at least one nozzle array wherein at least two adjacent nozzle arrays overlap forming at least one stitching zone in the overlap region; and a printer controller for generating a sequence of nozzle firing commands for each nozzle array to selectively deposit droplets of print fluid on said print medium from said nozzle arrays in accordance with an image to be printed, wherein the printer controller further applies masks having decorrelated patterns to said sequence of firing commands for at least those overlapping nozzles of the nozzle arrays coinciding with the at least one stitching zone to obtain a predetermined optical parameter of the printed image in the stitching zone, irrespective of an offset between two adjacent nozzle arrays.
US10226919B2 Articles and structures prepared by three-dimensional printing method
The present invention relates to articles prepared using a three-dimensional printing method, an auxiliary structure being additionally formed beyond an extension of the one or more components during the construction of components. The invention also relates to an auxiliary structure for components produced by means of three-dimensional printing methods, the auxiliary structure being constructed along with the component and extending beyond a dimension of the one or more components.
US10226914B2 Flexible metal laminate
Disclosed herein is a flexible metal laminate including: a first thermosetting polyimide resin layer containing 5 wt % to 75 wt % of a fluorine-based resin; a second thermosetting polyimide resin layer formed on at least one surface of the first thermosetting polyimide resin layer, and containing 1 wt % or less of the fluorine-based resin; and a thermoplastic polyimide resin layer formed on one surface of the second thermosetting polyimide resin layer so as to face the first thermosetting polyimide resin layer, wherein the first thermosetting polyimide resin layer and the second thermosetting polyimide resin layer include the same thermosetting polyimide resin.
US10226913B2 Decorative sheet
Provided is a decorative sheet which comprises a top surface layer, a rear surface layer and at least one intermediate layer between the top surface layer and the rear surface layer, wherein: the top surface layer and the rear surface layer each independently are formed from a first composite resin composition comprising a glycol-modified polyethylene terephthalate resin and an ester-based resin; the intermediate layer(s) is (are) formed from a second composite resin composition comprising a glycol-modified polyethylene terephthalate resin, a polyethylene terephthalate resin and an ester-based resin; the glass-transition temperature of the ester-based resin is lower than the glass-transition temperature of the glycol-modified polyethylene terephthalate resin; the glass-transition temperature of the ester-based resin is lower than the glass-transition temperature of the polyethylene terephthalate resin; and the content of the polyethylene terephthalate resin in the second composite resin composition is between about 5 and about 30 wt %.
US10226912B2 Intermediate film for laminated glass, and laminated glass
An interlayer film for laminated glass that can improve a sound insulation property of an obtained laminated glass when the interlayer film for laminated glass is used for configuring the laminated glass is provided. The interlayer film for laminated glass according to the present invention includes a first layer and a second layer laminated on a first surface of the first layer. The first layer includes a polyvinyl acetate resin and a plasticizer.
US10226910B2 Susceptor structure
A microwave energy interactive structure includes a first susceptor film including a first layer of microwave energy interactive material supported on a first polymer film, a moisture-containing layer joined to the first layer of microwave energy interactive material, an adjoining layer joined to the moisture-containing layer such that the moisture-containing layer is disposed between the susceptor film and the adjoining layer, and a second layer of microwave energy interactive material on a side of the adjoining layer opposite the moisture-containing layer. The adjoining layer may be joined to the moisture-containing layer by a discontinuous adhesive layer.
US10226909B2 Laminated moisture resistant poultry box and process
A moisture resistant poultry box having a composite structure with a fluted paper medium, a top backing board assembly secured to one side of the fluted medium and a bottom backing board assembly secured to the other side of the fluted medium. The backing board assemblies and the fluted medium are impregnated with a hydrogenated triglyceride, and each backing board assembly has PET film glued thereto covering an outside surface to provide moisture resistant recyclable poultry box so that it has a Cobb value ranging between about 0 to about 1.
US10226908B2 Nonwoven apertured elastic film with improved bonding features
The present invention relates to a nonwoven composite comprising an elastic film bonded to a nonwoven web at a plurality of strategic, geometric bond points to provide a tactile pattern, enhanced breathability and comfort to the end user.
US10226904B2 Apparatus for laminating object with fiber tow
A apparatus for laminating an object with a fiber tow, may include a fiber supply device provided with a plurality of first creels on which first fiber tows are wound and a plurality of second creels on which second fiber tows are wound; an impregnation device provided at a lower side of the fiber supply device, and impregnating the first fiber tows supplied from the first creels and the second fiber tows supplied from the second creels with a resin; and a lamination device provided at a lower side of the impregnation device, and laminating an object with the first and second fiber tows that are impregnated with the resin in accordance with a rolling motion of a laminating roller relative to the surface of the object.
US10226903B2 Reinforced plastic material having high smoothness
A fiber reinforced plastic material is provided, the material including a fiber layer comprising a plurality of continuous carbon fiber reinforced thermoplastic sheets, a veil layer comprising fibers selected from at least one of glass fiber and carbon fiber, and a resin layer comprising a resin film, wherein the veil layer is impregnated by at least a portion of the resin film.
US10226898B2 Method for connecting plastic pipes and structure for connecting the same
Disclosed herein is a method for connecting first (110) and second (120) plastic pipes. The method includes: placing an end of the second plastic pipe (120) on a target portion of the first plastic pipe (110) that is intended to form a connection hole (111), the end of the second plastic pipe (120) being provided with an arch-shaped heating element (130) made of conductive plastic material, electric connection terminals (140) disposed in the heating element (130) on opposite sides of the target portion, and a cover (121) covering at least an outer surface of the arch-shaped heating element (130); supplying power to the electric connection terminals (140) to heat the arch-shaped heating element (130) so that the second plastic pipe (120) is fused to the first plastic pipe (110); and forming the connection hole (111) in the cover (121), the arch-shaped heating element (130) and the side surface of the first plastic pipe (110), so that the first plastic pipe (110) and the second plastic pipe (120) communicate with each other.
US10226897B2 Apparatus and methods for impinging a fluid on a substrate
Apparatus and methods for impinging a heated fluid onto the surface of a substrate and then locally removing the impinged fluid. The apparatus and methods may be used to heat a surface of a substrate e.g. so that the substrate can be melt-bonded to another substrate.
US10226894B2 Method and apparatus for making tangible products by layerwise manufacturing
The invention relates to a method and a production line for making tangible products by layerwise manufacturing.The production line comprises (i) a first and a second building platform (102, 112) for carrying a tangible product, (ii) a deposition head (101) for providing a layer of construction material onto the building platforms, (iii) a conveyor (103) for conveying the building platforms in a conveying plane towards and away from the deposition head repeatedly, (iv) height adjustment means (107) to adjust the distance between the deposition head and the building platforms by displacing the building platforms relative to the conveyor in a direction (104) perpendicular to the conveying plane. The production line may further comprise a picking unit (106) for picking a product from the building platforms.The method allows making different tangible products in a continuous process by layerwise manufacturing. The method comprises a step of moving the platforms on which a product is made repeatedly past a material providing device for depositing subsequent layers and a step of adjusting the distance between such device and the building platforms by moving the platforms in a vertical direction.
US10226893B2 Load bearing surface
An elastomeric load hearing surface with different load support characteristics in different directions. In one embodiment, the surface includes an elastomeric membrane that is oriented in only a single direction, for example, by compression or stretching. In another embodiment, the surface includes mechanical structures, such as connectors and variations in thickness that vary the load support characteristics in different directions. In another embodiment, a surface is both oriented and includes mechanical structures.
US10226892B2 Method for manufacturing continuous composite tube, apparatus for manufacturing continuous composite tube
Method for manufacturing a continuous composite tube comprising translating a tube liner through a manufacturing station wherein the manufacturing station comprises a winding station and a consolidation station located at a distance downstream of the winding station; winding a composite tape on the tube liner at the winding station for forming a tape layer; consolidating the composite tape on the tube liner at a consolidation zone of the consolidation station by pressing and heating to the tape.
US10226891B2 Methods, system and apparatuses for in situ removal of window distortion
Methods systems and apparatuses for reducing or substantially eliminating distortion in a transparent substrate in situ are disclosed.
US10226889B2 Method of injection molding using one or more external sensors as a virtual cavity sensor
A injection molding method involves measuring, using at least one external sensor, a change in a parameter of a mold side of a mold cavity, approximating a condition within the mold cavity based on the change in the parameter, such as pressure within the mold cavity or flow front position, and comparing the approximated condition to a trigger point. If the approximated condition equals or exceeds the trigger point, activating a virtual cavity sensor having an optimal pre-defined pressure-time curve, and upon activation, the virtual cavity sensor tracks an approximated condition calculated from the change in parameter measurements measured by the at least one external sensor over time. In an embodiment, results of the approximated parameter tracking can be used in conjunction with an optimal pre-defined pressure-time curve.
US10226887B2 Mold apparatus and resin molding method
The mold apparatus (1) includes: the stationary mold (12) of the mold main body (2) that molds the main body part (81); the rotary core (20) that molds the undercut part (82) and mold releases by rotationally moving in a direction separating from the undercut part (82); and the restricting core (40) that restricts movement of the rotary core (20) sandwiching between the stationary mold (12) and rotary core (20) during molding, and releases restriction of the rotary core (20) by moving in a direction exiting from between the stationary mold (12) and rotary core (20) during mold release of the rotary core (20) from the undercut part (82).
US10226885B2 Porous insert for nozzle of an injection molding system
A nozzle assembly for an injection molding system has a nozzle adapter with one or more vent holes therein. A porous metal insert is provided in fluid communication with at least one of the vent holes. The porous metal insert is also in fluid communication with a flow channel through the nozzle assembly. As molten polymeric material advances through the flow channel from a barrel to a mold assembly, gases entrained in the molten polymeric material are vented through the porous metal insert and escape through the one or more vent holes. Pressurized air may be introduced through the vent holes, such as by one or more blow-back modules, to unclog pores of the one or more porous metal inserts between shots of the injection molding system.
US10226884B2 Method for making visor
Disclosed are a visor and a method of making the same. The method includes 1) preparing molds and molding material, 2) performing a primary injection molding, and 3) performing a secondary injection molding. According to the method, the first part and the second part are independently made on an injection mold, therefore the hardness of the first part and the second part can be made to be different so that the visor body consisting of the first part and the second part has different hardness at different positions. The disclosure further includes a visor, comprising a visor body which is composed of a first part and a second part, where the hardness of the first part is less than that of the second part.
US10226879B2 Cutting and sealing apparatuses and methods
A cutting apparatus configured to hold an elongate element, such as a ribbon, in a desired orientation as the elongate element is cut into two sections. A cutting element of such a cutting apparatus may be confined to a single orientation relative to that of the elongate element, reducing or eliminating the likelihood of misalignment between the cutting element and the elongate element immediately before the elongate element is cut. In some embodiments, the cutting apparatus, or even its cutting element, may be configured to seal the newly cut ends of the elongate element. Methods for cutting and or sealing elongate elements, such as ribbons, are also disclosed.
US10226878B2 Part pack optimization
A food slicing machine is provided for slicing food products such as bacon, cheese or cooked meat for sale as groups of slices in separate packs. The food slicing machine includes a cutter for cutting slices from the food product and a controller for controlling the thickness of the slices. The machine cuts slices according to a first value of a slicing parameter until the controller determines when the amount of food product remaining to be sliced in an end portion of the food product is less than a predetermined group weight threshold. The controller causes a slice to be cut according to a second, different value of the slicing parameter from the end portion for addition to an under-weight group of slices, so that its weight at least equals the predetermined group weight threshold.
US10226877B1 Systems and methods of separating tubing sleeves from a tubing holder
A method includes using a feed system to feed a tubing holder toward a cutting system. A plurality of sections of tubing are coupled at intervals along a first spine of the tubing holder, each of the plurality of sections of tubing extending away from the first spine in a direction that is transverse to a feed direction of the feed system. The method also includes using the cutting system to cut a first section of tubing of the plurality of sections of tubing. The cutting system cuts the first section of tubing at a plurality of locations to separate a plurality of subsections of the first section of tubing.
US10226876B2 Dual slice bread machine
A dual slice bread machine for cutting slits into loaves of bread perpendicular to a conventional bread slice. The present system has an actuating rack having a series of regularly spaced piercing knives mounted thereon. The actuating rack is configured to be raised and lowered automatically. In use, a loaf of bread is placed underneath the actuating rack. When the actuating rack is lowered, the knives puncture the loaf, creating a series of vertical slits along the length of the loaf. The loaf is then cut with a conventional bread slicing machine where the slices alternate between a slice that dissects a vertical slit and a cut that is positioned exactly in between two adjacent vertical slits. This creates a loaf with slices having a centered living hinge capable of being easily folded and separated into equal halves.
US10226870B1 Yaw slip handling in a robotic device
An example method may include determining a requested yaw for a body of a robot, where the biped robot comprises a foot coupled to the body via a leg. The robot may then detect, via one or more sensors, a yaw rotation of the body with respect to a ground surface, where the foot is in contact with the ground surface. Based on the detected yaw rotation of the body, the robot may determine a measured yaw for the body. The robot may also determine a target yaw for the body, where the target yaw for the body is between the measured yaw for the body and the requested yaw for the body. The robot may then cause the foot to rotate the body to the target yaw for the body.
US10226863B2 Industrial robot
The present invention is to provide an industrial robot, which is placed in vacuum for use, capable of efficiently cooling down hand- or arm-driving motors which are arranged inside the arm in air. The industrial robot is provided with a motor for rotating a second arm unit with respect to a first arm unit, a motor for rotating a hand with respect to the second arm unit, a reduction gear for reducing the rotation of the motor and transmitting it to the second arm unit, and a reduction gear for reducing the rotation of the motor and transmitting it to the hand; the hand and the arm are placed in vacuum. The reduction gears and are coaxially arranged so that the center of rotation of the second arm unit with respect to the first arm unit coincides with the axial centers of the reduction gears. The interior space of the hollow first arm unit is kept at atmospheric pressure in which the motors and the reduction gears are arranged.
US10226860B2 Enhanced action hand tool system
A cleaning implement is described, which can have an elongate handle with a proximal end, a distal end, and an interior surface. The interior surface of the elongate handle can define an interior cavity of the elongate handle. An elastic element can be secured within the interior cavity of the handle at the proximal end. A motion rod can also be concentrically secured within the interior cavity of the handle, adjacent to the elastic element. The motion rod can have an exposed end protruding out of the elongate handle at the distal end, and the exposed end can have a tip with a tool attachment feature.
US10226859B2 Power tool
It is an object of the invention to provide a technique for increasing the degree of freedom in designing a grip part in order to improve operability of a power tool. A representative electric vibration tool 100 is provided which mainly includes a body housing 101, an inner housing 110, a driving motor 115 and a spindle 124. A blade 145 as a tool accessory is held between the spindle 124 and a clamp shaft 127 and driven by the driving motor 115. The driving motor 115 and the spindle 124 are housed within the inner housing 110. The inner housing 110 is housed within a front region of the body housing 101. A grip part 107 is arranged behind the front region of the body housing 101.
US10226854B1 Methods of manufacturing a polycrystalline diamond compact including an at least bi-layer polycrystalline diamond table
In an embodiment, a polycrystalline diamond compact (“PDC”) includes a substrate and a polycrystalline diamond (“PCD”) table bonded to the substrate. The PCD table includes an upper surface. The PCD table includes a first PCD region including bonded-together diamond grains and exhibits a first diamond density. At least a portion of the first PCD region extending inwardly from the working surface is substantially free of metal-solvent catalyst. The PCD table includes an intermediate second PCD region bonded to the substrate, which is disposed between the first PCD region and the substrate. The second PCD region includes bonded-together diamond grains defining interstitial regions, with at least a portion of the interstitial regions including metal-solvent catalyst disposed therein. The second PCD region exhibits a second diamond density that is greater than that of the first diamond density of the first PCD region.
US10226850B2 Hand power tool having an electronically commutated electric motor
A hand power tool includes at least one electric-motor drive that is configured to act upon at least one motor shaft, and that is accommodated by a first housing part, the motor shaft and the first housing part defining a first common axis. The electric-motor drive is an electronically commutated electric motor. The hand power tool further includes at least one output shaft configured to drive a tool in an oscillating manner, and at least one second housing part that is configured to accommodate a rechargeable battery, the rechargeable battery and the second housing part defining a second common axis.
US10226847B2 Machining system
A machining system including a base; multiple work modules arranged in an arrangement direction on the base, at least one of the multiple work modules being a processing module, which processes a work with a tool, provided with a main shaft head including a main shaft on which a tool is attached and a main shaft rotating device that rotates the main shaft; a head raising and lowering device that moves the main shaft head in a vertical direction; a head moving device that moves the main shaft head in a horizontal plane by moving it in two perpendicular directions; and a work table that holds a work; the processing module being configured so as to be pulled from the base along a path extending in an intersecting direction, which is a direction perpendicular to the arrangement direction.
US10226840B2 Method of forming an optical device
A method of forming an optical device comprises applying a laser beam to a target area of the surface so as to selectively heat material of the surface thereby to provide transfer of material due to a surface tension gradient, wherein the surface is such that, when liquid, parts of the surface at higher temperatures have a higher surface tension than adjacent parts of the surface at lower temperatures.
US10226838B2 Laser light irradiation apparatus and laser peening treatment method
An embodiment is to provide a laser light irradiation apparatus and a laser peening treatment method, by which even a member to be processed, existing in a narrow portion, can be easily processed by laser peening. The laser light irradiation apparatus 1 according to the embodiment includes: an optical fiber 2 through which laser light is guided; a condensing lens 3 that is placed on one end of the optical fiber, the condensing lens and the optical fiber defining the light path of the laser light; a guide 4 that retains the optical fiber; and a movement mechanism 5 for changing the position of the optical fiber, wherein the light path of the laser light guided through the optical fiber is emitted at an angle changed to more than 0° and less than 90° with respect to the central axis of the optical fiber by the condensing lens.
US10226834B2 Welding gun alignment detection device
A welding gun alignment detection device is provided. The device includes an upper block, a lower block, a housing, and a side pressure sensor. The upper block includes a central portion that has an upper tip insertion bore opened upward. The lower block is disposed under the upper block and has a central portion with a lower tip insertion bore opened downward. The housing includes the upper block and the lower block disposed therein and includes inner sides each facing outer sides of the upper block and the lower block. The side pressure sensor is configured to detect a force transferred to the inner side of the housing due to a movement of the upper block and the lower block.
US10226827B2 Hand-held power-tool footplate apparatus
A hand-held power-tool footplate apparatus for portable power tools includes at least one main body unit configured to be removably positioned on a power-tool housing of a portable power tool, at least one housing abutment configured to abut against the power-tool housing, and at least one clamping surface located on a side that faces away from the housing abutment of the main body unit. The main body unit has a multi-point position fixing unit which has at least two pivot locking stops that differ from each other and that are configured to pivot angle lock the main body unit.
US10226821B2 Apparatus for producing fine particles and method for producing fine particles
An apparatus and a method for producing fine particles capable of increasing the production and producing fine particles at low costs by feeding a large quantity of material efficiently into the plasma. The apparatus includes a vacuum chamber, a material feeding device connected to the vacuum chamber and feeding material particles into the vacuum chamber from material feeing ports, a plurality of electrodes connected to the vacuum chamber, tip ends of which protrude into the vacuum chamber to generate plasma and a collecting device connected to the vacuum chamber and collecting fine particles, which generates discharge inside the vacuum chamber and produces the fine particles from the material, in which the material feeding ports of the material feeding device are arranged in a lower side than the plural electrodes in the vertical direction in the vacuum chamber.
US10226818B2 Process for joining powder injection molded parts
A process for joining two or more powder injection molded parts by preparing at least two green parts from a feedstock including a binder and an injection powder. Placing the two or more green part into intimate contact, and maintaining the two green parts in intimate contact at a position with a linkage between the at least two green parts to produce an interconnected green assembly. Placing the assembly under shape retaining conditions, melting the binder of the interconnected green assembly under shape retaining conditions to produce a seamless body.
US10226814B2 Cast component having corner radius to reduce recrystallization
A cast component includes a cast body that has a single crystal microstructure and an internal corner bounding an internal cavity. The single crystal microstructure defines a critical internal residual stress with respect to investment casting of the cast body using a refractory metal core beyond which the single crystal microstructure recrystallizes under a predetermined condition. The internal corner has a corner radius that is greater than a critical corner radius below which an amount of internal residual stress in the single crystal microstructure exceeds the critical internal residual stress. The internal cavity includes a cross section less than about 20 mils near the corner radius.
US10226809B2 Method for producing a shaped sheet metal part having wall thicknesses differing from each other by region, and axle subframe
A method for producing a shaped sheet metal component having wall thicknesses differing from each other is disclosed including providing a sheet metal material having a constant wall thickness, pre-shaping the sheet metal material into a preform by means of a hold-down press, producing at least one bulge in an inner region such that the material is stretched and has a reduced wall thickness, flattening and/or extending the produced preform, cutting the sheet metal material in order to form a blank before, during, or after the pre-shaping, and shaping the blank into the shaped sheet metal component.
US10226802B2 Cold pilger rolling mill and method for forming a tube shell to a tube
A cold pilger rolling mill for forming a tube shell to a tube includes a feed clamping carriage for receiving the tube shell and with a drive that is arranged to move the feed clamping carriage such that during the operation of the cold pilger rolling mill the tube shell moves step-by-step in the direction of the tool. A control and a sensor detect a measure of a force exerted during the operation of the cold pilger rolling mill by the tool onto the tube shell, and wherein the control is connected to the drive and the sensor. The control is arranged to regulate, during the operation of the cold pilger rolling mill, the step length per advance step with which the drive moves the feed clamping carriage to the tool as a function of the measure for the force, which measure is detected by the sensor.
US10226796B2 Method for cleaning drink filling system
An object of the present invention is to make short a manufacturing time at a time of switching a kind of a filling drink. In a cleaning method of a drink filling system provided with a drink supply pipe line for supplying a drink to a filling machine (2) and an aseptic chamber (3) surrounding at least the filling machine, the cleaning method is performed by executing program including at least two of first, second and third programs, wherein the first program corresponds to an aseptic carbonated drink and executes a COP treatment performed for an interior of the aseptic chamber and a CIP treatment performed for an interior of the drink supply pipe line, the second program corresponds to a high acidic drink and executes the COP treatment and an SOP treatment performed for the interior of the aseptic chamber and a CIP treatment and an SIP treatment performed in the interior of the drink supply pipe line, and the third program corresponds to a low acidic drink and executes the COP treatment and the SOP treatment performed for the interior of the aseptic chamber and the CIP treatment and the SIP treatment performed in the interior of the drink supply pipe line, and wherein either one of the three programs is enabled to be selectively executed, and in a case where the drink is an aseptic carbonated drink, the first program is selected, in a case where the drink is a high acidic drink, the second program is selected, and in a case where the drink is a low acidic drink, the third program is selected, to thereby clean the interiors of the aseptic chamber and the drink supply pipe line before filling of the drink in accordance with the selected program.
US10226795B2 Vision based item typing and separation system
A typing tunnel off-loading and sorting system includes an off-loading conveyor, cameras and photoelectric eye. The overhead cameras detect the item size and whether it is cubic in nature and type and size of its footprint. An in-line slide sorter having alternating conveyor rollers and pop-up belts pass through to, or divert articles from, a downstream conveyor. The vision based system may also be used to detect space between articles and insert articles in the unoccupied space.
US10226792B2 Synchronized array of vibration actuators in an integrated module
The disclosure relates to integrated modules for Synchronized Array of Vibration Actuators (FIG. 125A). The modules provide physical interface, power and communication interfaces. Each module may include vibration actuators (FIG. 123A) which can be precisely attached and aligned to the module housing, a microcontroller or other microprocessor, and one or more sensors for closed loop control of actuators (FIG. 126G). Interleaved pairs of ERMs having a center of mass in the same plane eliminate parasitic torque. A single module can produce a vibration force that rotates at a specific frequency and magnitude, which on its own could cancel out some types of periodic vibrations (FIG. 125B). Two modules paired together and counter-rotating with respect to each other can produce a directional vibration at a specific frequency and magnitude, which could prove even more useful for canceling out a vibration. Such modules are also employed to produce beating patterns (FIGS. 131-133). Both amplitude and frequency of the beating force are variable.
US10226791B2 Cold spray system with variable tailored feedstock cartridges
A feedstock cartridge for a cold spray system including at least one powder; and a binder that interconnects at least two particles of the at least one powder.
US10226788B2 Attachment coating method
An attachment coating method including, mixing a conductive attachment into an insulating liquid, immersing an attachment target in the insulating liquid in which the attachment is mixed, and applying ultrasonic vibration to the insulating liquid in which the attachment target is immersed and causing friction between the attachment target and the attachment to charge the attachment target and the attachment.
US10226787B2 Method for coating a cylinder wall of an internal combustion engine
A method for coating a cylinder wall of an internal combustion engine, in which the cylinder wall is roughened prior to coating, such that the cylinder wall is compressed prior to roughening by plastic deformation.
US10226786B2 Powder pipe coating booth
Apparatus for coating a heated pipe section with a fusible powder includes a booth enclosing a powder application volume, at least one powder dispensing device for dispensing powder supplied to the device in the direction of the heated pipe section as the heated pipe section passes through the volume, and a filter mechanism coupled to the booth for extracting from the booth a stream of air entraining fusible powder that does not stick to the heated pipe section and extracting the fusible powder that does not stick to the heated pipe section from the volume. The apparatus further includes an opening between the volume and the filter mechanism. The opening permits the mixing of cooler air into the stream of air entraining fusible powder that does not stick to the heated pipe section before the stream of air entraining fusible powder that does not stick to the heated pipe section reaches the filter mechanism.
US10226784B2 Dispensing device of a fluid substance
Fluid substance dispensing device including a dispensing button provided with a hole for tight coupling with a hollow stem of a pump or a valve, and a dispensing opening associated with a shutter that, at least when subjected to fluid substance to be dispensed pressure, translates in contrast to an elastic element freeing the dispensing opening. The shutter having at least one projection cooperating with mechanical opening element associated with the dispensing button. The opening element devoid of fluid substance passages and having a first fixing portion to the dispensing button and a second portion to abut, in use, a fixed part from which the stem extends. At least one elastically deformable part mutually interconnecting the first and second portions. An actuation lever extending from second portion cooperating with the projection to open the shutter when the second portion contacts fixed part consequently deforming elastically deformable part.
US10226781B2 On-demand, inline, adjustable PSI commercial grade battery powered fluid pump apparatus with manual pump option
An automated chemical fluid applicator apparatus includes a container of fluid chemical having an integrated pressurization device and an outlet for releasing the fluid chemical. A portable, battery-powered fluid pumping apparatus is retrofitable to the container and has housing having at least one fluid inlet port and at least one fluid outlet port, wherein the at least one fluid inlet port is connectable to the outlet of the container. A liquid diaphragm pump is positioned within the housing. A battery is removably connectable to a battery terminal connector formed on the housing, wherein the battery powers the liquid diaphragm pump. A control switch is positioned on the housing and controls activation of the liquid diaphragm pump to expel the quantity of fluid chemical from the at least one fluid outlet port.
US10226779B2 Spray for cleaning products
The sprayer comprises a container (1) intended to hold liquid for forming the cleaning mass and pressurized air for spraying it, the container (1) being dismantlably attachable to a head (3) bearing a manual pump (4) to increase the pressure of the air, the head (3) also having a supporting handle (23) with a pushbutton (24) operating the outlet valve (18) for the cleaning mass to the delivery nozzle (22), the sprayer having a manually replaceable mixing device (7, 26) located between the outlet conduit (8) for the liquid from the sprayer container (1) and the outlet of damping mass (20) controlled by the manual valve (18), the mixing device (7, 26) having different passage cross-sections for the liquid and the air present in the container (1) in order to adjust the sprayer to provide cleaning masses with a drier or wetter foam consistency.
US10226778B2 Systems, lances, nozzles, and methods for powder injection resulting in reduced agglomeration
A lance for powder injection resulting in reduced agglomeration, including an outer tubular member having a first end, a second end, and an inner flowpath extending from the first end to the second end; an inner tubular member having a first end, a second end, and a, inner flowpath extending from the first end to the second end, the inner tubular member disposed within the inner flowpath of the outer tubular member for providing an annular space between the outer tubular member and the inner tubular member; and one or more orifices in the inner tubular member for providing a flowpath between the annular space and the inner flowpath of the inner tubular member. Additional lances, systems, and methods are also included.
US10226775B2 Apparatus for removing particulate matter from liquids
A dielectrophoretic separator has a separator vessel having a fluid ingress at a first side and a fluid egress at a second side, an electrode electrically connected to a power source and contained within the vessel, along the central axis, a plurality of high permittivity dielectric rods within the vessel positioned around and parallel to the electrode, wherein the electrode has a first polarity and the vessel has a second polarity such that an electromagnetic field is generated between the electrode and the vessel. A method of performing a separation cycle has the steps of: i) powering up an electrode within a vessel such that the electrode and vessel have an opposite polarity, wherein a plurality of high permittivity dielectric rods are contained within the vessel, ii) the fluid passing through channels between the rods, iii) the solid particles within the fluid being retained against the rods by electrical field(s).
US10226772B2 Combined thermal devices for thermal cycling
The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.
US10226768B2 Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
In certain embodiments this invention provides a pulsed-laser triggered microfluidic switching mechanism that can achieve a switching time of 70 μs. This switching speed is two orders of magnitude shorter than that of the fastest switching mechanism utilized in previous μFACS.
US10226759B2 Overpotential and selectivity in the electrochemical conversion of CO2 into fuels
The invention provides a catalyst and method for producing hydrocarbons from a carbon dioxide source comprising carbides, in particular one or more metal carbides. The one or more metal carbides are formed with one or more elements selected from the group consisting of molybdenum, titanium, tungsten, iron, and tantalum. In one embodiment, the one or more metal carbides are nanostructures. In another embodiment, the one or more metal carbide nanostructures are supported by a carbon substrate. In a further embodiment, the one or more metal carbides nanostructures is dimolybdenum carbide. In still another embodiment, the carbon substrate is graphene or graphene oxide. In another embodiment, the dimolybdenum carbide nanostructures are supported by the graphene or graphene oxide substrate.
US10226756B2 Catalytic composition for synthesizing carbon nanotubes
The present invention relates to a catalytic composition for the synthesis of carbon nanotubes, comprising an active catalyst and a catalytic support, the active catalyst comprising a mixture of iron and cobalt in any oxidation form and the catalytic support comprising exfoliated vermiculite.
US10226753B2 Process for producing superabsorbents
The invention relates to a process for producing superabsorbents, comprising the preparation of partly neutralized acrylic acid by the steps (i) preparing an over-neutralized acrylic acid having a degree of neutralization of at least 100.1 mol-% by mixing of an acrylic acid 1 and a base and (ii) preparing a neutralized acrylic acid having a degree of neutralization from 50 to 85 mol-% by mixing of the over-neutralized acrylic acid and an acrylic acid 2, wherein the content of dimeric acrylic acid in the acrylic acid 2 is lower than the content of dimeric acrylic acid in the acrylic acid 1.
US10226752B2 Adsorbent for adsorbing virus and/or bacterium, carbon/polymer composite and adsorbent sheet
[Object] To provide an adsorbent, an adsorbent sheet, and a carbon/polymer composite for adsorbing a virus having further improved virus adsorption capability.[Solving Means] An adsorbent for adsorbing a virus according to the present invention has a specific surface area value as measured by the nitrogen BET method of 10 m2/g or more and a pore volume as measured by the BJH method of 0.1 cm3/g or more. An adsorbent sheet for adsorbing a virus according to the present invention includes a porous carbonaceous material having a specific surface area value as measured by the nitrogen BET method of 10 m2/g or more and a pore volume as measured by the BJH method of 0.1 cm3/g or more. A carbon/polymer composite for adsorbing a virus according to the present invention includes a porous carbonaceous material having a specific surface area value as measured by the nitrogen BET method of 10 m2/g or more and a pore volume as measured by the BJH method of 0.1 cm3/g or more; and a binder.
US10226747B2 Multiple batch system for the preparation of a solution of calcium hydrogen carbonate suitable for the remineralization of desalinated water and of naturally soft water
The invention relates to a multiple batch system for the preparation of a solution of calcium hydrogen carbonate and the use of such a dual batch system for the preparation of a solution of calcium hydrogen carbonate.
US10226746B2 Removable nozzle assembly and gas transfer system
The present technology relates to a gas transfer system having removable nozzle assemblies, ejectors or other gas transfer device(s). The nozzle assemblies are removably connected to a monolithic liquid/gas manifold. The present technology also provides nozzle assemblies having an inner nozzle, an outer nozzle adapted for connection to the inner nozzle, and a pipe adapter for connecting the inner nozzle to a liquid manifold.
US10226740B2 Membrane and electrodialysis based seawater desalination with salt, boron and gypsum recovery
A method of producing desalinated water and recovering minerals from the feedwater uses membrane separation and electrodialysis brine concentration. This process can recover all of the minerals as high purity industrial minerals, including capturing the calcium and sulfate as agricultural grade gypsum and boron as high purity boric acid. In addition the process allows the use of low cost lime or dolime to produce valuable magnesium hydroxide.
US10226739B2 Methods relating to isotopic water filtration
Methods for manufacturing an isotopic filtration module and methods for filtering water according to its isotopic forms. In some implementations, graphene oxide flakes may be dispersed in an aqueous medium to form a graphene oxide solution. The graphene oxide solution may be applied to a substrate to form a laminated graphene oxide membrane comprising a plurality of graphene oxide sheets coupled together in a layered, interlocking structure.
US10226738B2 Apparatus and method for gaseous emissions treatment using front end induction heating
An assembly for treating gaseous emissions includes a substrate body having a front and a rear and cells for the passage of emissions gas. Inductance heating metal is located in the substrate body and an induction heating coil is mounted adjacent the substrate body for generating a varying electromagnetic field for inductively heating the metal and thereby heating the substrate body. A greater concentration of the metal is located near the front of the substrate body than near the rear.
US10226737B2 Catalyst modules and applications thereof
In one aspect, catalyst modules and catalytic reactors are provided which, in some embodiments, mitigate inefficiencies and/or problems associated with fluid stream pressure drop A catalyst module comprises a layer of structural catalyst bodies arranged in a pleated format, the structural catalyst bodies forming pleat inlet faces and pleat outlet faces, wherein fluid flow channels defined by inner partition walls of the structural catalyst bodies extend from the pleat inlet faces to the pleat outlet faces. The pleat inlet faces form an angle (δ) with an inlet face of the module.
US10226735B2 Integrated enhanced heat exchange method by combining boundary layer control with mainstream disturbance
An integrated enhanced heat exchange method by boundary layer control with mainstream disturbance comprises a multiple of heat transfer enhancement units, in which a periodic vortex is formed along a extending direction of the flow control channel by setting boundary layer flow control devices, the vortex cleans the cold and hot side walls, as a result the flow boundary layer that hinders heat transfer is destroyed, and rapidly transferring cold and heat energy generated from the cold and hot side walls to a flow mainstream channel is realized. A mainstream disturbance device is set on the mainstream of flow to form an axial vortex at the back of the mainstream disturbance device, the axial vortex cooperates with a stream from the flow boundary layer to rapidly transfer the cold and heat energy from the flow boundary layer to entire field to form an even temperature field.
US10226734B2 Hybrid solvent formulations for selective H2S removal
A method of treating oil and gas streams including hydrogen sulfide (H2S) comprising treating the gas stream with an aqueous solution of an amine and a physical solvent which, when mixed in equal mass ratio with the amine or amine mixture, display a dielectric constant of at least about 20, wherein the pKa of the amine is at least about 9.0 and the amine boiling point is at least 200° C.
US10226733B2 Process for CO2 capture using carbonates and biocatalysts
A formulation and process for capturing CO2 use an absorption mixture containing water, biocatalysts and a carbonate compound. The process includes contacting a CO2-containing gas with the absorption mixture to enable dissolution and transformation of CO2 into bicarbonate and hydrogen ions, thereby producing a CO2-depleted gas and an ion-rich solution, followed by subjecting the ion-rich solution to desorption. The biocatalyst improves absorption of the mixture comprising carbonate compounds and the carbonate compound promotes release of the bicarbonate ions from the ion-rich solution during desorption, producing a CO2 gas stream and an ion-depleted solution.
US10226732B2 Diagnostic breather dryer
A breather including desiccant for humidity control includes an electronic end of life detection system. A temperature sensor and humidity sensor provide a temperature and humidity of the desiccant to a controller. The controller determines the relative humidity of the desiccant. The controller determines that the desiccant, and thus breather, has reached its end of life (i.e., end of useful life) when the relative humidity reaches a predetermined relative humidity (e.g., 40%). Optionally, a pressure sensor provides a pressure of the reservoir to the controller. The controller determines a fault condition or end of life condition of the breather when the pressure exceeds a predetermined pressure.
US10226731B2 Xenon collection method and system
A method and system for collecting xenon (Xe) is described. A microchannel heat exchanger is used in combination with a mechanical cooler and an absorbent. A combination of components makes up a Xe Collection Subsystem that is adapted for use in an efficient process for collecting, purifying, and measuring Xe isotopes collected from air as part of the International Monitoring System.
US10226730B2 Filter medium for air filter, filter pack, air filter unit, and method for producing filter medium for air filter
A filter medium includes first and second porous films mainly containing fluororesin, and a pre-collection member upstream of the first film. The second film is downstream of the first film. The pre-collection member has a pressure drop when air is passed through at a flow rate of 5.3 cm/s of between 15 Pa and 55 Pa, a collection efficiency of NaCl particles having a particle diameter of 0.3 μm when air containing the particles is passed hrough at a flow rate of 5.3 cm/s of between 25% and 80%, a thickness of 0.4 mm or less, and a PF value between 7 and 15. The PF value={−log((100−collection efficiency (%))/100)}/(pressure drop (Pa)/1000). A ratio of the PF value of the pre-collection member to the PF value when the first and second films are overlapped, is between 0.20 and 0.45. The filter medium can be used in a filter pack or filter unit, and may be produced by integrating the first and second films and the pre-collection member using heat lamination.
US10226728B2 Sterilizing method and apparatus
Methods and apparatus for sterilization are presented. An exemplary embodiment includes a sterilizing cabinet assembly. The sterilizing cabinet includes a cabinet having an access port, a door connected to the cabinet, the door moveable between an open position permitting passage through the access port to an interior of the cabinet and a closed position precluding passage through the access port. The sterilizing cabinet assembly also includes at least one of the cabinet and the door having a vent port. The sterilizing cabinet has a primary filter overlying the vent port and forming a sealed interface with an adjacent portion of the one of the cabinet and the door and a secondary filter overlying at least a portion of the primary filter.
US10226727B2 Filter assembly with cam-lock filter interface
A filter assembly may include a housing and a cover movably connected to the housing and movable between an open position and a closed position. The filter assembly may also include at least one projection extending from the cover towards an interior of the housing and a filter element that fits at least partially within the housing. When the cover is moved from the open position to the closed position, at least one projection interfaces with the filter element and causes the filter element to pivot within the housing, such that the at least one projection seals the filter element and the housing together when the cover is in the closed position.
US10226724B2 Dust collector with a constant suction force
A separator provides mechanical separation of suspended particles or debris within a fluid. The separator includes a cylindrical body having an inlet pipe for directing the fluid generally tangentially into the cylindrical body, causing the fluid to spin around the inside diameter of the cylindrical body. An outlet pipe, having an outer diameter smaller than the inside diameter of the cylindrical body, can extend from a top end of the cylindrical body into the cylindrical body. Directional blades can be disposed on an outer surface of the outlet pipe, with a gap between the directional blades and the inside surface of the cylindrical body. A baffle dome disposed an a lower end of the cylindrical body slows down the fluid flow, causing the particles and debris to remain below the baffle and settle. The fluid then exits out the outlet pipe as a cleaned fluid.
US10226723B2 Liquid filtration media, filter elements and methods
A filter and filter media configured and arranged for placement in a fuel stream is disclosed. The filter and filter media allow for filtering of liquid fuels, such as diesel fuel. In certain embodiments the filter media includes a media fiber (such as glass) and a binder fiber (such as bicomponent) that combine to create a media structure having low solidity and relatively low compressibility, and which contain a pore structure that avoids premature fouling of the filter by fuel degradation products.
US10226719B2 Adsorptive separation of multi-component fluid mixtures
An adsorptive separation process and system are used for separation of multi-component fluid mixtures. The separation process and system may include establishing, in a fluid flow within the system, a concentration distribution of the fluid mixture components based upon the components' relative affinities to the adsorbent. The concentration distribution could be establishing using a simulated moving bed system, wherein it is possible to maintain separately-identifiable portions of the fluid flow, respectively rich in strongly-adsorbing, intermediately-adsorbing, and weakly-adsorbing compounds of the fluid mixture. An intermediate raffinate of high purity in the intermediately-adsorbing compound is directly withdrawn from the portion of the fluid flow rich in intermediately-adsorbing compound(s), providing a single-stage adsorptive separation of a compound having intermediate affinity to the adsorbent. The portion of the fluid flow rich in intermediately-adsorbing compound(s) may be established directly upstream from the point of fluid mixture feed injection into the fluid flow.
US10226717B2 Method of recovering solvent from tailings by flashing under choked flow conditions
A tailings solvent recovery unit (TSRU) recovers a solvent from a solvent diluted tailings and includes a separation apparatus which has a flash vessel, tailings outlet, solvent outlet and an inlet spray system for supplying the diluted tailings to the flash vessel. The spray nozzle system may include multiple nozzles arranged around the periphery of the flash vessel for flash-atomization over its cross-section of the flashing chamber, a nozzle sized and configured to provide choked flow of the diluted tailings, multiple nozzles each being operable in an on/off mode to regulate a total feed flow, or multiple nozzles associated with a distributor and multiple feed conduits.
US10226716B2 Device for reducing the alcohol content of wines and other alcoholic beverages
A device for reducing the alcohol content of wines and other alcoholic beverages, comprising a distillation column (71) of the liquid to be treated, a first sensor (31) for measuring the temperature of the liquid, a heating resistance (41) for heating the liquid, a second sensor (55) for measuring the temperature of the vapors in the column (71) and an outlet pipe (60) of the vapors, which is connected to a condenser (18) and then reaches a collection container (24), inside of which the vacuum is provided by means of a setting solenoid valve (20) and a vacuum pump (21), which are connected to a pressure sensor (19); an electronic control circuit (16) detects the measurements made by the temperature sensors (31, 55) and by the pressure sensor (19) and adjusts the power of the heating resistance (41) and the opening of the setting solenoid valve (20).
US10226712B2 Walking animal toy apparatus and methods of making and using the same
Mechanical toy animals include internal mechanisms that allow the toy animals to simulate live animals. The present invention allows children to physically “walk” the toy animal on a leash. Methods of making and using the same are further provided.
US10226711B1 Arbitrarily shaped skeleton
An arbitrarily shaped skeleton, comprising: a main frame body and limbs disposed on the main frame body; wherein the main frame body is formed with mounting holes for mounting the limbs, one end of the limb is mounted in the mounting hole, and the limb is made of a telescopic structure which can be arbitrarily bent and stretched. The doll made by the skeleton can make a variety of poses, and when the limbs are stretched, the limbs can have the sound of plastic deformation, it is more interesting. The main frame and limbs are made of plastic injection molding, and its cost is low and easy to assemble, simplifying the production process and having more market competitiveness.
US10226708B2 Interactive gameplay playback system
The disclosure provides a video playback system for use within a game application and/or other interactive computing environments. The video playback system can be used to capture gameplay during execution of a game application. The captured gameplay video can be processed and stored within the game application or in a network accessible location.
US10226706B2 Method, system and computer readable recording medium for providing a game ranking in a game service platform
A ranking method and system for providing a ranking of a game friend. The method includes registering a game friend who has joined a game service. The method further includes calculating a ranking of the user with respect to a game friend based on a ranking inquiry request received from the user terminal, and providing the user terminal with the calculated ranking of the user. The user terminal drives a game service platform associated with a plurality of games and provides some information needed for automatic friend registration and the ranking inquiry request information through the game service platform.
US10226701B2 System and method for identifying spawn locations in a video game
Disclosed is a system and method of generating, for a given game map, an LOS catalog before gameplay and identifying a spawn location during gameplay based on the LOS catalog. For every unique pair of map nodes in a game map, the LOS catalog may indicate the minimum distance that must be traveled from a first map node of the pair to achieve LOS to a second map node of the pair, an identifier for the first map node, and an identifier for the second map node. When a gameplay session is initiated, the LOS catalog may be retrieved and used to identify relatively safe spawn points based on distances that must be traveled from enemy positions to achieve LOS to potential spawn points.
US10226699B2 Computer-readable storage medium having game program stored therein, and game apparatus
Approach moving image storage means 10, 12 stores, in a predetermined storage section, display data used for displaying an approach moving image representing an approach method for a predetermined scene in the game, so as to associate the display data with the predetermined scene. Game process means S21 performs the game process, and display process means displays a game image on a display device. Moving image display instruction means S16, S17 receives an input made by a user for providing an instruction for displaying the approach moving image, and game scene determination means S31, S32 determines a scene in the game when the moving image display instruction means receives the input from the user. Moving image display means S36 reads, from the predetermined storage section, the approach moving image associated with the scene determined by the game scene determination means, and displays the approach moving image on the display device.
US10226697B2 Input device with sector geared feedback trigger
A user-input device includes a user-actuatable trigger configured to pivot about a trigger axis, the user-actuatable trigger including a sector gear, a posture sensor configured to determine a posture of the user-actuatable trigger about the trigger axis, and a force-feedback motor configured to drive the sector gear based on a force-feedback signal.
US10226693B2 Smart trigger-stops for videogame controllers
Videogame controllers with smart trigger stops may include: a housing including a trigger, the trigger movable along a path of travel; a sensor configured to detect the position of the trigger and to generate a signal representing trigger position; a processor configured to interpret signals generated by the sensor and cause an output signal to be transmitted to a gaming console; a trigger-stop that is movable between an engaged position and a disengaged position, the trigger-stop in the disengaged position allowing the trigger to move along the entire path of travel, the trigger-stop in the engaged position blocking the trigger from moving along the entire path of travel; and a switch coupled with the housing and the trigger-stop, wherein movement of the trigger-stop from the disengaged position to the engaged position flips the switch and causes the processor to map received signals to generated signals in a different manner.
US10226687B2 Method and apparatus for using upstream communication in a card shuffler
A security system for a casino table card game has a casino table with i) indicia thereon for the placement of wagers, ii) a data entry system with an associated computer, and iii) sensors that can detect the placement of at least one specific category of wager; a shuffling device with a microprocessor integral to the shuffler for providing information regarding cards or hands; a central table gaming computer that receives information from the shuffler in real time, receives information from the sensors, and receives information from the data entry system, the associated computer, the microprocessor and the central table gaming computer communicating data among each other in real time.
US10226682B2 Ball safety netting systems having gate access/egress
A ball safety netting system for use between a field and spectators and above an access/egress gate includes, for example, a main netting defining an opening over an access/egress gate, a gate netting positionable over the opening of the main netting, and wherein the gate netting is disposable in a first position operable to cover the opening in said main netting above the access/egress gate, and disposable in a second position operable to uncover the opening above the access/egress gate.
US10226681B2 Golf clubs and golf club heads having a plurality of sensors for detecting one or more swing parameters
A golf club having a sensor that is releasably connected is disclosed, where the sensor comprises a plurality of inertial measurement units. Each inertial measurement unit is able to measure linear accelerations along three orthogonal axes and angular rates of rotation along the same three orthogonal axes. Each inertial measurement unit is positioned such that at least two of the axes of each inertial measurement unit are oriented differently. Additionally, a process may be implemented by a processor to expand the measurement range of the sensor.
US10226675B2 Water resistant audio upgrade kit for bag toss game
A game surface, such as a top surface of a cornhole game, can be configured to produce a sound by using a sound system mounted on an underside of the cornhole platform. The sound system can use one or more exciters to produce sound through the top surface of each of the two cornhole platforms used for game play. In some embodiments, a communication protocol may link the two sound systems, in each of the two cornhole platforms, so that each platform generates the same sound from a single source. The sound system may be easily retro-fitted to existing cornhole game platforms or may be formed during manufacture thereof.
US10226670B2 Multi-layer core golf ball
Golf balls comprising a multi-layer core and a cover are disclosed. The multi-layer core comprises at least three layers, including at least one thermoset layer and at least one thermoplastic layer. At least one core layer has a plurality of projections disposed thereon.
US10226669B2 Golf ball resin composition and golf ball
A golf ball resin composition includes (A) a styrene-based thermoplastic elastomer having a Shore D hardness of not more than 48 and (B) a thermoplastic resin having a Shore D hardness of at least 49 and containing either styrene monomer units or diene monomer units on the molecule, in a compounding ratio A/B therebetween of from 85/15 to 15/85. Using this resin composition as a golf ball cover material provides the ball with an excellent controllability around the green on shots with a short iron such as a sand wedge. In addition, a sufficient reduction in the spin rate of the ball on shots with a driver is achieved, enabling the distance of the ball to be increased.
US10226668B1 Swim fin
A swim fin and a method proving thrust propulsion during a swimmer's kicking cycle may include a foot pocket and a fin blade extending from the foot pocket. Fin rails may extend along the lateral edges of the fin blade. The fin rails may include an integral fin spine or separately assembled fin spine configured to provide a swim fin with predetermined hydrodynamic characteristics.
US10226667B2 Athletic performance user interface
Athletic data may be recorded and displayed using a computing device such as a mobile communication device during performance of physical activity. In some examples, the device may provide options for defining and recording athletic activity performed by the user. Such options may include various content item selection and rendering controls. Additionally or alternatively, route selection and controls may be provided through the device. Recorded activity data may further be transmitted to a remote site through a network.
US10226660B2 Weight stand assembly
A weight stand assembly for use in assisting a user prior to performing an exercise movement or repetition by way of holding exercise weights used by the user in a relatively stable and proper starting position for the user. More particularly, the weight stand assembly is retractable in that it pivotally falls in a relatively backwards direction away from the user and towards a ground surface after the exercise weights have been lifted by the user, thereby preventing injury and thus enhancing performance of the user by allowing the user to complete a full set of exercise repetitions without being inhibited by a placement and location of the weight stand assembly.
US10226659B2 Clamping device
A clamping device for securely engaging one or more objects through an application of pressure. The clamping device includes a primary member having opposed interior and exterior surfaces. The primary member has a generally cylindrical shape such that the interior surface defines a generally circular space about a center point of the primary member. The clamping device can receive an elongated member through the generally circular space circumscribed by the primary member. The primary member is adapted for clamping and releasing such that the clamping device may releasably engage the elongated member. The elongated member is securely retained by the clamping device through the application of pressure.
US10226656B2 Automatic fire extinguisher system having a safety assembly
A safety assembly provided with an automatic fire extinguisher system includes an engagement member, a blocking member, and an extension member. The engagement member is slidably received within an outlet port of a valve housing. A blocking member having a first blocking member portion and a second blocking member portion is at least partially received within a cavity defined by the valve housing. The extension member extends between the engagement member and the blocking member.
US10226655B2 Fire extinguishing device
An example fire extinguishing apparatus may include a housing comprising at least one escape hole, a first compartment within the housing containing a first extinguishant agent, and a second compartment within the housing containing a second extinguishant agent. The first compartment may be rotatable relative to the second compartment. The apparatus may further include a barrier disposed between the first compartment and the second compartment configured to separate the first extinguishant agent from the second extinguishant agent, and a barrier rupture mechanism. The barrier rupture mechanism may be configured to rupture the barrier in response to rotation of the first compartment relative to the second compartment to permit the first extinguishant agent to mix with the second extinguishant agent and cause a pressure generating reaction that forms an extinguishant mixture and forces the extinguishant mixture through the at least one escape hole of the housing.
US10226652B2 Stovetop fire suppressor with thermal glass bulb actuation and method
An automatic stovetop fire suppressor using a compressed spring to lower a bottom lid upon thermal glass bulb fracture is provided herein. A plastic lid seals on the bottom of a can and forms a closed container. The closed container is filled with a fire suppressing agent. A compressed spring extends when a thermal glass bulb fractures. The extending spring lowers the bottom lid to open the closed container. Fire suppressing agent flows out of the radial opening, suppressing a stovetop fire with minimal or no splashing of cooking oil. A center post is secured to a top wall of the container. A ledge, or bottom support, secured to the container catches the bottom lid to limit the radial opening height. A gradual release of a fire suppressing agent in a desired distribution pattern and method of gradual and spatial agent release can be provided with a cone-shaped bottom lid.
US10226648B2 Agents for dyeing keratin fibres, containing at least one dimeric, dicationic azo dye and at least one non-ionic surfactant
The present disclosure relates to agents for dyeing keratin fibres, in particular human hair, containing, in a cosmetic carrier (a) at least one direct dye of formula (I), and (b) at least one non-ionic surfactant.
US10226647B2 Agents for dyeing keratin fibers, containing at least one dimeric, dicationic azo dye and at least one anionic surfactant
The present disclosure relates to agents for dyeing keratin fibers, in particular human hair, containing, in a cosmetic carrier, (a) at least one direct dye of formula (I), and (b) at least one anionic surfactant.
US10226646B2 Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics
A system and method for adjusting or selecting the treatment parameters for HIFU signals to treat a target treatment site, and/or to aid in visualizing the likely degree and location of HIFU effects on patient tissue. The system transmits one or more test signals into patient tissue and receives signals created in response to the test signals. The signals are analyzed to determine a response curve of how a characteristic of the signal varies with the one or more test signals. The response curve of the detected signals is used to select a treatment parameter.
US10226641B2 Phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems and methods
The present disclosure is directed to a phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems methods. In one embodiment a phototherapeutic apparatus can include a housing at least partially defining an irradiation zone, and an ultraviolet (UV) radiation source carried by the housing. The irradiation zone can be configured to accommodate at least a portion of a human patient. The phototherapeutic apparatus can further include a filter between the UV radiation source and the irradiation zone. The filter can be configured to at least substantially remove UV radiation outside of a predetermined spectrum centered at about 297 nm and having a bandwidth of at most 10 nm.
US10226638B2 Wearable therapeutic device
A wearable monitoring device is provided. The wearable monitoring device includes a garment to hold an electrode, be worn about a subject, and include an orientation circuit. The monitoring device also includes a control unit coupled to the orientation circuit capable of measuring at least one parameter associated with the orientation circuit and determine whether the electrode is positioned in the garment with the conductive surface oriented towards the subject based on the at least one parameter.
US10226636B2 Managing recharge power for implantable medical devices
Devices, systems, and techniques for estimating energy transfer to tissue of a patient during battery charging for an implantable medical device are disclosed. Implantable medical devices may include a rechargeable power source that can be transcutaneously charged. An external charging device may calculate an estimated energy transfer to tissue of the patient that may include a resistive heat loss from the rechargeable power source and/or electromagnetic energy transfer directly to tissue. Based on the estimated energy transfer, the external charging device may select a power level for charging of the rechargeable power source. In one example, the charging device may select a high power level when the estimated energy transfer has not exceeded an energy transfer threshold and select a low power level when the estimated energy transfer has exceeded the energy transfer threshold.
US10226634B2 System and method for analyzing medical device programming parameters
The technology disclosed herein relates to a system and method for analyzing medical device programming parameters. One aspect of the current technology is a method where an overall performance metric is detected for a cardiac medical device that is outside of a threshold at a first cardiac location in a patient. Processing circuitry identifies a first operating condition and sensing circuitry measures a first sensor response during the first operating condition. An adjustment is proposed to one or more programming parameters of the medical device based on the performance metric, the first operating condition, and the sensor response to the operating condition.
US10226629B2 Analyzer for behavioral analysis and parameterization of neural stimulation
Embodiments are directed to a computer implemented neural stimulation system having a first module configured to derive neural data from muscle contractions or movements of a subject. The system further includes a second module configured to derive a neural state assessment of the subject based at least in part on the neural data. The system further includes a third module configured to derive at least one neural stimulation parameter based at least in part on the neural state assessment. The system further includes a fourth module configured to deliver neural stimulations to the subject based at least in part on the at least one neural stimulation parameter.
US10226625B2 Surgical techniques for implantation of a retinal implant
A method is provided for implanting, in an eye, apparatus having an electrode array including stimulating electrodes shaped to define distal tips protruding from the array, a plurality of photosensors, and driving circuitry, configured to drive the electrodes to apply currents to the retina. The method includes removing a lens of the eye and a vitreous body of the eye, creating a corneoscleral incision and inserting the apparatus through the corneoscleral incision into a vitreous cavity of the eye. During the inserting, an orientation of the distal tips is maintained pointing towards a cornea of the eye. Subsequently to the inserting, the apparatus is rotated such that the distal tips point towards a macula of the eye. Subsequently to the rotating, the apparatus is positioned epi-retinally, such that the distal tips of the electrodes penetrate the retina. Other applications are also described.
US10226621B2 Pacemakers and pacemaker electrodes
A pacemaker is provided. The pacemaker includes an electrode line having a lead and an electrode. The electrode includes a carbon nanotube composite structure having a matrix and at least one carbon nanotube structure located in the matrix. A first end of each carbon nanotube structure protrudes out of a first surface of the matrix for stimulating the human tissue, and a second end of each carbon nanotube structure protrudes out of a second surface of the matrix to electrically connect to the lead.
US10226620B2 Anchor elements, medical devices including one or more anchor elements and related assemblies and methods
Anchor elements include at least one protrusion configured to extend transversely from a longitudinal axis of the anchor element when the anchor element is in a deployed state. Anchor element assemblies and medical device assemblies may include such anchor elements. Methods of anchoring a medical device within a subject include securing at least a portion of the medical device within a lumen of at least one anchor element and deploying at least one protrusion of the at least one anchor element.
US10226619B2 Medical leads with segmented electrodes and methods of fabrication thereof
In one embodiment, a neurostimulation lead comprises: a lead body comprising a plurality of conductor wires; and a molded stimulation tip end comprising a plurality of segmented electrodes, hypotubes, and an annular frame structure: wherein (i) each segmented electrode of the plurality of segmented electrodes has an inner surface, an outer surface, and step-down region embedded within polymer material of the molded stimulation tip end, (ii) each respective hypotube is directly welded to the inner surface of a corresponding segmented electrode of the plurality of segmented electrodes.
US10226615B2 Electrode set, in particular for a defibrillator
An electrode set is disclosed for a defibrillator, the set including at least two electrodes each having a carrier layer, a conductive contact layer, a conductive gel layer, and a non-conductive electrode cover. In the storage state of the electrode set, the electrode covers lie against each other in a planar relationship at least portion-wise, on the side that is remote from the gel layer of the at least two electrodes. The gel layers of the electrodes are directly in contact with each other in a portion-wise manner by way of two openings in the electrode covers.
US10226613B2 Multi-purpose protective covering for use on a medical device
A multi-purpose covering for use with a medical device having a housing and an access port includes a substrate with a first end and a second end. The substrate defines the structure of the covering. The covering also includes a first securing portion nearer the first end of the substrate for securing at least one protective cap to the substrate, and a second securing portion nearer the second end for securing the substrate to the medical device. To protect the access port when the covering is sealed to the medical device, the covering can also include a sealing portion configured to be releasably secured to the medical device.
US10226612B2 Percutaneous ports with wire coils
The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.
US10226610B2 Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability
A wound treatment system includes a housing. A processor is located in the housing. A pressure monitoring system is coupled to the processor. A power delivery system is located in the housing and coupled to the processor. An oxygen concentrator is located in the housing and coupled to the power delivery system. The oxygen concentrator includes a plurality of oxygen outlets. The processor is configured to receive pressure information from the pressure monitoring system that is indicative of a pressure in a restricted airflow enclosure provided by a dressing and located adjacent a wound site; and use the pressure information to control the power provided from the power delivery system to the oxygen concentrator in order to control an oxygen flow created by the oxygen concentrator and provided through one of the plurality of oxygen outlets to the restricted airflow enclosure.
US10226608B2 Optical capsule and spectroscopic method for treating and diagnosing the intestinal tract
A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length.
US10226604B2 Systems and methods for treatment of fluid overload
Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
US10226601B2 Non-compliant medical balloon
A non-compliant fiber-reinforced medical balloon comprises a first fiber layer and a second fiber layer embedded in a continuous matrix of thermally-weldable polymer material defining a barrel wall, cone walls and neck walls. The fibers of the first fiber layer have a pattern of different lengths and are divisible into a first group and a second group based on length. The length of the fibers of the second group varies progressively in accordance to their proximity to the fibers of the first group; the fibers of the second group closest to the fibers of the first group being longer than the fibers of the second group further from the fibers of the first group. The fiber of the second fiber layer winds circumferentially around the longitudinal axis of the balloon substantially over the entire length of the balloon.
US10226594B1 Closed system with intermittent urinary catheter feed
A sterile closed intermittent urinary catheter system which is an easier to use by virtue of ergonomic shaping to facilitate advancement and retrieval of the catheter from the collection bag. The bag may have a closed internal hole adjacent an indent in one edge that creates a narrow channel through which the catheter passes. The narrow channel is located near to and in alignment with an outlet assembly so that the catheter extends from the narrow channel directly to the outlet. A user may easily grasp the catheter from outside the bag at the narrow channel and urge the catheter forward or backward to alternately extend and retract it through the outlet. A flexible pusher sleeve with gripper features may be added around the narrow channel to further facilitate catheter advancement.
US10226592B2 Systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement
The present invention generally relates to systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement. At least some of these enhanced BCG flow measurements can be used to address some surprising phenomena that may, at times, occur when wild stream blending therapeutic gas into breathing gas that a patient receives from a breathing circuit affiliated with a ventilator. Utilizing at least some of these enhanced BCG flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives from a ventilator can at least be more accurate and/or over delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.
US10226591B1 Methods and devices for carbon dioxide-based sleep disorder therapy
The present invention pertains to a system, method, and device for treating sleep disorders. The present invention is particularly useful in the delivery of carbon dioxide (CO2) to a subject and in the treatment of sleep apnea. Furthermore, integration of components with various sensors and apparatuses associated therewith and attached thereto preferably complete a rebreathing circuit in the present invention. In various embodiments of the present invention where the above components are integrated as a rebreathing circuit, a subject is both the source and recipient of a controlled concentration of carbon dioxide. In such embodiments, treatment of sleep disorders becomes much more efficient and effective.
US10226590B2 Compensating for variations in air density in a pressure support device
A pressure support device implements compensation for variations in air density of its operating environment. A pressurized flow of breathable gas is generated for delivery to the airway of a subject. One or more parameters associated with the ambient environment of the pressure support device are determined. These parameters can include one or more of an ambient barometric air pressure, an ambient air temperature, or ambient air humidity. In some embodiments, one or more assumed parameters associated with the ambient environment of the pressure support device are determined based on typical sleeping conditions of the subject. An ambient air density of the ambient environment of the pressure support device is estimated based on one or more of the parameters and/or assumed parameters. A flow rate of the pressurized flow of breathable gas is adjusted based on the estimated ambient air density of the ambient environment of the pressure support device.
US10226587B2 Adhesive and peripheral systems and methods for medical devices
A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
US10226581B2 Hand-held drug injection device and dose setting limiter mechanism therefor
The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the piston rod (120), when a maximum dose configuration has been reached.
US10226580B2 Drug delivery device and method for a drug delivery device
A drug delivery device is provided comprising a container, a first product and a second product. The device is configured to mix the first product and the second product with each other within the container for forming a drug mixture. The device is further configured for dispensing the drug mixture. The device comprises a mixing member. The device is switchable from a first state, in which the first product and the second product are separated, into a second state, in which the first product and the second product are mixed. The mixing member is configured to exert a force onto the container in order to move the container to mix the first product and the second product with each other. Furthermore, a method for maintaining a predetermined property of a drug mixture to be dispensed from a drug delivery device is provided.
US10226579B2 Drive mechanisms suitable for use in drug delivery devices
The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.
US10226578B2 Arrangement and method for determining a stopper position
An arrangement for determining a position (x) of a stopper relative to a container in a drug delivery device includes an acoustic source configured to emit an acoustic signal and an acoustic sensor configured to detect an acoustic signal, a processing unit for controlling the acoustic source and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper. A method for determining a position (x) of a stopper relative to a container in a drug delivery device includes the steps of emitting an acoustic signal from an acoustic source, detecting an acoustic signal caused by the emitted acoustic signal by means of an acoustic sensor, and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper by means of a processing unit.
US10226576B2 Sepsis monitor
Sensors are attached to a living being so as to generate corresponding sensor signals. A monitor is in communications with the sensors so as to derive physiological parameters responsive to the sensor signals. Predetermined limits are applied to the physiological parameters. At least one indicator responsive to the physiological parameters and the predetermined limits signal the onset of a sepsis condition in the living being.
US10226573B2 Fluid occlusion detection apparatus and method
A fluid occlusion detection apparatus is disclosed. The fluid occlusion detection apparatus includes: a structure disposed on a fluid delivery device and that is deformed according to pressure; and a change detection sensor in a surrounding region of the structure, wherein the fluid delivery device includes a fluid reservoir container and/or a fluid delivery passageway for connecting a human body and the fluid reservoir container, and the change detection sensor detects a change in a value related to the change detection sensor due to deformation of a shape of the structure according to an increase in pressure inside the fluid delivery device by fluid occlusion inside the fluid delivery device.
US10226571B2 Pump segment placement
A pump cassette is configured for coupling with a pump device. The pump cassette may include a fluid lumen adapted for passage and propulsion of an infusion fluid toward a patient; a valve assembly that can be actuated to regulate fluid flow through the fluid lumen; and a frame coupled to the fluid lumen and the valve assembly. The frame is adapted to be inserted into a seat of a pump device. The frame is configured to be inserted into the seat only when aligned in a predetermined orientation relative to the seat.
US10226565B2 Tube for extra-corporeal circuit with double connector
The present invention relates to a double connector for a tubular insert intended to connect an extra-corporeal circuit to a peristaltic pump. The double connector comprises: a first channel with an axis a1, a second channel with an axis a2 not parallel to a1, a pressure chamber arranged along the first channel and suitable for co-operation with a pressure sensor. The pressure chamber is closed, on the opposite side with respect to the second channel, by a membrane which extends mainly in a plane π substantially parallel to both the axes a1 and a2.Moreover, a straight line r, passing through both axes a1 and a2 and perpendicular thereto, crosses the membrane. The invention also relates to a tubular insert comprising the double connector and an extra-corporeal circuit comprising the tubular insert.
US10226564B2 Vascular access port systems and methods
In certain systems disclosed herein, one or more of a first vascular access port and a second vascular access port can be selected by a customer. Each of the first and second vascular access ports can be implanted subcutaneously within a patient, and each can include a base configured to be attached to a vessel, a body that extends away from the base, and a guidance passageway that extends through the body and the base and includes a funnel region. A maximum height defined by the base and body of the second vascular access port can be greater than a maximum height defined by the base and body of the first vascular access port.
US10226563B2 Methods and systems for treatment of acute ischemic stroke
Methods and devices are disclosed that enable safe, rapid and relatively short and straight access to the cerebral arteries for the introduction of interventional devices to treat acute ischemic stroke. In addition, the disclosed methods and devices provide means to securely close the access site to the cerebral arteries to avoid the potentially devastating consequences of a transcervical hematoma.
US10226559B2 Guidewire system and method of pump installation using same
In one embodiment, the present invention is a method of positioning in a mammalian heart of a patient a blood pump including an inflow cannula, a pump housing and an outflow cannula, the method including forming an incision in a low-pressure location on the heart wall; passing the outflow cannula of the blood pump through the incision and into a left ventricle of a heart; positioning a tip of a guidewire into an aorta, distal to an aortic valve; advancing the tip through the aortic valve and into the left ventricle; connecting the tip to the outflow cannula; pulling the blood pump with the guidewire to advance at least a portion of the outflow cannula through the aortic valve and into the aorta; securing the blood pump to the heart, the aorta, or both; disconnecting the tip from the blood pump; and removing the guidewire from the patient.
US10226555B2 Thermally controlled illumination devices
An illumination element such as an optical waveguide for illuminating a surgical field in a patient has a light input section, a light transmitting section, and a light output section. The light input section is optically coupled to a proximal section of the light transmitting section and inputs light into the illumination element. The light transmitting section transmits the light preferably by total internal reflection or by other transmission means. The light output section is adjacent a distal section of the light transmitting section which has a light extraction area from which the light exits with an energy density. The light extraction area is large enough to maintain the energy density at a level that prevents melting of the illumination element or burning of the patient, and the light extraction area has a profile that does not interfere with access to the surgical field.
US10226552B2 Materials, systems, devices, and methods for endoluminal electropolymeric paving and sealing
Methods, materials, devices, and systems for electropolymeric paving and sealing (ePEPS) are provided. The methods include delivering paving materials to an interior surface of a blood vessel, tissue lumen or other hollow space, delivering electronic components to the surface, and forming a conformal device that contains the paving material and the integrated electronic components. Integrated electronic components can be homogenously or heterogeneously distributed in the material, such as on the top, middle, and/or bottom of the polymeric material. The devices are biocompatible, and preferably biodegradable or bioerodible. The devices integrated electrical properties useful for sensing or detecting one or more analytes, signals or conditions, transmitting or generating a signal, or releasing a therapeutic, prophylactic or diagnostic agent. Optionally, the devices are smart devices that include feedback and logic means to respond to a change in local conditions.
US10226548B2 Autogenic living scaffolds and living tissue matrices: methods and uses thereof
The present invention is drawn to a 3-dimensional cell-produced scaffold construct comprising cells and the extracellular matrix that has been produced and arranged by these cells.
US10226546B2 Air purification assembly and method of using same
An air purification assembly is described. The air purification assembly includes an intake portion, a flow apparatus coupled to the intake portion; and a chamber portion coupled to the flow apparatus. The intake portion includes a surface and at least one first opening in the surface such that the intake portion is enabled to receive contaminated air flow through the at least one first opening. The chamber portion includes at least one second opening and further comprises an activated nonmetallic element and an ultraviolet (UV) light assembly. The flow apparatus is adapted to draw contaminated air into the air purification assembly through the at least one first opening and direct the contaminated air out of the air purification assembly through the second openings.
US10226545B2 New-generation fluid particle diffuser
A new-generation GMP (Good Manufacturing Practice) compliant hygienic fluid particle diffuser allowing to release the particles of fluids such as bottled drugs, extracts and natural oils by generating a particular pressure without any heating process without degrading the essence of the fluid thanks to a disposable fluid chamber.
US10226542B2 Device for the sterilization of stethoscopes
This invention relates to a device for sanitising of medical instruments, in particular stethoscopes. In particular, this invention relates to a sanitisation or sterilisation device (1) for a stethoscope (S) comprising a case (2) that accommodates sanitisation or sterilisation means (3, 3′, 3″), a command and control unit (4) and a battery (5), said device (1) comprising means for coupling to the stethoscope (S) to be sanitised or sterilised, said coupling means being magnetic or electromagnetic coupling means (12), mechanical coupling means (13) or a combination of them, characterised in that said case (2) presents to the outside a recess which forms an inverted cone (11), the base of which is open and substantially at the level of the outer surface of the case (2), said sanitisation or sterilisation means (3, 3′, 3″) being arranged in correspondence to said cone (11).
US10226537B2 Transduction
This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.
US10226534B2 Semi-solid delivery systems
The invention provides semi-solid systems for delivering biologically active materials that include a polymer comprising 1) one or more polycaprolactone (PCL) units and 2) at least one or more polyethylene glycol (PEG) units; wherein at least one of said polycaprolactone units is conjugated to a PEG forming an acetal group.
US10226525B2 Group B Streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
US10226524B2 Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
US10226523B2 Clostridium difficile vaccine and methods of use
Embodiments of the present disclosure include vaccine compositions comprising a TcdB toxin or toxoid derived therefrom. The TcdB toxin may be derived from a hypervirulent strain of C. difficile. A further embodiment is directed to a method of conferring an active immunity against a C. difficile infection in a subject by administering the vaccine composition to the subject.
US10226522B2 Compositions and methods for the treatment or prevention of tuberculosis
Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
US10226517B2 DNA vaccines encoding heat shock proteins
A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
US10226513B2 Method and composition to prevent or improve symptoms of musculoskeletal distress degeneration
The present invention relates generally to compositions and methods of using compositions comprised of undenatured cartilage in the form of an isolated native Type II collagen that may be combined in a synergistic blend with one or more edible metals with acceptable chemical counter-ions or other health promoting ingredients to be orally consumed as a method for preventing and improving symptoms of musculoskeletal distress degeneration, including symptoms selected from temporary loss of range of motion, temporary inflammation, temporary muscle soreness, and combinations thereof. The synergistic compositions of the present invention also protect, promote and improve recovery from and prevention of cartilage and ligament wear, thinning and damage to bone, and repetitive motion injuries and stress resulting from intense periods of activity or workout routines that contribute to such musculoskeletal distress degeneration symptoms.
US10226510B2 Carrier-free biologically-active protein nanostructures
The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
US10226495B2 Hair loss compositions and methods of making and using same
A composition for promoting hair growth comprises hinoki oil, red clover extract, and a peptide. The hinoki oil can comprise from about 0.01% to about 5% by weight of the composition, the red clover extract can comprise from about 1 ppmw to about 1,000 ppmw of the composition, and the peptide can comprise from about 0.01 ppmw to about 500 ppmw of the composition.
US10226491B2 Synergistic antimicrobial effect
The present invention is related to the field of bioprotection, in particular to an antimicrobial composition comprising a Lactobacillus rhamnosus strain and/or a Lactobacillus paracasei strain. Furthermore, the present invention concerns uses for such an antimicrobial composition, food, feed and pharmaceutical products comprising such an antimicrobial composition, a method of manufacturing such food, feed and pharmaceutical products and a method for reducing the content of unwanted microorganisms of such food, feed and pharmaceutical products.
US10226490B2 Probiotic compositions and methods for inducing and supporting weight loss
A probiotic composition for inducing or supporting weight loss in a subject, the probiotic composition including an effective amount of a bacteria selected from the genus Bacteroides and a carrier for delivering the bacteria to the subject.
US10226487B2 Derivation and self-renewal of lsl1+ cells and uses thereof
The present invention relates to methods for deriving multipotent Isl1+ cells (i.e. methods for inducing a cell to enter a multipotent Isl1+ lineage), methods for differentiating Isl1+ cells to cardiac cells, cells obtainable by such methods, kits and compositions for carrying out the methods in accordance with the invention, and also medical applications and pharmaceutical compositions of said cells.
US10226486B2 Method for preparation of induced dopaminergic progenitors using direct reprogramming
The present invention relates to a method for preparing induced dopaminergic neuronal progenitors (iDPs) comprising inducing an expression of Oct4, Sox2, Klf4, and c-Myc genes in adult cells and direct reprogramming of the adult cells to the iDPs by treating the cells with sonic hedgehog (SHH) and fibroblast growth factor 8 (FGF8); and a cell therapy product and a composition for treating or preventing Parkinson's Disease (PD) which comprises the iDPs as active ingredients. In addition to this, the present invention relates to a method for preparing midbrain dopaminergic neurons comprising isolating NSC-like colony by culturing the iDPs, dissociating the isolated NSC-like colony, and culturing the cells on the neural cell differentiation medium. Further, the present invention relates to a method for treating PD or a method for screening medicine for preventing or treating PD using the cells of the present invention. The progenitors prepared by the method for preparing the iDPs of the present invention can be widely used in the known art since the neuronal progenitors have significantly higher efficiency in differentiating to the dopaminergic neurons compared to conventional methods and lack side effects such as immunogenicity and ethical issues because patients' own somatic cells can be used.
US10226485B2 Multipotent adult stem cells and methods for isolation
The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
US10226484B2 Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof
A pharmaceutical composition of the present invention is used for improving health, cure abnormalities and degenerative disease; achieve anti-aging effect of therapy and therapeutic effect on mammals. The pharmaceutical composition includes a pharmaceutical carrier and an isotope selective ingredient including at least one of a chemical element and a chemical compound containing the chemical element whereby isotope distribution in the at least one of the chemical element and the chemical compound containing the chemical element is different from natural distribution of at least one of isotopes wherein the part of selected isotope of the chemical element ranges from 0 to 100%. A method of the present invention uses the inventive pharmaceutical composition to improve health, cure abnormalities and degenerative disease and achieve therapeutic effect on mammals.
US10226482B2 Copolymer and method for treatment of bacterial infection
A method of treatment of infection in a subject comprising administering to the subject a copolymer comprising an acrolein derived segment or a polyacrolein oligomer segment and a polyalkylene glycol oligomer segment, the copolymer having a molecular weight of no more than 1500 Daltons.
US10226480B2 Biomaterial from Wharton's jelly umbilical cord
The present invention relates to a biomaterial, specifically a hydrogel, based on the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans present exclusively in the Wharton's jelly of the umbilical cord (which can optionally be combined with cells as a combination therapy), and also to the methods for the production and use thereof.
US10226475B2 Compound and method for the treatment and diagnosis of neurodegenerative conditions
A reagent selected from cholestenoic acid or an inhibitor of an enzyme in the cholestenoic acid biosynthetic or metabolic pathway for use in the treatment of neurodegenerative conditions. In particular, the reagent is a cholestenoic acid of a particular form, such as 3β,7α-dihydroxycholest-5-en-26-oic (3β,7α-diHCA), not previously associated with neural tissue or CSF. Pharmaceutical compositions, methods of treatment or prevention of neurodegenerative conditions as well as diagnostic methods and novel biomarkers form further aspects of the invention.
US10226469B2 Use of substituted 2,3-dihydroimidazo[1,2-C]quinazolines for treating lymphomas
Described herein are pharmaceutical combinations and compositions comprising a) a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or a salt thereof, and b) one more additional active agents. The pharmaceutical combinations described herein may be useful for treating non-Hodgkin's lymphoma (NHL), particularly 1st line, 2nd line, relapsed, refractory, indolent or aggressive non-Hodgkin's lymphoma (NHL); follicular lymphoma (FL); chronic lymphocytic leukemia (CLL); marginal zone lymphoma (MZL); diffuse large B-cell lymphoma (DLBCL); mantle cell lymphoma (MCL); transformed lymphoma (TL); or peripheral T-cell lymphoma (PTCL).
US10226466B2 Methods of treating fibrosis
Disclosed are methods of treating fibrosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of an ACK inhibitor (e.g., a BTK inhibitor, such as for example an irreversible BTK inhibitor, such as for example, ibrutinib).
US10226457B2 Systems and methods for treating an opioid-induced adverse pharmacodynamic response
Disclosed in certain embodiments is a method of treating or preventing an opioid induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
US10226454B2 Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound
The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
US10226453B2 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
US10226445B2 Pharmaceutical preparations
Pharmaceutical preparations are proposed, comprising bitter-masking acting substances for reducing and/or inhibiting gastric acid secretion induced by food constituents.
US10226443B2 Methods for treating psoriatic arthritis
Methods, agents and compositions thereof for treating psoriatic arthritis (PsA) are encompassed herein.
US10226437B2 Materials and methods for controlling infections
The subject invention provides materials methods for reducing infections in subjects. The materials methods utilize chlorhexidine, which has been found to be surprisingly non-toxic. The lack of toxicity facilitates the use of chlorhexidine in contexts that were not previously thought to be possible.
US10226436B2 Norepinephrine compositions and methods therefor
The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.
US10226434B2 Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
US10226433B2 Use of cannabinoids in the treatment of degenerative skeletal muscle diseases
The present invention relates to the use of cannabinoids in the treatment of degenerative skeletal muscle disease. In particular the degenerative skeletal muscle disease is Duchenne muscular dystrophy (DMD). Preferably the cannabinoids are one or more of: Cannabidiol (CBD); Cannabidivarin (CBDV); and Tetrahydrocannabivarin (THCV).
US10226431B2 Microbiota restoration therapy (MRT) compositions and methods of manufacture
Microbiota restoration therapy (MRT) compositions (e.g., oral MRT compositions) and methods for manufacturing MRT compositions are disclosed. An example method for manufacturing an MRT composition may include collecting a stool sample, purifying the stool sample to form a purified sample, stabilizing the purified sample to form a stabilized sample, converting the stabilized sample to a solid, adding one or more additives and/or excipients to the solid to form a treatment composition, and encapsulating the treatment composition.
US10226429B2 Enteric coated, soluble creatine and polyethylene glycol composition for enhanced skeletal uptake of oral creatine
An oral creatine formulation includes soluble creatine and polyethylene glycol, coated with an enteric coating. The most preferred soluble creatine is creatine HCl. The most preferred polyethylene glycols have an average molecular weight of from 3150 to 3685, although for particular formulation formulations and particular uses, the average molecular weight polyethylene glycols may range from 190 to 9000.
US10226428B2 Oral drug delivery system
An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a swellable composition located in an immediate vicinity of one or more preselected surfaces. The coating comprises a defect wherein said defect is not a passageway through the preselected portion of the coating and operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.
US10226427B2 Surface binding of nanoparticle based drug delivery to tissue
Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.
US10226425B2 Pharmaceutical preparation and method of its production and use
Thus, the present invention provides a composition in powder form comprising highly dispersed silica particles, polymethylsiloxane particles, and at one or both of a cationic surfactant and an antimicrobial substance, wherein at least 25% by weight of the cationic surfactant is present in primary polymethylsiloxane particles carrying the cationic surfactant on their surface and/or in agglomerates of these primary particles, and/or at least 25% by weight, of the antimicrobial substance is present in primary highly dispersed silica particles carrying the antimicrobial substance on their surface and/or in agglomerates of these primary particles.
US10226423B1 Colchicine drug-to-drug interactions
The use of oral colchicine solutions in combination with other therapeutics, while minimizing toxic drug to drug interactions are described herein. Related compositions are also provided.
US10226420B2 Methods of eye treatment using therapeutic compositions containing dipyridamole
A method comprising administering an effective amount of a topical dipyridamole to a subject in need thereof due to conjunctivitis.
US10226419B2 Methods for manufacturing implants
Pharmacologically active implants, in particular subcutaneous implants, intrauterine devices, and intravaginal rings, are provided herein. Methods for forming an active ingredient-containing core are described. Methods for laminating an active ingredient-containing core to form a rate-controlling sheath are also described.
US10226412B2 Hair coloring method with liquid gloves
A method for reducing skin staining during the coloring of hair includes the following steps in the indicated sequence: A1) applying a coloring agent (F) to the hair, A2) allowing the coloring agent (F) to act for a time period from 30 seconds to 45 minutes, B1) applying an undiluted cleaning agent (R) to skin areas that can come into contact with the coloring agent (F) when the latter is washed out, C1) jointly washing out the coloring agent (F) and cleaning agent (R), wherein the coloring agent (F) includes at least one oxidation dye precursor and/or at least one direct dye and the cleaning agent (R) includes at least one anionic surfactant. A multicomponent packaging unit includes the coloring agent (F) and the cleaning agent (R).
US10226411B2 Dyeing composition comprising a fatty substance, a non-ionic guar gum, an amphoteric surfactant and a non-ionic or anionic surfactant, and an oxidizing agent, dyeing process and suitable device
The subject of the present invention is a composition for dyeing human keratin fibers such as the hair, comprising: (a) at least one oxidation dye precursor; (b) at least one first amphoteric or zwitterionic surfactant; (c) at least one second non-ionic or anionic surfactant; (d) one or more fatty substances; (e) at least one cationic polymer; (f) at least one non-ionic guar gum; (g) at least one oxidizing agent other than atmospheric oxygen. The present invention also relates to a process for dying human keratin fibers, in which this composition is applied to said fibers, and also to a suitable multicompartment device.
US10226406B2 Light attenuating formulations
A preparation provides light or radiation attenuation between about 190 and 800 nm has an amount of diamond nanoparticles in a medium, where the diamond nanoparticles have a size between about 1 nm and 1000 nm are modified to enhance absorption or photoluminescence. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
US10226404B2 Method for preparing antidandruff hair care compositions comprising a step of injecting antidandruff agents, perfumes and/or silicones
Disclosed is a method of preparing a hair care composition comprising a step of injecting antidandruff agent, perfume and/or silicone, to an emulsion. The method of the present invention provides reduced agglomeration of the antidandruff agent selected from metal pyrithiones.
US10226402B2 Vented liquid container
A vent system for a liquid container having a container body with a top dispensing opening and a bottom portion having coupling elements and a bottom opening, the vent system including a solid closure member for closing the bottom opening; a sealing member disposed in the closure member, the sealing member including a sealing element configured to seal a rim of the container bottom opening and having a bore, and a one-way valve sealing the bore against liquid passage from the container and selectively permitting air passage through the bore into the container; complementary coupling elements on the closure member for coupling to the coupling elements on the bottom portion of the container, configured so that ambient air can enter between the container body and the closure member; and an air conduit extending from the coupling elements to a space in the vent system which is in operative communication with the bore, and a method for making it.
US10226401B2 Closed vial fill system for aseptic dispensing
A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.
US10226399B2 Medicine sorting apparatus
An object of the present invention is to automatically identify a direction, a posture and characteristics such as a shape, a size, a type and an expiration date of a medicine and store the medicine with ensuring a high degree of freedom. A medicine supplying apparatus 1 includes an identifying part and a storing part. A storing area is defined at the time of storing the medicine according to a size of a medicine contained in characteristics of the medicine identified by the identifying part. The medicine is stored in the storing part in a state that identification information of the medicine is associated with the storing area. Further, the medicine supplying apparatus has a determination processing part which can determine whether or not the medicine is a target to be treated based on the characteristics of the medicine identified by the identifying part.
US10226396B2 Post workout massage device
A massage system includes a frame, a first massage mechanism connected to a first region of the frame to massage a first portion of a user, a second massage mechanism connected to a second region of the frame to massage a second portion of a user, and memory and a processor. The memory is programmed with instructions executable by the processor to determine a massage plan for massaging the at least one of first portion and the second portion.
US10226395B2 Locomotion assisting device and method
An exoskeleton bracing system includes: a trunk support for affixing to the trunk of a disabled person and leg braces for connecting to the legs of the person, each leg brace including limb segment braces. Motorized joints are adapted to provide relative angular movement between the limb segment braces of the leg braces and between the leg braces and the trunk support. One or more ground force sensors are designed to sense ground force exerted on each of the leg braces. The system also includes a controller for receiving sensed signals from said one or more ground force sensors, with an algorithm for identifying a stance from the sensed signals and, based on the identified stance, actuating the motorized joints to perform an action relating to a mode of locomotion selected from a set of predefined actions corresponding to the identified stance.
US10226394B2 Range of motion flexibility device and method of use
A stretching device comprises a wearable body harness with an adjustable central hold arranged around the upper body connected with an adjustable extension strap configured to engage a foot at a distal end. The extension strap is slidably connected to the central strap to move along the length of the central strap. The extension strap comprises a non-elastic material, divided by a single elastic segment. The extension strap having incremental markings designating amount of adjustment. The device and method of using the device provides a comfortable tension, facilitates hands free stretching in the supine position, improving duration of stretching and range of motion. An independent adjustable stretching strap for upper body and shoulder stretching, further comprises a non-elastic material looped at each distal end, divided by a discrete elastic segment and having incremental visual markings designating amount of adjustment.
US10226393B1 Method of and apparatus for assisting persons from a lying position to a sitting position and a sitting position to a lying position
A method and apparatus for assisting persons from a lying position to a sitting position comprises a mechanical support support board for supporting a body of the person while lying in bed. An extension of the support board reaches away from the bed to accommodate the legs and thighs of the person. The support board is pivoted and tilted upwards in order to move the person from a lying position to an upright and sitting position. The support board assists caregivers with lifting a patient in and out of bed while minimizing both risk of injury to the caregiver and physical and emotional discomfort to the patient.
US10226391B2 Devices and methods for body protection against moisture and contaminants
A nonpermeable enclosure formed from a clear, waterproof fabric, has a cover ridge for insertion into a channel so as to produce a barrier against moisture and contaminants, and is attached to a closure band for securing the nonpermeable enclosure over a wearer's hand.
US10226390B2 Rolled absorbent personal care articles and methods of making same
A rolled absorbent personal care article includes a longitudinal direction, a transverse direction and a depth direction. The absorbent article component, absorbent article extension component, wrapper sheet component each have a longitudinal, transverse, and depth direction. Each of the absorbent article component and absorbent article extension component includes at least a topsheet layer and a backsheet layer, wherein the backsheet layer includes a garment-facing surface on which is situated a garment adhesive. The absorbent article component and the absorbent article extension component each include a peripheral edge, with the components being attached to the wrapper sheet component with the garment adhesive, such that the peripheral edges are adjacent one another. The absorbent article component and the absorbent article extension component are in a rolled configuration within the wrapper sheet component and secured in the rolled configuration.
US10226388B2 Stretch breathable protective absorbent article using tri-laminate
A disposable absorbent article of a brief or pull-up type incorporates a breathable laminate material composed of three layers. The laminate is an elastic material and may include non-elastic portions created by deactivating the material. The laminate material may be made breathable by the ultrasonic bonding process used to create the laminate. The absorbent article includes an absorbent assembly that overlaps with the non-elastic portions of the laminate.
US10226384B2 Anisotropic drapes and systems
An anisotropic wound drape for treating a wound on a patient includes a flexible sheet for placing over a tissue site. The flexible sheet includes a first isotropic zone, and a second isotropic zone. The first isotropic zone and the second isotropic zone are configured to provide the flexible sheet with anisotropic stretching properties. The anisotropic drape may used as part of a reduced-pressure wound treatment system. Other systems and methods are also presented.
US10226375B2 Urinary incontinence pad
A urinary incontinence pad for females. The urinary incontinence pad includes an absorbent, tubular pad having a hollow interior. The pad includes a rounded first end and an open second end, wherein the rounded end serves as a barrier against the clitoris of a female user so as to prevent the pad from sliding when worn. The urinary incontinence pad further includes a channel that extends from the second end of the pad towards the first end thereof. The sides of the channel are flexible and biased towards one another so as to removably secure the pad to the labia of a user. In operation, the pad is removably secured between the labia majora and labia minora, wherein the channel is positioned facing the urethral meatus so as to absorb urine within the interior of the pad.
US10226374B2 Cervical brace
A neck support apparatus (10) has a base portion (21) for positioning on the torso (18) of the user (11) and a support portion (23) extending from the base portion and having a rest (25) upon which the mandible (17)) of the user (11) can rest when the head (13) of the user is at the forwardmost tilted position. The rest (25) has two rest members (27) configured to receive the mandible (17), typically adjacent the underside of the posterior mandibles (17a) of the user (11). The support portion (23) further comprises two struts (31) which are mounted on the base portion (21) and on which the rest members (27) are mounted. The two struts (31) are adapted to be disposed angularly with respect to each other.
US10226367B2 Apparatus and methods for filling a drug eluting medical device via capillary action
Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, at least a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is at least partially filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.
US10226364B2 Prosthesis socket with insertion aid
A prosthesis stem includes a stem body for receiving an amputation stump and an insertion aid apparatus, which facilitates the insertion of the amputation stump into the stem body, wherein the insertion aid apparatus comprises an insertion inlay which is connected in the proximal edge region thereof to a holding apparatus which is fixed to the stem body. The insertion inlay has an insertion stocking, which is movable between an outer position, in which the insertion inlay is at least partially located outside of the stem body, and an inner position, in which the insertion stocking covers the stem body.
US10226361B2 Quasi passive assistive device
Implementations of a quasi-passive assistive device are disclosed. Such a device may comprise a spring mechanism that increases stiffness similar to a biological ankle. In one implementation, the spring mechanism may comprise a piston, valve, springs, or other elements to match a biological stiffness profile similar to that of a biological ankle. In one implementation, an apparatus for an artificial ankle is disclosed, comprising a piston coupled to a spring and the piston connected to a valve. The spring and the piston may store energy during dorsiflexion of the ankle and the spring and the piston release energy during plantarflexion of the ankle. The piston may store and release energy through the use of the valve.
US10226360B2 PLIF hinged spacer
A spinal implant formed from a hinged distractor having an upper and lower support body that is hinged by use of pinions. An insert body is constructed and arranged to slide between the section to expand both in height and width, and to maintain a space therebetween. The insert body includes a leading edge that is tapered to allow ease of insertion. A trailing edge that extends beyond a front edge of the upper support body will cause the insert body to be locked into position. A trailing edge engages the rear of the upper support body to prevent over insertion. A lower surface of the insert body may include locking surfaces.
US10226357B2 Interbody cage
An interbody cage, which has lattice-like or grid-like areas for better connection/fusion into the area of the vertebra. The cage has especially an outer frame, which includes massive support parts and, and an inner grid body. The frame determining the outer contour and the lattice or grid areas located within same are made in one piece. The cage is prepared by sintering, such as by electron beam melting or laser sintering.
US10226353B2 Spinal implant system and method
A spinal implant comprises an implant body extending between an anterior surface and a posterior surface and includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body includes an inner surface that defines at least one cavity that is oriented to implant a fastener oblique relative to a lateral axis of a subject body and adjacent an intervertebral space of the subject body. At least one indicia is disposed with the implant body to facilitate orientation of the implant body with the subject body. Systems and methods are disclosed.
US10226352B2 Implant
An implant for insertion between vertebral bodies of the spinal column, with a main body which is formed along a longitudinal axis and at least one end of which an attachment plate with a contact surface for attachment to an adjacent vertebral body is disposed, which plate is mounted on main body pivotably about a pivot axis, arranged substantially perpendicular to the longitudinal axis, and which can be fixed at an angle relative to it or relative to the longitudinal axis. The main body is assigned at least one clamping element. The attachment plate has a clamping surface on a side facing the main body, and the clamping element is movable between a pivot configuration, in which the attachment plate is pivotable, and a clamping configuration, in which the angle and thereby the attachment plate are fixed by an interaction of the clamping element with the clamping surface.
US10226345B2 Version-replicating instrument and orthopaedic surgical procedure for using the same to implant a revision hip prosthesis
A modular femoral prosthesis for use during performance of a hip revision procedure includes a proximal body component, a distal stem component, and a locking bolt. Surgical instruments and methods for use in implanting such a modular femoral prosthesis are disclosed.
US10226344B2 Percutaneous valve, system and method
Apparatus, systems, and methods for percutaneous valve replacement and/or augmentation are provided. The apparatus includes a valve having a valve frame, a valve leaflet coupled to the valve frame, and a leaflet transition member coupled to the valve leaflet. The valve leaflet and leaflet transition member can transition from a first position where the valve leaflet and leaflet frame are at least partially outside a lumen of the valve frame to a second position where the valve leaflet and the leaflet transition member are within the lumen of the valve frame.
US10226335B2 Actively controllable heart valve implant and method of controlling same
A mitral valve implant includes a force-expanding mitral valve lattice having an interior orifice and a self-expanding valve trampoline attached at the interior orifice of the force-expanding mitral valve lattice. The mitral valve lattice is self-expandable to a first configuration and force expandable from the first configuration to a second configuration. The configurations can be circular or D-shaped. The mitral valve lattice comprises jack screws adjusting configurations of the mitral valve lattice. The valve trampoline has a cylindrical central region comprising valve leaflets. An outwardly flaring implant skirt is attached to the mitral valve lattice exterior. Wall-retaining wires are attached to the mitral valve lattice, are petal-shaped, and have a pre-set, radially outward, memory shape. The wires and skirt impart a force on a respective side of the native mitral valve when the mitral valve lattice is expanded within an annulus of the native mitral valve.
US10226333B2 Anatomically-orientated and self-positioning transcatheter mitral valve
Described herein is a mitral valve and systems and methods for implanting the same. The mitral valve device is designed to easily orient to and conform to the mitral orifice natural morphology. This mitral valve system may be implanted using a system of 2 guide wires that facilitate orientation of the flat portion of the stent properly with the flat portion of the mitral valve that is adjacent to the aortic valve. Additionally, the disclosed valve may have multiple mounds distributed across the outer surface of the valve/stent complex so as to prevent or reduce paravalvular leak after implantation.
US10226331B2 Conformable prostheses for implanting two-piece heart valves and methods for using them
A heart valve assembly includes an annular prosthesis and a valve prosthesis. The annular prosthesis includes an annular ring for dilating tissue within a biological annulus and a conformable sewing cuff extending radially from the annular member. The valve prosthesis includes a frame and a valve component. The annular ring is introduced into the biological annulus to dilate tissue surrounding the biological annulus and the sewing cuff conforms to tissue above the biological annulus. Fasteners are directed through the sewing cuff to secure the annular prosthesis to the biological annulus. The annular prosthesis may include a baleen element for biasing fabric on the annular ring outwardly to enhance sealing against the biological annulus. A valve prosthesis is then advanced into the sinus cavity, and secured relative to the annular prosthesis. The sewing cuff may enhance a seal between the valve prosthesis and annular prosthesis.
US10226325B2 Medical device delivery system and method
A tendon repair implant delivery system and methods incorporating a guide member having a temporary fixation member on or adjacent to the distal end. The point of fixation defines a target site for placement of the tendon repair implant which is subsequently affixed to the tendon.
US10226323B2 Double cone biodegradable filter
The present disclosure provides for a double cone filter and a delivery apparatus for deploying the filter within the body. The filter may have superior and inferior rings connected to each other by a plurality of connectors. The rings may have a first degradation rate, and the connectors may have a second degradation rate. The second degradation rate may be faster than the first degradation rate, such that the connectors degrade faster than the rings. In this way, the filter has a filtering state when the connectors are present. After the connectors degrade or partially degrade, the rings may relax against the vessel wall in an open state. After a sufficient length of time, the rings also degrade such that the filter is completely removed from the body.
US10226322B2 Jugular femoral vena cava filter system
An embolus filter introducer system has a symmetric introducer sheath with a filter inside. The introducer sheath can be attached at either end to a deployment actuator. The deployment actuator can thereby be used to push the filter out of the introducer sheath. Since the sheath can be oriented in a selectable direction, so can the filter, allowing the sheath to be introduced via a jugular or femoral approach to the vena cava.
US10226318B2 Method of treating urinary incontinence by implanting a tube providing a pressure-regulating storage compartment
A method of treating urinary incontinence includes providing a device having a cuff configured to coapt a urethra of a patient in treating diagnosed urinary incontinence, a pump, and a tube attachable between the cuff and the pump. The method includes providing the tube with a first lumen separated from a second lumen by a wall internal to the tube, and providing at least a portion of an exposed exterior wall of the second lumen to expand to provide the second lumen with an inflatable storage compartment.
US10226316B2 Method for producing an artificial anal sphincter and prosthesis thereof
A method for producing an artificial sphincter comprises the steps of effecting a skin incision (2), forming a passage (3) for a prosthesis (4) and releasing the prosthesis (4) inside the passage (3). Said prosthesis passing from one miniaturized state in the step preceding the release, to an expanded state in the step following the release. The steps mentioned above are repeated at least seven times in order to release at least seven prosthesis (4), which are uniformly distributed along a circumferential arc (5) surrounding the anal canal (AC); said at least seven prosthesis (4) defining a plurality of prosthesis (40) forming a third artificial sphincter.
US10226312B2 Orthodontic appliance with snap fitted, non-sliding archwire
An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
US10226308B2 Method of controlling a medical master/slave system
A method of controlling the medical master/slave system comprising a bendable master apparatus operated by an operator and a slave apparatus inserted through the body. The control method includes an ordinary actuation mode (Step S101) in which, based on a bending state of the master apparatus, the slave apparatus is actuated in such a way as to become similar in operation to the master apparatus, a reversal actuation mode (Step S105) in which, based on a bending state of the master apparatus, the slave apparatus is actuated in such a way as to be reversed relative to the operation of the master apparatus, and a transition mode (Step S103, S104, S107, S108) for transition between the ordinary actuation mode and the reversal actuation mode.
US10226305B2 Surgical end effectors and pulley assemblies thereof
An end effector of a surgical tool includes a first jaw and a second jaw rotated by a driving pulley. A first driven pulley is attached to the first jaw and a second driven pulley is attached to the second jaw. A first end portion of a first cable is connected to a first radial side of the first driven pulley, a second end portion of the first cable is connected to a second radial side of the second driven pulley, and an intermediate portion of the first cable is connected to the driving pulley. A first end portion of a second cable is connected to a first radial side of the second driven pulley, a second end portion of the second cable is connected to a second radial side of the first driven pulley, and an intermediate portion of the second cable is connected to the driving pulley.
US10226303B2 System and method for advanced data management with video enabled software tools for video broadcasting environments
Video editing software tools platform utilizing a video display to provide access to specific video editing software tools, such as video oriented applications or widgets, that can assist those in a video broadcasting team, such as a camera operator or video editor, with a video broadcast feed. Various video editing software tools can provide features and functions that can add visual context to video data presented in the image stream from the video camera and provide archived information pertaining to the same. Various embodiments relate to systems and methods for simultaneously switching input image streams to output devices, while providing optional image processing functions on the image streams. Certain embodiments may enable multiple users/viewers to collaboratively control such systems and methods.
US10226300B2 System and method for aligning an elongated tool to an occluded target
A system and a method for aligning an elongated tool to an occluded target are disclosed. The system comprises an adjustment mechanism configured to adjust an angular orientation of the elongated tool relative to a pivot point spaced from the target; an imaging device configured to capture one or more X-ray images of the elongated tool and the target; and a processor communicatively coupled with the adjustment mechanism and imaging device, wherein the processor is configured to: extract Euclidean vector data of the elongated tool based on image data of an X-ray image received from the imaging device; and control the adjustment mechanism to iteratively adjust the angular orientation of the elongated tool based on the Euclidean vector data to align a longitudinal axis of the elongated tool with the target and the pivot point.
US10226297B2 Medical devices and methods incorporating frustrated total internal reflection for energy-efficient sealing and cutting of tissue using light energy
A medical instrument includes two jaw members, at least one of which creates conditions of frustrated total internal reflection at a tissue-contacting surface when tissue is grasped between the two jaw members. The first jaw member may include an optical element having a tissue-contacting surface. The medical instrument also includes a light source that provides a light beam for sealing tissue. The light source is positioned so that the light beam is totally internally reflected from an interface between the tissue-contacting surface and air when tissue is not grasped by the jaw members. When tissue is grasped by the jaw members, at least a portion of the light beam is transmitted through that portion of the tissue-contacting surface that is in contact with the tissue. The light source may be movably coupled to a jaw member to scan the light beam and/or to change the incident angle based on optical properties of the tissue.
US10226292B2 Combined intramedullary-extramedullary bone stabilization and alignment system
Disclosed is a combined intramedullary and extramedullary bone stabilization and alignment system, which includes both methods and apparatuses for the alignment and stabilization of a first bone or piece of bone to a second bone or piece of bone. Embodiments of the system may include an implant device which has an elongated framework within intramedullary portion and an extramedullary portion which are cannulated. The cannulated aspect of the framework includes a wire aperture through both the intramedullary portion and the extramedullary portion.
US10226291B2 Bone plate system
Bone plate systems are provided for surgical implants and bone repair. The bone plate is multi-tiered for receiving bone anchors screws for securing a plurality of bones or bone fragments in a desired relationship. The plate members include throughbores for receiving a pivot base therein, with head ends of the bone anchors being secured in the pivot bases. The throughbores may permit and define a translation path for the pivot base and the bone anchor secured therein relative to the plate. Pivot members extending between the pivot base and the plate member facilitate pivoting and optional translation of the pivot base relative to the plate. With the bone anchor seated within the pivot base, an apparatus for inhibiting screw back out is employed.
US10226286B2 Devices and methods for bone fixation using axial implants
The invention comprises a method for fixating bones in the foot by aligning the bones in their desired position, inserting a screw in the aligned bones, inserting at least one transverse element near the head or tip of the screw, and tightening the screw to compress the bones. The screw comprises a shaft having first and second ends with spirally wound screw threads beginning near the first end and extending along the shaft. Advantageously, the screw is cannulated and screw threads are formed on an interior surface of the cannulation. Illustratively, the transverse elements may be staples, open-ended washers, or open-ended nuts. Reduction instruments and drill guides used in the invention are also disclosed.
US10226285B2 Vertebral joint implants and delivery tools
A spinal joint distraction system for treating a facet joint including articular surfaces having a contour is disclosed and may include a delivery device including a generally tubular structure adapted to engage a facet joint, an implant adapted to be delivered through the delivery device and into the facet joint, the implant comprising two members arranged in opposed position, and an implant distractor comprising a generally elongate member adapted to advance between the two members of the implant causing separation of the members and distraction of the facet joint, wherein the implant is adapted to conform to the shape of the implant distractor and/or the articular surfaces of the facet upon being delivered to the facet joint. Several embodiments of a system, several embodiments of an implant, and several methods are disclosed including a method for interbody fusion.
US10226284B2 Laminoplasty plates, systems, and devices, and methods relating to the same
Disclosed are laminoplasty devices and systems, kits that include such laminoplasty devices or systems or components thereof; and methods of assembling and using such laminoplasty devices and systems. In particular, articulating laminoplasty devices are provided that allow lamina plates to be adjusted angularly and transitionally with respect to a cage connecting the lamina plates. Also provided are laminoplasty plates that are configured so as to be assembled with a bone graft housing, and which provide an opening configured to facilitate bone graft insertion into the housing. Further provided are expandable laminoplasty fixation systems that include a lateral mass plate, a lamina plate and a set screw that when screwed and unscrewed, allows one to contract and expand the plates with respect to one another.
US10226283B2 Spinous process fixation system and methods thereof
An implantable device may comprise a barrel, the barrel having an upper portion and a lower portion. The barrel may be configured to transition from a collapsed form having a first height to an expanded form having a second height and wherein the second height is greater than the first height. The implantable device may further include an actuator assembly disposed in the barrel, the actuator assembly comprising a front ramped actuator in engagement with the barrel, a rear ramped actuator in engagement with the barrel, and a central screw that extends from the rear ramped actuator through the front ramped actuator. The implantable device may further comprise a first plate and a second plate.
US10226278B2 Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
US10226272B2 Arthroscopic surgery method for osteochondritis dissecans of talus
The therapeutic method of an arthroscopic surgery method for osteochondritis dissecans or osteochondral lesion of a talus of the embodiment carries out the cutting treatment safely, without being able to avoid non-treatment target region, being able to reach a treatment target region and doing damage to any peripheral tissues, when performing a treatment since an ultrasonic treatment device is used.
US10226269B2 Surgical forceps
A forceps includes an end effector assembly having first and second jaw members, each including a proximal flange and a distal jaw body defining a tissue-treating surface. The second jaw member is both proximally offset and spaced-apart from the first jaw member. One or more resilient bands extends between and interconnects the proximal flanges of the jaw members. The resilient band(s) is configured to bias the first and second jaw members towards an open position. The resilient band(s) is configured to flex in response to distal translation of the second jaw member relative to the first jaw member to thereby move the second jaw member relative to the first jaw member to a closed position for grasping tissue between the tissue-treating surfaces thereof. In the closed position, the second jaw member is disposed in an aligned orientation and is approximated relative to the first jaw member.
US10226268B2 Clot retrieval system
Catheter-delivered endovascular medical devices are described. The devices may include a pull wire attached to a distal body. The distal body may be formed of a basket or other lattice that has a plurality of cells and an impermeable or permeable film that prevents a clot captured by the basket from escaping distally out of the basket. Methods of using and making the devices are also described.
US10226267B2 Treatment instrument
A treatment instrument is that a maximum dimension of the loop portion in a direction orthogonal to the longitudinal axis in a state where half of a total length of the loop portion in a direction of the longitudinal axis of the loop portion is pulled into the sheath is 40% to 60% of a maximum dimension of the loop portion in the orthogonal direction in a state where the whole loop portion protrudes from a distal end of the sheath.
US10226265B2 Shock wave device with polarity switching
Described here are devices and methods for forming shock waves. The devices may comprise an axially extending elongate member. A first electrode pair may comprise a first electrode and a second electrode. The first electrode pair may be provided on the elongate member and positioned within a conductive fluid. A controller may be coupled to the first electrode pair. The controller may be configured to deliver a series of individual pulses to the first electrode pair, where each pulse creates a shock wave. The controller may cause current to flow through the electrode pair in a first direction for some of the pulses in the series and in a second direction opposite the first direction for the remaining pulses in the series.
US10226260B2 Dynamic locking device
A surgical instrument including a tool, a handpiece, and a locking member. The handpiece includes both a coupling member configured to cooperate with the tool, and a driver for rotating the tool. The locking member is movable from an unlocked position to a locked position in response to centrifugal force generated during rotation of the locking member. The locking member is configured to secure the tool to the handpiece when in the locked position.
US10226253B2 Firing assembly for circular stapler
A surgical instrument includes a body, a shaft assembly, a stapling head assembly, and a drive assembly. The shaft assembly includes an actuator. The stapling head assembly is operable to drive an annularly arranged array of staples into tissue in response to translation of the actuator along a first axis relative to the body. The drive assembly is operable to translate the actuator along the first axis. The drive assembly comprises first and second rotary members. The first rotary member is rotatable about a second axis. The second axis is non-parallel with the first axis. The second rotary member is rotatable about a third axis. The third axis is non-parallel with the first axis and non-parallel with the second axis. The first rotary member is operable to drive the second rotary member to rotate about the third axis to thereby drive the actuator along the first axis.
US10226248B2 Surgical fastener applier
A surgical fastener applier includes a variable drive mechanism disposed within a housing and operably coupled between an input member and an output member, the variable drive mechanism being transitionable between at least a first condition, wherein rotation of the input member by a fixed amount effects rotation of the output member a first amount, and a second condition, wherein rotation of the input member by the fixed amount effects rotation of the output member a second amount different from the first amount.
US10226246B2 Tissue stapler anvil feature to prevent premature jaw opening
A surgical instrument includes a handle assembly having a trigger operable to fire a staple driver to staple tissue. The instrument includes a pointed rod to which an anvil may be coupled. An anvil detection feature is included to determine when the anvil is coupled to the rod. In some versions, the anvil detection feature comprises a translatable rod that inhibits a lockout feature from disengaging. In other versions, an anvil sensing tube is disposed about the pointed rod and interferes with actuation of the trigger in a first position. A recess in the tube permits trigger to actuate when the anvil sensing tube is in the second position. Alternatively, a resilient tab is coupled to the pointed rod and resists actuation of the staple driver. A trigger lockout assembly may include a spring-loaded button that “pops” out when a push rod is actuated, thereby freeing a pivotable lockout feature.
US10226245B2 Automatically reloading suture passer devices that prevent entanglement
Suture passers and methods of use. Described herein are suture passers preloaded with suture, including cartridges that couple to a suture passer to form a loaded suture passer that are configured to prevent a length of suture (e.g., already-passed suture) from re-entering the channel of the suture passer jaw and getting recaptured and/or entangled by the tissue penetrator. In particular, described herein are preloaded and automatically re-loading suture passers that are adapted to include a gate, guide, or shield on one of the jaws of the suture passer, and methods of operating such suture passers for surgical use including repairing tissue.
US10226243B2 Transosseous suture anchor
A knotless suture anchor may include an anchor body with a proximal end, a distal end, an interior longitudinal passageway, a proximal opening communicating with the longitudinal passageway nearer the proximal end, and a distal opening communicating with the longitudinal passageway nearer the distal end. A first suture portion extends within the longitudinal passageway between the proximal opening and the distal opening, a second suture portion is contiguous to the first portion and extending out of the anchor body, a third suture portion is contiguous to the second portion and extends within the longitudinal passageway proximally to distally, and a fourth suture portion is contiguous to the third portion, extending along the exterior surface distally to proximally. A proximal member may be joined to the anchor body by a frangible connection and may have a proximal member axial passage containing an interference member coaxially aligned with the longitudinal passageway.
US10226242B2 Noninvasively adjustable suture anchors
In one embodiment, an adjustable implant system includes a bone anchor having first and second ends, a bone engagement surface adjacent the first end, and a housing extending between the first and second ends. The adjustable implant system can further include a non-invasively actuatable driving element within the housing and coupled to an adjustment component configured to couple to a flexible elongate tension member which is capable of engaging a patient's soft tissue (e.g., rotator cuff or ACL). Non-invasive actuation of the driving element can cause the adjustment component to change the amount of tension on the flexible elongate tension member and consequently on the patient's soft tissue. The adjustable implant system can include an external adjustment device configured to be placed on or adjacent the patient's skin and comprising at least one energy transferring component configured to energize/actuate the driving element inside the housing of the adjustable implant.
US10226236B2 Ultrasound imaging system and method with automatic adjustment and/or multiple sample volumes
Adjustment of operation of an ultrasound imaging system may be based at least in part on one or more characteristics represented in ultrasound return signals from two or more sample volumes. Adjustment may include adjusting a principal sample volume location or selecting a new principal sample volume. For example, a location of a principal sample volume may be adjusted or new principal sample volume selected so as to remain focused on an identified region of interest or to maintain the principal sample volume relative to some structure or reference. The principal sample volume may be maintained in the center or along a centerline of an artery or other structure, as the transducer array is moved along the artery or structure.
US10226227B2 System and method for classifying and characterizing tissues using first-order and second-order statistics of quantitative ultrasound parametric maps
Systems and methods for classifying tissue using quantitative ultrasound techniques. Parameters are calculated directly from raw echo signal data acquired from a region-of-interest during an ultrasound scan and parametric maps are produced using these parameters. These parameters can be calculated after normalizing the echo signal data using reference data so as to mitigate the effects of variations in instruments settings, ultrasound beam diffraction, and attenuation effects. First-order and second-order statistical measures are computed from these parametric maps, and are used to classify the tissue or tissues in the region-of-interest. Using these systems and methods, tissue can be classified with different levels of classification. For example, a tissue characterized as malignant cancer can additionally be graded (e.g., Grade I, II, or III).
US10226225B2 Feature characterization for breathing monitor
A method of identifying a breath comprises sensing a signal generated by a living human or animal body and separating the signal into a plurality of frequency bands to identify a breath candidate.
US10226222B2 X-ray diagnostic apparatus and foot switch used for the same
According to one embodiment, an X-ray diagnostic apparatus which can improve operability is provided. This apparatus comprises a top configured to move, a bed including the top, an X-ray tube configured to generate X-rays applied to an object placed on the top, a peripheral unit used around the bed, and control processing circuitry configured to generate a control signal. The peripheral unit moves in a self-propelled manner between a first position and a second position by a motor. The control processing circuitry generates a control signal for controlling the movement of the peripheral unit.
US10226220B2 Detecting, assessing and managing a risk of death in epilepsy
A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
US10226219B2 Interactive surgical drape, system, and related methods
Embodiments disclosed herein relate to an interactive surgical drape and system including at least one sensor and at least one controller that operates indicating sensing feedback from the at least one sensor to cause display of information on a dynamic display integrated with the interactive surgical drape. The dynamic display assists the surgical team while performing surgery and can operate to improve the efficiency and/or effectiveness of the surgical team.
US10226218B2 Pressure sensing implant
A wireless circuit includes a housing having at least one opening, and sensor connected to the housing at the opening. The sensor includes a first layer having a first dimension and a second layer having a second dimension shorter than the first dimension. The second layer may be positioned entirely within the housing and a surface of said first layer may be exposed to an exterior of the housing.
US10226217B2 System, method and computer program product for physiological monitoring
A system for measuring physiological parameters, including: a portable measurement system, operable to acquire physiological measurement from an examined body location; an external camera operable to capture visible light, oriented toward the examined body location; a synchronization module, operable to receive a triggering indication, and in response to the triggering indication to associate to the physiological measurement a positioning image captured by the camera, the positioning image including at least a part of the portable measurement system adjacent to the examined body location; and a communication module operable to obtain the physiological measurement and the positioning image, and to transmit to a remote system: a physiological measurement record based on the physiological measurement, an orientation image based on the positioning image, and including at least a part of the portable measurement system adjacent to the examined body location, and association data associating the orientation image and the physiological measurement record.
US10226211B2 System and method for determining user's deep vein thrombosis prevention and diagnosis system utilization compliance
A system and method determines a user's compliance with a prescribed therapeutic pneumatic compression treatment by applying external pressure to a body limb using a pneumatic compression sleeve having a pneumatically fillable cell; measuring pneumatic pressure within the pneumatically fillable cell; generating a pressure signal corresponding to the measured pneumatic pressure; determining biological events associated with the user based upon the pressure signal; generating a positive detection signal for each determined biological event associated with the user; and determining a user's compliance with a prescribed therapeutic pneumatic compression treatment when a predetermined number of positive detection signals have been generated within a predetermined time interval.
US10226209B2 Method and apparatus for classification of seizure type and severity using electromyography
A method and apparatus for monitoring a patient for seizure activity including collecting and processing EMG signal data and categorizing the detected data to execute risk stratification. A transmission protocol that is tailored for detected events may be selected and executed.
US10226208B2 Analyte detection devices and methods with hematocrit/volume correction and feedback control
Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
US10226206B2 Systems and methods for measuring neonatal cerebral oxygenation
Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
US10226205B2 Systems and methods for a continuous monitoring of analyte values
Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.
US10226204B2 Method for detecting and responding to falls by residents within a facility
One variation of a method for detecting and responding to falls by residents within a facility includes: at a wearable device worn by a resident, writing sensor data from a sensor integrated into the wearable device to a buffer, inputting sensor data into a compressed fall detection model—defining a compressed form of a complete fall detection model and stored locally on the wearable device—to detect a fall event at a first time, and transmitting a corpus of sensor data from the buffer and a cue for confirmation of the fall event to a local wireless hub in response to detecting the fall event; and, remotely from the wearable device, inputting the corpus of sensor data into the complete fall detection model—stored remotely from the wearable device—to confirm the fall event and dispatching a care provider to assist the resident in response to confirming the fall event.
US10226199B2 Medical-image processing apparatus, method for controlling the same, and storage medium
An information processing apparatus includes an acquisition unit, a specification unit, a determination unit, a generation unit, and a display control unit. The acquisition unit acquires a three-dimensional image containing at least a tubular structure. The specification unit specifies a first point inside the tubular structure and specifies a lesion outside the tubular structure in the three-dimensional image. The determination unit determines whether a blood vessel is present in a region between the first point and the lesion based on signal values of voxels of the three-dimensional image in the region between the first point and the lesion. The generation unit generates a two-dimensional image of the tubular structure viewed from the first point based on the three-dimensional image. The display control unit displays information indicating a region of the lesion on the two-dimensional image to be distinguishable in determining whether a blood vessel is present in the region.
US10226198B2 Electrode attachment state determination system, electrode attachment state determination method, and program thereof
An electrode attachment state determination system includes: an electroencephalogram measurement section for measuring an electroencephalogram signal of a user by using at least one set of electrodes including a ground electrode, a reference electrode, and a measurement electrode; a frequency analysis section for performing a frequency analysis of the electroencephalogram signal; an insufficient electrode determination section for extracting at least one parameter of a total frequency power and a noise amount from a result of the frequency analysis, and through a comparison of a value of the parameter against a predetermined threshold value, determining whether the ground electrode, the reference electrode, or the measurement electrode has an insufficient state of attachment; and an output section for, when an insufficient state of attachment is determined, presenting information indicating the insufficient state of electrode attachment to the user.
US10226196B2 Non-invasive prediction of risk for sudden cardiac death
A method and apparatus for the quantitative determination of an individual's risk for sudden cardiac death (SCD) is described. Risk stratification is accomplished (and may have a sensitivity and specificity of greater than about 90%) by determining the presence in any individual being tested for SCD risk of sequences identified herein to correlate quantitatively with SCD risk. Both the number of such sequences present and their alignment scores (similarity) with the SCD risk sequence ensemble are used to calculate quantitative SCD risk.