Document Document Title
US08994109B2 High-K heterostructure
A method for preparing a multilayer substrate includes the step of deposing an epitaxial γ-Al2O3 Miller index (001) layer on a Si Miller index (001) substrate.
US08994096B2 Multi-transistor memory cell with an enhancement junction field effect transistor (JFET) as the access gate transistor
The invention relates to a multi-transistor, e.g. a two-transistor memory cell with an enhancement junction field effect transistor (JFET) as the access gate transistor. In one embodiment, the JFET is provided as a self-aligned JFET. Accordingly, and advantageous over the prior art, the invention allows for a method for manufacturing a multi-transistor, e.g. a two-transistor memory cell comprising a JFET as the access transistor without adding any additional masks and/or processing steps. Such a multi-transistor, e.g. a two-transistor memory cell according to invention, provides an improved reliability.
US08994094B2 Nonvolatile semiconductor memory device and method for manufacturing same
According to one embodiment, a nonvolatile semiconductor memory device includes first and second stacked body, first and second semiconductor pillars, a connecting portion, a first memory film, and a dividing portion. The stacked bodies include a plurality of electrode films stacked along a first axis and as interelectrode insulating film provided between the electrode films. The first and second semiconductor pillars penetrate through the first and second stacked bodies along the first axis, respectively. The connecting portion electrically connects the first and second semiconductor pillars. The first memory film is provided between the electrode film and the semiconductor pillar. The dividing portion electrically divides the first and second electrode films from each other between the first semiconductor pillar and the second semiconductor pillar, is in contact with the connecting portion, and includes a stacked film including a material used for the first memory film.
US08994090B2 Nonvolatile semiconductor storage device and method of manufacturing the same
A nonvolatile semiconductor storage device including a memory cell region including a memory cell having a charge storing layer above a gate insulating film and a control electrode above the charge storing layer via an interelectrode insulating film; and a peripheral circuit region including a peripheral element having a first polysilicon and a first insulating film above the first polysilicon; wherein the charge storing layer includes a polysilicon doped with P-type impurity including a first upper region contacting the interelectrode insulating film and having a first doped layer doped with carbon or nitrogen, and at least a portion of a region below the first doped layer is neither doped with carbon nor nitrogen, and wherein the first polysilicon includes a second upper region contacting the first insulating film and having a second doped layer doped with carbon or nitrogen, the first and the second doped layers having equal thickness.
US08994082B2 Transistors, methods of manufacturing thereof, and image sensor circuits with reduced RTS noise
Transistors, methods of manufacturing thereof, and image sensor circuits with reduced random telegraph signal (RTS) noise are disclosed. In one embodiment, a transistor includes a channel disposed between two isolation regions in a workpiece. The channel has edge regions proximate the isolation regions and a central region between the edge regions. The transistor includes a gate dielectric disposed over the channel, and a gate disposed over the gate dielectric. The transistor includes a voltage threshold modification feature proximate the edge regions configured to increase a voltage threshold of the transistor proximate edge regions relative to the central region of the channel.
US08994079B2 Graphene electronic devices having multi-layered gate insulating layer
A graphene electronic device includes a multi-layered gate insulating layer between a graphene channel layer and a gate electrode. The multi-layered gate insulating layer includes an organic insulating layer and an inorganic insulating layer on the organic insulating layer.
US08994077B2 Field effect transistor-based bio sensor
An apparatus comprises: a sensing element formed on a buried oxide layer of a substrate and providing communication between a source region and a drain region; a gate dielectric layer on the sensing element, the gate dielectric layer defining a sensing surface on the sensing element; a passive surface surrounding the sensing surface; and a compound bound to the sensing surface and not bound to the passive surface, the compound having a ligand specifically configured to preferentially bind a target molecule to be sensed. An electrolyte solution in contact with the sensing surface and the passive surface forms a top gate of the apparatus.
US08994073B2 Hydrogen mitigation schemes in the passivation of advanced devices
Embodiments of a Silicon Nitride (SiN) passivation structure for a semiconductor device are disclosed. In general, a semiconductor device includes a semiconductor body and a SiN passivation structure over a surface of the semiconductor body. In one embodiment, the SiN passivation structure includes one or more Hydrogen-free SiN layers on, and preferably directly on, the surface of the semiconductor body, a Hydrogen barrier layer on, and preferably directly on, a surface of the one or more Hydrogen-free SiN layers opposite the semiconductor body, and a Chemical Vapor Deposition (CVD) SiN layer on, and preferably directly on, a surface of the Hydrogen barrier layer opposite the one or more Hydrogen-free SiN layers. The Hydrogen barrier layer preferably includes one or more oxide layers of the same or different compositions. Further, in one embodiment, the Hydrogen barrier layer is formed by Atomic Layer Deposition (ALD).
US08994072B2 Reduced resistance SiGe FinFET devices and method of forming same
A method for forming a fin field-effect transistor (FinFET) device, comprises forming a plurality of silicon fins on a substrate, depositing silicon germanium (SiGe) on the plurality of fins, forming a gate region by forming a dummy gate stack on a predetermined area of the fins including the SiGe, removing the SiGe from an area of the fins not covered by the dummy gate stack, forming a merged region in the area of the fins not covered by the dummy gate stack to form a source drain region, removing the dummy gate stack to expose the remaining SiGe in the gate region, mixing the SiGe with the silicon fins in the gate region to form SiGe fins, and depositing a gate dielectric and gate metal on the SiGe fins.
US08994071B2 Semiconductor devices grown on indium-containing substrates utilizing indium depletion mechanisms
We have observed anomalous behavior of II-VI semiconductor devices grown on certain semiconductor substrates, and have determined that the anomalous behavior is likely the result of indium atoms from the substrate migrating into the II-V layers during growth. The indium can thus become an unintended dopant in one or more of the II-VI layers grown on the substrate, particularly layers that are close to the growth substrate, and can detrimentally impact device performance. We describe a variety of semiconductor constructions and techniques effective to deplete the migrating indium within a short distance in the growth layers, or to substantially prevent indium from migrating out of the substrate, or to otherwise substantially isolate functional II-VI layers from the migrating indium, so as to maintain good device performance.
US08994065B2 High-voltage vertical power component
A vertical power component including: a silicon substrate of a first conductivity type; on the side of a lower surface of the substrate supporting a single electrode, a lower layer of the second conductivity type; and on the side of an upper surface of the substrate supporting a conduction electrode and a gate electrode, an upper region of the second conductivity type, wherein the component periphery includes, on the lower surface side, a porous silicon insulating ring penetrating into the substrate down to a depth greater than that of the lower layer.
US08994057B2 Light emitting devices for light emitting diodes (LEDS)
Light emitting devices for light emitting diodes (LEDs) are disclosed. In one embodiment a light emitting device can include a submount and a light emission area disposed over the submount. The light emission area can include one or more light emitting diodes (LEDs), a fillet at least partially disposed about the one or more the LEDs, and filling material. The filling material can be disposed over a portion of the one or more LEDs and a portion of the fillet.
US08994056B2 LED-based large area display
An improved approach is described to implement an LED-based large area display which uses an array of single color solid state lighting elements (e.g. LEDs). In some embodiments, the panel comprises an array of blue LEDs, where each pixel of the array comprises three blue LEDs. An overlay is placed over the array of blue LEDs, where the overlay comprises a printed array of phosphor portions. Each pixel on the PCB comprised of three blue LEDs is matched to a corresponding portion of the overlay having the printed phosphor portions. The printed phosphor portions of the overlay includes a number of regions of blue light excitable phosphor materials that are configured to convert, by a process of photoluminescence, blue excitation light generated by the light sources into green or red and colored light. Regions of the overlay associated with generating blue light comprise an aperture/window that allows blue light to pass through the overlay.
US08994054B2 Nitride LED with a schottky electrode penetrating a transparent electrode
According to one embodiment, a semiconductor light emitting device includes a stacked structural body, a first electrode, a second electrode, a third electrode, and a fourth electrode. The stacked structural body includes a first semiconductor layer, a second semiconductor layer, and a light emitting layer provided between the first semiconductor layer and the second semiconductor layer. The first electrode is electrically connected to the first semiconductor layer. The second electrode forms an ohmic contact with the second semiconductor layer. The second electrode is translucent to light emitted from the light emitting layer. The third electrode penetrates through the second electrode and is electrically connected to the second electrode to form Shottky contact with the second semiconductor layer. The third electrode is disposed between the fourth electrode and the second semiconductor layer. A shape of the fourth electrode as viewed along a stacking direction of the first semiconductor layer, the light emitting layer, and the second semiconductor layer is same as a shape of the third electrode as viewed along the stacking direction.
US08994052B2 High-efficiency light-emitting device and manufacturing method thereof
A light-emitting device includes a first semiconductor layer; an active layer formed on the first semiconductor layer; a second semiconductor layer formed on the active layer; and a first pad formed on the second semiconductor layer, wherein the second semiconductor layer comprises a first region right under the first pad and a plurality of voids formed in the first region, wherein the region outside the first region in the second semiconductor layer is devoid of voids, and an area of the first region is smaller than that of the first pad in top view and the area of the first pad is smaller than that of the second semiconductor layer in top view, and the light emitted from the active layer is extracted from a top surface of the second semiconductor layer opposite the first semiconductor layer.
US08994051B2 Light emission module, light emission module manufacturing method, and lamp unit
In a light emission module (40), a light wavelength conversion ceramic (52) is formed in a sheet shape which converts the wavelength of the light emitted from a semiconductor light emission element (48) when emitting the light. The light wavelength conversion ceramic (52) has a tapered plane (52a) which is inclined to approach the semiconductor light emission element (48) toward the brim portion. The light wavelength conversion ceramic (52) is transparent and is arranged so that the light emission wavelength band after the conversion has an all ray permeability of 40% or above.
US08994049B2 Light emitting component and manufacturing method thereof
A light emitting component, and more particularly to a white light emitting component with high light emitting efficiency are provided. The white light emitting component with high light emitting efficiency has properties of high driving voltage, high color render index and concentrated optical density. The light emitting component includes a plurality of different light emitting diode chip groups for emitting a number of lights in different wavelength ranges and a wavelength conversion fluorescent material. A manufacturing method by stacking miniature light emitting diode chip groups to form the white light emitting component is also provided.
US08994047B2 Arrangement comprising at least one optoelectronics semiconductor component
An arrangement having at least one optoelectronic semiconductor component includes a carrier element suitable for carrying the at least one optoelectronic semiconductor component. The arrangement comprises a housing body formed from a light-absorbing plastic. The housing body is arranged at the carrier element The housing body comprises an elevated region and a recessed region. An oblique flank is formed between the elevated and recessed regions. The recessed region reaches as far as the optoelectronic semiconductor component in order to reduce reflections.
US08994045B2 Lighting device having luminescent material between a reflective cup and a solid state light emitter
A lighting device comprising a light emitter chip, a reflective cup and a lumiphor positioned between the chip and the cup. Also, a lighting device comprising a light emitter chip, a wire bonded to a first surface of the chip and a lumiphor which faces a second surface of the chip. Also, a lighting device comprising a light emitter chip, and a lumiphor, a first surface of the chip facing a first region of the lumiphor, a second surface of the chip facing a second region of the lumiphor. Also, a lighting device comprising a light emitter chip and first and second lumiphors, a first surface of the chip facing the second lumiphor, a second surface of the chip facing the first lumiphor. Also, methods of making lighting devices.
US08994044B2 Electro-optical device, electrode therefore, and method and apparatus of manufacturing an electrode and the electro-optical device provided therewith
The present invention relates to an electro-optical device provided with an electrode (10). The electrode comprising an electrically conductive structure extending in a plane. The structure comprises a grid of elongated elements (12) with length L and a width dimension D in said plane. The electrically conductive structure further comprises one or more contactfields (14) having an inscribed circle with a radius of at least 2D and a circumscribed circle with a radius of at most three times L. The area occupied by the contactfields (14) is at most 20% of the area occupied by the grid of elongated elements (12).
US08994040B2 Method of producing an optoelectronic component and component
A method of producing an optoelectronic component including providing an epitaxially grown layer sequence on a growth substrate, which comprises a suitable layer for light emission; applying a metal layer to the epitaxially grown layer sequence; applying a molding support to the metal layer, the molding support including a support material with a first coefficient of thermal expansion and a fiber mesh with a second coefficient of thermal expansion functionally bonded to the support material; and detaching the growth substrate.
US08994039B2 Lighting module
A lighting module may include a lighting band with a band-shaped flexible substrate, wherein at least one semiconductor light source is applied to a top side of the substrate, wherein the lighting module is faced with a protective layer such that at least one emission area of the at least one semiconductor light source is exposed thereby.
US08994036B2 Semiconductor device with heat removal structure and related production method
According to the invention, a semiconductor device composite structure is provided which comprises an initial substrate with discrete, integrated devices and a heat removal structure. The heat removal structure comprises: a bond layer which is attached to the initial substrate or the devices, a heat removal structure which is attached on the bond layer and which consists of a material with a specific thermal conductivity which is at least double the level of the average specific heat conductivity of the initial substrate or the devices, and one or more metallic thermal bridges which thermally connect the devices with the heat removal structure via the bond layer. The thermal bridges are designed as vertical through connections (vias) through the bond and heat removal structure. The invention furthermore relates to an associated production method.
US08994035B2 Semiconductor device with low-conducting buried and/or surface layers
A device including one or more low-conducting layers is provided. A low-conducting layer can be located below the channel and one or more attributes of the low-conducting layer can be configured based on a minimum target operating frequency of the device and a charge-discharge time of a trapped charge targeted for removal by the low-conducting layer or a maximum interfering frequency targeted for suppression using the low-conducting layer. For example, a product of the lateral resistance and a capacitance between the low-conducting layer and the channel can be configured to be larger than an inverse of the minimum target operating frequency and the product can be smaller than at least one of: the charge-discharge time or an inverse of the maximum interfering frequency.
US08994032B2 III-N material grown on ErAIN buffer on Si substrate
III-N material grown on a buffer on a silicon substrate includes a single crystal electrically insulating buffer positioned on a silicon substrate. The single crystal buffer includes rare earth aluminum nitride substantially crystal lattice matched to the surface of the silicon substrate, i.e. a lattice co-incidence between REAlN and Si better than a 5:4 ratio. A layer of single crystal III-N material is positioned on the surface of the buffer and substantially crystal lattice matched to the surface of the buffer.
US08994027B2 Thin film transistor array substrate, organic light-emitting display device including the same, and method of manufacturing the same
A thin film transistor (TFT) array substrate includes a TFT including an active layer, a gate electrode, a source electrode, a drain electrode, a first gate insulating layer and a second gate insulating layer formed between the active layer and the gate electrode, and an interlayer insulating layer formed between the gate electrode and the source electrode and the drain electrode; a pixel electrode formed in an opening of the interlayer insulating layer, the pixel electrode including transparent conductive oxide; a translucent electrode formed in a region corresponding to the pixel electrode, between the first gate insulating layer and the second gate insulating layer; and a capacitor including a lower electrode formed from the same layer as the active layer, and an upper electrode formed from the same layer as the translucent electrode.
US08994026B2 Structure, structure and method of latch-up immunity for high and low voltage integrated circuits
Design structures, structures and methods of manufacturing structures for providing latch-up immunity for mixed voltage integrated circuits. The structure includes a diffused N-Tub structure embedded in a P-wafer and provided below a retrograde N-well to a non-isolated CMOS logic.
US08994019B2 Semiconductor device
The invention is to provide a structure of a semiconductor device which achieves quick response and high-speed drive by improving on-state characteristics of a transistor, and to provide a highly reliable semiconductor device. In a transistor in which a semiconductor layer, a source and drain electrode layers, a gate insulating film, and a gate electrode are sequentially stacked, a non-single-crystal oxide semiconductor layer containing at least indium, a Group 3 element, zinc, and oxygen is used as the semiconductor layer. The Group 3 element functions as a stabilizer.
US08994015B2 Organic light-emitting display device
An organic light-emitting display device includes a display substrate comprising a plurality of pixel regions at least partially defined by a plurality of non-pixel regions; a sealing substrate facing the display substrate; and a spacer on one of the non-pixel regions of the display substrate between the display substrate and the sealing substrate to maintain a space between the display substrate and the sealing substrate. The plurality of pixel regions include a first pixel; a second pixel spaced apart from the first pixel and having a center corresponding to a first corner of a virtual rectangle having a center corresponding to a center of the first pixel; and a third pixel spaced apart from the second pixel and having a center corresponding to a second corner adjacent to the first corner of the virtual rectangle. The spacer is adjacent to the second pixel.
US08994013B2 Light-emitting element, light-emitting device, display device, electronic device, and lighting device
An object is to provide a light-emitting element which includes an exciplex being used as an energy donor capable of efficiently transferring energy to a substance exhibiting thermally activated delayed fluorescence. The exciplex comprises two kinds of substances and its singlet and triplet excited states are close to each other. Thus, by making light emission of the exciplex overlap with an absorption band on the longest wavelength side which corresponds to absorption by the substance exhibiting thermally activated delayed fluorescence, i.e., an energy acceptor, in a singlet excited state, it becomes possible to achieve efficient energy transfer from a singlet excited state of the exciplex to a singlet excited state of the substance exhibiting thermally activated delayed fluorescence, and it also becomes possible to achieve efficient energy transfer from a triplet excited state of the exciplex to a triplet excited state of the substance exhibiting thermally activated delayed fluorescence.
US08994011B2 Organic light-emitting device
The present invention provides an organic light emitting device including: a substrate; and two or more stacked light emitting elements, which comprise a first electrode, at least one intermediate electrode, a second electrode, and an organic material layer disposed between the electrodes, the stacked organic light emitting elements including a first group of electrodes electrically connected to each other such that among the electrodes, at least two electrodes, which are not adjacent to each other, become a common electric potential, and a second group of electrodes which include one electrode among electrodes which are not electrically connected to the first group of electrodes, or at least two electrodes which are not electrically connected to the first group of electrodes and are electrically connected to each other so as to be a common electric potential without being adjacent to each other, in which the stacked organic light emitting elements are disposed at an interval apart from each other on the substrate and driven by an alternating current power source such that a form, in which a first group of electrodes of one stacked organic light emitting element among the stacked organic light emitting elements are directly connected to a second group of electrodes of another stacked organic light element, is continuously repeated.
US08994010B2 Organic light-emitting display device and method of manufacturing the same
An organic light-emitting display device and a method of manufacturing the organic light-emitting display device are provided. The organic light-emitting display device includes a plurality of pixels each including: a first region including a light-emitting region for emitting light, a first electrode and an emission layer covering the first electrode being located in the light-emitting region; and a second region including a transmissive region for transmitting external light through the display device. The display device also includes: a third region between the pixels; a first auxiliary layer in the first and third regions; a second electrode on the first auxiliary layer in the first and third regions; a second auxiliary layer covering the second electrode and located in the first and second regions and not in the third region; and a third electrode on the second electrode in the third region.
US08994008B2 Reverse printing ink composition, printing method using the same, method of manufacturing display unit using the same
A reverse printing ink composition capable of realizing printing with a uniform film thickness and high-definition patterning, a printing method using the same, and a method of manufacturing a display unit using the same are provided. The reverse printing ink composition includes a solvent containing an aromatic carbon hydride and a straight-chain carbon hydride and a low-molecular material.
US08994000B2 Optoelectronic semiconductor chip
An optoelectronic semiconductor chip comprises the following sequence of regions in a growth direction (c) of the semiconductor chip (20): a p doped barrier layer (1) for an active region (2), the active region (2), which is suitable for generating electromagnetic radiation, the active region being based on a hexagonal compound semiconductor, and an n doped barrier layer (3) for the active region (2). Also disclosed are a component comprising such a semiconductor chip, and to a method for producing such a semiconductor chip.
US08993999B2 Semiconductor light emitting device and method for manufacturing same
According to an embodiment, a semiconductor light emitting device is configured to emit light by energy relaxation of an electron between subbands of a plurality of quantum wells. The device includes an active layer and at least a pair of cladding layers. The active layer is provided in a stripe shape extending in a direction parallel to an emission direction of the light, and includes the plurality of quantum wells; and the active layer emits the light with a wavelength of 10 μm or more. Each of the cladding layers is provided both on and under the active layer respectively and have a lower refractive index than the active layer. At least one portion of the cladding layers contains a material having a different lattice constant from the active layer and has a lower optical absorption at a wavelength of the light than the other portion.
US08993998B2 Electro-optic device having nanowires interconnected into a network of nanowires
An electro-optic device includes a first electrode, an active layer formed over and electrically connected with the first electrode, a buffer layer formed over and electrically connected with the active layer, and a second electrode formed directly on the buffer layer. The second electrode includes a plurality of nanowires interconnected into a network of nanowires. The buffer layer provides a physical barrier between the active layer and the plurality of nanowires to prevent damage to the active layer while the second electrode is formed.
US08993989B1 Apparatuses and methods employing multiple layers for attenuating ionizing radiation
Radiation shields and radiation shielding systems for attenuating ionizing radiation include two or more attenuating elements, such as layers. The two or more attenuating elements may include different attenuating materials. The two or more attenuating elements may be configured to attenuate ionizing radiation differently than one another. In some embodiments, different attenuating elements may be configured for use with different energies or ranges of energies of ionizing radiation. The concurrent use of two or more layers or other attenuating elements may optimize the ability of a radiation shield to attenuating ionizing radiation. Systems and methods for attenuating ionizing radiation are also disclosed.
US08993981B2 Charged particle source with light monitoring for tip temperature determination
Systems and methods for heating an apex of a tip of a charged particle source are disclosed. The charged particle source can be, for example, a gas ion source. The systems can include a detector configured to detect light generated by the tip apex, and a controller coupled with the charged particle source and the detector so that the controller can control heating of the tip apex based on the light detected by the detector.
US08993980B1 Dual stage scanner for ion beam control
An ion beam scanner includes a first scanner stage having a first opening to transmit an ion beam, the first scanner stage to generate, responsive to a first oscillating deflection signal, a first oscillating deflecting field within the first opening; a second scanner stage disposed downstream of the first scanner stage and having a second opening to transmit the ion beam, the second scanner stage to generate, responsive to a second oscillating deflection signal, a second oscillating deflecting field within the second opening that is opposite in direction to the first oscillating deflecting field, and a scan controller to synchronize the first oscillating deflection signal and second oscillating deflection signal to generate a plurality of ion trajectories when the scanned ion beam exits the second stage that define a common focal point.
US08993979B2 Beam control assembly for ribbon beam of ions for ion implantation
A beam control assembly to shape a ribbon beam of ions for ion implantation includes a first bar, second bar, first coil of windings of electrical wire, second coil of windings of electrical wire, first electrical power supply, and second electrical power supply. The first coil is disposed on the first bar. The first coil is the only coil disposed on the first bar. The second bar is disposed opposite the first bar with a gap defined between the first and second bars. The ribbon beam travels between the gap. The second coil is disposed on the second bar. The second coil is the only coil disposed on the second bar. The first electrical power supply is connected to the first coil without being electrically connected to any other coil. The second electrical power supply is connected to the second coil without being electrically connected to any other coil.
US08993978B2 Method for assessing an alpha particle emission potential of A metallic material
A method for assessing an alpha particle emission potential of a metallic material. A metallic material is initially subjected to a secular equilibrium disruption process, such as melting and/or refining, to disrupt the secular equilibrium of the radioactive decay of one or more target parent isotopes in the material. A sample of the material is treated to diffuse target decay isotopes within the sample such that the measured alpha particle emission directly corresponds to the concentration or number of target decay isotope atoms within the entirety of the sample, enabling the concentration of target decay isotopes in the sample to be determined. The concentration of target parent isotopes in the material may then be determined from the concentration of target decay isotopes and time elapsed from the secular equilibrium disruption process, and may be used to determine a maximum alpha particle emission that the metallic material will exhibit.
US08993977B2 Detector and a method for simultaneously detecting both gamma rays and neutron using the same
The present invention discloses a detector. The detector includes a detector crystal, configured to detect incident rays therein; a plurality of moderator layers, configured to moderate neutrons entering the moderator layer; and a plurality of converter layers, configured to react with said moderated neutrons. The moderator layers and the converter layers are overlapped with each other, and the moderator layers and the converter layers are located outside the detector crystal.
US08993976B2 Energy sensors for light beam alignment
An apparatus includes a drive laser system producing an amplified light beam of pulses that travels along a drive axis; a beam delivery system that directs the amplified light beam of pulses toward a target region; a target material delivery system that provides a target mixture containing a target material in the target region; two or more sensors radially separated from a main axis that crosses the target region, the two or more sensors being configured to detect energy of ultraviolet electromagnetic radiation emitted from a plasma state of the target material when the amplified light beam of pulses intersects the target mixture; and a controller that receives the output from the two or more sensors. The controller is configured to estimate a relative radial alignment between the target mixture and the drive axis within the target region based on an analysis of the detected energy.
US08993972B2 Fluorescence based sensors utilizing a mirrored cavity
A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.
US08993971B2 High resolution positron emission tomography
A method for extracting photon depth of interaction information in a positron emission tomography system is provided. A pulse is detected in a photodetector. A height of the pulse is measured. A determination of whether the pulse height is within a set range is made. Photon depth of interaction is extracted from the pulse height. An energy of interaction is calculated from the pulse height and calibration data. The extracted photon depth and calculated energy spectrum are used in image reconstruction.
US08993968B2 Materials, method, and apparatus for detecting neutrons and ionizing radiation
Embodiments of the invention provide a scintillator material, a scintillator system, and/or a method of detecting incident radiation using a scintillator material, or scintillator system, comprising a polymer material that comprises chromophores. Additional embodiments provide a scintillator material, scintillator system, and/or a method of detecting incident radiation using a scintillator material, or scintillator system, comprising a polymer material having one, two, three, or more, organic dyes dissolved therein wherein the polymer material having the one, two, three, or more dyes dissolved therein comprises chromophores. At least one of the dyes, termed the base dye, has a concentration in the range 0.5 to 3.5 mol/L. In a specific embodiment, the base dye has a concentration in the range 1.0 to 3.0 mol/L. This base dye concentration is high enough to achieve a substantial triplet-triplet state annihilation rate despite the negligible diffusion of the dye in the rigid polymer matrix.
US08993960B2 Beam imaging sensor
The present invention relates generally to the field of sensors for beam imaging and, in particular, to a new and useful beam imaging sensor for use in determining, for example, the power density distribution of a beam including, but not limited to, an electron beam or an ion beam. In one embodiment, the beam imaging sensor of the present invention comprises, among other items, a circumferential slit that is either circular, elliptical or polygonal in nature.
US08993959B2 Screening for phthalates in food samples
A method includes the steps of dipping a capillary (e.g., a disposable glass capillary) into a food matrix to deposit a food sample on the capillary; attaching the capillary onto an Atmospheric Solids Analysis Probe (ASAP); loading the ASAP into an atmospheric pressure ionization (API) source enclosure; ionizing the food sample on the capillary within the API source enclosure; and analyzing the ionized sample for the presence of one or more phthalates.
US08993957B2 Downhole sensor tool for nuclear measurements
A downhole measurement apparatus includes a tool body supporting a logging tool. The logging tool includes a detector outsert coupled into and exposed through an exterior pocket of the tool body to position the outer surface of the outsert adjacent or in close proximity to the outer diameter of the tool body. A stabilizer or off-center stabilizer may be provided to further deflect the outsert portion of the logging tool toward an earth formation to increase detector proximity to the formation. The axial distance between the detector and a nuclear source can be calibrated using configurations of the nuclear source holder and the outsert. Retention mechanisms for the source holder and the outsert further enhance proximity and calibration.
US08993955B2 Encoder and apparatus using the same
The encoder includes a scale including first and second periodic patterns, and a detector relatively movable with respect to the scale and whose detection state is switchable between a first detection state to read the first periodic pattern and output a first signal and a second detection state to read the second periodic pattern and output a second signal. A processor performs a first process to detect a first absolute position by using the first and second signals and then performs a second process to calculate a relative movement amount by using a specific signal that is one of the first and second signals and detect a second absolute position by using the relative movement amount and the first absolute position. The specific signal is obtained from the detector set in a same detection state as that set last in the first process.
US08993948B2 Rolling vehicle having collar with passively controlled ailerons
A spinning, rolling, or roll-stabilized vehicle, such as a projectile, includes a fuselage that rotates about its longitudinal axis (spins) during flight. A collar is positionable relative to the fuselage to steer the projectile, with the collar having ailerons to provide a roll force to position the collar. The collar also has elevators to provide lateral force to steer the projectile. The positioning of the collar may be accomplished by moderating the roll force of the ailerons to hold the position of the collar substantially constant with regard to a longitudinal axis of the projectile. The ailerons passively change angle of attack with changes in the dynamic pressure of the projectile. At low speeds the ailerons have a relatively large angle of attack, and at high speeds, the ailerons resiliently reduce their angles of attack, avoiding large rolling forces on the collar.
US08993945B2 Oven circulating heated air
An oven which runs on a 20 ampere single phase electrical service includes a cooking chamber comprising a top wall, a bottom wall, a first side wall and a second side wall, at least one microwave generator, at least one set of nozzles, tubes or apertures disposed above a food product disposed within the oven, at least one blower having an RPM in the range between about 3000 to about 4000 at 100 percent velocity, wherein the blower circulates at least a portion of gas from the nozzles, tubes or apertures into the cooking chamber substantially toward the food product and back to the nozzles, tubes or apertures, and a thermal energy source that heats the gas, wherein the heated gas at or near the food product disposed in the cooking chamber exhibits a flow rate of at least about 150 CFM.
US08993941B2 Induction heating device
Plural induction heating coils for inductively heating to-be-heated object are provided under a top plate on which to-be-heated object is placed, and plural inverter circuits for supplying high-frequency currents to the plural induction heating coils, respectively, are adapted to be cooled by cooling air flows from cooling portions, and placed in a longitudinal row along the cooling air flows, in air-flow blowing path spaces through which cooling air flows from the cooling portions are blown, so as to facilitate cooling designing for an induction heating device and to improve the cooling performance of the induction heating device.
US08993938B2 Heater with a level switch safety mechanism
An indoor or outdoor heater with a safety bar, a tiltable heater head, a power controlling and power limiting device serving as safety mechanisms.
US08993930B2 Cooking device with electrodes in a lower face of the top plate
The cooking device includes a top plate on which a container is to be placed, heating devices provided below the top plate, electrodes provided in a lower face of the top plate and including a boiling-over detection parts placed near an outer periphery of a portion of the top plate positioned above the heating devices, contact parts for supplying an AC current to the boiling-over detection parts, and contact parts for connecting the contact parts and one-side ends of the boiling-over detection parts to each other, respectively, an electrode-use capacitance detection device for detecting changes in capacitance of the boiling-over detection parts, and a control device for controlling the heating devices based on changes in capacitance detected by the electrode-use capacitance detection device. The contact parts are provided at positions farther from the heating devices and on a more front side of the cooking device than the boiling-over detection parts, and the connection parts run through on the outer peripheral side of the boiling-over detection parts.
US08993929B2 Heated/cooled thermoelectric steering wheel
A steering wheel includes a central portion connected to the steering column for rotation about an axis, and a rim extending around the central portion. A steering wheel includes a passageway extending through portions of the steering wheel. A plurality of spaced apart rings are disposed on the rim, and a plurality of N-type and P-type thermoelectric (“TE”) elements are disposed on the rings. The thermoelectric elements may comprise Peltier devices in the form of relatively thin plate-like units having generally planar opposite surfaces, and rectangular perimeters. An electrical conductor interconnects the P-type and N-type elements in series. The steering wheel includes first and second thermal conductors thermally connected to inner and outer surfaces of the thermoelectric elements. An air circulation device moves air through the passageway to cool the rim of the steering wheel.
US08993918B2 Spot-welding method and spot-welding device
When spot-welding a workpiece including a thin plate, a first thick plate, and a second thick plate, the workpiece is clamped by a fixed electrode in contact with the second thick plate, a movable electrode in contact with the thin plate, and control-pressure applying unit set adjacent to the movable electrode and in contact with the thin plate. Pressure is applied to the second thick plate by the fixed electrode, and pressure and control pressure are respectively applied by the movable electrode and the control-pressure applying unit to the thin plate. The pressure from the fixed electrode is controlled to be smaller than the pressure from the movable electrode. The current density between the thin plate and the first thick plate increases.
US08993917B2 Fabrication method of electrode for spark surface modification, and spark surface modification electrode
A forming 7 die is filled with a powder (11) of electrode material, the powder (11) of electrode material filled in the forming die is compressed to form a porous powder compact (27), the porous powder compact (27) is set in place in a chamber (25) of a heat-treating furnace (23), the chamber (25) is supplied with inert gas or hydrogen gas, and inert gas or hydrogen gas is heated by heaters (39) in the heat-treating furnace (23) and blown toward the powder compact (27), as blows circulating in the chamber (25), whereby the powder compact is heated with heat of convection flows of inert gas or hydrogen gas, or mixed gas containing inert gas as principal component and hydrogen gas, so the electrode material of the powder compact is sintered.
US08993915B2 Sector gear and gas-insulated switchgear having the same
Provided is a sector gear including: a drive gear having a drive part that forms a part of a circle and has a plurality of teeth and a non-drive part that forms a remaining part of the circle and provides a non-contact angle of at least approximately 90 degrees; first and second movers forming a disconnector and a grounded breaking switch, respectively; and first and second driven gears engaged with the drive gear and respectively engaged with the first and second movers and configured to make the first mover or the second mover operate in conjunction with the drive part of the drive gear according to a direction of rotation of the drive gear, wherein an intermediate angle between the first and second movers is between approximately 90-135 degrees. The present invention can reduce the size of the gas-insulated switchgear having the sector gear.
US08993913B2 Cover glass pressure button
A cover glass pressure button (CGPB) is disclosed for an electronic device that has an image display module which is protected by a cover glass. When the cover glass is pressed, the CGPB senses the pressure to output a corresponding physical parameter to a control circuit for triggering a function of the image display module.
US08993912B2 Switching apparatus
A switching apparatus for an electrical switching device, the switching device including a rotor housing rotatable between an open position and a closed position; at least one contact arm with a moving contact; and a switching unit with a switching lever, movable between an ON position and an OFF position, a switching frame, and a lever mechanism in functional contact with the switching frame and the rotor housing such that movement of the switching lever into the ON position allows the rotor housing to be moved into the closed position and movement of the switching lever into the OFF position allows the rotor housing to be moved into the open position. The lever mechanism includes at least one stop, configured to prevent movement of the switching lever into the OFF position, independently of the movement of the rotor housing, when the rotor housing is in the closed position.
US08993904B2 Tap changer with improved switch construction
An on-load tap changer is provided having a pair of bypass switches, each of which includes a plurality of contacts at least partially disposed in a contact carrier. The contacts are arranged in a stack and cooperate to form a groove and a mounting bore. A mounting post extends through the mounting bore such that the contacts are pivotable about the mounting post between an open and a closed position. When an actuation assembly moves the contacts to the open or closed position, the contacts move longitudinally relative to the contact carrier.
US08993900B2 Solar cell module terminal and solar cell module terminal box
A solar cell module terminal to be electrically connected to an electrode portion provided on a back face of a solar cell module for outputting an electric current generated by a solar cell to the outside. The terminal includes a terminal body, a fixing portion to be fixed to the electrode portion, and a deforming portion provided between the terminal body and the fixing portion for allowing the terminal body and the fixing portion to be movable relative to each other along an anticipated direction of displacement of the electrode portion.
US08993896B2 Lead electrode and preparation method thereof
A lead electrode and a preparation method thereof are provided. The lead electrode includes an inner terminal, a lead, and an outer terminal, which are sequentially connected. The lead includes: an insulating substrate; an adhesive material coated on the insulating substrate, the adhesive material defining a trenched mesh; and a conductive material filled in the trenched mesh, wherein an angle formed by a grid line of the trenched mesh and a demolding direction is from 0° to 90°. Since the angle formed by the grid line and the demolding direction is very small, little adhesive material will be attached to the mold, such that the residues of the adhesive material are prevented.
US08993895B2 Membrane wiring board
The present invention is a membrane wiring board provided with an insulating substrate, and at least one circuit portion provided on the insulating substrate and obtained by coating a circuit layer, formed by an electrically conductive paste containing electrically conductive particles, with an insulating coating layer, wherein the circuit layer contains a resin component having a gel fraction of 90% or more.
US08993892B2 Wiring board and method of manufacturing the wiring board
A wiring board includes: a substrate; first connection electrode portions which are disposed on a surface of the substrate and which are to be connected to individual-electrode connection terminals of an actuator via first bumps; first wires having electrical continuity with the first connection electrode portions; a second connecting electrode portion which is disposed on the surface of the substrate and which is to be connected to the a common-electrode connection terminal of the actuator via a second bump; and a second wire having electrical continuity with the second connection electrode portion. The second connecting electrode portion is located in an edge portion of the substrate. The second wire has a conducive-material absent portion that is located between an edge of the substrate and the second connecting electrode portion.
US08993890B2 Electric cable and electric connector
An electric cable includes: a flat electric wire that is hard to bend in a longitudinal direction and easy to bend in a lateral direction; and a terminal that is coupled to a terminal end of the flat electric wire and connected to an inverter. The terminal has a wire connection portion coupled to the terminal end of the flat electric wire and a connecting portion connected to the inverter. The terminal is formed so that, when the terminal is connected to the inverter, a plane that includes a flat surface of the connecting portion is oriented in the direction in which the flat electric wire is easy to bend and intersects with the predetermined direction.
US08993886B2 Hardware casing with spring loaded friction fitting cover
Disclosed is a hard-framed housing that provides a cover for electronic hardware components. According to one example, the housing may include a front cover portion that includes at least two spring loaded friction inducing side arms extending from a faceplate portion of the front cover portion at approximately a 90 degree angle. The housing may also include a rear cover portion that includes at least two receiving plates which provide a planar surface for the at least two spring loaded friction inducing side arms to rest when the front cover portion is engaged with the rear cover portion.
US08993885B2 Hardware retainer mounted on faceplate
A hardware retainer detachably mounted on faceplate and selectively locked to a fixed body behind the faceplate includes a tray, at least two brackets and a faceplate box. The brackets are detachably mounted on the tray. The faceplate box is detachably mounted on the faceplate and is formed with a plurality of wire passages. The tray is detachably mounted on the faceplate box allowing for objects of varying dimensions to be installed on the faceplate.
US08993884B1 Wire theft deterrent system
A wire theft deterrent system includes a first U-shaped portion and a second U-shaped portion for encapsulating wire in a riser that is associated with a telephone pole. The first and second U-shaped portions are both made of stainless steel, so as to be substantially resistant to saw blades and hammers. The first U-shaped portion and the second U-shaped portion are connected to one another by high-security fasteners, each of which passes through an aperture in a flange of the first U-shaped portion and a corresponding aperture in a flange of the second U-shaped portion. The high-security fasteners restrict access to the encapsulated wires, so as to deter wire theft.
US08993879B2 Solar cell structure and composition and method for forming the same
A semiconductor structure including a bonding layer connecting a first semiconductor wafer layer to a second semiconductor wafer layer, the bonding layer including an electrically conductive carbonaceous component and a binder component.
US08993878B2 Electrode for photovoltaic device
An electrode for a photovoltaic device includes a Mo layer and a sulfurization-resistant layer formed on the Mo layer. The sulfurization-resistant layer contains at least one element X selected from a group consisting of Nb, Ti, Ta, Au, V, Mn, and W. A molar ratio of the element X to Mo contained in the sulfurization-resistant layer preferably satisfies X/(Mo+X)>about 0.5. A thickness (initial thickness) of the sulfurization-resistant layer before being exposed to sulfurizing atmosphere is preferably about 3 to about 200 nm.
US08993876B2 Solar cell and method for manufacturing the same
A solar cell includes a silicon semiconductor substrate; an emitter layer formed on a surface of the silicon semiconductor substrate; an antireflection layer formed on the emitter layer: and a front electrode electrically connected to the emitter layer by penetrating the antireflection layer. The front electrode includes a finger line and a busbar electrode electrically connected to the finger line, and the busbar electrode includes at least a first electrode line and a second electrode line electrically connected to each other. The first and second electrode lines have a width same as or larger than a width of the finger line, and the first and second electrode lines have the width of 100 μm or less.
US08993875B2 Solar battery module and method for manufacturing the same
Provided is a solar battery module wherein solar battery cells are electrically connected to each other by using a wiring board having a predetermined wiring pattern formed on a resin base material. A method for manufacturing such solar battery module is also provided. In the wiring board of the solar battery module, a direction wherein a design margin is small is permitted to be a direction wherein the thermal contraction ratio of the resin base material is small, by the shape of an electrode pattern on the solar battery cell and that of the wiring pattern on the wiring board. At the time of manufacturing such solar battery module, temperature in a heat treatment step is set at 100° C. or higher but not higher than 180° C. Electrode designing at a fine pitch is made possible and the solar battery module exhibits high solar battery characteristics, even when the solar battery cells are connected by using wiring boards composed of various types of resin materials having thermal compression ratio not sufficiently low.
US08993874B2 Photonic bandgap solar cells
A photovoltaic cell having multiple stacked layers has a thickness from the top of its top layer to the bottom of its bottom layer of less than one micron. Metal conducting layers are positioned between semiconductor layers with semiconductor layers having higher bandgaps being located above semiconductor layers having lower band gaps. The layers of the photovoltaic cell are arranged and stacked, and the thicknesses and materials for the semiconductor layers and conductive layers are selected to realize desired absorption, transmission, and reflection characteristics. The geometry and thicknesses of the respective layers of the cell allows incident light of various angles to be absorbed by all of the semiconductor layers of the cell.
US08993873B2 Solar cell with a backside via to contact the emitter layer
A solar cell structure is provided for reducing shadow losses without increasing series resistance in the solar cell device. The solar cell device may form an electrical contact to a solar cell emitter layer from the backside of the solar cell device. With this structure, the emitter contact shadow losses may be reduced significantly while simultaneously decreasing device series resistance.
US08993871B2 Condensing lens array, and solar cell provided with same
A concentrating lens array according to the present disclosure includes a plurality of unit structures arranged at least one-dimensionally. Each unit structure includes: a first surface through which light enters inside of the structure; a second surface which reflects the light that has entered the structure through the first surface; a third surface which reflects the light that has been reflected from the second surface; and a fourth surface which lets the light that has been reflected from the third surface go out of the structure. In each unit structure, the second and third surfaces are located between an incident plane including the first surface and an emitting plane including the fourth surface. At least one of the second and third surfaces reflects the light after having converged the incoming light. When viewed from over the incident plane, the second surface of each unit structure is laid upon the third surface of an adjacent unit structure, and is located closer to the incident plane than the third surface of the adjacent unit structure is.
US08993867B2 Mobile communication device with musical instrument functions
Describes a mobile communication device (1, 20, 55, 111, 150, 200, 220, 335) having musical instrument (percussion, keyboards, string and blow) function, which “can be scrapped onto the user's body through an adjustable elastic belt (151). It is also able to receive commands from a remote sensor (4, 70, 75, 160, 210, 257, 392,412), which has a musical instrument interface (percussion, keyboards, string and blow), preferably scrapped onto the user's body by means of an adjustable elastic belt (151). A sound system (6) or an audio/video equipment might receive audio and/or video from the mobile communication device (1, 20, 55, 111, 150, 200, 220, 335) through an adapter (5, 56, 63, 68). The use of this device is intended to be an occupational therapy, satisfying, entertaining and relaxing for the user, which will provide user's mental and physical health benefits. Its technical classification is under “electronics”.
US08993863B1 Harmonica and technology for retrofitting harmonica
A harmonica with a tube plate that provides production of sweeter, clearer notes with a minimum of skill. The tube plate has a plurality of tubes and sits over the reeds and the comb under the cover plate, a tube coupled with each air chamber in the comb. The tubes form tunnels with the air chambers, enhancing reverberation and separating the sound waves emanating from the reed in each chamber. The tube plate can be added to a conventional harmonica. The harmonica has a plurality of reed units, each reed in a separate unit. Each reed unit is individually replaced when a reed requires replacement or when modification of the harmonica key is desired. The reed units can replace a reed plate in a conventional harmonica.
US08993859B1 Maize hybrid X13D062
A novel maize variety designated X13D062 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X13D062 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X13D062 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X13D062, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X13D062. This invention further relates to methods for producing maize varieties derived from maize variety X13D062.
US08993856B2 Tomato hybrid PS01533588
The invention provides seed and plants of tomato hybrid PS01533588 and the parent lines thereof, such as inbred tomato line FDR 15-2090. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PS01533588 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US08993854B1 Soybean variety XB41T13
A novel soybean variety, designated XB41T13 is provided. Also provided are the seeds of soybean variety XB41T13, cells from soybean variety XB41T13, plants of soybean XB41T13, and plant parts of soybean variety XB41T13. Methods provided include producing a soybean plant by crossing soybean variety XB41T13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB41T13, methods for producing other soybean varieties or plant parts derived from soybean variety XB41T13, and methods of characterizing soybean variety XB41T13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB41T13 are further provided.
US08993852B2 Soybean variety XB11K13
A novel soybean variety, designated XB11K13 is provided. Also provided are the seeds of soybean variety XB11K13, cells from soybean variety XB11K13, plants of soybean XB11K13, and plant parts of soybean variety XB11K13. Methods provided include producing a soybean plant by crossing soybean variety XB11K13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB11K13, methods for producing other soybean varieties or plant parts derived from soybean variety XB11K13, and methods of characterizing soybean variety XB11K13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB11K13 are further provided.
US08993850B2 Lettuce variety ‘E01L.1935’
A new lettuce variety designated ‘E01L.1935’ is described. ‘E01L.1935’ is a cutting lettuce variety exhibiting stability and uniformity.
US08993849B2 Truchas lettuce variety
A new lettuce variety designated ‘Truchas’ is described. ‘Truchas’ is a grass-type lettuce variety exhibiting stability and uniformity.
US08993842B2 Modified xylan production
Methods and means for producing xylan structures in plants having a non-native saccharide moiety substitution side chain component, plants and plant cells comprising modified xylan structures, methods of identifying mutant plants comprising xylan structures in plants having a non-native saccharide moiety substitution pattern side chain component, uses thereof, and isolated xylan structures and uses thereof.
US08993837B2 Chimeric promoters and methods of use
Compositions and methods comprising promoters from the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene and active variants and fragments thereof, as well as chimeric promoters employing regulatory regions of the HPPD promoters are provided. Further provided are expression cassettes and plants comprising the various promoters disclosed herein operably linked to a polynucleotide of interest. Methods employing the various promoters described herein to modulate the expression of polynucleotides of interest are further provided.
US08993835B2 Pygmy sesame plants for mechanical harvesting
Methods for improved sesame agriculture comprising growing a pygmy sesame line homozygous for the py/py recessive pygmy allele and a character selected from non-dehiscence or improved non-dehiscence are disclosed.Pygmy sesame plants homozygous for the py/py recessive pygmy allele and a character selected from non-dehiscence or improved non-dehiscence, and a method for breeding the same, are disclosed.
US08993833B2 Model of Alzheimer's Disease
A modified non-human warm-blooded vertebrate animal in which a biologically active human APP polypeptide is expressed, and in which function of its inducible Nitric Oxide Synthase (iNOS) protein is reduced as compared to a non-modified animal, methods of making the animal, and methods of testing a candidate composition for activity in the treatment of Alzheimer's Disease using the animal.
US08993831B2 Foam and delivery system for treatment of postpartum hemorrhage
Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
US08993829B2 Device and method for securing sutures and the like
A bandage and method for securing a tension member comprising a central body and a plurality of tabs disposed about the central body. A tension member may be disposed across or through a slit or aperture of the central body. A body adhesive on the lower surface of the central body may secure the bandage to the patient. The tension member may then be pulled across the upper surface of the central body and a first tab may be folded over and adhered to the tension member and central body. The tension member may then be pulled back across the first tab and a second tab may be folded over and adhered to the tension member and first tab. Likewise, the tension member may then be pulled back across the second tab and a third tab may be folded over and adhered to the tension member and second tab.
US08993826B2 Nano flex HLW/spent fuel rods recycling and permanent disposal
Methods for converting toxic waste, including nuclear waste, to quasi-natural or artificial feldspar minerals are disclosed. The disclosed methods may include converting, chemically binding, sequestering and incorporating the toxic waste into quasi-natural or artificial Feldspar minerals. The quasi-natural or artificial feldspar minerals may be configured to match naturally occurring materials at a selected disposal site. Methods for the immediate, long term, quasi-permanent disposal or storage of quasi natural or artificial feldspar materials are also disclosed.
US08993823B2 Olefin metathesis process using a catalyst containing tungsten fluorine bonds
A process for the metathesis of olefins has been developed. The process comprises contacting a hydrocarbon feedstock with a catalyst at metathesis conditions. The catalyst comprises a tungsten compound, which contains at least one tungsten-fluoro bond, dispersed or grafted onto a support. A specific example of the catalyst is the compound WOF(CH2CMe3)3 grafted onto a silica support. The feedstock comprises a first and a second olefin wherein the second olefin has a carbon number of at least two greater than the first olefin and the product is an olefin with a carbon number intermediate between the first and second olefin. Specifically the process produces propylene from ethylene and butylene.
US08993822B2 Methods of preparation of an olefin oligomerization catalyst
A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a halide-containing compound, and optionally a solvent, the method comprising contacting a composition comprising the chromium-containing compound and a composition comprising the metal alkyl, wherein the composition comprising the chromium-containing compound is added to the composition comprising the metal alkyl.
US08993818B2 Combination of zeolite upgrading with hydrogenation upgrading to produce renewable gasoline from biomass
Technologies to convert biomass to liquid hydrocarbon fuels are currently being developed to decrease our carbon footprint and increase use of renewable fuels. Since sugars/sugar derivatives from biomass have high oxygen content and low hydrogen content, coke becomes an issue during zeolite upgrading to liquid hydrocarbon fuels. A self-sustainable process was designed to reduce the coke by co-feeding sugars/sugar derivatives with the paraffin products from hydrogenation of sugars/sugar derivatives. Paraffins without complete conversion result in products with less aromatics and relatively low density compared with the products directly from zeolite upgrading. Thus, the process is more economically favorable.
US08993813B2 Method for producing parathymol
The present invention relates to a process for the preparation of 4-isopropyl-3-methylphenol (p-thymol) from distillation residues of thymol production.
US08993812B2 Method for preparing 2-methyl-4-phenylbutan-2-OL
A method of preparing 2-methyl-4-phenylbutan-2-ol from a Grignard-type reaction of a benzylmagnesium halide with isobutylene oxide, and the use of the 2-methyl-4-phenylbutan-2-ol as a fragrance or flavoring, cosmetic agent, or detergent component.
US08993810B2 Preparation method of lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde
Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.
US08993801B2 Process for preparing V-Ti-P catalysts for synthesis of 2,3-unsaturated carboxylic acids
The invention relates to a catalyst composition comprising a mixed oxide of vanadium, titanium, and phosphorus. The titanium component is derived from a water-soluble, redox-active organo-titanium compound. The catalyst composition is highly effective at facilitating the vapor-phase condensation of formaldehyde with acetic acid to generate acrylic acid, particularly using an industrially relevant aqueous liquid feed. Additionally, the catalyst composition is catalytically active towards the formation of acrylic acid from methylene diacetate and methacrylic acid from methylene dipropionate; both reactions are carried out with high space time yields.
US08993800B2 Process for producing optically active α-methylcysteine derivative
The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.
US08993798B2 Isomerized alpha olefin sulfonate and method of making the same
The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C12-C20 normal alpha olefins; and neutralizing the isomerized alpha olefin sulfonic acid with a source of an alkali metal or ammonium or substituted ammonium ion.
US08993797B2 Crystalline solid and amorphous forms of (−)-halofenate and methods related thereto
The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (−)-halofenate.
US08993795B2 Methylidene malonate process
Novel improved processes for the production and isolation of methylidene malonates via direct and indirect adduct processes.
US08993794B2 Method for preparing a polyorganosiloxane
A method for preparing a polyorganosiloxane, wherein the method includes a step of subjecting at least one organic silicon compound having at least one —OX group bonding to a silicon atom in the molecule, wherein X is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or an alkoxyalkyl group having 2 to 10 carbon atoms, to a condensation reaction in the presence of a catalyst, wherein the catalyst is one obtained by surface treating at least one selected from the group consisting of hydroxides of elements in Group II of the periodic table, hydrates of hydroxides of elements in Group II of the periodic table and oxides of elements in Group II of the periodic table with a silane coupling agent.
US08993793B1 Multifunctional mesoporous silica catalyst
The present invention provides bifunctional silica mesoporous materials, including mesoporous silica nanoparticles (“MSN”), having pores modified with diarylammonium triflate and perfluoroaryl moieties, that are useful for the acid-catalyzed esterification of organic acids with organic alcohols.
US08993792B2 Polyglycol ether-free sulphosuccinates based on polyglycerol partial esters and use thereof
The invention relates to polyglycol ether-free, polyglycerol partial ester-based sulphosuccinates, the preparation thereof, and the use of these in cosmetic formulations and also in cleaning compositions in the industrial and domestic sector and formulations comprising these sulphosuccinates.
US08993790B2 Oxetane-ring-containing (meth)acrylic acid ester compound
Provide is an oxetane-ring containing (meth) acrylic ester compound which can give, through polymerization, a cured article being highly flexible or thermally stable. The oxetane-ring-containing (meth) acrylic ester compound is represented by formula (1) below, in which R1 represents a hydrogen atom or an alkyl group; R2 represent a hydrogen atom or a methyl group; and “A” represent either a linear alkylene group represented by following formula (a1) or a branched-chain alkylene group represented by following formula (a2).
US08993788B2 Chiral intermediates useful for the preparation of hydroxyphosphine ligands
A compound of formula (I), wherein R1 is hydrogen or a hydroxyl protecting group; and R2 and R3 are same or different and are independently selected from halogen or —O—SO2—X; wherein X is —C1-C4 alkyl; C1-C4 alkyl substituted with one or more halogen; or substituted or unsubstituted phenyl wherein said phenyl substituent is selected from halogen, nitro and C1-C4 alkyl; provided that when R3 is bromine, X is not p-toluoyl; and a process for the preparation thereof.
US08993787B2 Method for preparing 1,3,5-trioxane
The present invention relates to a method for preparing 1,3,5-trioxane using a distillation tower including a reactor, a distillation section, and an extraction section. Particularly, the present invention relates to a method for preparing 1,3,5-trioxane, in which the water phase separated from the stream discharged through the extraction unit of the reaction distillation tower is used in the process of extracting 1,3,5-trioxane.
US08993781B2 Fluorescent boron-substituted dipyrromethenes and use thereof for diagnosis
The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.
US08993780B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators
The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
US08993776B2 Heterocyclic alkanol derivatives
The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
US08993774B2 Process for production of aromatic alcohol or heterocyclic aromatic alcohol
A process of production of an aromatic alcohol or a heterocyclic aromatic alcohol, containing a step of reacting an aromatic amine or a heterocyclic aromatic amine having an aromatic ring or a heterocyclic aromatic ring having thereon at least one substituent —CHR1NR2R3 (wherein R1, R2 and R3 each independently represent hydrogen, an alkyl group having from 1 to 4 carbon atoms, or a benzyl group), with an alcohol, in the presence of a basic catalyst.
US08993770B2 Process for the manufacture of dabigatran etexilate
An improved process for preparing dabigatran etexilate, as well as analogous compounds of formula 7, is described.
US08993769B2 Processes to produce certain 2-(pyridine-3-yl)thiazoles
The invention disclosed in this document is related to the field of processes to produce certain 2-(pyridine-3-yl)thiazoles as intermediates for the synthesis of pesticidal thiazole amides.
US08993764B2 Use of oripavine as a starting material for buprenorphine
There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
US08993761B2 Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.
US08993760B2 Rock inhibitors and uses thereof
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death.
US08993758B2 Substituted quinoxalines and uses thereof
Disclosed herein are compounds of formula (I) and methods of inhibiting IKKβ and the NF-κB signaling and mTOR pathways.
US08993757B2 N-piperidin-4-yl derivatives
The invention relates to a N-piperidin-4-yl derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same and to the use of said N-piperidin-4-yl derivatives for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, or for the treatment of uterine fibroids or other menstrual-related disorders.
US08993756B2 Pyrrolopyrimidines as janus kinase inhibitors
The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I.
US08993755B2 Modulators of toll-like receptor 7
The present application includes a compound of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.
US08993754B2 Iridium complex and light emitting material formed from same
Provided is an iridium complex having a substructure represented by the following formula (1), which is a luminescent element material capable of luminescence with high brightness/high efficiency and excellent in durability and can be used in a luminescent element, etc.
US08993750B2 5HT2C receptor modulators
The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
US08993748B2 Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars
Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars, consisting of the activation of the sugar by oxidation with nascent bromine generated in situ by reaction between an alkaline or alkaline earth bromine and an alkaline hypochlorite, the complexation of the activated sugar in solution with a ferric salt dissolved in an aqueous solution, the purification of the resulting solution through ultrafiltration and finally the stabilization of the trivalent iron-sugar complex by heating at a temperature between 60° C. and 100° C. for a period between 1 and 4 hours at a pH between 9.0 and 11.0.
US08993747B2 Process for improved production of alkali cellulose and cellulose derivatives
The present invention relates to a process for the production of alkali cellulose for the production of alkali cellulose and, optionally, cellulose ethers from cellulose in the presence of alkali and, if applicable, with alkylating and/or hydroxyalkylating agent(s) comprising the reaction of a cellulose with an alkali metal hydroxide, wherein the alkali metal hydroxide is mixed with cellulose in a mixing apparatus, the mixing apparatus (1) having an upper region (20, 102a, 202a) with a first cross-section and a lower region (21, 102b, 202b) with a second cross-section, the second cross-section being the same as or smaller than the first cross-section and comprising at least one non-horizontally oriented mixing device (23, 27, 121, 221, 224).
US08993746B2 Nuclease resistant double-stranded ribonucleic acid
This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
US08993742B2 Tubulo-vesicular structure localization signals
The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the tubulo-vesicular structures of polarized cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.
US08993741B2 SMNdelta7 degron: novel compositions and methods of use
The present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMNΔ7 degron and the encoded polypeptide. The invention also includes inhibitors of SMNΔ7 degron. The invention also includes compositions and methods for mitigating SMN deficiency by targeting inhibition of factors that mediate SMNΔ7-degron dependent degradation of SMNΔ7.
US08993738B2 Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides and analogs thereof that are useful for incorporation at the terminus of an oligomeric compound. Such oligomeric compounds can also be included in a double stranded composition. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
US08993734B2 Method to produce an immunoglobulin preparation with improved yield
The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
US08993733B2 Procedure for obtaining a composition containing growth factors from a blood compound, and composition obtained by said procedure
Procedure for obtaining a composition that contains growth factors, which comprises the steps of heat-treating a platelet-rich plasma or the supernatant of a platelet-rich plasma that contains released growth factors in order to increase its temperature, for eliminating the complement and reducing the immunoglobulins present therein, and lyophilizing the plasma or supernatant in order to obtain a final dry composition that can easily be transported, handled and stored, thereby facilitating periodic or chronic treatments with blood compounds. It has been shown that when the final dry composition is resuspended, a once again humid composition is obtained that maintains its biological properties intact.
US08993731B2 PD-1 antibody
A humanized agonistic antibody which binds human PD-1 comprising a heavy chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO: 2 for CDR-H2 and the sequence given in SEQ ID NO: 3 for CDR-H3 and the heavy chain framework region is derived from human sub-group sequence VH4 3-1 4-30.4+JH4 (SEQ ID NO: 33). The disclosure also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules.
US08993726B2 Antibodies to NTB-A
Anti-NTB-A antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are described. Also described are methods of using such antibodies and antigen-binding regions to bind NTB-A and treat diseases, such as hematologic malignancies, which are characterized by expression of NIB-A.
US08993719B2 Methods and compositions related to mutant Kunitz domain I of TFPI-2
Disclosed are methods and compositions relating to plasmin inhibition.
US08993718B2 Methods and compositions for detecting and modulating O-glycosylation
The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.
US08993716B2 Peptides used in the treatment and/or care of the skin, mucous membranes and/or hair and its use in cosmetic or pharmaceutical compositions
Peptides of general formula (I): R1—Wn—Xm-AA1-AA2-AA3-AA4-Yp—Zq—R2 (I) its stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, a preparation process, cosmetic or pharmaceutical compositions which contain them and their use in the treatment and/or care of the skin, mucous membranes and/or hair and the treatment and/or care of those conditions, disorders and/or diseases which are improved or prevented by Hsp stimulation.
US08993715B2 Labeled protein and method for obtaining the same
It is an object of the present invention to obtain a labeled protein, and specifically, to separate a labeled protein and the same unlabeled protein. There is provided a labeled protein including: a protein to be labeled having a target protein, at least one or more affinity interaction domains for binding to an affinity support, and at least one or more labeling sites; and a labeling reagent binding to at least one of the labeling sites; wherein the affinity of the labeled protein for the affinity support is difference from that of the protein to be labeled for the affinity support.
US08993713B1 Solution processable n-type ladder polymer for hetero-junction devices
A n-type ladder copolymer including, a n-type ladder copolymer formed with alternating perylene and pyridine units having chemical structure A having two end groups, where perylene units having at least one solubilizing group attaching at position(s) 1, 6, 7, and/or 12, where R1, R2, R3, and R4 solubilizing group(s) are each independently selected from the group consisting of aryl, alkyl aryl, alkoxy aryl, and aryloxy aryl, and where n repeat units ranging from about 4 to about 400
US08993710B1 Polyimides derived from novel asymmetric benzophenone dianhydrides
This invention relates to the composition and processes for preparing thermoset polyimides derived from an asymmetric dianhydride, namely 2,3,3′,4′-benzophenone dianhydride (a-BTDA) with at least one diamine, and a monofunctional terminal endcaps. The monofunctional terminating groups include 4-phenylethynylphthalic anhydride ester-acid derivatives, phenylethyl trimellitic anhydride (PETA) and its ester derivatives as well as 3-phenylethynylaniline. The process of polyimide composite comprises impregnating monomer reactants of dianhydride or its ester-acid derivatives, diamine and with monofunctional reactive endcaps into glass, carbon, quartz or synthetic fibers and fabrics, and then stack up into laminates and subsequently heated to between 150-375° C. either at atmosphere or under pressure to promote the curing and crosslinking of the reactive endcaps to form a network of thermoset polyimides.
US08993709B2 Process for producing oxymethylene polymers
The present invention relates to a process for the preparation of oxymethylene polymers, the oxymethylene polymers obtained therefrom as well as their use.
US08993699B2 Photosensitive resin composition for microlens
There is provided a photosensitive resin composition for a microlens. A photosensitive resin composition for a microlens, comprising a component (A), a component (B) and a component (C), wherein the component (A) is a polymer having a maleimide structural unit of Formula (1), the component (B) is a cross-linking agent, and the component (C) is a photosensitizing agent.
US08993694B2 Advanced transition metal catalytic systems in terms of comonomer incorporations and methods for preparing ethylene homopolymers or copolymers of ethylene and alpha-olefins using the same
Provided is a homogeneous catalytic system for use in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, and more particularly a Group 4 transition metal compound in which a cyclopentadienyl derivative 3,4-positions of which are substituted with alkyls and an electron-donating substituent are crosslinked around a Group 4 transition metal. Also provided is a method of preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having high molecular weight, under high-temperature solution polymerization conditions using the catalytic system including such a transition metal compound and a co-catalyst composed of an aluminum compound, a boron compound or a mixture thereof. The catalyst according to present invention has high thermal stability and enables the incorporation of α-olefin, and is thus effective in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having various properties, in industrial polymerization processes.
US08993692B2 Self limiting catalyst composition for ethylene polymerization
A process for polymerizing ethylene to produce an ethylene-based polymer including contacting ethylene with a Ziegler-Natta procatalyst, an alkylaluminum cocatalyst and a self limiting agent selected from the group of aliphatic, cycloaliphatic, substituted cycloaliphatic or aromatic esters, anhydrides and amides such that the self limiting agent reduces polymerization rates to no greater than 40% of the polymerization rate in the absence of the self limiting agent at temperatures equal to or greater than 120° C. is provided.
US08993688B1 Polyphenols and high-performance resins from syringaldehyde
A method to generate renewable high performance composites and thermoplastics. These materials can be generated from a renewable phenol (syringaldehyde) that can be derived from lignocellulosic biomass. The use of syringaldehyde as a precursor to composites has the potential to reduce the cost and environmental impact of structural materials, while meeting or exceeding the performance of current petroleum derived resins.
US08993686B2 Multiamino acid-based poly(ester amide)s
Biodegradable saturated and unsaturated polyester amides (PEA)s made from multiamino acid monomers and methods of making biodegradable saturated and unsaturated PEAs.
US08993677B2 Reactive polyamide resins and polyamide resin compositions
Provided is a polyamide resin composition comprising an elastomer etc, and a reactive polyamide resin excellent in reactivity. The polyamide resin composition comprises 0.5 to 100 parts by mass of an elastomer per 100 parts by mass of a reactive polyamide resin, wherein the reactive polyamide resin obtained by polycondensing a diamine (A) containing 70 mol % or more of a diamine structural unit derived from xylylenediamine and a dicarboxylic acid (B) containing 50 mol % or more of a dicarboxylic acid structural unit derived from sebacic acid, and has a concentration of reactive functional groups of 100 μeq/g or more and a molar ratio of reacted diamine to reacted dicarboxylic acid (the number of moles of reacted diamine/the number of moles of reacted dicarboxylic acid) of 1.0 or more.
US08993673B2 Water-based coating composition and method of forming multilayered coating film
An object of the present invention is to provide an aqueous coating composition with excellent finished appearance and removability in bell cleaning, and a method for forming a multilayer coating film having excellent smoothness by a 3-coat-1-bake method including successively applying an aqueous first colored coating composition, an aqueous second colored coating composition, and a clear coating composition to a substrate, and heat-curing the resulting three layers of the multilayer coating film all at once. The present invention provides an aqueous coating composition containing an acrylic resin (A), a curing agent (B), and a urethane resin emulsion (C) with a weight average molecular weight of 2,000 to 50,000, the urethane resin emulsion (C) being prepared using constituent components containing a polyisocyanate component and a polyol component as starting materials, wherein the polyisocyanate component contains an alicyclic diisocyanate, and the polyol component contains a polycarbonate diol in an amount of 50 mass %, based on the total amount of the polyol component.
US08993671B2 Poly(aliphatic ester)-polycarbonate copolymer/polylactic acid blend
The present invention is directed to a blended composition comprising one or more polycarbonates wherein at least one of the polycarbonates is a polyesterpolycarbonate having at least one unit derived from a soft block ester unit, e.g., sebacic acid, and at least one unit derived from bisphenol A, and a polylactic polymer wherein the composition has an overall biocontent of at least 10% according to ASTMD6866.
US08993667B2 Redox polymers for improved dirt and water resistance for elastomeric wall and roof coatings
The present invention provides elastomeric roof coatings and aqueous coating compositions of (i) an acrylic emulsion copolymer that comprises (ii) a reductant and has a high molecular weight, (iii) a combination of a hydrophilic polymeric dispersant and a pigment, extender or filler, and (iv) a multivalent transition metal ion or multivalent transition metal ion compound or salt. The composition and coating provide excellent swelling resistance and a balance of tensile and elongation in an acrylic roof coating composition.
US08993663B2 Acrylic block copolymers for aerosols and aerosol adhesives
An aerosol is described comprising a composition comprising an acrylic block copolymer, a solvent, and a propellant. An article is described comprising the aerosol contained within a pressurized containment vessel comprising a valve. An aerosol mist is also described comprising droplets of an adhesive composition, wherein the adhesive composition comprises an acrylic block copolymer, a glass transition temperature modifier, and optionally an additive.
US08993661B2 Chloroprene rubber and chloroprene rubber composition
Provided is a chloroprene rubber superior in the effectiveness of preventing mold staining.The chloroprene rubber contains at least one compound selected from phosphite ester compounds (such as tris(nonylphenyl)phosphite ester and tributyl phosphite ester) and phosphate ester compounds (such as tri(nonylphenyl)phosphate ester and tributyl phosphate ester) in a total amount of 0.1 to 5.0 mass % and additionally at least one compound selected from sulfonic acid compounds (such as benzenesulfonic acid and dodecylbenzenesulfonic acid) and fatty acid compounds in a total amount of 0.1 to 3.0 mass %.
US08993659B2 Rubber composition and pneumatic tire
A rubber composition contains diene-based rubber, silica, a sulfur-containing silane coupling agent, and an amine compound. The amine compound is indole, indigo, and derivatives thereof each of which is represented by a predetermined formula. The content of the silica is 20 to 120 parts by mass based on 100 parts by mass of the diene-based rubber. The content of the sulfur-containing silane coupling agent is 3 to 15 parts by mass based on 100 parts by mass of the silica. The content of the amine compound is 0.5 to 20 parts by mass based on 100 parts by mass of the silica. By the use of the rubber composition with this composition, a tire having improved dispersibility of silica, excellent wet performance, and excellent rolling resistance and showing a suppressed decrease in reinforcing property can be produced.
US08993652B2 Dual-cure curable material kit
A dual-cure curable material kit comprising: (A) a radical-polymerizable monomer component; (B) a photopolymerization initiator component comprising (b1) an α-diketone compound, (b2) an aliphatic tertiary amine compound having a tertiary amino group in which three saturated aliphatic groups are bonded to a nitrogen atom and one of the saturated aliphatic groups has an electron-withdrawing group as a substituent, and (b3) an s-triazine compound having a trihalomethyl group as a substituent, or a diaryliodonium salt compound; and a chemical polymerization initiator component (C) comprising (c1) an organic peroxide, and (c2) an N,N-di(hydroxyalkyl)-p-toluidine compound; which is packed separately at least in two packages so that the component (b2) and the component (b3) of the photopolymerization initiator component (B) are not packed together in a single package and the component (c1) and the component (c2) of the chemical polymerization initiator component (C) are not packed together in a single package.
US08993651B2 Polymerizable chain-extended polysiloxanes with pendant hydrophilic groups
The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polysiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR-S— in which DR is a divalent organic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.
US08993647B2 Foams, foaming compositions and applications thereof
[Objects] It is an object to provide a foam having a low specific gravity and a small compression set, more preferably a foam having a low specific gravity, a small compression set and uniform quality, a foaming composition, and applications of the foam.[Means for Solution] The foam is obtained by foaming an olefin polymer, wherein the foam has a specific gravity (d) in the range of 0.03 to 0.30, and a compression set (CS, %) and the specific gravity (d) satisfy the formula of CS≦−279×(d)+95. The foam is preferably obtained from a foaming composition that includes an ethylene polymer (A) including a specific ethylene/α-olefin copolymer (A1) and an ethylene/polar monomer copolymer (A2) in a specific mass ratio, and a specific ethylene/C3-20 α-olefin/non-conjugated polyene copolymer (B).
US08993644B2 Medical devices formed from recycled medical waste and methods of manufacture
Methods of reclaiming plastic from plastic medical waste containers containing medical waste and manufacturing recycled medical devices are described. Recycled medical devices made from plastic medical waste containers containing medical waste are also described.
US08993643B2 Methods of producing iodinated anion exchange resins
Methods for producing or regenerating an iodinated anion exchange resin are presented. The methods include treating an iodide loaded anionic resin with an aqueous solution comprising an in situ formed I2 to produce the iodinated resin. The iodinated resins show reduced and stable levels of iodine elution compared to resins produced by conventional methods. Methods and systems for purifying water are also presented.
US08993635B2 Method of increasing or maintaining the reproductive performance of sows
The present invention relates to methods and feed compositions for increasing or maintaining the reproductive performance of sows. More particularly, the present invention relates to methods of increasing or maintaining the reproductive performance of sows by administering a biologically active compound during lactation, and food compositions comprising said biologically active compound for the purposes of increasing or maintaining the reproductive performance of sows. The present invention also relates to a method of increasing or maintaining ovarian function in sows.
US08993634B2 Methods and use of compounds that bind to Her2/neu receptor complex
This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor.
US08993633B2 Treatment of muscle disease characterized by insulin resistance
It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The present disclosure relates to therapeutic agents, compositions and methods for treating a muscle disease or condition characterized by impaired insulin-dependent signaling by targeting components of the defective insulin signaling pathway. The disease or condition may be treated by administering a therapeutic agent that activates the insulin signaling pathway, in particular, therapeutic agents that act post-insulin receptor to modulate intracellular effector molecules. An exemplary modulator is metformin. Metformin may be administered alone or may be coadministered with another therapeutic agent for treating the muscle disease or condition, such as a corticosteroid.
US08993632B2 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
US08993629B2 Viscoelastic system for drift reduction
The invention relates to a viscoelastic system for drift reduction for pesticidal formulations, and the use thereof, wherein said formulation comprising at least one nitrogen-based cationic surfactant and at least one pesticide, wherein said pesticide contains at least one acid functional group associating with said cationic surfactant thereby forming a viscoelastic formulation.
US08993620B2 Cinnamic acid-based oligomers and uses thereof
Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
US08993619B2 Cyclic bridgehead ether DGAT1 inhibitors
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
US08993612B2 Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
US08993605B2 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
US08993603B2 Pharmaceutical composition and method using antifungal agent in combination
A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula: (wherein R1 represents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may be substituted; R2 and R3 identically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifungal agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection. A pharmaceutical composition containing the arylamidine derivative represented by the above general formula or a salt thereof and an immunosuppressant has a strong antifungal activity and is useful for the treatment of fungal infection and a skin disease such as atopic dermatitis. A method for using them in combination is useful as an excellent therapeutic method for fungal infection and a skin disease such as atopic dermatitis.
US08993594B2 Isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention.
US08993593B2 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
This invention provides a compound of formula A The compound provided herein can affect the opening of, or otherwise modulate, voltage-gated potassium channels. The compound provided herein is useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
US08993590B2 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.
US08993582B2 Processes for preparing JAK inhibitors and related intermediate compounds
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
US08993581B2 Methods for treating viral disorders
Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent for an additional period of about sixteen days for a total cycle of about 21 days.
US08993580B2 Benzothiazole kinase inhibitors and methods of use
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating lipid kinases such PI3 kinases, tyrosine kinases and protein kinases such as mTOR. For example, the invention provides compounds of Formula: Also provided in the present invention are methods of using these compositions to modulate these kinases especially for therapeutic applications.
US08993579B2 Polymorphic forms of Lapatinib ditosylate and processes for their preparation
There is provided a crystalline form of Lapatinib, termed APO-I, and methods for making APO-I. There is also provided a crystalline solvate form of Lapatinib, termed APO-II, and methods for making APO-II.
US08993577B2 Cyclopropyl amide derivatives
Disclosed herein is at least one cyclopropyl amide derivative, at least one pharmaceutical composition comprising at least one cyclopropyl amide derivative disclosed herein, and at least one method of using at least one cyclopropyl amide derivative disclosed herein for treating at least one histamine H3 receptor associated condition therewith.
US08993574B2 Pyrrole antifungal agents
The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
US08993572B2 Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines derivatives and [1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole derivatives
The invention relates to particular substituted heterocycle fused gamma-carbolines of formula I: as described herein, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D2 receptor signaling systems.
US08993568B2 Morpholinyl derivatives useful as MOGAT-2 inhibitors
The present invention provides compounds of Formula I or a pharmaceutical salt thereof, methods of treating hypertriglyceridemia using the compounds; and a process for preparing the compounds.
US08993566B2 Quinoline compound composing 1,2,4-triazine-dione and use thereof
The present invention relates to a quinoline derivative represented by general formula (I) or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof wherein Ar, R1, R2, R3, X, Y and n have the meanings given in the description. The present invention also relates to the comparatively strong effect of the compound represented by general formula (I) on inhibiting c-Met kinase. The present invention further relates to the use of this compound or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof in the manufacturing of a medicament for treating the disease caused by abnormally over-expressing c-Met kinase, in particular, for treating or preventing cancer.
US08993561B2 Nitrobenzothiazole derivatives, preparation thereof and therapeutic applications thereof
The invention relates to the nitrobenzothiazole derivatives of general formula (I): and to the use thereof for treating tuberculosis.
US08993559B2 Use of ibogamine congeners for treating obesity
The present invention relates to a method of treating obesity in a subject by administering to the subject a compound having the formula: wherein n is from 0 to 8; R1 is CH2OH, CH(OH)R5, CH2OR5, CO2R5, C(O)NH2, C(O)NHR5, C(O)NR5R6, C(O)NHNH2, C(O)NHNHR5, C(O)NHNR5R6, C(O)NR5NH2, C(O)NR5NHR6, C(O)NR5NR6R7, C(O)NHNH(C(O)R5), C(O)NHNR5(C(O)R6), C(O)NR5NH(C(O)R6), C(O)NR5NR6(C(O)R7), CN, or C(O)R5; R2 is H, unsubstituted or substituted alkyl, YH, YR8, YR8R9, YR8YR9YR10, YC(O)R8, C(O)YR8, C(O)NH2, C(O)NHR8, C(O)NR8R9, NH2, NHR8, NR8R9, NHC(O)R8, or NR8C(O)R9; R3 and R4 are the same or different and are selected from the group consisting of H, halogens, unsubstituted or substituted alkyl, OH, OR10, NH2, NHR10, NR10R11, NHC(O)R10, or NR10C(O)R11; R5, R6, R7, R8, R9, R10, and R11 are the same or different and are selected from the group consisting of H, unsubstituted alkyl, substituted alkyl, unsubstituted aryl and substituted aryl; R12 is selected from the group consisting of H, unsubstituted alkyl, and substituted alkyl; and Y is O or S; and pharmaceutically acceptable salts thereof.
US08993555B2 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
US08993552B2 Compositions and methods for treatment of leukemia
The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.
US08993549B2 Natural combination hormone replacement formulations and therapies
Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
US08993548B2 Natural combination hormone replacement formulations and therapies
Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
US08993546B2 Parasiticidal composition
An anti-parasiticidal composition presented as a topical “pour-on” product for treating animals infected by parasites which are known to be susceptible to salicylanilides, especially closantel, alone or together with at least one other anti parasitic compound of the avermectin or milbemycin type and offers enhanced bioavailability of the salicylanilide by provision of a delivery system comprising at least 20% (v/v) of one or more alcohols, and optionally including a polymeric moiety selected from the group consisting of polyvinylpyrrolidone (PVP), polyoxypropylene/polyoxyethylene block copolymers (poloxamer), and polyethylene glycols (PEG), thereby improving the bioavailability of e.g. closantel (as assessed with respect to blood plasma levels of closantel).
US08993545B2 Carbonate prodrugs and methods of using the same
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.
US08993543B2 Diphenyl sulfide derivative and pharmaceutical product which contains same as active ingredient
[Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.
US08993542B2 Methods of treating viral infections
The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective treat the HIV and/or HBV infection and at least substantially inhibit the development of resistance to said antiviral compounds in the subject. Pharmaceutical compositions are also provided.
US08993540B2 Compositions and methods for delivering an agent to a wound
The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
US08993539B2 Dietary fiber supplements for appetite suppression
The present invention provides a composition of dietary fiber supplements for satiety enhancement and appetite suppression in treatment of overweight, obesity, or eating disorders. The composition of the dietary fiber supplements consist of at least one cationic polymer and at least one anionic polymer. The cationic polymers and the anionic polymers in the composition can be dissolved or dispersed in an aqueous solution. When the pH of the aqueous solution is lowered, such as the solution is ingested into the stomach with a gastric pH environment or the aqueous solution is added with some acidifying agents, the aqueous solution will turn into a gel. The formation of a gel from the aqueous solution after it being ingested into the stomach before a meal would provide a satiety enhancement and appetite suppression effect.
US08993535B2 Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
The compounds are of the class of pyrimidine analogs useful for treating cancer, for example:
US08993531B2 PKD ligands and polynucleotides encoding PKD ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to cellular localization signals, epitope tags and/or reporters. The invention also includes polynucleotides encoding the ligands and polyligands.
US08993529B2 Antisense modulation of superoxide dismutase 1, soluble expression
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
US08993528B2 Oligomeric compounds comprising tricyclic nucelosides and methods for their use
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
US08993526B2 Method for counteracting the perception of sweat malodour by decreasing the function of carboxylic acid-binding olfactory receptors
The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
US08993524B2 Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. Such immune suppressive mechanisms include immunosuppressive cytokines (for example, Transforming growth factor beta (TGF-β) and regulatory T cells and/or immunosuppressive myeloid dendritic cells (DCs). By counteracting tumor-induced immune tolerance, the present invention provides effective compositions and methods for cancer treatment, optional in combination with another existing cancer treatment. The present invention provides strategies to counteract tumor-induced immune tolerance and enhance the antitumor efficacy of chemotherapy by activating and leveraging T cell-mediated adaptive antitumor immunity against resistant or disseminated cancer cells.
US08993522B2 Materials and methods for improving gastrointestinal function
The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.
US08993517B2 Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
US08993516B2 Meal-time insulin analogues of enhanced stability
A method treating a patient includes administering a physiologically effective amount of a fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof to the patient. The fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof, contains an insulin A-chain sequence modified at position A8 and an insulin B-chain sequence or an analogue thereof. The fibrillation-resistant insulin analogue may exhibit thermodynamic stability similar to or exceeding that of wild-type human insulin and displays a susceptibility to fibrillation similar to or exceeding that of wild-type human insulin. An insulin analogue may display greater in vitro insulin receptor binding than normal insulin while displaying binding to IGFR less than twice that of normal insulin and less than that of fast-acting insulin analogs. The fibrillation-resistant insulin may be used to treat a patient by subcutaneous injection or by using an implantable or external insulin pump, due to its fibrillation resistance.
US08993515B2 Peptidomimetics comprising N-amino cyclic urea residues and uses thereof
Novel peptidomimetics comprising N-amino cyclic urea residues are disclosed. Use of such peptidomimetics for modulating the activity of CD36 or IL-1 receptor in a cell, and for treating CD36- or IL-1-related disease, disorder or condition is also described.
US08993514B1 Prion protein based hemin binders and methods of use
Methods of using portions of the N-terminal domain of prion protein for binding hemin are disclosed. In a particular embodiment, a method comprises administering at least one isolated amino acid sequence comprising a peptide from the octarepeat region of PrPC to a solution containing hemin, wherein the isolated amino acid sequence is effective for forming one or more chemical bonds with hemin.
US08993513B2 Molecular device, single-molecular optical switching device, functional device, molecular wire, and electronic apparatus using functional device
A molecular device including: at least one molecule of zinc cytochrome c; in which an electron or a hole is transferred within the at least one molecule of zinc cytochrome c bar utilizing transition of an electron between molecular orbitals of the at least one molecule of zinc cytochrome c. The molecular orbitals, for example, are a first molecular orbital localized in a first amino acid residue of the at least one molecule of zinc cytochrome c, and a second molecular orbital which is localized in a second amino acid residue of the at least one molecule of zinc cytochrome c and which has a maximum transition probability per unit time with respect to the first molecular orbital. In this case, the electron or the hole is transferred between the first amino acid residue and the second amino acid residue.
US08993512B2 Compositions and method for treatment of ischemic neuronal reperfusion injury
A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
US08993508B1 Laundry care composition comprising mono-azo carboxylate dye
The present invention relates to a laundry care composition comprising from 0.00001 wt % to 0.5 wt % mono-azo carboxylate dye having the structure of Formula I: wherein each R3 is independently selected from the group consisting of alkyl, oxyalkyl, oxyaryl, sulfonamidoalkyl, sulfonamidoaryl, amidoalkyl, amidodialkyl, amidoaryl, amidodiaryl, halogen, thioalkyl and thioaryl; wherein the index a is an integer from 0 to 4, preferably from 0 to 2; wherein D is an aromatic or heteroaromatic group, with the proviso that the heteroaromatic group is not a thiophene; wherein R1 is independently selected from the group consisting of: (a) unsubstituted or substituted C1 to C12 alkyl chains, optionally the alkyl chains comprise ether (C—O—C), ester and/or amide links, optionally the alkyl chains are substituted with —Cl, —Br, —CN, —NO2, —SO2CH3, —OH and mixtures thereof; and (b) (CH2CH2O)y((CH2)wNH)zQ; wherein R2 is (CH2CH2O)y′((CH2)w′NH)z′Q′.
US08993504B2 Oxidation catalyst for bleaching, and bleaching composition using the same
The present invention provides an oxidation catalyst for bleaching containing a component (a) which is an anion caused from a chelating agent having less than or equal to coordination position 5 and/or the chelating agent, and a component (b) which is a copper and/or manganese compound; and a binder compound (c); a hydrogen peroxide-based compound (d) which dissolves in water and generates hydrogen peroxide, the bleaching composition containing a granulated product or a molded product in which at least the component (b) and the component (c) are granulated or molded together. According to the invention, an oxidation catalyst that promotes the oxidation effect of hydrogen peroxide-based compounds with a trace amount of the composition, and has excellent effects of suppressing the decomposition of hydrogen peroxide-based compounds and suppressing coloration of the catalyst itself, and a bleaching composition containing the oxidation catalyst can be utilized.
US08993502B2 Cleaning composition having high self-adhesion to a vertical hard surface and providing residual benefits
A composition for treating a hard surface. The composition has: (a) at least one adhesion promoter; (b) at least one surfactant selected from the group consisting of: anionic, non-ionic, cationic, amphoteric, zwitterionic, and combinations thereof; (c) mineral oil; (d) a blend of linear primary alcohols, wherein each alcohol of said blend includes a carbon chain containing 9 to 17 carbons or an ethoxylated blend thereof; (e) water; (f) optionally, at least one solvent; and wherein the composition is self-adhering upon application to a surface to be treated, and wherein the composition provides a wet film to said surface when water passes over said composition and surface.
US08993501B2 Sprayable gel cleaner for optical and electronic surfaces
A sprayable homogeneous and high viscosity surface cleaning gel or gel foam composition and method of cleaning is provided. The composition may include from about 70% to about 99% of a liquid carrier; from about 0.002% to about 10% of surfactant selected from the group of non-ionic, anionic, amphoteric, and zwitterionic surfactants, and mixtures thereof; from about 0.005% to about 5% of a water-soluble polymeric thickening agent; and from about 0.001 to about 1.0% of a pH balancing agent. The sprayable gel cleaner composition may be completely clear without any suspended encapsulated particles in it and includes a viscosity range from about 200 centipoise to about 30,000 centipoise at standard temperature and pressure.
US08993494B2 Compositions comprising reverse micelles and methods for their use
Compositions containing a reverse micelle comprising a first compound and a second compound are disclosed, wherein the second compound is configured to change conformation in response to a stimulus, a first conformation selected for formation of the reverse micelle, and a second conformation selected for disruption of the reverse micelle; and wherein the first compound is selected to interact with the first conformation of the second compound to form the reverse micelle.
US08993489B2 Coated and cured proppants
Solid proppants are coated with a phenol-urethane coating in one or more layers by a method comprising coating a proppant solid and then curing the coated proppant under conditions sufficient to substantially cure said proppant, wherein said coating comprises a substantially homogeneous mixture of (i) an isocyanate component having at least 2 isocyanate groups, (ii) an amine reactant, and optionally (iii) an amine that is a latent curing agent for said isocyanate.
US08993486B2 Ultra-high throughput screening methods to detect synergistic drug interactions
Synergy occurs when combined agents induce a response greater than the sum of their individual effects. The present invention provides new high throughput screening methods to detect agents acting synergistically in orthogonally pooled mixtures. Computational de-convolution of the pooled data with software reveals single-actives in the pools with twice the statistical power and with much greater efficiency than common high throughput screening approaches. Cross-correlating the orthogonal data reveals pools with activity that cannot be ascribed to any single compound. The components of such ‘Orphan’ activity pools are then tested individually and in all possible combination-pairs to identify and confirm synergy. The high throughput screening invention disclosed, which we name “Ultra-High Throughput Screening for Synergy (uHTSS)”, is applicable for more efficiently discovering nucleic acids, proteins and small molecules that act synergistically without having to systematically test each possible pair, as is required by known screening practices.
US08993484B1 Methods for improving plant growth
Methods of improving the growth of a plant by applying a plant growth effective amount of a plant growth composition that includes a hydrated aluminum-magnesium silicate and at least one dispersant selected from the group consisting of a sucrose ester, a lignosulfonate, an alkylpolyglycoside, a naphthalenesulfonic acid formaldehyde condensate and a phosphate ester to plant propagation material in the absence of insect pest pressure.
US08993481B2 Method of controlling pest
Provided is a method which exerts an excellent effect in controlling a pest in a field of soybean, corn or cotton, using a SDHI compound and a PPO-inhibiting compound. A method of controlling a pest (a weed and/or a plant pathogen) in a field of soybean, corn or a cotton, including treating a field before, at or after seeding with a seed of soybean, corn or cotton treated with one or more compounds selected from the group consisting of SDHI compounds, with one or more PPO-inhibiting compounds selected from the group consisting of flumioxazin, sulfentrazone, saflufenacil, oxyfluorfen, fomesafen and a compound of the formula:
US08993478B2 Activated carbon for electric double layer capacitor electrode and method for producing the activated carbon
The present invention provides a method for producing an activated carbon for an electric double layer capacitor, with which the wettability of a carbon material with an alkali activator is improved, thereby improving contact efficiency between the carbon material and the alkali activator and efficiently promoting reaction between the carbon material, which is a starting material and the activator. The method comprises adjusting a carbon material as it is or after having been calcined to produce a carbon powder having an average particle diameter of 0.5 to 15 μm, oxidizing the carbon powder to contain 3 percent by mass or more of oxygen, and activating the oxidized product with an alkali activator.
US08993474B2 Dehydrogenation catalyst
This invention relates to a dehydrogenation catalyst having a macropore size and a high active density of platinum, suitable for use in dehydrogenation of a hydrocarbon gas. This dehydrogenation catalyst having a macropore size and a high active density of platinum is highly active, has high active density per unit catalytic surface area, facilitates material transfer of reactants and products, delays deactivation due to coke formation, keeps the initial activity constant after being regenerated thanks to the disposal of coke, has high strength and so is resistant to external impact, and undergoes neither structural changes due to heat nor changes in the properties of active materials.
US08993470B2 Catalysts for the alkyne metathesis
Organometallic compounds of the general formula (I), in which M=Mo, W, are claimed.
US08993465B2 Glass composition having high thermal and chemical stability
Described herein are alkali-free, boroalumino silicate glasses exhibiting desirable physical and chemical properties for use as substrates in flat panel display devices, such as, active matrix liquid crystal displays (AMLCDs) and active matrix organic light emitting diode displays (AMOLEDs). In accordance with certain of its aspects, the glasses possess good dimensional stability as a function of temperature. The glasses comprise in mol percent on an oxide basis: 70-74.5 SiO2, 10.5-13.5 AL2O3, 0-2.5 B2O3, 3-7 MgO, 3-7 CaO, 0-4 SrO, 1.5-6 BaO, 0-0.3 SnO2, 0-03 CeO2, 0-0.5 As2O3, 0-0.5 Sb2O3, 0.01-0.08 Fe2O3 and F+Cl+BrRO/Al2O31.7 and 0.2MgO/RO0.45, RO being the sum of MgO, BaO, SrO and CaO.
US08993462B2 Surface sealed reinforced building element
A building element (1) that is suitable for use as a structural element in wet areas or external docking. The building element (1) comprises a rigid substrate (2) having an upper face (3). Over the first face (3) lies a radiation curable resin (4) into which a layer of reinforcing material (5) is at least partially embedded. The reinforcing material (5) and resin (3) can be applied separately or together onto the first face (3) of the rigid substrate (2) or in some cases can be applied to both faces. An apparatus and method for producing the building sheet are also disclosed.
US08993461B2 Method for curing defects in a semiconductor layer
A method for curing defects associated with the implantation of atomic species into a semiconductor layer transferred onto a receiver substrate, wherein the semiconductor layer is thermally insulated from the receiver substrate by a low thermal conductivity layer having thermal conductivity that is lower than that of the transferred semiconductor layer. The method includes applying a selective electromagnetic irradiation to the semiconductor layer to heat that layer to a temperature lower than its temperature of fusion to cure defects without causing an increase in the temperature of the receiver substrate beyond 500° C.
US08993460B2 Apparatuses and methods for depositing SiC/SiCN films via cross-metathesis reactions with organometallic co-reactants
Disclosed herein are methods of forming SiC/SiCN film layers on surfaces of semiconductor substrates. The methods may include introducing a silicon-containing film-precursor and an organometallic ligand transfer reagent into a processing chamber, adsorbing the silicon-containing film-precursor, the organometallic ligand transfer reagent, or both onto a surface of a semiconductor substrate under conditions whereby either or both form an adsorption-limited layer, and reacting the silicon-containing film-precursor with the organometallic ligand transfer reagent, after either or both have formed the adsorption-limited layer. The reaction results in the forming of the film layer. In some embodiments, a byproduct is also formed which contains substantially all of the metal of the organometallic ligand transfer reagent, and the methods may further include removing the byproduct from the processing chamber. Also disclosed herein are semiconductor processing apparatuses for forming SiC/SiCN film layers.
US08993458B2 Methods and apparatus for selective oxidation of a substrate
Methods and apparatus for improving selective oxidation against metals in a process chamber are provided herein. In some embodiments, a method of oxidizing a first surface of a substrate disposed in a process chamber having a processing volume defined by one or more chamber walls may include exposing the substrate to an oxidizing gas to oxidize the first surface; and actively heating at least one of the one or more chamber walls to increase a temperature of the one or more chamber walls to a first temperature of at least the dew point of water while exposing the substrate to the oxidizing gas.
US08993457B1 Method of fabricating a charge-trapping gate stack using a CMOS process flow
A method of fabricating a memory device is described. Generally, the method includes: forming on a surface of a substrate a dielectric stack including a tunneling dielectric and a charge-trapping layer overlying the tunneling dielectric; depositing a first cap layer comprising an oxide over the dielectric stack; forming a second cap layer comprising a nitride over the first cap layer; patterning the first and second cap layers and the dielectric stack to form a gate stack of a memory device; removing the second cap layer; and performing an oxidation process to form a blocking oxide over the charge-trapping layer, wherein the oxidation process consumes the first cap layer. Other embodiments are also described.
US08993455B2 ZrAlON films
Atomic layer deposition (ALD) can be used to form a dielectric layer of zirconium aluminum oxynitride (ZrAlON) for use in a variety of electronic devices. Forming the dielectric layer may include depositing zirconium oxide using atomic layer deposition and precursor chemicals, followed by depositing aluminum nitride using precursor chemicals, and repeating. The dielectric layer may be used as the gate insulator of a MOSFET, a capacitor dielectric, and a tunnel gate insulator in flash memories.
US08993452B2 Method of patterning a metal gate of semiconductor device
Provided are methods of patterning metal gate structures including a high-k gate dielectric. In an embodiment, a soluble hard mask layer may be used to provide a masking element to pattern a metal gate. The soluble hard mask layer may be removed from the substrate by water or a photoresist developer. In an embodiment, a hard mask including a high-k dielectric is formed. In a further embodiment, a protection layer is formed underlying a photoresist pattern. The protection layer may protect one or more layers formed on the substrate from a photoresist stripping process.
US08993447B2 LED device with improved thermal performance
An apparatus includes a wafer with a number of openings therein. For each opening, an LED device is coupled to a conductive carrier and the wafer in a manner so that each of the coupled LED device and a portion of the conductive carrier at least partially fill the opening. A method of fabricating an LED device includes forming a number of openings in a wafer. The method also includes coupling light-emitting diode (LED) devices to conductive carriers. The LED devices with conductive carriers at least partially fill each of the openings.
US08993440B2 Method of manufacturing a semiconductor device with processes carried out without atmospheric exposure
A method of manufacturing a semiconductor device according to an embodiment, includes forming a wiring in a surface of a first insulating film on a semiconductor substrate, exposing the first insulating film in whose surface the wiring is formed to a plasma containing a rare gas so as to form a densified layer on the surface of the first insulating film, removing an oxide film formed on the wiring, after the densified layer is formed and forming a second insulating film on the wiring from which the oxide film is removed and on the densified layer, wherein the processes from the removal of the oxide film to the formation of the second insulating film are carried out without being atmospherically-exposed.
US08993436B2 Method for fabricating semiconductor device that includes forming passivation film along side wall of via hole
A method for fabricating a semiconductor device includes sequentially forming an etch stop film and an insulating film on a substrate including a lower pattern forming a conductive mask pattern including a first opening on the insulating film, forming a via-hole in the insulating film using the conductive mask pattern as an etch mask, the via-hole exposing the etch stop film, removing the conductive mask pattern, and forming a passivation film along a side wall of the via-hole after removing the conductive mask pattern.
US08993432B2 Test structure and method of testing electrical characteristics of through vias
A method and apparatus for testing the electrical characteristics, such as electrical continuity, is provided. A substrate, such as a wafer or an interposer, having a plurality of through vias (TVs) is provided. Along one side of the substrate, a conductive layer electrically couples two or more of the TVs. Thereafter, the electrical characteristics of the TVs may be test by, for example, a probe card in electrical contact with the TVs on the other side of the substrate. During testing, current passes through a first TV from a first side of the substrate, to the conductive layer on a second side of the substrate, to a second TV, and back to the first side of the substrate through the second TV.
US08993431B2 Method of fabricating bump structure
A method for fabricating bump structure forms an under-bump metallurgy (UBM) layer in an opening of an encapsulating layer, and then forms a bump layer on the UBM layer within the opening of the encapsulating layer. After removing excess material of the bump layer from the upper surface of the encapsulating layer, the encapsulating layer is removed till a top portion of the bump layer protrudes from the upper surface of the encapsulating layer.
US08993420B2 Methods of forming epitaxial layers
A method of forming an epitaxial layer includes forming a plurality of first insulation patterns in a substrate, the plurality of first insulation patterns spaced apart from each other, forming first epitaxial patterns on the plurality of first insulation patterns, forming second insulation patterns between the plurality of first insulation patterns to contact the plurality of first insulation patterns, and forming second epitaxial patterns on the second insulation patterns and between the first epitaxial patterns to contact the first epitaxial patterns, the first epitaxial patterns and the second epitaxial patterns forming a single epitaxial layer.
US08993414B2 Laser scribing and plasma etch for high die break strength and clean sidewall
In embodiments, a hybrid wafer or substrate dicing process involving an initial laser scribe and subsequent plasma etch is implemented for die singulation. The laser scribe process may be used to cleanly remove a mask layer, organic and inorganic dielectric layers, and device layers. The laser etch process may then be terminated upon exposure of, or partial etch of, the wafer or substrate. In embodiments, a multi-plasma etching approach is employed to dice the wafers where an isotropic etch is employed to improve the die sidewall following an anisotropic etch. The isotropic etch removes anisotropic etch byproducts, roughness, and/or scalloping from the anisotropically etched die sidewalls after die singulation.
US08993413B2 Method of manufacturing semiconductor device
A method of manufacturing a semiconductor device includes the steps of preparing a semiconductor wafer having a thick portion in an outer circumferential end portion and a thin portion in a central portion, attaching a support material to one surface of the semiconductor wafer, dividing the semiconductor wafer into the thick portion and the thin portion, and cutting the thin portion, after the division, while supporting the thin portion by the support material.
US08993411B2 Method for forming pad in wafer with three-dimensional stacking structure
A method for forming a pad in a wafer with a three-dimensional stacking structure is disclosed. The method includes bonding a device wafer that includes an Si substrate and a handling wafer, thinning a back side of the Si substrate, depositing an anti-reflective layer on the thinned back side of the Si substrate, depositing a back side dielectric layer on the anti-reflective layer, defining a space for a pad in the back side dielectric layer and forming vias that pass through the back side dielectric layer and the anti-reflective layer and contact back sides of super contacts which are formed on the Si substrate, filling one or more metals in the vias and the defined space for the pad, and removing a remnant amount of the metal filled in the space for the pad through planarization by a CMP (chemical mechanical polishing) process.
US08993410B2 Substrate cleaving under controlled stress conditions
A thickness of material may be detached from a substrate along a cleave plane, utilizing a cleaving process controlled by a releasable constraint plate. In some embodiments this constraint plate may comprise a plate that can couple side forces (the “P-plate”) and a thin, softer compliant layer (the “S-layer”) situated between the P-plate and the substrate. In certain embodiments a porous surface within the releasable constraint plate and in contact to the substrate, allows the constraint plate to be secured to the substrate via a first pressure differential. Application of a combination of a second pressure differential within a pre-existing cleaved portion, and a linear force to a side of the releasable constraint plate bound to the substrate, generates loading that results in controlled cleaving along the cleave plane.
US08993409B2 Semiconductor optical device having an air media layer and the method for forming the air media layer thereof
A method for fabricating air media layer within the semiconductor optical device is provided. The step of method includes a substrate is provided, a GaN thin film is formed on the substrate, a sacrificial layer is formed on the GaN thin film, and a nitride-containing semiconductor layer is formed on the sacrificial layer. The semiconductor optical device is immersed with an acidic solution to remove the portion of sacrificial layer to form an air media layer around the residual sacrificial layer.
US08993407B2 Compact localized RRAM cell structure realized by spacer technology
An RRAM is disclosed with a vertical BJT selector. Embodiments include defining a STI region in a substrate, implanting dopants in the substrate to form a first polarity well around and below a bottom portion of the STI region, a second polarity channel over the well on opposite sides of the STI region, and a first polarity active area over each channel at the surface of the substrate, forming an RRAM liner on the active area and STI region, forming a sacrificial top electrode on the RRAM liner, forming spacers on opposite sides of the sacrificial top electrode, implanting a second polarity dopant in the active area on opposite sides of the sacrificial top electrode, forming a silicon oxide adjacent the spacers, removing at least a portion of the sacrificial top electrode forming a cavity, forming in the cavity inner spacers adjacent the spacers and a top electrode.
US08993406B1 FinFET device having a merged source drain region under contact areas and unmerged fins between contact areas, and a method of manufacturing same
A method for manufacturing a fin field-effect transistor (FinFET) device, comprises forming a plurality of fins on a substrate, forming a plurality of gate regions on portions of the fins, wherein the gate regions are spaced apart from each other, forming spacers on each respective gate region, epitaxially growing a first epitaxy region on each of the fins, stopping growth of the first epitaxy regions prior to merging of the first epitaxy regions between adjacent fins, forming a dielectric layer on the substrate including the fins and first epitaxy regions, removing the dielectric layer and first epitaxy regions from the fins at one or more portions between adjacent gate regions to form one or more contact area trenches, and epitaxially growing a second epitaxy region on each of the fins in the one or more contact area trenches, wherein the second epitaxy regions on adjacent fins merge with each other.
US08993404B2 Metal-insulator-metal capacitor formation techniques
Techniques and structure are disclosed for providing a MIM capacitor having a generally corrugated profile. The corrugated topography is provisioned using sacrificial, self-organizing materials that effectively create a pattern in response to treatment (heat or other suitable stimulus), which is transferred to a dielectric material in which the MIM capacitor is formed. The self-organizing material may be, for example, a layer of directed self-assembly material that segregates into two alternating phases in response to heat or other stimulus, wherein one of the phases then can be selectively etched with respect to the other phase to provide the desired pattern. In another example case, the self-organizing material is a layer of material that coalesces into isolated islands when heated. As will be appreciated in light of this disclosure, the disclosed techniques can be used, for example, to increase capacitance per unit area, which can be scaled by etching deeper capacitor trenches/holes.
US08993403B2 Socket, and capacitor element producing jig using socket
The present invention provides a socket by which a capacitor element can be produced without causing contamination of chemical conversion treatment liquid or semiconductor layer forming liquid even if the chemical conversion treatment liquid or the semiconductor layer forming liquid has a corrosive property, and a lead wire of a positive electrode can be stably retained even if diameters of the lead wires are difference. The socket (1) of the present invention is provided with a conductive socket body portion (2) having an insertion port, a resin insulation portion (5) covering a part of the socket body portion (2) so as not to close an insertion port (37), and a resin coating portion (3) coating at least the insertion portion (37) of the socket body portion (2).
US08993399B2 FinFET structures having silicon germanium and silicon fins
A finned structure is fabricated using a bulk silicon substrate having a carbon doped epitaxial silicon layer. A pFET region of the structure includes silicon germanium fins. Such fins are formed by annealing the structure to mix a germanium containing layer with an adjoining crystalline silicon layer. The structure further includes an nFET region including silicon fins formed from the crystalline silicon layer. The germanium containing layer in the nFET region is removed to create a space beneath the crystalline silicon layer in the nFET region. An insulating material is provided within the space. The pFET and nFET regions are electrically isolated by a shallow trench isolation region.
US08993396B2 Capacitor and method for fabricating the same
A method for fabricating a capacitor includes forming a mold structure over a substrate, wherein the mold structure has a plurality of open parts and has a mold layer stacked with a support layer; forming cylinder type lower electrodes in the open parts; forming a first upper electrode over an entire surface of a structure including the cylinder type lower electrodes to fill the cylinder type lower electrodes; defining a through hole that passes through portions of the first upper electrode and the support layer; removing the mold layer through the through hole and exposing the cylinder type lower electrodes; forming a second upper electrode to fill the through hole and spaces between the cylinder type lower electrodes; and forming a third upper electrode to connect the second upper electrode and the first upper electrode with each other.
US08993393B2 Multiple silicide integration structure and method
A structure and method for providing a multiple silicide integration is provided. An embodiment comprises forming a first transistor and a second transistor on a substrate. The first transistor is masked and a first silicide region is formed on the second transistor. The second transistor is then masked and a second silicide region is formed on the first transistor, thereby allowing for device specific silicide regions to be formed on the separate devices.
US08993384B2 Semiconductor device and fabrication method thereof
A semiconductor device includes a fin structure, an isolation structure, a gate structure and an epitaxial structure. The fin structure protrudes from the surface of the substrate and includes a top surface and two sidewalls. The isolation structure surrounds the fin structure. The gate structure overlays the top surface and the two sidewalls of a portion of the fin structure, and covers a portion of the isolation structure. The isolation structure under the gate structure has a first top surface and the isolation structure at two sides of the gate structure has a second top surface, wherein the first top surface is higher than the second top surface. The epitaxial layer is disposed at one side of the gate structure and is in direct contact with the fin structure.
US08993380B2 Structure and method for 3D IC package
Provided is a chip package structure and a method for forming the chip package. The method includes bonding a plurality of first dies on a carrier, encapsulating in a first molding compound the first dies on the carrier, coupling a plurality of second dies on the first dies using conductive elements, adding an underfill between the second dies and the first dies surrounding the conductive elements, and encapsulating in a second molding compound the second dies and the underfill. The chip package comprises a chip encapsulated in a molding compound, and a larger chip coupled to the first chip via conductive elements, wherein the conductive elements are encapsulated in an underfill between the chip and the larger chip without an interposer, and wherein the larger chip and the underfill are encapsulated in a second molding compound in contact with the molding compound.
US08993379B2 Chip stack with electrically insulating walls
A method of forming a chip stack is provided and includes arraying solder pads along a plane of a major surface of a substrate forming walls of electrically insulating material between adjacent ones of the solder pads.
US08993378B2 Flip-chip BGA assembly process
A method for assembling a flip chip ball grid array package includes mounting solder spheres to a ball grid array substrate, applying flux to a plurality of flip chip solder bumps provided on a diced wafer, aligning the ball grid array substrate over a chip on the diced wafer, picking and separating the chip from the diced wafer by urging the chip upwards towards the ball grid array substrate until the flip chip solder bumps on the chip come in contact with the ball grid array substrate, whereby the chip attaches to the ball grid array substrate in an upside-down orientation, and subjecting the chip and the ball grid array substrate to a thermal process whereby the solder spheres reflow and form solder balls and the flip chip solder bumps reflow and form solder joints between the chip and the ball grid array.
US08993368B2 Method for manufacturing an opto-microelectronic device
Method for manufacturing a microelectronic device from a first substrate (10), including the production of at least one electronic component in the semi-conductor substrate after transferring the first substrate (10) onto a second substrate (20), characterized in that it comprises: a first phase carried out prior to the transfer, and including forming at least one pattern made of a sacrificial material in a layer of the first substrate (10), a second phase carried out after the transfer and including the substitution of the electronic component for the pattern.
US08993366B2 High efficiency, lightweight, flexible solar sheets
The method of the invention includes the sequential steps of providing a plurality of solar cells, interconnecting the solar cells using one or more interconnect tabs, attaching the interconnect tabs to a top side of the solar cell to interconnect the plurality of solar cells by coupling an exposed top surface of a first solar cell to a top surface of an adjacent second solar cell, attaching one or more bypass diodes to a top side of the solar cell, then next applying an adhesive to a first film layer, placing the plurality of solar cells onto the first film layer, then next applying an adhesive to a second film layer, placing the plurality of solar cells and first film layer onto the second film layer to form a sheet assembly, and then forming the solar sheet from the sheet assembly.
US08993358B2 Deposition of phosphor on die top by stencil printing
A method for depositing a layer of phosphor-containing material on a plurality of LED dies includes disposing a template with a plurality of openings on an adhesive tape and disposing each of a plurality of LED dies in one of the plurality of openings of the template. The method also includes disposing a stencil over the template and the plurality of LED dies. The stencil has a plurality of openings configured to expose a top surface of each of the LED dies. Next, a phosphor-containing material is disposed on the exposed top surface of each the LED dies. The method further includes removing the stencil and the template.
US08993357B2 Method for manufacturing liquid discharge head
A method for manufacturing a liquid discharge includes a process of forming a plurality of blind holes extending from a first surface of the silicon substrate toward a second surface which is a surface opposite to the first surface in the silicon substrate and a process of subjecting the silicon substrate in which the plurality of blind holes are formed to anisotropic etching from the first surface to form a liquid supply port in the silicon substrate, in which, in the process of forming the liquid supply port, the silicon in a region sandwiched by the plurality of blind holes when the silicon substrate is seen from the second surface side is left without being removed by the anisotropic etching to use the left silicon as a beam.
US08993356B2 Method for constructing an electrical circuit, and electrical circuit
A method for constructing an electrical circuit that includes at least one semiconductor chip encapsulated with a potting compound is disclosed. The method includes applying a galvanic layer arrangement for forming an electrochemical element on an element of the electrical circuit including the at least one semiconductor chip.
US08993350B2 Sensitive method to analyse free PEG-maleimide
The present invention relates generally to a novel method using HPLC and fluorescence detection of free PEG-mal in PEGylated proteins and PEG-mal raw materials by adding a fluorescent label to the free PEG-mal.
US08993342B2 Magnetic separation unit, magnetic separation device and method for separating magnetic substance in bio-samples
A magnetic separation unit is provided, including a first member made of non-magnetic materials comprising a trench extending within the first member and a second member made of magnetic materials including a protrusion portion protruding over a surface of the second member, wherein the first member connects the second member such that the trench functions as a fluid channel formed between the first and second members, and the protrusion portion of the second member is contained by the trench of the first member.
US08993341B2 Removal of PCR inhibitors
Provided herein is technology relating to processing and preparing samples and particularly, but not exclusively, to methods, systems, and kits for removing assay inhibitors, e.g, compounds that inhibit polymerase chain reaction, from samples comprising nucleic acids. In particular, the technology is directed toward treating crude sample preparations, such as supernatants from homogenized stool samples, with insoluble polyvinylpyrrolidone (PVP) to form PVP-assay inhibitor complexes, and spin filtration to separate the PVP-assay inhibitor complexes from the crude sample preparations to produce clarified samples that exhibit reduced assay inhibition.
US08993333B2 Method of evaluating cancer risk in human
Disclosed is a method of providing a risk evaluation and diagnosis of human cancer, by examining the presence, in the volatile fraction of a human saliva sample, of a combination of particulate biochemical volatile organic compounds, which is indicative of an increased risk of developing cancer.
US08993332B2 Method for characterising the biological activity of helminth eggs, in particular Trichuris eggs
A method for determining the biological activity of embryonated Trichuris eggs is described, in which at least one of the following determinations is carried out: a) Determination and/or confirmation of the stage of the embryonal development of helminth eggs with the aid of quantitative PCR analysis by using suitable marker sequences for ascertaining the copy number of the genomic DNA, b) Determination of the metabolic activity of embryonated helminth eggs by means of biochemical and/or molecular biological methods, c) Determination of the inducibility of gene expression in embryonated helminth eggs, d) Microscopic determination of the motility of helminth larvae in the egg over long periods of observation after pre-incubation at increased temperatures and/or e) Determination of the hatching rate of Trichuris larvae in a laboratory animal, wherein the intact embryonated eggs recovered from the contents of the intestine are quantified compared to an internal standard.
US08993329B2 Method of efficiently establishing induced pluripotent stem cells
Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic cell on which Lin28 is ineffective or less effective than Lin28B in improving iPS cell establishment efficiency, and a method of producing an iPS cell, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B and a nuclear reprogramming substance to a somatic cell. Also provided are an iPS cell comprising a nucleic acid that encodes Lin28B, that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate into a somatic cell.
US08993328B2 Media conditioning for improving gene delivery efficiency to differentiating embryonic stem cells
The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells for one to three days prior to transfection. Such a serum starvation surprisingly resulted in increased expression of a constitutively-controlled plasmid from 50.4% to 83.2% of the population and increased expression of a promoter/enhancer controlled plasmid from ˜1.4% to ˜3.7% of the population.
US08993321B2 Container for preparing serum and regenerative medical process using the same
A blood storage container suitable for quick and efficient production of a large amount of serum while ensuring high safety, and a method of separating blood and a regenerative medical process using the same are provided. A blood component separation storage apparatus is provided for separating a plurality of blood components of blood so as to be stored therein. The blood component separation storage apparatus includes a blood reservoir for holding the blood and a component storage part connected to the blood reservoir aseptically and in an air-tight manner. The blood reservoir contains an anticoagulant which suppresses coagulation of the blood. The blood reservoir has a serum producing function to remove coagulation factors from the blood to an extent enabling use in practical applications as a serum, and the component storage part stores each blood component generated by separation of the blood in the blood reservoir.
US08993320B2 Culture method to obtain and maintain a pure or enriched population of mammalian neural stem cells and/or neural/progenitor cells that are prone to differentiate into oligodendrocyte-lineage cells in vitro
An isolated expandable human neural stem or progenitor cell wherein the cell is a progenitor cells or stem cell, maintains its capability to differentiate into neurons, astrocytes, and oligodendrocytes, maintains its ability to differentiate into oligodendrocyte lineage cells efficiently throughout subsequent passages, and the cell expresses at least cell surface antigens CD133 and CD140α. Also provided is a method of in vitro culturing an expandable neural progenitor or stem cell isolated from a mammalian central nervous system, and the culture itself, wherein said cell maintains its capability to differentiate into neurons, astrocytes, and oligodendrocytes and its ability to differentiate into oligodendrocyte-lineage cells efficiently. In addition, a method of treating a condition caused by a loss of myelin or a loss of oligodendrocytes is provided as is a composition comprising an isolated expandable neural stem cell or one cultured by the methods of the invention.
US08993317B2 Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with reduced or no contaminating baculoviral virions.
US08993316B2 Methods and compositions for gene therapy and GHRH therapy
A composition and method comprising an anti-adjuvant such as DOI (an anti-inflammatory) together with any gene therapy plasmid is disclosed. A method for GHRH production in-vivo using a set of compositions and methods for use of those compositions is provided.
US08993314B2 Algae growth system for oil production
A system for culturing photosynthesizing microorganisms includes a source of a gaseous fluid a mixer that creates micron bubbles within an aqueous medium using the gaseous fluid. The mixing chamber holds the aqueous medium including the micron bubbles before the micron bubbles and aqueous medium are mixed with a culture of photosynthesizing microorganism in a reaction chamber.
US08993313B2 Analytical instrument and analytical method
Provided are an analytical instrument and an analytical method that allow for the direct analysis of a target substance in an undiluted specimen by a transmission photometry in a tightly closed cell container space. An analytical instrument is an analytical instrument for analyzing a target substance contained in a specimen flown in the tightly closed cell container by utilizing an oxidative color-developing agent and an oxidative enzyme reaction, in which an upper substrate and a lower substrate are arranged facing each other and at least a part of the upper substrate and/or at least a part of the lower substrate are/is made of a material transmitting light used for the analysis and having oxygen transmission properties.
US08993311B2 Multi-stage cartridge for MEMS particle storing system
A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
US08993308B2 Storage device for cryopreservation of biological samples
A cryopreservation storage device (100), in particular for cryopreservation of biological samples, comprises a plurality of multi sample modules (20) being adapted for accommodating the biological samples and sample memories, a module control device (30) controlling an access to sample memories accommodated by the multi sample modules (20), and a data interface (41) for accessing to the module control device (30), wherein the module control device (30) includes a data management processor (31), which can be controlled via the data interface (41). Furthermore, a cryopreservation apparatus including at least one cryopreservation storage device (100) and a method for cryopreservation of biological samples are described.
US08993307B2 High multiplex arrays and systems
Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
US08993306B2 Method and kit for separating viral and prokaryotic nucleic acids from eukaryotic nucleic acids
A method for at least partially separating viral and/or prokaryotic nucleic acids from eukaryotic nucleic acids from a biological sample includes re-suspending the cells in the presence of a chelating agent, lysis of the cells by chemical lysis, and/or mechanical lysis, neutralizing the cell lysate and separating the precipitated eukaryotic nucleic acids and obtaining the viral and/or prokaryotic nucleic acids. A kit includes a re-suspension buffer with chelating agent and optionally a saccharide and RNAse, lysis buffer including at least one base and a detergent and neutralizing buffer for at least partially separating viral and/or prokaryotic nucleic acids from eukaryotic nucleic acids from a biological sample. The acid constant of the weak anion defines the pH value and kosmotropic property of the salt (cation+anion) in conjunction with the detergent, which determines the protein solubility and precipitation.
US08993302B2 Mutants of Francisella tularensis and uses thereof
The present invention relates to a mutant Francisella tularensis strain comprising an inactivated clpB gene and compositions comprising such mutant. Methods of producing the mutant are also described. The present invention also encompasses a method of conferring immunity against F. tularensis in a host, comprising administering the described mutant F. tularensis strain.
US08993289B1 High-performance biocomposites, biopolymers, bioexplosives, and bioadhesives made from biomesitylene
A biomass is used to prepare bio-acetone which is converted to bio-mesitylene in high chemical yield and selectivity and the latter is converted using continuous flow chemical processes to a variety of functionalized bioaromatics that are useful in the preparation of high performance biopolymers, biocomposites, bio-explosives, and bio-adhesives.
US08993288B2 Method for converting biomass to methane
A method for enhancing the treatment of lignocellulose-containing materials by biotreatment wherein such lignocellulose-containing materials, normally resistant to biotreatment, are first subjected to a low-temperature, long-residence time pyrolysis at about 175° C. to about 325° C. for about 0.1 hour to about 2.0 hours, wherein a substantial portion of the incoming material is distilled into water-soluble compounds amenable to anaerobic biotreatment. Exemplary applications of the method include pyrolytic pre-treatment of wastewater sludges, cellulosic wastes, wood, peat, plant residues, low-grade coal, and the like to enhance methane gas production in anaerobic digestion and/or oxygen-limited or oxygen-starved fermentation to produce ethanol.
US08993287B2 Biocatalysts and methods for conversion of hemicellulose hydrolysates to biobased products
The invention relates to processes and biocatalysts for producing ethanol and other useful products from biomass and/or other materials. Initial processing of lignocellulosic biomass frequently yields methylglucuronoxylose (MeGAX) and related products which are resistant to further processing by common biocatalysts. Strains of Enterobacter asburiae are shown to be useful in bioprocessing of MeGAX and other materials into useful bioproducts such as ethanol, acetate, lactate, and many others. Genetic engineering may be used to enhance production of desired bioproducts.
US08993285B2 Organisms for the production of isopropanol, n-butanol, and isobutanol
A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. A non-naturally occurring microbial organism having an n-butanol pathway includes at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism have n-butanol or isobutanol pathways. The organisms are cultured to produce isopropanol, n-butanol, or isobutanol.
US08993284B2 Terpene synthases from Santalum
An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5; b) a nucleic acid molecule that is a fragment of (a); c) a nucleic acid molecule comprising a sequence of nucleotides that is complementary to (a) or (b); and d) a nucleic acid molecule that encodes a terpene synthase having at least or at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% identity to any one of (a)-(c); wherein the nucleic acid molecule encodes a terpene synthase.
US08993282B2 Carotenoid fermentation method
The present invention provides a method for producing a carotenoid, which comprises culturing a carotenoid-producing bacterium in an amino acid-supplemented medium, and collecting the carotenoid from the resulting cultured product, wherein the amino acid is at least one selected, from the group consisting of glutamic acid, aspartic acid, glutamine, asparagine, alanine, glycine, serine, threonine, arginine, tyrosine, proline, phenylalanine and leucine, and salts thereof.
US08993281B2 Genetically modified Acinetobacter hosts for lipid production
The present invention relates to a genetically modified Acinetobacter host for lipid production. The Acinetobacter host has been genetically modified to be deficient of one or more of genes A) a gene encoding fatty acyl-CoA reductase (EC1.2.1.n2), wherein said host is capable of increased production of TAGs and/or of total lipids compared to the parent host; and/or B) a gene encoding lipase (EC:3.1.1.3), a gene encoding pyruvate dehydrogenase (EC:1.2.2.2), and/or gene ACIAD 2177, or functional equivalents of any of said genes, wherein said host is capable of increased production of wax esters and/or total lipids compared to the parent host.
US08993279B2 Method for production of L-amino acid
A method for producing an L-amino acid is described, which is characterized by culturing a Vibrio bacterium capable of producing the L-amino acid in a culture medium to produce and accumulate the L-amino acid in the culture medium and collecting the L-amino acid from the culture medium.
US08993272B2 Microorganisms of Corynebacterium with improved 5′-inosinic acid productivity, and method for producing nucleic acids using same
The present invention relates to a microorganisms of the genus Corynebacterium producing 5′-inosinic acid, in which the expression of genes encoding purine biosynthesis related enzymes is increased higher than the intrinsic expression, and to a method for producing 5′-inosinic acid, comprising culturing the microorganisms of the genus Corynebacterium with improved 5′-inosinic acid productivity.
US08993271B2 Method of nucleic acid amplification
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other primer can be extended. Both extended primers can then be separated from one another and can be used to provide further extended primers. The process can be repeated to provide amplified, immobilized nucleic acid molecules. These can be used for many different purposes, including sequencing, screening, diagnosis, in situ nucleic acid synthesis, monitoring gene expression, nucleic acid fingerprinting, etc.
US08993263B2 PKA ligands and polynucleotides encoding PKA ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate PKA activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
US08993258B2 Fluorinated voltage sensitive dyes, preparation thereof, and optical methods of use
A fluorinated voltage sensitive dye has the structure wherein p is 0, 1, or 2; Xq− is an anionic counterion having a charge, q, that is 1 or 2; n is 1 or 2; R1 is an optionally substituted C1-C12, alkyl; R2 is hydrogen, and R3 is hydrogen or fluorine; or R2 and R3 collectively form a divalent —CH═CH—CH═CH— group; R4 and each occurrence of R5 are each independently hydrogen or fluorine; R6 is hydrogen or fluorine or trifluoromethyl; and each occurrence of R7 is independently C1-C6 alkyl; provided that the dye comprises at least one fluorine atom. The dye is particularly useful for monitoring the dynamics of action potentials in axons and/or dendrites.
US08993255B2 Protein having fructosyl valyl histidine oxidase activity, modified protein, and use of the protein or the modified protein
The present invention provides: a protein having a fructosyl amino acid oxidase activity which protein is useful for measurement of a glycosylated protein (particularly, glycosylated hemoglobin); a modified protein thereof; and use of the protein or the modified protein. The protein of the present invention is, for example, a fructosyl valyl histidine oxidase derived from Phaeosphaeria nodorum, the fructosyl valyl histidine oxidase having excellent thermal stability and substrate specificity and also having a small Km value to fructosyl valyl histidine. This allows a glycosylated protein measuring reagent to be stored in a long time and measurement accuracy of the glycosylated protein measuring reagent to be improved.
US08993253B2 Protease detection
A polypeptide comprising a chromogenic amino acid. The chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof. The amine group of the chromogenic amino acid has a pKa of less than 5. The chromogenic amino acid is capable of reacting with a conjugated aldehyde. The polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid.
US08993251B2 Genes from 20q13 amplicon and their uses
The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
US08993250B2 Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Clusterin, Heart-type fatty acid binding protein, Hepatocyte growth factor, Interferon gamma, Interleukin-12 subunit beta, Interleukin-16, Interleukin-2, 72 kDa type IV collagenase, Matrix metalloproteinase-9, Midkine, and Serum amyloid P-component as diagnostic and prognostic biomarkers in renal injuries.
US08993247B2 Assay for vascular calcification
An assay for identifying an individual having or at risk of developing vascular calcification, said assay comprising obtaining a blood sample from an individual and measuring the level of a vesicular compound in a matrix vesicle present in the blood sample from said individual; wherein an increased level of said compound indicates an individual at risk of developing vascular calcification.
US08993246B2 Luminescence assay method
A bioassay employing a first group including a lanthanide ion carrier chelate and a first recognition element, a second group including an antenna ligand and a second recognition element; where the lanthanide ion carrier chelate binds strongly to lanthanide, or the lanthanide ion carrier chelate binds moderately to lanthanide, and an agent complexing the lanthanide ion is additionally employed at a concentration of at least 1 pmol/l. The antenna ligand binds weakly to the lanthanide ion. Analyte recognition by the first recognition element and by the second recognition element results in either chelate complementation and increased fluorescence, or chelate discomplementation and decreased fluorescence.
US08993243B2 Method for isolating weakly interacting molecules from a fluidic sample
Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.
US08993241B2 Reaction device, reaction method and method of synthesizing cDNA
Provided is a device and a method whereby plural kinds of reaction operations and washing operations can be conducted in parallel without washing or replacing an instrument used in transferring a solution in each operation. A reaction device having a plurality of projecting barriers provided in a line on one surface of a substrate. The projecting barrier has a cutoff portion and an inner space capable of holding a droplet and having a contact angle to pure water of from 90 to 150 degrees. A reaction method using the reaction device wherein a substance immobilized on magnetic beads is sequentially transferred in and between droplets of a solution containing a surface tension reducing agent that are held in the spaces for holding a droplet by means of a magnet located on the opposite surface of the substrate to thereby conduct reactions and washings.
US08993238B2 Brassica GAT event and compositions and methods for the identification and/or detection thereof
Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-073496-4 event which imparts tolerance to glyphosate. The Brassica plant harboring the DP-073496-4 event at the recited chromosomal location comprises genomic/transgene junctions within SEQ ID NO: 2 or with genomic/transgene junctions as set forth in SEQ ID NO: 12 and/or 13. The characterization of the genomic insertion site of the event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event are provided.
US08993235B2 Encapsulated reagents and methods of use
The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated in microcapsules or nanocapsules that can be added to an aqueous or non-aqueous carrier solution or liquid required for medical and research laboratory testing of biological or non-biological specimens.
US08993232B2 Identification of the causative mutation for leopard complex spotting and congenital stationary night blindness in equines and a method for testing for same
Methods are provided for determining whether or not a horse is genetically normal, is a carrier of, or is affected with or predisposed to Congenital Stationary Night Blindness and/or leopard complex spotting. The method is based on detection of an insertion in an intron in the horse Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) gene.
US08993231B2 Methods for stem cell production and therapy
The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates to methods for increasing the sensitivity of cancer stem cells to chemotherapeutic agents by culturing the cancer stem cells under microgravity conditions and in the presence of omega-3 fatty acids. The methods of the present invention can also be used to proliferate cancer cells by culturing them in the presence of omega-3 fatty acids. The present invention also relates to methods for testing the sensitivity of cancer cells and cancer stem cells to chemotherapeutic agents by culturing the cancer cells and cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce tissue for use in transplantation by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors to promote differentiation of cancer stem cells under microgravity conditions.
US08993226B2 Method of testing for a milk trisaccharide
A method of testing for a trisaccharide in milk includes the step of providing a predetermined amount of milk. The method also includes the step of isolating a trisachharide of the milk with a hydride insertion reaction to identify the molecule as phosphorylated. Also included in the method is the step of obtaining a mass spectrum of the isolated milk trisaccharide sample. The method further includes the step of identifying a molecular structure of the isolated milk trisaccharide sample.
US08993220B2 Immersion lithographic apparatus and a device manufacturing method
An immersion lithographic apparatus has a surface that in use is contacted by the immersion liquid and the surface has a surface roughness Ra that is less than or equal to 0.2 μm. Immersion liquid on the surface may have a contact angle of 60° or greater. The surface may be able to maintain its properties so that immersion liquid on the surface may have the contact angle for a prolonged period of immersion in the immersion liquid.
US08993218B2 Photo resist (PR) profile control
One or more techniques or systems for controlling a profile for photo resist (PR) are provided herein. In some embodiments, a first shield layer is formed on a first PR layer and a second PR layer is formed on the first shield layer. A first window is formed within the second PR layer during a first exposure with a mask. A second window is formed within the first shield layer based on the first window. A third window is formed within the first PR layer during a second exposure without a mask. Because, the third window is formed while the first shield layer and the second PR layer are on the first PR layer, a profile associated with the first PR layer is controlled. Contamination during ion bombardment is mitigated due to the controlled profile.
US08993216B2 Method of producing a planographic printing plate
A method for producing a planographic printing plate is provided, which includes: subjecting a planographic printing plate precursor to image-wise exposure, wherein the precursor includes plural recording layers at least one of which contains (A) an infrared absorbing agent on a support, the upper recording layer contains (B) a water-insoluble and alkali-soluble polymer compound having a repeating unit containing a fluoroalkyl group or a siloxane structure; and developing the precursor using an alkali developer containing (C)an ammonium salt compound of Formulae (C-1) to (C-3), wherein R1 represents a methyl group or an ethyl group, R2 and R3 represent a hydrocarbon group having 3 to 20 carbon atoms, R4 represents a hydrocarbon group, A represents an atomic group which forms a nitrogen-containing aliphatic ring with N+, B represents an atomic group which forms a nitrogen-containing aromatic ring with N+, and X−represents a counter anion.
US08993214B2 Positive photosensitive siloxane composition
A positive photosensitive siloxane composition comprising at least three types of following polysiloxanes (A), (B) and (C) obtained by hydrolyzing and condensing a silane compound represented by general formula (1) R1nSi (OR2)4-n, a diazonaphthoquinone derivative, and a solvent: a polysiloxane (A) such that if pre-baked the film thereof will be soluble in a 5 weight % TMAH aqueous solution and the solution rate of said film will be 1,000 Å/sec or less; a polysiloxane (B) such that if pre-baked the solution rate of the film thereof will be 4,000 Å/sec or more relative to a 2.38 weight % TMAH aqueous solution; and a polysiloxane (C) such that if pre-baked the solution rate of the film thereof will be between 200 and 3,000 Å/sec relative to a 2.38 weight % TMAH aqueous solution. (In the formula, R1 represents a C1-20 linear or branched cyclic alkyl group, in which any methylene may be substituted by oxygen, or a C6-20 aryl group, in which any hydrogen may be substituted by fluorine; n represents a 0 or a 1; and R2 represents a C1-5 alkyl group.)
US08993212B2 Fluorine-containing sulfonic acid salts, photo-acid generator and resist composition and pattern formation method utilizing same
A resist composition according to the present invention includes at least a base resin, a photoacid generator and a solvent, wherein the photoacid generator comprises a fluorine-containing sulfonic acid salt of the following general formula (4). In the formula, X independently represents a hydrogen atom or a fluorine atom; n represents an integer of 1 to 6; R1 represents a hydrogen atom, or an alkyl, alkenyl, oxoalkyl, aryl or aralkyl group; any of hydrogen atoms on carbons in R1 may be substituted with a substituent; R2 represents RAO or RBRCN; and A represents a divalent group. This fluorine-containing sulfonic acid salt can serve as a photoacid generator having high solubility in a resist solvent and thus can suitably be used for a resist composition such that the resist composition shows high resolution, wide DOF, small LER and high sensitivity to form a good pattern shape in lithographic processes.
US08993208B2 Foil transferring method and toner for forming foil transferring layer
A foil transferring method employing an electrophotography is disclosed, in which a toner used for forming a foil transferring layer contains at least a vinyl based resin and a polyester based resin as a binder resin and an amount of the vinyl based resin is 50 to 95% by weight based on the total amount of the binder resin.
US08993205B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus
An electrophotographic photosensitive member comprises a support, an undercoat layer formed on the support, and a photosensitive layer formed on the undercoat layer, wherein the undercoat layer has a structure represented by the formula (C1) or the formula (C2).
US08993202B2 Color filter for low temperature applications
A color filter comprising a cured layer of a photosensitive resist composition comprising a highly reactive polyacrylate monomer and an alkali soluble binder having a side chain containing an ethylenically unsaturated bond in the side chain and a process for the preparation thereof are provided. The color filter is especially useful for low temperature applications such as electrophoretic displays, polymer dispersed liquid crystal displays, OLED devices and the like.
US08993200B2 Optimization of BZCYYb synthesis
The present invention relates to a novel method for preparing a BZCYYb material to be used in a solid oxide fuel cell. In particular, the method comprises mixing particular nano-sized and micro-sized ingredients and the size selection provides greatly improved performance characteristics of the resulting material. In particular, barium carbonate powder, zirconium oxide powder having particle diameters in the nanometer range, and cerium oxide powder having particle diameter in the micrometer range are used together with ytterbium oxide powder, and yttrium oxide powder.
US08993198B2 Process of preparing PT/support or PT alloy/support catalyst, thus-prepared catalyst and fuel cell comprising the same
Disclosed is a method for preparing a platinum/support catalyst or a platinum alloy/support catalyst, including: a) preparing a dispersion solution including urea, a support and a water-soluble salt of at least one metal(s) having catalytic activity; (b) reacting the dispersion solution at high temperature so as to deposit the metal hydroxide particles derived from the at least one metal(s) on the support; and (c) reducing the metal hydroxide particles. The size and distribution of the platinum particles or platinum alloy particles are greatly improved by the use of urea.
US08993194B2 Fuel cell, cell stack, fuel cell module, and fuel cell device
A fuel cell includes a solid electrolyte layer containing Zr; an intermediate layer containing CeO2 solid solution having a rare-earth element excluding Ce; an air electrode layer containing Sr, the intermediate layer and the air electrode layer being stacked in this order on one surface of the solid electrolyte layer; and a fuel electrode layer on another surface of the solid electrolyte layer which is opposite to the one surface. A value obtained by dividing a content of the rare-earth element excluding Ce by a content of Zr is equal to or less than 0.05 at a site of the solid electrolyte layer, the site being 1 μm away from an interface between the solid electrolyte layer and the intermediate layer.
US08993192B2 Electrolyte membrane and membrane-electrode assembly
An electrolyte membrane having a structure wherein fine rubber particles having substantially no ion-conducting group and having an average particle size of 20 nm to 1 μm are uniformly dispersed in a matrix including a resin component having ion-conducting group. The electrolyte membrane has high bonding ability to electrodes and does not cause cracks and ruptures because it is kept flexible even under low humid or absolutely dried condition, in addition, shows high ion conductivity even under low humid or absolutely dried condition because the matrix having ion-conducting groups are continuous.
US08993188B2 Fuel cell and separator constituting the same
Each separator of a fuel cell stacked alternately with the power generation bodies has a first surface facing the first electrode of the power generation body, a second surface facing the second electrode of another power generation body, a first reactant gas channel that supplies or discharges a first reactant gas to or from the first electrode and that extends in the separator and has an opening portion opened in the first surface, and a second reactant gas channel that supplies and discharges a second reactant gas to or from the second electrode facing the second surface and that extends in the separator and has an opening portion opened in the second surface. The opening portion of the first reactant gas channel and the opening portion of the second reactant gas channel are both disposed along a first portion of a peripheral border of a power generation region.
US08993184B2 Fuel cell system
A fuel cell system is provided that includes a fuel cell stack, an air pump, a first convertor, a motor, and an ECU for controlling the air pump and the first convertor based on the target voltage and the switching voltage of the single cell. The ECU executes the first mode such that the actual voltage of the single cell corresponds to the target voltage, when the target voltage is equal to or less than the switching voltage, while the ECU executes the second mode such that the actual voltage of the single cell is kept at the switching voltage, when the target voltage is more than the switching voltage. Further, the ECU executes the second mode thereby to change the actual current of the single cell.
US08993181B2 Valve for fuel cell, and fuel cell vehicle
A valve-closing pressure chamber and a valve-opening pressure chamber are arranged on both sides of a main diaphragm inside an outlet shutoff valve. An upper supply/discharge tube and a lower supply/discharge tube are connected to a housing forming the outlet shutoff valve. The upper and lower supply/discharge tube supply and discharge air to and from the valve-closing pressure chamber and the valve-opening pressure chamber, respectively. An opening end, which is on the pressure chamber side, of each supply/discharge tube is obliquely cut relative to the direction of axis of the supply/discharge tube, which increases the opening area of the opening end. This prevents water present in the pressure chamber from adhering to the opening end of each supply/discharge tube and prevents the adhered water from freezing. As a result, operation performance of the outlet shutoff valve is enhanced.
US08993176B2 Sulfide solid electrolyte glass, method for producing sulfide solid electrolyte glass, and lithium solid state battery
An object of the present invention is to provide a sulfide solid electrolyte glass producing a tiny amount of hydrogen sulfide. The present invention attains the above-mentioned object by providing a sulfide solid electrolyte glass including Li3PS4, characterized in that Li4P2S7 is not detected by 31P NMR measurement and the content of Li2S as determined by XPS measurement is 3% by mol or less.
US08993174B2 Electrode assembly having novel structure and secondary battery using the same
Disclosed is an integrated electrode assembly having a structure in which a cathode, an anode, and a separation layer disposed between the cathode and the anode are integrated with one another, wherein the separation layer has a multilayer structure including at least one two-phase electrolyte including a liquid phase component and a polymer matrix and at least one three-phase electrolyte including a liquid phase component, a solid component, and a polymer matrix, wherein the polymer matrices of the separation layer are coupled to the cathode or the anode and the liquid phase components of the separation layer are partially introduced into an electrode in a process of manufacturing the electrode assembly.
US08993170B2 Composite carbon material of negative electrode in lithium ion battery and its preparation method
A composite carbon material of negative electrode in lithium ion, which is made of composite graphite, includes a spherical graphite and a cover layer, wherein the cover layer is pyrolytic carbon of organic substance. Inserted transition metal elements are contained between layers of graphite crystal. Preparation of the negative electrode includes the steps of: crushing graphite, shaping to form a spherical shape, purifying treatment, washing, dewatering and drying, dipped in salt solution doped by transition metal in multivalence, mixed with organic matter, covering treatment, and carbonizing treatment or graphitization treatment. The negative electrode provides advantages of reversible specific capacity larger than 350 mAh/g, coulomb efficiency higher than 94% at first cycle, conservation rate for capacity larger than 8-% in 500 times of circulation.
US08993169B2 Electrode compositions, energy storage devices and related methods
A positive electrode composition is presented. The composition includes at least one electroactive metal; at least one alkali metal halide; and at least one additive including a plurality of nanoparticles, wherein the plurality of nanoparticles includes tungsten carbide. An energy storage device, and a related method for the preparation of an energy storage device, are also presented.
US08993167B2 Cathode materials and lithium secondary battery containing the same
Provided is a cathode active material composed of lithium nickel oxide represented by Formula 1, wherein the lithium nickel oxide contains nickel in an amount of 40% or higher, based on the total weight of transition metals, and the cathode active material comprises a first coating layer provided on the surface thereof and a second coating layer provided on the surface of the first coating layer, wherein the first coating layer is composed of a non-reactive material selected from the group consisting of oxides, nitrides, sulfides and mixtures or complexes thereof and the second coating layer is composed of a carbon-based material.
US08993166B2 Anode active material and battery
A battery with the high capacity, the superior cycle characteristics, and the superior initial charge and discharge efficiency, and an anode active material used for it are provided. The anode active material contains at least tin, cobalt, carbon, and phosphorus as an element. A carbon content is from 9.9 wt % to 29.7 wt %, a phosphorus content is from 0.1 wt % to 2.2 wt %, and a cobalt ration to the total of the tin and the cobalt is from 24 wt % to 70 wt %.
US08993165B2 Clathrate allotropes for rechargeable batteries
The present disclosure is directed at clathrate (Type I) allotropes of silicon, germanium and tin. In method form, the present disclosure is directed at methods for forming clathrate allotropes of silicon, germanium or tin which methods lead to the formation of empty cage structures suitable for use as electrodes in rechargeable type batteries.
US08993161B2 Lead-acid battery formulations containing discrete carbon nanotubes
Compositions of discrete carbon nanotubes for improved performance lead acid batteries. Further disclosed is a method to form a lead-acid battery with discrete carbon nanotubes.
US08993160B2 Positive electrode for lithium ion battery, method for producing said positive electrode, and lithium ion battery
The present invention provides a positive electrode for lithium ion battery reducing a contact resistance of a battery and achieving an excellent output property. The positive electrode for lithium ion battery comprising a mixed layer comprising: metal forming a current collector, and positive electrode active material dispersed in a state of layer in the metal forming the current collector.
US08993152B2 Rechargeable battery with terminal through-out portion, terminal plate, and fastening portion
A rechargeable battery includes an electrode assembly including wound positive and negative electrodes with a separator therebetween, a case configured to contain the electrode assembly, a cap plate configured to seal an opening of the case, the cap plate including a terminal hole therethrough, an electrode terminal through the terminal hole of the cap plate, the electrode terminal including a terminal through-out portion extending through the terminal hole, a terminal plate connected to the terminal through-out portion outside the case, and a fastening portion including a terminal fastening portion connected to the terminal plate, and a lead tab inside the case, the lead tab connecting the terminal through-out portion of the electrode terminal to the electrode assembly.
US08993146B2 Cable-type secondary battery
The present invention relates to a cable-type secondary battery having a horizontal cross section of a predetermined shape and extending longitudinally, comprising: a core for supplying lithium ions, which comprises an electrolyte; an inner electrode, comprising an open-structured inner current collector surrounding the outer surface of the core, and an inner electrode active material layer formed on the surface of the inner current collector; a separation layer surrounding the outer surface of the inner electrode to prevent a short circuit between electrodes; and an outer electrode surrounding the outer surface of the separation layer and comprising an outer electrode active material layer and an outer current collector.The core disposed in the inner electrode having an open structure, from which the electrolyte of the core for supplying lithium ions can be easily penetrated into an electrode active material, thereby facilitating the supply and exchange of lithium ions.
US08993141B2 Cap assembly and secondary battery using the same
Cap assembly, coupled to an open end of a battery can free from a beading portion, includes a top cap at an uppermost portion in a protrusive form forming a cathode terminal, a safety element below the top cap contacting the top cap, a safety vent contacting the safety element, a gasket surrounding outer circumferences of top cap, the safety element and vent, a cover surrounding the gasket so the top cap, safety element and vent adhere to each other, and a welding member at an upper portion of the cover having an outer end protruding more outwards than the outer end of the cover placed on the open end of the battery can, the welding member having a first notch at an upper surface thereof, protruding more than the outer end of the cover, and welded to the open end of the battery can where first notch is formed.
US08993140B2 Rechargeable battery cell and battery
A rechargeable battery cell has at least one energy-optimized cell unit and at least one power-optimized cell unit. The power-optimized cell unit is configured in such a way that it can be used to generate a higher power than with the energy-optimized cell unit. The energy-optimized cell unit is configured in such a way that it can be used to store a higher quantity of energy per volume of the energy-optimized cell unit and/or per mass of the energy-optimized cell unit than with the power-optimized cell unit. The at least one energy-optimized cell unit and the at least one power-optimized cell unit are arranged in a common cell housing.
US08993139B2 Sealed secondary battery
Disclosed is a sealed secondary battery provided with a current cut-off device which employs an inexpensive and uncomplicated construction, without the need to mount a separate current cut-off device on the battery body. A sealed secondary battery (10) comprises a battery casing (11) and a sealing plate (12), an electrode body (21) and current collecting plates (22, 22) provided on the inside of this casing (11). A contact section (11c) formed as part of the bottom (11a) of this battery casing (11) is bowed further inwards towards the negative electrode-side current collecting plate (22b) than the peripheral section of the bottom (11a) of this battery casing (11). At this contact section (11c), the inside face of the bottom (11a) of the battery casing contacts the current collecting plate (22b) at the negative electrode end, but this electrical contact between the contact section (11c) and the current collecting plate (22b) at the negative electrode end is cut off when outward swelling of the contact section (11c) takes place, produced by a rise in internal pressure in the casing in a sealed condition.
US08993138B2 Rechargeable battery
A rechargeable battery according to the present invention includes an electrode assembly that includes a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode, a case that contains the electrode assembly and a cap assembly that is connected to the case. The positive electrode includes a current collector and a positive active material layer that includes an NCM-based positive active material disposed at the collector. The cap assembly includes a vent plate having a notch, and a current interrupt portion that interrupts electrical connection in a case of an increase in pressure inside the case. When a current interrupt pressure of the current interrupt portion is “A,” a vent fracture pressure at which the vent plate fractures at the notch is “B,” and the capacity of the rechargeable battery is “X,” they satisfy a formula of A/B=1.22−0.39X+D (−0.08≦D≦0.08).
US08993137B2 Emergency cooling device
An energy storage system, in particular a battery having a plurality of battery cells. These battery cells are accommodated in a first container. The first container is separated from a second container by a separating element, which allows for establishing a pressure difference Δp for expansion of a gas out of the first container into the second container.
US08993135B2 Fuel cell stack for hydrogen fuel power generator
A flexible fuel cell stack is also described that includes an anode electrode layer, an adhesive and anode gas diffusion layer coupled to the anode electrode layer, an ion exchange membrane coupled on a first side to the gas diffusion layer opposite the anode electrode layer, an adhesive and cathode gas diffusion layer coupled to a second side of the ion exchange membrane, and a cathode electrode layer coupled to the adhesive and cathode gas diffusion layer opposite the ion exchange membrane. The fuel cell stack may be incorporated into a power generator that includes a hydrogen producing fuel.
US08993133B1 Intermediate layer for perpendicular magnetic recording medium with high permeability grain boundaries
A perpendicular magnetic recording (PMR) media including a non-magnetic or superparamagnetic grain isolation magnetic anisotropy layer (GIMAL) to provide a template for initially well-isolated small grain microstructure as well as improvement of Ku in core grains of a magnetic recording layer. The GIMAL composition may be adjusted to have lattice parameters similar to a bottom magnetic recording layer and to provide a buffer for reducing interface strains caused by lattice mismatch between the bottom magnetic recording layer and an underlying layer.
US08993130B2 Organic compound and organic electroluminescent device using the same
The present invention discloses a novel organic compound is represented by the following formula(I), the organic EL device employing the organic compound as host material or dopant material of emitting layer and/or as electron transporting material can lower driving voltage, prolong half-lifetime and increase the efficiency. wherein m represent an integer of 0 to 10, n represent an integer of 0 to 2. X is a divalent bridge selected from the atom or group consisting from O, S, C(R5)2, N(R5), Si(R5)2. Ar, R1 to R4 are substituents and the same definition as described in the present invention.
US08993126B2 Light-emitting element including a layer having a concentration gradient, light-emitting device, display, and electronic device
In the light-emitting element in which a plurality of EL layers is separated from each other by a charge generation layer, provided are an electron relay layer in contact with an anode side of the charge generation region and an electron transport layer in contact with the electron relay layer. The electron transport layer contains an alkaline earth metal. A concentration gradient of the alkaline earth metal contained in the electron transport layer is such that the concentration of the alkaline earth metal becomes lower from an interface between the electron transport layer and the electron relay layer to the anode.
US08993122B2 Method for forming sputter target assemblies having a controlled solder thickness
The present invention relates to a method and apparatus of forming a sputter target assembly having a controlled solder thickness. In particular, the method includes the introduction of a bonding foil, between the backing plate and the sputter target, wherein the bonding foil is an ignitable heterogeneous stratified structure for the propagation of an exothermic reaction.
US08993121B2 Metal laminated structure and method for producing the same
There is provided a metal laminated structure in which a first metal layer containing tungsten is provided on a first surface of a second metal layer containing copper and a third metal layer containing tungsten is provided on a second surface of the second metal layer opposite to the first surface, and the first metal layer contains crystal grains of tungsten in a form of a columnar crystal extending in a direction perpendicular to the first surface of the second metal layer and the third metal layer contains crystal grains of tungsten in a form of a columnar crystal extending in a direction perpendicular to the second surface of the second metal layer, and a method for producing the metal laminated structure.
US08993120B2 High-strength hot-dip galvanized steel sheet having excellent delayed fracture resistance and manufacturing method thereof
A hot-dip galvanizing layer or an alloyed hot dip galvanizing layer is formed on the surface of a base steel sheet in which in volume fraction, 40 to 90% of a ferrite phase and 5% or less of a retained austenite phase are contained, and a ratio of non-recrystallized ferrite to the entire ferrite phase is 50% or less in volume fraction, and further a grain diameter ratio being a value of, of crystal grains in the ferrite phase, an average grain diameter in the rolling direction divided by an average grain diameter in the sheet width direction is 0.75 to 1.33, a length ratio being a value of, of hard structures dispersed in island shapes, an average length in the rolling direction divided by an average length in the sheet width direction is 0.75 to 1.33, and an average aspect ratio of inclusions is 5.0 or less.
US08993116B2 Blends of fluoroalkyl-containing ester oligomers with polydicarbodiimide(S)
For imparting enhanced water-repellency and oil-repellency properties to substrates compositions comprising blends of (A) one or more ester oligomers and (B) one or more polycarbodiimides. Also methods for applying such compositions and articles treated with such compositions.
US08993114B2 Hard coat film, polarizer and image display device
Provided is a hard coat film having high hardness and excellent restorability in view of the above circumstances. A hard coat film comprising: a light-transmitting substrate; and a hard coat layer, the hard coat layer comprising a cured product of a composition for a hard coat layer, the composition including an isocyanuric skeleton-containing urethane(meth)acrylate.
US08993110B2 Coated fiber cement article with crush resistant latex topcoat
A coated fiber cement article in the form of an unattached fiber cement board substrate having a first major surface at least a portion of which is covered with a crush resistant final topcoat composition comprising a multistage latex polymer, and a method for making a crush resistant coated fiber cement article by coating a fiber cement board substrate with such a composition and stacking the coated boards.
US08993108B2 Multilayer polyimide film, laminate, and metal-clad laminate
An object of this invention is to provide a polyimide film suitable for use in flexible printed circuit boards and the like which have high flexibility and dimensional stability, and to provide a laminate and metal-clad laminate which uses such a polyimide film. This invention relates to a multilayer polyimide film being a polyimide film having a multilayer structure, including: a core layer; and clad layers provided on each side of the film, which clad layers are exposed, the core layer being a non-thermoplastic polyimide having an average coefficient of linear expansion at a temperature from 100° C. to 200° C. in a range of 5 ppm/° C. to 20 ppm/° C., each of the clad layers being a polyimide having a peeling strength of 3 N/cm or less, the film as a whole having an average coefficient of linear expansion at a temperature range of 100° C. to 200° C. in a range of 9 ppm/° C. to 30 ppm/° C., and (a)>(b), where (a) is an average modulus of elasticity of the core layer and (b) is an average modulus of elasticity of the clad layers.
US08993107B2 Porous glass and optical member
The present invention provides a porous glass having excellent antireflection performance for visible light.A porous glass includes a porous layer which is mainly composed of silica and which has pores attributed to spinodal phase separation and pores attributed to binodal phase separation.
US08993106B2 Coated paper having a coating structure with controlled distribution of latex and method for preparing the same
Disclosed is coated paper having a coating structure in which styrene-butadiene latex distribution of a paper coating layer is controlled in order to reduce fold cracking of the coated paper and a method for manufacturing the same. The coated paper in which different types of latexes are separately applied to two coating layers exhibits considerably improved stiffness and reduced fold crack, as compared to the existing coated paper.
US08993103B2 Process for creating three-dimensional patterns in coatings
The present invention relates to a process for the production of three-dimensional patterns in coatings which comprise flake-form effect pigments, to patterned coatings produced thereby and to the use thereof in decoration and security products.
US08993102B2 Glass panel
A glass panel includes a first surface, and a second surface and wherein the first and second surfaces are spaced apart by thickness of the glass panel. A first image is printed on the first surface of the glass panel and a second image is printed on same first surface of the glass panel and at least partially overlapping the first image. The second image printed on the first surface and at least partially overlapping the first image forms at least partially opaque imbedded into the glass panel image that when covered by a fluid becomes transparent to reveal the first image printed on the second surface of the glass panel.
US08993100B2 Transparent sheet having a pattern for infrared reflection
An infrared ray reflection pattern-printed transparent sheet is provided which can be applied to a data input system of a type of handwriting directly on a screen of a display device and provides a coordinate detect means and which is lightweight, low in a cost, readily increased in an area, possible in mass production and excellent in a read performance. It is an infrared ray reflection pattern-printed transparent sheet in which infrared ray reflective transparent patterns are printed on a surface of a transparent substrate and which is disposed oppositely to a front face of a display device. A cross section obtained by cutting the infrared ray reflective transparent patterns printed on the above transparent substrate in a face orthogonal to the above transparent substrate is formed so that it assumes a multilayer structure comprising a fixed repeating cycle when observed under a scanning electron microscope.
US08993099B2 Stretch laminate having novel adhesive pattern and methods of making the same
A stretch laminate having a first nonwoven material, a second nonwoven material, an elastic film. The elastic film may be interposed between said first and second nonwoven material. The elastic film has a first longitudinal side edge and a second longitudinal side edge. The stretch laminate further has a first plane of adhesive having differing amounts of adhesive as measured laterally within the stretch laminate. The differing amounts of adhesive being controllable. The first plane of adhesive being interposed between the first nonwoven material and the elastic film. The stretch laminate further has a second plane of adhesive having differing amounts of adhesive as measured laterally within the stretch laminate. The differing amounts of adhesive being controllable. The second plane of adhesive being interposed between the second nonwoven material and the elastic film. Each of the above elements are substantially laminated together to form a laminate. The laminate is activated to form the stretch laminate.
US08993097B2 Tapered height curved composite stringers and corresponding panels
Apparatus and methods provide for utilizing continuous curved composite stringers to control the loads and corresponding moments within curved regions of an aircraft or other vehicle without delamination or other interlamina failures. According to embodiments described herein, any number of tapered height curved composite stringers may be coupled to continuous skin components to create a curved continuous panel. The tapered height curved composite stringers may have webs that taper to a reduced height within curved regions and corresponding base flanges that widen during web tapering. Reinforcement fittings may be coupled to the base flanges in the curved regions for further strengthening and to provide for the attachment of supplemental panels to the stringers.
US08993095B2 Composite material and coated cutting tool
The present invention provides a composite material that is excellent in the bonding ability between a cemented carbide layer and a cermet layer is excellent and deformation after sintering can be suppressed and a coated cutting tool having a base containing the composite material. A composite material 10ii is obtained by laminating a cemented carbide layer 11 and a cermet layer 12 and has the cemented carbide layer 11 on the surface side. The boundary between both the layers 11 and 12 has a concave portion 23, and the maximum depth Dmax of the concave portion 23 is 50 μm or more and 500 μm or lower. When the thickness of the composite material is defined as h1 and the thickness of the cemented carbide layer 11 is defined as h2, h2/h1 is in the range of more than 0.02 and 0.4 or lower. By providing the concave portion 23 to the boundary, both the layers 11 and 12 are sufficiently bound and the bonding ability therebetween is excellent. Due to the fact the cemented carbide layer 11 satisfies the given thickness mentioned above, the composite material 10 is difficult to deform.
US08993094B2 Door skin, a method of etching a plate for forming a wood grain pattern in the door skin, and an etched plate formed therefrom
The present invention is directed to a door skin having an exterior surface with a wood grain pattern formed therein, and an etched plate for use as an embossing plate or with a molded die set, for forming the woodgrain pattern in the door skin.
US08993089B2 Closed cell materials
Fabrics made for watersports and outerwear apparel, tents, sleeping bags and the like, in various composites, constructed such that there is at least one metal layer, forming a radiant barrier to reduce heat loss via radiation, and insulating this metal layer from conductive heat loss, and a process for its manufacture.
US08993083B1 Self adhering fabric patch
A flame retardant patch may include a sheet of fabric having a top side and a bottom side, wherein the sheet of fabric is flame resistant. The flame retardant patch may further include a flame retardant pressure sensitive adhesive bonded to the bottom side of the sheet of fabric.
US08993079B1 Insulated foam bag and fabrication method
An insulated container includes a first laminated structure having a metal layer and a second laminated structure having a metal layer. The metal layer of the first laminated structure faces the metal layer of the second laminated structure. The insulated container also includes a foam material layer disposed between the first laminated structure and the second laminated structure. The metal layer of the first laminated structure is bonded to the metal layer of the second laminated structure at a plurality of locations.
US08993075B2 Stretched film, process for producing the same, and liquid crystal display device
A stretched film comprised of a “B1” layer comprised of a thermoplastic resin 1, an “A” layer comprised of a styrene-based resin, and a “B2” layer comprised of a thermoplastic resin 2 stacked in that order and having a width of over 1000 mm, wherein a ratio of the “A” layer in the stretched film is 45 wt % or less, an average value of an orientation angle θ with respect to a width direction across at least 1000 mm of the width direction is 0°±1°, a variation in orientation angle θ is 0.5° or less, and a value of an Nz coefficient is −3.5 to −0.5 in range.
US08993074B2 Liquid crystal display device and method of manufacturing the same
There is provided a liquid crystal display device including a liquid crystal display element including a first alignment film and a second alignment film provided on opposing surfaces of a pair of substrates, and a liquid crystal layer arranged between the first alignment film and the second alignment film and including crystal molecules having negative dielectric constant anisotropy. At least the first alignment film includes a compound in which a polymer compound having a first side chain and a second side chain is crosslinked or polymerized. The first side chain has a crosslinkable functional group or a polymerizable functional group. The second side chain has a structure inducing dielectric anisotropy. The liquid crystal molecules are pretilted by the first alignment film.
US08993072B2 Halogenated organoaminosilane precursors and methods for depositing films comprising same
Described herein are precursors and methods of forming films. In one aspect, there is provided a precursor having Formula I: XmR1nHpSi(NR2R3)4-m-n-p  I wherein X is selected from Cl, Br, I; R1 is selected from linear or branched C1-C10 alkyl group, a C2-C12 alkenyl group, a C2-C12 alkynyl group, a C4-C10 cyclic alkyl, and a C6-C10 aryl group; R2 is selected from a linear or branched C1-C10 alkyl, a C3-C12 alkenyl group, a C3-C12 alkynyl group, a C4-C10 cyclic alkyl group, and a C6-C10 aryl group; R3 is selected from a branched C3-C10 alkyl group, a C3-C12 alkenyl group, a C3-C12 alkynyl group, a C4-C10 cyclic alkyl group, and a C6-C10 aryl group; m is 1 or 2; n is 0, 1, or 2; p is 0, 1 or 2; and m+n+p is less than 4, wherein R2 and R3 are linked or not linked to form a ring.
US08993067B2 Composition for oil- and/or water-repellent finishing of fiber materials
Described are 8 aqueous compositions useful for treating textile materials to impart oil- and/or water-repellent properties thereto. The compositions contain inter alia polymers containing perfluoroalkyl groups (RF groups), wherein 55 to 100% of the RF groups contain 6 carbon atoms.
US08993066B2 Microencapsulation of reactive diisocyanates and the application to self-healing anticorrosion coatings
The disclosure provides a polyurethane microcapsule consisting of a polymerization product of methylene diphenyl diisocyanate (MDI) prepolymer with a polyol, the polyurethane microcapsule comprising a liquid isocyanate compound encapsulated within the microcapsule. The disclosure also provides self-healing coating compositions comprising such polymeric microcapsules and methods of preventing or slowing corrosion using such coating compositions.
US08993065B2 Substrate coating with aqueous-based multifunctional core shell particles
The present invention relates to a method of making a coated substrate, and products therefrom, using a coating possessing a nanoparticle having a shell containing a hydrophilic nitrogen containing compound and a vinylic polymer having quaternary ammonium compounds, and a core made of at least a hydrophobic vinylic polymer, wherein such coated substrate exhibits antibacterial properties without the use of harmful organic preservatives.
US08993063B2 Low-temperature synthesis of silica
An ambient pressure Atomic Layer Deposition (ALD) technique to grow uniform silica layers onto organic substrates at low temperatures, including room temperature, is described. For example, tetramethoxysilane vapor is used alternately with ammonia vapor as a catalyst in an ambient environment.
US08993047B2 Method of manufacturing granule coated asphaltic articles
A method of manufacturing a granule coated asphaltic article comprising the steps of applying liquid asphalt to a reinforcing sheet to create an asphaltic sheet, the asphaltic sheet having a top surface and a bottom surface; bending the asphaltic sheet to form an arcuate top surface of the sheet; and applying a coating of granules over the arcuate top surface of the asphaltic sheet.
US08993046B2 Method for fabricating image sensors
An image sensor is provided. The image sensor includes a pixel sensor, a color filter array comprising a plurality of color filters formed on the pixel sensor, wherein two adjacent color filters have a gap therebetween, and a gapless microlens array comprising a plurality of microlenses formed on the color filter array. The invention also provides a method for fabricating the image sensor.
US08993045B2 Method of manufacturing cards that include at least one electronic unit
The invention relates to a method for manufacturing boards that comprises depositing a liquid resin (22) on and/or under a plurality of electronic units for forming a plate defining a plurality of boards or board bodies. In order to do so, and in order to reduce as much as possible the residual air bubbles in the manufactured plate, the method comprises depositing the resin in the form of resin beads (26) initially having between them grooves (28) defining air discharge channels. The resin in uniformly spread using a pressing roller for one end of the plate to a second opposite end of the plate.
US08993044B2 Methods of forming capacitors having dielectric regions that include multiple metal oxide-comprising materials
Capacitors and methods of forming capacitors are disclosed, and which include an inner conductive metal capacitor electrode and an outer conductive metal capacitor electrode. A capacitor dielectric region is received between the inner and the outer conductive metal capacitor electrodes and has a thickness no greater than 150 Angstroms. Various combinations of materials of thicknesses and relationships relative one another are disclosed which enables and results in the dielectric region having a dielectric constant k of at least 35 yet leakage current no greater than 1×10−7 amps/cm2 at from −1.1V to +1.1V.
US08993043B2 Method for fabricating color filter layer of liquid crystal display device and method for fabricating liquid crystal display device using the same
A method for fabricating color filter layer of an LCD comprises forming a plurality of black matrixes separated at certain intervals on a color filter substrate, and forming R, G and B color filter layers by using a plurality of needles between the plurality of black matrixes on the color filter substrate.
US08993023B2 Process for reducing spore levels in compositions
The present invention relates to a process effective for reducing the number of spores, especially psychrotrophic spores, in compositions. More specifically, a method is provided for heating a composition at a temperature, pressure and for a time effective for reducing the number of psychrotrophic spores in the composition by at least about 3 logs. In one important aspect, the invention relates to producing vacuum packed or modified atmosphere packed chilled food products.
US08993022B1 Carry out bowl having convertible base
A carry out food bowl comprising a bowl and a removable cover. The bowl includes a conversion demarcation, which defines a conversion section. The conversion section includes a portion of a sidewall of the bowl and a bottom portion of the bowl. The user would depress the conversion section inward creating a new bowl support surface, wherein the new support surface tilts an opening of the bowl. A condiment container receptacle can be integrated into the cover to retain a condiment container assembly. This associates the condiment with the contents of the bowl. The bowl and lid can include a stacking interface enabling one to attach a second bowl onto a cover of a first bowl.
US08993018B2 Capsule for the preparation of a beverage comprising an identification element
The invention relates to a capsule for the preparation of a beverage. The capsule includes first and second covering walls connected at a peripheral seam for forming a cavity containing a beverage ingredient, and a contactless element for identifying the capsule by detecting means of a beverage producing device. The identifying element is oriented along its longer dimension substantially orthogonally relative to the transversal plane passing along the seam of the capsule.
US08993015B2 Method for manufacturing pure guar flour
A method for producing pure guar flour and the use of hydroxy propyl trimethyl ammonium chloride—guar flour obtained according to the method in clear aqueous cosmetic formulations which are intended to be applied on hair and/or skin and which can be washed out or rinsed off as conditioning agents or depositing agents to dilute cosmetic formulations.
US08993013B2 Composition to enhance the bioavailability of curcumin
A composition for enhanced bioavailability of curcumin including purified curcuminoid and purified essential oil of turmeric. A method to prepare a composition for enhanced bioavailability of curcumin having purified curcuminoid and purified essential oil of turmeric.
US08993012B2 Plant derived seed extract rich in essentially fatty acids derived from Salvia hispanica L. seed: composition of matter, manufacturing process and use
A Salvia hispanica L. derived seed oil extract composition of matter containing from 60-88% PUFAs in a ratio of from 3.1:1-3.3:1 of ALA to LA, 4-10% of C-18 mono-unsaturated fatty acid, 1-5% of C-18 saturated fatty acid and 4-8% of C-16 saturated fatty acid in a mixed triglyceride form stable at room temperature of 12-24 months containing a mixture of selected antioxidants.
US08993011B2 Swinglea glutinosa leaves derived material in combination with pyrethroids for control of acari
The invention of the present application provides a natural material derived from Swinglea glutinosa leaves that in combination with low doses of pyrethroids, maintains the effect of high doses of pyrethroids over mites. The material derived from Swinglea glutinosa leaves, in a preparation with pyrethroids, results in a mix material with the potential to lower the doses of synthetic pyrethroids, eliminating the need to use high doses of synthetic pesticides for acari control.
US08993010B2 Insect repellent compound, material and animal mask, and method for making the same
An insect repellent compound that includes naturally occurring oil that emits an odor which repels insects is described. The compound is not harmful to animals, to humans or to the environment. The compound may be incorporated into materials such as yarn that is woven to form a mesh. The material may be used for making an animal mask, for screen doors and other applications. A method of making the compound and incorporating it into materials and products is described.
US08993006B2 Topical skin care formulations
Disclosed is a topical skin composition comprising an effective amount of Malpighia punicifolia (acerola) extract, Myrciaria dubia (camu camu) extract, and Ribes nigrum (black currant) extract, and a dermatologically acceptable vehicle comprising water, glycerin, dimethicone or cyclomethicone, stearic acid, carbomer, and sodium hydroxide.
US08993005B2 Food compositions comprising lemon balm extracts
Disclosed are food compositions, comprising aqueous extracts of Melissa officinalis (Lemon balm) and/or its active principle rosmarinic acid. Methods of preparing a food composition, and of making a medicament, both methods comprising rosmarinic acid and/or aqueous extracts of Melissa officinalis, are also disclosed.
US08993004B2 Pest control composition
A composition contains at least one pest control active and a mixture of unsaturated C12-C26 fatty acids and/or salts thereof and saturated C6-C14 fatty acids and/or salts thereof. The pest control active is preferably at least one plant essential oil. The composition is suitably in the form of an emulsion, particularly a transparent microemulsion. The mixture of fatty acids and/or salts thereof can be used as part of, or as the sole, emulsifying system. The emulsion can exhibit improved pest control properties.
US08993002B2 Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
US08992998B2 MAPK inhibition by H2
A method of treating inflammation in a subject by administering a composition including hydrogen, releasing hydrogen in the subject, suppressing mitogen-activated protein kinase (MAPK) phosphorylation and upregulating expression of MKP-1, and down-regulating inflammatory responses of monocyte lineage cells.
US08992992B2 Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography
The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
US08992988B2 Coating film, and granules and tablets each utilizing same
A coating film comprising ethyl cellulose as a component A and an (ethyl acrylate)-(methyl methacrylate) copolymer or a plasticized vinyl acetate polymer as a component B, and having a tensile elongation of 150% or more and a tensile strength of 9 N or more.
US08992987B2 Polysaccharide derivatives and dosage forms
Polysaccharide derivatives having a median Equivalent Projected Circle Diameter (EQPC) of less than 140 micrometers and a particle size and shape distribution meeting condition A or B or both are useful for preparing dosage forms, particularly for preparing compressed sustained-release dosage forms: A. non-compacted polysaccharide derivative particles have a flowability of at least 45 g/sec through a vertically inverted cone having a vertex angle of about 40 and an outlet diameter of about 50 mm, or B. i) no more than 40 volume percent of the polysaccharide derivative particles are fine particles having a particle length LEFI of less than 40 micrometers and ii) no more than 40 volume percent of the polysaccharide derivative particles are fibrous particles, and the sum of the fine particles and the fibrous particles does not exceed 50 volume percent.
US08992978B2 Material compositions which comprise adult stem cells obtained from exocrine glandular tissue, in particular for use in regenerative medicine
The invention relates to material compositions comprising adult stem cells obtained from exocrine gland tissue and a supporting matrix having the shape of a thread structure and/or of a net. The supporting matrix preferably consists of a plastic material which is physiologically acceptable and degradable in the body. The material compositions of the invention are in particular suited for use in regenerative medicine, e.g. for regeneration of injured or damaged myocard tissue.
US08992977B2 Multi-day delivery of biologically active substances
Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.
US08992972B1 Capsule for sublingual and gastro-intestinal delivery of a liquid medication in a single volume limited dose
A capsular design is disclosed for self-administered delivery of a pre-determined amount of liquid medication. The capsular design can be constructed as having either a single piece or two piece capsular wall construction where a portion of the liquid medication contained within can be administered sublingually and the remaining portion can be subsequently swallowed for gastro-intestinal absorption.
US08992969B2 Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery
This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.
US08992966B2 Artificial bone capable of being absorbed and replaced by autogenous bone and its production method
An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body comprising at least an apatite/collagen composite layer and a collagen layer.
US08992965B2 Bone matrix compositions and methods
An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.
US08992963B2 Immobilised biological entities
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
US08992962B2 Two-piece, internal-channel osmotic delivery system flow modulator
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
US08992960B2 Multifunctional silica-based compositions and gels, methods of making them, and methods of using them
Briefly described, embodiments of this disclosure, among others, include compositions, gels, methods for synthesizing multifunctional silica based nanoparticle gel, method of treating, preventing, or both treating and preventing, a disease in a plant species, method for simultaneously treating citrus plants for citrus canker and preventing the invasion of an Asian Citrus Psyllid (ACP) vector that carries the pathogen and spreads the citrus greening disease in citrus plants, and the like.
US08992955B2 Oil-in-water emulsion composition
Disclosed is an oil-in-water emulsion base which is stable even when ethanol in an amount of 50% by mass or less is blended therein and which exhibits excellent water resistance after being applied to the skin or the like. Specifically disclosed is an oil-in-water emulsified cosmetic composition which is characterized by containing (A) 0.1-10% by mass of a polyether-modified silicone having an HLB(Si) of 5-10, (B) 5-50% by mass of ethanol, (C) 0.01-3% by mass of a hydrophilic thickening agent and (D) 0.1-15% by mass of a polyol. Preferably, the oil-in-water emulsified cosmetic composition additionally contains a UV absorbent, thereby forming a sunscreen cosmetic composition.
US08992952B2 Compositions for delivery of therapeutics into the eyes and methods for making and using same
The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
US08992951B2 Formulations, procedures, methods and combinations thereof for reducing or preventing the development, or the risk of development, of neuropathology as a result of trauma
Novel formulations and methods for their use in treating neuropathology incident to trauma are provided. Multiple-component formulations of the invention, and especially those having four components, comprise biologically active compounds configured for preventing or reducing the incidence and severity of damage caused by neurotrauma. Formulations and methods of the invention effect both neuroprotective actions to prevent or reduce secondary injuries, and neurotrophic actions to repair and restore cells and tissues affected by the trauma. Formulations and methods of the invention are especially useful in treating neurological trauma, such as those caused by sports injuries and improvised explosive devices in combat.
US08992946B2 Method and membrane for tissue regeneration
Tissue regeneration or grafting is promoted utilizing a structure including a multi-layer sheet of collagen membrane material which includes a purified collagen barrier sheet material derived from natural collagen-containing tissue, the barrier sheet material including a barrier layer with an outer smooth barrier face and a fibrous face opposite the smooth barrier face. The structure further includes a matrix layer of collagen sponge material adjacent to the fibrous face. The matrix layer of collagen sponge material is resorbed by a body of a subject at a substantially faster rate than the barrier sheet material.
US08992943B2 Vaccine for protection against Shigella sonnei disease
Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
US08992942B2 Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
US08992932B2 Binder-drug conjugates (ADCs) and use thereof
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practiced as a monotherapy or else in combination with other medicaments or further therapeutic measures.
US08992931B2 Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than either RAIT alone, ADC alone, or the sum of effects of RAIT and ADC. The unexpected synergy resulted in decreased tumor growth rate and increased survival, with a high incidence of tumor-free survival in Capan-1 human pancreatic cancer xenografts in nude mice.
US08992927B1 Targeting human NAV1.7 variants for treatment of pain
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
US08992921B2 Metal-citrate transporter antigen from Streptomyces coelicolor and uses thereof
The present invention relates to an isolated antigen from Streptomyces coelicolor that is useful for developing, inter alia, vaccines against pathogenic bacteria of humans and animals. The present invention also relates to vaccines and antibodies developed using the isolated antigen. The present invention also relates to methods of using the antigen, vaccines, and antibodies of the present invention to detect, treat, and prevent infection and diseases associated with pathogenic bacteria.
US08992918B2 Reactivation of axon growth and recovery in chronic spinal cord injury
Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal growth during and after treatment with an axonal growth promoting agent.
US08992916B2 Methods of using anti-IL13 human antibodies
The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
US08992912B2 Methods of use for antibodies that specifically bind to the EphA2 receptor
Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors.
US08992905B2 Oral composition containing interferon-α
The present invention provides oral compositions which contain interferon α (IFNα) as an active ingredient for preventing and/or treating periodontal disease. The number of causative microorganisms of periodontal disease can be suppressed by administering the compositions into the oral cavity. IFNα of the present invention can produce a sufficient effect even when administered at a very low dose. Furthermore, the compositions of the present invention can also be readily administered to animals such as dogs by formulating them into feed or such.
US08992904B2 Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity
The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
US08992900B2 Shaving process
A process for shaving that includes the steps of moisturizing the hair, using a sealing agent for sealing the moisture inside the hair keeping the moisture in the hair while smoothing the skin to be shaved applying mineral oil to the hair and skin to create a buffer for the lubricating agent that is applied next. Then, using sufficient water to form a lather. Next, the moisture from the blade after the blade is washed with water by utilizing alcohol. In the final step of the process oil is applied to the blades to prevent contact with the atmospheric moisture and thus extending its useful life.
US08992899B2 Clean volume mascara compositions comprising at least one film former and at least one silicone elastomer
Disclosed herein are cosmetic compositions comprising at least one film-forming polymer, at least one silicone elastomer blend, and at least one wax. Also disclosed herein are methods for making up and/or enhancing the appearance of a keratinous substrate comprising applying said composition to the keratinous substrate.
US08992897B2 Skin lightening compositions
Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.
US08992892B2 Use of 1-(2,4-dihydroxy-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-propan-1-one
The invention concerns the use of a deoxy hesperetin dihydrochalcone or a salt of the deoxy hesperetin dihydrochalcone (I) or a mixture comprising or consisting of a plurality of salts of the deoxy hesperetin dihydrochalcone (I) or a mixture comprising or consisting of deoxy hesperetin dihydrochalcone (I) and a salt or a plurality of salts of the deoxy hesperetin dihydrochalcone (I), to influence the strength of taste impressions of sweet-tasting, unpleasant-, in particular bitter-, tasting or both sweet- and unpleasant-, in particular bitter-, tasting substances or mixtures of substances.
US08992888B2 Radiographic contrast agent for postmortem, experimental and diagnostic angiography
A contrast agent for angiography is disclosed, in particular, for examining animal or human bodies or components thereof such as members or organs thereof, comprising an essentially oil-based apolar contrast component for X-ray examinations, the contrast component having a contrast component viscosity in the range of 30-100 mPas. The contrast agent is characterized in that the contrast component is present in a mixture with at least one further apolar component, the viscosity of which is less than or at most equal to the contrast component viscosity. Methods for angiography examination are also disclosed, in which such a contrast agent or also a polar contrast agent are used at least periodically and applications of such contrast agents.
US08992886B2 Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells
Compositions, methods of using and methods of making a cyclic peptide analog imaging agent that includes at least portions of a peptide or protein that binds specifically to the GLP-1 receptor (GLP-1R) and the cyclic analog has one or more conformational restrictions including, but not limited to, lactam bridges, disulfide bridges, hydrocarbon bridges, and their combinations, salts and derivatives thereof wherein the cyclic analog is more stable than a non-cyclic analog when incubated in the presence of enzymes that degrade GLP-1 and have an increased serum half-live, wherein the cyclic analog comprises at least a portion of a GLP-1 peptide or at least a portion of an Exendin peptide salts, derivatives or combinations thereof.
US08992885B2 UZM-39 aluminosilicate zeolite
A new family of coherently grown composites of TUN and IMF zeotypes have been synthesized. These zeolites are represented by the empirical formula. NanMmk+TtAl1−xExSiyOz where “n” is the mole ratio of Na to (Al+E), M represents a metal or metals from zinc, Group 1, Group 2, Group 3 and or the lanthanide series of the periodic table, “m” is the mole ratio of M to (Al+E), “k” is the average charge of the metal or metals M, T is the organic structure directing agent or agents, and E is a framework element such as gallium. These zeolites are similar to TNU-9 and IM-5 but are characterized by unique compositions and synthesis procedures and have catalytic properties for carrying out various hydrocarbon conversion processes and separation properties for carrying out various separations.
US08992883B2 Polymer-mediated synthesis of ZnO nanostructures
Disclosed are methods for producing ZnO nanostructures, the methods comprising heating an aqueous solution comprising a zinc compound, a base, and a polymer which is polyvinylpyrrolidinone or poly(ethylene glycol).
US08992882B2 Ultra-high purity zinc bromides and quaternary ammonium bromides for use in zinc-bromine batteries
Ultra-high purity zinc bromide and quaternary ammonium bromides suitable for use in zinc-bromine batteries, and methods for making same, are provided.
US08992879B2 Method of producing carbon fiber
A method of producing carbon fibers, in which the producing method comprises allowing a supported type catalyst and a carbon atom-containing compound to come in contact with each other in a heating zone, wherein the supported type catalyst is prepared by a method comprising impregnation of a powdery carrier with colloid containing catalyst to support particles of the catalyst on the powdery carrier having a specifically developed crystal plane such as a powdery carrier being 4 or more in the ratio (I1/I2) of the intensity I1 of the strongest peak to the intensity I2 of the second strongest peak observed in X-ray diffraction, or a powdery carrier having the ratio (I1/I2) of the intensity I1 of the strongest peak to the intensity I2 of the second strongest peak observed in X-ray diffraction of 1.5 times or more the ratio (I1s/I2s) of the intensity I1s of the strongest peak to the intensity I2s of the second strongest peak described in JCPDS. A composite material is prepared by blending the carbon fibers prepared by the method with, for example, a resin.
US08992878B2 Composition containing carbon nanotubes, catalyst for producing carbon nanotubes, and aqueous dispersion of carbon nanotubes
Disclosed is a composition containing carbon nanotubes which meets all of the following conditions (1) to (4). (1) When observed via transmission electron microscopy, at least 50 out of every 100 carbon nanotubes are double-walled carbon nanotubes. (2) The carbon nanotubes have an average outer diameter in the range of 1.0 to 3.0 nm. (3) During thermogravimetric analysis under atmosphere at a temperature increase rate of 10° C./minute, a high temperature combustion peak is at 700 to 850° C., and the relationship between low temperature weight loss (TG(L)) and high temperature weight loss (TG(H)) is TG(H)/(TG(L)+TG(H))≧0.75. (4) The composition containing carbon nanotubes has a volume resistance value between 1.0×10−2 Ω·cm and 1.0×10−4 Ω·cm, inclusive. The disclosed composition containing carbon nanotubes primarily has double-walled carbon nanotubes with high electrical conductivity and high heat resistance.
US08992875B2 Production of high purity precipitated calcium carbonate
The present invention relates to a process for the preparation of precipitated calcium carbonate comprising the steps of a) providing and calcining calcium carbonate comprising material; b) slaking the reaction product obtained from step a) with an aqueous ammonium chloride solution; c) separating insoluble components from the calcium chloride solution obtained from step b); d) carbonating the calcium chloride solution obtained from step c); e) separating the precipitated calcium carbonate obtained from step d); the precipitated calcium carbonate obtained by this process, as well as uses thereof.
US08992871B2 CO shift catalyst, CO shift reactor, and method for purifying gasified gas
A CO shift catalyst according to the present invention reforms carbon monoxide (CO) contained in gas. The CO shift catalyst is prepared from one or both of molybdenum (Mo) and cobalt (Co) as an active ingredient and an oxide of one of, or a mixture or a compound of, titanium (Ti), silicon (Si), zirconium (Zr), and cerium (Ce) as a carrier for supporting the active ingredient. The CO shift catalyst can be used in a halogen-resistant CO shift reactor (15) that converts CO contained in gasified gas (12) generated in a gasifier (11) into CO2.
US08992867B2 Dry-scrubbing media compositions and methods of production and use
Dry-scrubbing media compositions, methods of preparation and methods of use are provided. The compositions contain activated alumina and magnesium oxide. Optionally, activated carbon and other impregnates, such as hydroxides of group 1A metals, are included. The compositions exhibit improved efficiency and capacity for the removal of compounds, such as hydrogen sulfide, from an air-stream. The compositions are particularly useful for reducing or preventing the release of toxic gaseous compounds from the areas such as landfills, petroleum storage areas, refineries, drinking water systems, sewage treatment facilities, swimming pools, hospital morgues, animal rooms, and pulp and paper production sites.
US08992857B2 Mixing device and mixing method
A mixing method and device are disclosed. The mixing method includes providing a drop generating device including a first drop ejector, a second drop ejector and a collector. The mixing method also includes ejecting a plurality of drops of a first reactant from the first drop ejector and ejecting a plurality of drops of a second reactant from the second drop ejector and collecting the drops with the collector.
US08992855B2 Low volume liquid specimen apportionment device
A liquid specimen collecting and testing device has two chambers, a first for collecting a liquid specimen and a second for exposing a measured volume preliminary screening aliquot of the specimen to preliminary screening test strips. The first chamber has a catch basin of defined volume which is less than the sample volume. The basin is simultaneously sealed from the rest of the first chamber, thus separating and apportioning the measured volume preliminary screening aliquot from the collected volume. Simultaneously, an opening made leading from the basin to the second chamber initiating the preliminary screening test. Thus intermingling of a preliminary screening aliquot and a remainder aliquot is avoided.
US08992854B2 Assay device for liquid sample
Disclosed is an assay device comprising liquid transport means adapted to take up a liquid sample and conduct the liquid to an analyte detection region operable to provide a test signal indicative of the presence and/or amount of an analyte in the liquid sample; the assay device further comprising a sample presence signal generation means, which is not generated by means of an immunoreaction. This sample presence signal generation means can comprise a colored portion, which is overlaid by a material (e.g. nitrocellulose) that is opaque, when dry, and translucent or transparent, when wet, to allow the colored portion to become visible to the user. In another embodiment the signal generation means comprises a color changing material which under-goes a change in its visible properties upon wetting (e.g. pH indication). A third embodiment uses a mobilizable detectable which, when wetted by the sample, is carried along resulting in a streaked line parallel with the flow direction.
US08992853B2 Devices, systems and methods for localized sterilization
A portable gas transfer device for point-of-use sterilization at a sterilization site includes: a housing; a pressurized gas canister held by the housing; a first passageway in fluid communication with the pressurized gas canister and configured to supply pressurized pre-sterilization gas from the pressurized gas canister to the site; a gas discharge canister held by the housing; and a second passageway in fluid communication with the gas discharge canister and configured to supply post-sterilization gas from the site to the gas discharge canister. Additional related devices, systems and methods are provided.
US08992848B2 Apparatus for delivering electromagnetic energy into a solution
The present invention relates to a delivery apparatus for delivering electromagnetic energy into a solution. The delivery apparatus comprises a coil means arranged within an outer housing for delivering a magnetic field into the solution, a voltage assembly means coupled to the coil means for delivering an electric field into the solution, and connection means for delivering an electromagnetic signal to the coil from electromagnetic signal generation circuitry contained within the housing. The arrangement of the present invention confers significant physical stability on the delivery apparatus and ensures that heat generated by heat generating components of the apparatus is conducted away from the electromagnetic signal generation circuitry so that the apparatus can be operated continuously.
US08992845B2 Catalyst functionalized buffer sorbent pebbles for rapid separation of carbon dioxide from gas mixtures
A method for separating CO2 from gas mixtures uses a slurried media impregnated with buffer compounds and coating the solid media with a catalyst or enzyme that promotes the transformation of CO2 to carbonic acid. Buffer sorbent pebbles with a catalyst or enzyme coating are provided for rapid separation of CO2 from gas mixtures.
US08992843B2 Catalytic converter for confined areas
The catalytic converter for confined areas is installed with a vehicular tunnel, parking garage, or other confined area subject to motor vehicle operation therein. The converter catalyzes internal combustion engine exhaust by-products by selective catalytic reduction. The heat required for the catalytic reaction is provided by an electric heater installed with the converter, the converter being thermally insulated to retain the heat. The carbon dioxide and water vapor resulting from the catalytic reactions are gathered by the same fan or pump and the water vapor condensed to liquid form, and distributed to vegetation external to and adjacent to the tunnel or enclosure.
US08992842B2 Systems and methods of making ammonia using hydrogen and nitrogen gases
A system for producing ammonia includes sources of hydrogen and nitrogen gas, a hydrogen gas booster for producing produce pressurized hydrogen gas, a nitrogen gas booster for producing pressurized nitrogen gas, and a synthesis reactor that receives a mixture of the pressurized hydrogen and nitrogen gases. The synthesis reactor includes an inlet for receiving the pressurized gas mixture, a heating zone adjacent the inlet for heating the gas mixture, a catalyst zone downstream from the heating zone for catalyzing a reaction of the mixture to form ammonia and a by-product, and a cooling zone downstream from the catalyst zone for cooling the ammonia and the by-product. The system has a separator for separating the ammonia from the by-product, an ammonia storage tank for collecting the ammonia, and a recycle loop for re-circulating the by-product back to the synthesis reactor.
US08992839B2 Apparatus for a radial-flow reactor and method for assembly thereof
An apparatus for a radial-flow reactor according to various approaches includes an inner partition assembly having an inwardly tapered bottom portion. According to various approaches, an inner partition assembly support includes a socket with a tapered upper rim. A process according to various aspects includes assembling a radial-flow reactor by installing an inner partition assembly by aligning a bottom portion of the inner partition assembly with an opening of a inner partition assembly support socket and lowering the bottom portion into the opening.
US08992836B2 Cavity-enhanced on-chip absorption spectroscopy
Embodiments of optofluidic devices or methods according to the application can provide on-chip, label-free, massively parallel analysis of analytes. An embodiment of the optofluidic device can comprise a microresonator, a waveguide optically coupled to the microresonator, and a fluidic channel that exposes an analyte to an evanescent field from the microresonator, wherein the light signal has a linewidth lesser than the width of at least one resonance of the light signal propagating in the microresonator. The light signal can be tuned across a spectrum of light wavelengths, wherein the spectrum of wavelengths includes one or more wavelengths defining the at least one resonance in the microresonator. The light transmission through the waveguide over the spectrum of wavelengths of the input light can be detected, and an absorption spectrum of the analyte can be determined.
US08992833B2 System and method for multi-analyte detection
The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material that is associated with the incubation carousel for assisting in separation beads from reagent and wash solution. A robot, associated with the housing is configured to manipulate at least either the reagent carousel or the incubator carousel and transfer materials therebetween. Reaction vessels hold samples and reaction vessels handlers move the reaction vessels. Sample analysis is determined by at least one laser based detector.
US08992832B2 Luminescence method of detecting an analyte in a liquid sample and analysis system
The present disclosure relates to a luminescence method of detecting an analyte in a liquid sample comprising marking the analyte with a marker capable of effecting luminescence upon application of excitation energy, wherein reference data descriptive of the luminescence decay is stored in an electronic memory; applying the excitation energy for causing the luminescence; time-resolved measuring of the luminescence over a period of time for acquisition of a measurement signal; reading the reference data from the electronic memory; comparing the measurement signal with the luminescence decay described by the reference data; generating an output signal indicative of the presence of the analyte in the liquid sample using the measurement signal; in case of a mismatch of the measurement signal and the luminescence decay described by the reference data, generating an error signal.
US08992829B2 Sports equipment and facility disinfection
A process for treating sports equipment and sports facility rooms to inactivate “superbug” bacteria such as MRSA, VRE and P. aeroginosa, which comprises subjecting the equipment or the room, and surfaces therein, to a disinfecting atmosphere which includes ozone at a concentration of 2-350 ppm by weight and hydrogen peroxide at an amount of 0.2-10 wt. %, at a relative humidity of at least 60%, and for a period of at least 30 minutes sufficient for an effective kill of the bacteria; and subsequently removing ozone from the atmosphere, down to 0.04 ppm or less.
US08992828B2 Titanium, titanium alloy and NiTi foams with high ductility
A method for manufacturing a high ductility Ti-, Ti-alloy or NiTi-foam, meaning a compression strain higher than 10%, includes: preparing a powder suspension of a Ti-, NiTi- or Ti-alloy powder, bringing the said powder suspension into a desired form by gelcasting to form a green artifact. The method also includes a calcination step wherein the green artifact is calcined, and sintering the artifact. The calcination step includes a slow heating step wherein said green artifact is heated at a rate lower or equal to 20° C./hour to a temperature between 400° C. and 600° C. and the Ti-, NiTi- or Ti-alloy powder has a particle size less than 100 μm. A high ductility Ti-, Ti-alloy or NiTi foam, with a compression higher than 10%, with a theoretical density less than 30%, pore size (cell size) between 50 to 1000 μm can be obtained with such a method.
US08992826B2 Method for producing a semifinished product and semifinished product for electrical contacts and contact piece
The method relates to a method for producing a strand-like, particularly band-like semi-finished part for electrical contacts, wherein the semi-finished part has a top side intended for making the electrical contact, said top side made from a silver-based composite material in which one or multiple metal oxides or carbon are embedded, and has a carrier layer supporting the composite material made of easily solderable or weldable ignoble metal, and method having the following steps: Powder-metallurgic production of a block made from the silver-based composite material, encasing of the block made of the composite material with a powder made from the easily solderable or weldable ignoble metal, compressing the block, encased by the metal powder, to condense the metal powder, sintering the compressed block in a reducing atmosphere or in an inert atmosphere or in a vacuum, avoiding the formation of fluid eutectics from the silver of the composite material and from the non-precious metal with which the block made from the silver-based composite material is encased, reshaping of the sintered block by extrusion pressing, creating a partial strand with a top side made from composite material and a bottom side made from non-precious metal.
US08992821B2 Pass-through catalytic substrate including porous ceramic beveled corner portions and methods
A pass-through catalytic substrate can comprise a plurality of porous ceramic substrate walls defining flow channels extending between an inlet end and an outlet end of the catalytic substrate. The pass-through catalytic substrate can include a plurality of porous ceramic beveled corner portions positioned at intersecting corners of the substrate walls within the flow channels. In one example, the porous ceramic beveled corner portions each include a heat capacity less than about 1.38 J/cm3/K. In another example, a catalytic washcoat layer can be provided for coating the porous ceramic substrate walls and the porous ceramic beveled corner portions. Methods for producing a pass-through catalytic substrate also provide porous ceramic beveled corner portions.
US08992819B2 Method for producing a wind turbine rotor blade part with a prefabricated main spar cap
Method for producing a wind turbine rotor blade part with a prefabricated main spar cap, comprising the following steps: providing a mold having a blade-root end and with a blade-tip end, inserting at least one outer root reinforcement layer (28) made of a fibrous material into the mold, arranging the prefabricated main spar cap on the at least one outer root reinforcement layer, arranging, in the mold, at least one inner root reinforcement layer made of a fibrous material on the main spar cap, closing the mold, extracting the air from the mold through at least one extraction channel arranged at a lateral distance from the main spar cap, feeding a liquid plastics material through a first sprue channel which has a plurality of outlet openings below the main spar cap, feeding a liquid plastics material through a second sprue channel which has a plurality of outlet openings above the main spar cap.
US08992816B2 Method and apparatus for producing three-dimensional objects
The invention concerns a method for producing three-dimensional objects (6) layer by layer using a powdery material which can be solidified by irradiating it with a beam (4) of charged particles, which method comprises the following steps: successive application of powder layers to a working area (5), and fusing together successive layers of said three-dimensional object (6) by successively irradiating the powdery layers with said beam (4). The invention is characterized in that it comprises the following steps: determining whether lifting of powdery material from the working area (5) occurs using a powder-lifting detection device (10, 10a, 10b, 10c, 1Od, 1Oe) capable of generating a signal (S) upon detection of lifting of powdery material from the working area (5), and interrupting the irradiation of at least a part of the working area (5) where powder lifting occurs using the signal (S) generated by the powder-lifting detection device (10, 10a, 10b, 10c, 10d, 1Oe) for automatically trigging the interruption. The invention also concerns an apparatus (1) for producing three-dimensional objects (6) layer by layer using a powdery material which can be solidified by irradiating it with a beam (4) of charged particles, said apparatus (1) comprising means for successive application of powder layers to a work table, and a radiation gun (3) for delivering said beam (4) of charged particles, wherein the inventive apparatus (1) comprises a powder-lifting detection device (10, 10a, 10b, 10c, 10d, 10e) capable of generating a signal (S) upon detection of lifting of powdery material from the working area (5).
US08992815B2 Production of organic compound nanoparticles with high repetition rate ultrafast pulsed laser ablation in liquids
Disclosed is a method of producing a chemically pure and stably dispersed organic nanoparticle colloidal suspension using an ultrafast pulsed laser ablation process. The method comprises irradiating a target of an organic compound material in contact with a poor solvent with ultrashort laser pulses at a high repetition rate and collecting the nanoparticles of the organic compound produced. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beam, an organic compound target in contact with a poor solvent, and a solvent circulating system to cool the laser focal volume and collect the produced nanoparticle products. By controlling various laser parameters, and with optional poor solvent flow movement, the method provides stable colloids of dispersed organic nanoparticles in the poor solvent in the absence of any stabilizing agents.
US08992812B1 Self-reinforced composite made of recycled materials and process of making the same
The invention is directed to a “Self-Reinforced Composite” (SRC) made of recycled thermoplastic polymers, methods and an apparatus for their manufacture. In one embodiment of the invention, the SRC is a self-reinforced composite comprising (a) a fiber comprising a first recycled thermoplastic polymer and having a Young's modulus at least about 500 MPa and (b) a matrix comprising a second recycled thermoplastic polymer. In one aspect of the invention, the source mixture is recycled immiscible thermoplastic polymers, obtained from the waste stream in the carpet and automotive industries. In another embodiment of the invention, the method for making the self-reinforced composites, comprising the steps of (a) melt-blending recycled immiscible polymers, (b) phase-migration fiber spinning the recycled immiscible polymers to form a fiber having a first recycled thermoplastic polymer substantially surrounded by a second recycled thermoplastic polymer, and (c) drawing the fiber to form a high modulus fiber.
US08992811B2 Method for manufacturing shaped product by low-pressure molding
This method for manufacturing a shaped product is characterized in preparing a specific random mat including a thermoplastic resin and carbon fiber bundles having an average fiber length of 5-100 mm, impregnating a thermoplastic resin into the random mat, pressing the random mat in a metal mold in a range of 0.1-20 MPa, and then taking out the random mat from the metal mold.
US08992809B2 Anti-bonding coatings for inhibiting material adhesion to equipment in thin layer fiber composite manufacturing
Methods and systems for forming a thin-layer moisture-resistant fiber composite material involve pressing a mixture of fibers and resin between a pair of heated dies at least one of which includes a working surface coated with a hard ormosil coating including a cross-linked organically-modified silica network. The use of such coatings may yield composite sheet materials having improved surface quality, sharper edges, and greater draw angles than previously possible. Some systems for making thin-layer fiber composite materials may utilize ormosil coatings on various working surfaces of equipment coming into contact with the fiber and resin mixture, such as surfaces of machinery for mixing or conveying the mixture to the dies.
US08992808B2 Method of manufacturing pre-sintered Si-mixture granule for porous sintered reaction-bonded silicon nitride, porous pre-sintered granule manufactured by the method, and method of manufacturing porous sintered reaction-bonded silicon nitride
The present invention relates to a method of manufacturing a porous pre-sintered granule for a sintered reaction-bonded silicon nitride, to which a pressure forming technology can be applied to obtain a porous sintered reaction-bonded silicon nitride having high porosity and having a structure in which macropores and micropores coexist with each other, and to a porous pre-sintered granule manufactured by the method. The method includes the steps of: granulating a raw material comprising silicon and sintering additives including yttrium, aluminum and at least one alkali earth metal compound; and pre-sintering the granulated raw material at a temperature of 1300˜1375° C. under an inert atmosphere. According to the present invention, a porous pre-sintered granule for porous sintered reaction-bonded silicon nitride, which can increase the air permeability and trapping efficiency by controlling the size of a pore channel such that macropores and micropores coexist, can be manufactured.
US08992805B2 Liquid crystal polyester resin composition, molded body, and LED reflector
A liquid crystal polyester resin composition of the present invention comprises: 100 parts by mass of a liquid crystal polyester; and 50 to 150 parts by mass of titanium oxide, wherein the liquid crystal polyester comprises 2 to 30 mole % of a repeating structural unit represented by the following formula (1), and 40 to 80 mole % of a repeating structural unit represented by the following formula (2).
US08992804B2 Use of 2-((1-methylpropyl)amino)ethanol as additive in aqueous suspensions of calcium carbonate-comprising materials
Use of 2-((1-methylpropyl)amino)ethanol as an additive in an aqueous suspension, containing from 25 to 62 vol. % of at least one calcium carbonate-comprising material, wherein the use provides improved stability with regard to the conductivity of the suspension.
US08992802B2 Crosslinked poly(ether ether ketone) intermediate transfer members
An intermediate transfer member that includes a crosslinked poly(ether ether ketone) polymer, an optional conductive component, an optional polymer, and an optional release additive.
US08992801B2 Electroactive material, and use thereof in anodes for lithium-ion cells
The present invention relates to a novel electroactive material which comprises a graphitic carbon phase C and a (semi)metal phase and/or a (semimetal) oxide phase (MOx phase) and also to the use of the electroactive material in anodes for lithium ion cells. The invention further relates to a process for producing such materials. The electroactive material comprises: a) a carbon phase C; b) at least one MOx phase, where M is a metal or semimetal, x is from 0 to
US08992799B2 Polymers containing functionalized carbon nanotubes
A polymer composite composed of a polymerized mixture of functionalized carbon nanotubes and monomer which chemically reacts with the functionalized nanotubes. The carbon nanotubes are functionalized by reacting with oxidizing or other chemical media through chemical reactions or physical adsorption. The reacted surface carbons of the nanotubes are further functionalized with chemical moieties that react with the surface carbons and selected monomers. The functionalized nanotubes are first dispersed in an appropriate medium such as water, alcohol or a liquefied monomer and then the mixture is polymerized. The polymerization results in polymer chains of increasing weight bound to the surface carbons of the nanotubes. The composite may consists of some polymer chains imbedded in the composite without attachment to the nanotubes. The resulting composite yields superior chemical, physical and electrical properties over polymer composites that are only physically mixed and without binding to the surface carbons of the nanotubes.
US08992798B2 Liquids
The present invention relates to an ionic liquid comprising an anion and a cation, wherein the cation is a primary, secondary or tertiary ammonium ion containing a protonated nitrogen atom.
US08992797B2 Phosphor and production method thereof, phosphor-containing composition, light emitting device, illuminating device, display, and nitrogen-containing compound
To provide a new phosphor of which fluorescence contains much red light component and has a large full width at half maximum, the crystal phase represented by the formula [I] is included in the phosphor. R3−x−y−z+w2MzA1.5x+y−w2Si6−w1−w2AlW1+w2Oy+w1N11−y−w1  [I] (R represents La, Gd, Lu, Y and/or Sc, M represents Ce, Eu, Mn, Yb, Pr and/or Tb, A represents Ba, Sr, Ca, Mg and/or Zn, and x, y, z, w1 and w2 are the numeric values in the following ranges: (1/7)≦(3−x−y−z+w2)/6<(1/2), 0<(1.5x+y−w2)/6<(9/2), 0
US08992795B2 Method for manufacturing positive electrode active material for power storage device
In a manufacturing process of a positive electrode active material for a power storage device, which includes a lithium silicate compound represented by a general formula Li2MSiO4, heat treatment is performed at a high temperature on a mixture material, grinding treatment is performed, a carbon-based material is added, and then heat treatment is performed again. Therefore, the reactivity between the substances contained in the mixture material is enhanced, favorable crystallinity can be obtained, and further microparticulation of the grain size of crystal which is grown larger by the high temperature treatment and crystallinity recovery are achieved; and at the same time, carbon can be supported on the surfaces of particles of the crystallized mixture material. Accordingly, a positive electrode active material for a power storage device, in which electron conductivity is improved, can be manufactured.
US08992787B2 Anode foils for electrolytic capacitors and methods for making same
Anode foils suitable for use in electrolytic capacitors, including those having multiple anode configurations, have improved strength, reduced brittleness, and increased capacitance compared to conventional anode foils for electrolytic capacitors. Exemplary methods of manufacturing an anode foil suitable for use in an electrolytic capacitor include disposing a resist material in a predetermined pattern on an exposed surface of an anode foil substrate such that a first portion of the exposed surface of the anode foil substrate is covered by the resist material, and a second portion of the exposed surface remains uncovered; polymerizing the resist material; exposing at least the second portion of the exposed surface to one or more etchants so as to form a plurality of tunnels; stripping the polymerized resist material; and widening at least a portion of the plurality of tunnels. The resist material may be deposited, for example, by ink-jet printing, stamping or screen printing.
US08992785B2 Method for modifying an etch rate of a material layer using energetic charged particles
A method of etching a material layer on a substrate is described. In one embodiment, the method includes modifying an etch resistance of a material layer to a pre-determined etch process by doping the material layer using energetic charged particles, and etching the modified material layer using the pre-determined etch process.
US08992782B2 Skimming systems and methods
Skimming systems are provided which include one or more externally positioned fluid jet generating devices to generate one or more fluid jets to impinge on a target surface to collectively impart motion of the surface and any contaminants thereon toward a collection device for ultimate collection and removal of the contaminants. Related skimming methods are also provided.
US08992778B2 Methods and apparatus for generating solvent gradients in liquid chromatography
Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate.
US08992776B2 Methods for treating waste water
A system of treating high nitrogen content waste water is disclosed, where the system includes a precipitation and conditioning subsystem, an ammonia stripper subsystem, and a denitrification subsystem. The system is adapted to reduce nitrogen contamination to level below about 10 ppm and in certain embodiments below 3 ppm.
US08992772B2 Bioreactor system for aquarium and septic tank
An aeration and microbial reactor system for use in decontaminating water including a housing adapted to float and/or submerged within the medium such that a top portion thereof remains adjacent a top surface of the contaminated water while the bioreactor containing inoculated carrier media is attached below. Beneficial microbial populations thrive and spread throughout the liquid medium, and consume or fix the contaminant such that the contaminant is removed from the water.
US08992769B2 Process, method, and system for removing heavy metals from fluids
Trace amount levels of heavy metals such as mercury in crude oil are reduced by contacting the crude oil with a sufficient amount of a reducing agent to convert at least a portion of the non-volatile mercury into a volatile form of mercury, which can be subsequently removed by any of stripping, scrubbing, adsorption, and combinations thereof. In one embodiment, at least 50% of the mercury is removed. In another embodiment, the removal rate is at least 99%. In one embodiment, the reducing agent is selected from sulfur compounds containing at least one sulfur atom having an oxidation state less than +6; ferrous compounds; stannous compounds; oxalates; cuprous compounds; organic acids which decompose to form CO2 and/or H2 upon heating; hydroxylamine compounds; hydrazine compounds; sodium borohydride; diisobutylaluminium hydride; thiourea; transition metal halides; and mixtures thereof.
US08992768B2 Method for the desulfurization of fuels and highly active nickel carrier catalyst based on aluminum oxide suitable for said method
A highly active nickel carrier catalyst based on aluminium oxide has a nickel content of approximately 20 to 70 wt.-% (as Ni) and optionally comprises a bonding agent and optionally a promoter, selected from the compounds of Mg, Ti, Pb, Pt, Ba, Ca and/or Cu, wherein the size of the Ni crystallites in the reduced state is in the range of approximately 3.5 to 4.5 nm and the distortion factor of the Ni crystallites is approximately 2 to 5%. In a method for the reduction of the content of sulphur compounds in hydrocarbon-based fuels by selective adsorption of the sulphur compounds on a nickel catalyst, a nickel catalyst based on aluminium oxide is used, particularly the nickel catalyst described above. A nickel catalyst based on aluminium oxide may be used for reducing the sulphur compound content in hydrocarbon-based fuels by selective adsorption of the sulphur compounds on said catalyst and/or for the hydrogenation of aromatic compounds.
US08992767B2 Ionic liquid desulfurization process incorporated in a contact vessel
Initial high sulfur levels of a hydrocarbon feedstock are reduced to desired low levels without the need for integration of substantial new equipment or hardware with existing hydroprocessing reactors. Ionic liquids are utilized as organic sulfur extraction agents and are added to and mixed with the hydrocarbon feedstock containing organosulfur compounds downstream of an existing cold separator vessel. The ionic liquid and hydrocarbon mixture is maintained in a contact vessel under conditions which promote the formation of ionic sulfur-containing derivatives that are soluble in the ionic liquid to be formed, thereby enabling extractive removal and separation of the organosulfur compounds from the feedstock.
US08992758B2 Apparatus and method for reduction of a solid feedstock
In a method for reduction of a solid feedstock, such as a solid metal compound, in an electrolytic apparatus a portion of the feedstock is arranged in each of two or more electrolytic cells (50, 60, 70, 80). A molten salt is provided as an electrolyte in each cell. The molten salt is circulated from a molten salt reservoir (10) such that salt flows through each of the cells. Feedstock is reduced in each cell by applying a potential across electrodes in each cell, the potential being sufficient to cause reduction of the feedstock. The invention also provides an apparatus for implementing the method.
US08992755B2 Microdevice and method for separating an emulsion
An active method for decanting the dispersed phase in the continuous phase of an emulsion. According to the method, repulsive forces created by an electric field are used on the drops constituting the dispersed phase. The electric field scans the reservoir containing the emulsion, enabling the dispersed phase to be concentrated in a determined region of the reservoir, for the recovery and/or analysis of the emulsion. A device implements the method.
US08992754B2 Method and apparatus for the characterizing and counting particles, in particular, biological particles
The present invention relates to a method and an apparatus for the characterization and/or the counting of particles by means of non uniform, time variable force fields and integrated optical or impedance meter sensors. The force fields can be of positive or negative dielectrophoresis, electrophoresis or electro-hydrodynamic motions, characterized by a set of stable equilibrium points for the particles (solid, liquid or gaseous); the same method is suitable for the manipulation of droplets (liquid particles) by exploiting effects known to the international scientific community with the name of Electro-wetting on dielectric. The aim of the present invention is to act on the control of the position of each particle which is present in the sample, for the purpose of displacing such particles in a deterministic or statistical way, in order to detect their presence with the integrated optical or impedance meter sensors and/or characterize their type, for the purpose of counting or manipulating them in an efficient way.
US08992753B2 Electrodepositable aqueous resinous dispersions and low gloss coatings produced therefrom
Disclosed are aqueous resinous dispersions that are electrodepositable and exhibit good anti-settling properties, as well as to their use to produce smooth, low gloss coatings. The aqueous resinous dispersions include an active hydrogen-containing, cationic salt group-containing polymer; a curing agent; and oxidized polyolefin particles.
US08992749B2 Sputtering apparatus
Provided is a sputtering apparatus which deposits a metal catalyst on an amorphous silicon layer at an extremely low concentration in order to crystallize amorphous silicon, and particularly minimizes non-uniformity of the metal catalyst caused by a pre-sputtering process without reducing process efficiency. This sputtering apparatus improves the uniformity of the metal catalyst deposited on the amorphous silicon layer at an extremely low concentration. The sputtering apparatus includes a process chamber having first and second regions, a metal target located inside the process chamber, a target transfer unit moving the metal target and having a first shield for controlling a traveling direction of a metal catalyst discharged from the metal target, and a substrate holder disposed in the second region to be capable of facing the metal target. A distance difference between a linear distance, which is a distance between a substrate loaded on the substrate holder and the metal target, and a length of the first shield is less than 3 cm.
US08992748B2 Sputtering target
A sputtering target made of aluminum and one or more alloying elements including Ni, Co, Ti, V, Cr, Mn, Mo, Nb, Ta, W, and rare earth metals (REM). The addition of very small amounts of alloying element to pure aluminum and aluminum alloy target improves the uniformity of the deposited wiring films through affecting the target's recrystallization process. The range of alloying element content is 0.01 to 100 ppm by weight, which is sufficient to prevent dynamic recrystallization of pure aluminum and aluminum alloys, such as 30 ppm Si alloy. The addition of small amount of alloying elements increases the thermal stability and electromigration resistance of pure aluminum and aluminum alloys thin films while sustaining their low electrical resistivity and good etchability. This invention also provides a method of manufacturing microalloyed aluminum and aluminum alloy sputtering target.
US08992739B2 Method for manufacturing silicon-based nanocomposite anode active material for lithium secondary battery and lithium secondary battery using same
A method for manufacturing a silicon-based nanocomposite anode active material for the lithium secondary battery and the lithium secondary battery using same, comprising the following steps: a first step of mounting a silicon-based wire between two electrodes, which are placed in a methanol-based solvent atmosphere, and manufacturing a dispersion solution in which silicon-based nanoparticles are dispersed by means of high-voltage pulse discharging; and a second step of manufacturing a silicon-based nanocomposite body by compositing the silicon-based nanoparticles in the solution and a different type of material. By using the silicon-based nanocomposite anode in the lithium secondary battery according to the method, the advantages provided are of improving electronic conductivity and lithium-ion conductivity by means of the different type of material having a high-capacity characteristic, which encases the silicon-based nanoparticles, and of providing the lithium-ion secondary battery having enhanced battery capacity and charge/discharge cycle properties.
US08992737B2 Trihalosilane refining method
A trihalosilane refining device and a trihalosilane refining method are provided. The trihalosilane refining device can be useful in obtaining high-purity trihalosilane from a feed containing a trihalosilane while consuming a small amount of energy.
US08992736B2 Selective temperature quench and electrostatic recovery of bio-oil fractions
A process for quenching, separating and collecting targeted components of a hot pyrolysis product stream from the pyrolysis of biomass is provided. The process utilizes sequential steps of rapid quenching and electrostatic precipitation comprising injecting a coolant comprising at least one of nitrogen, a noble gas and mixtures thereof into a hot pyrolysis vapor to selectively condense a first fraction of components from the hot pyrolysis vapor at a first predetermined temperature which is then collected by electrostatic precipitation in a first electrostatic precipitator at about the first predetermined temperature, where a wall temperature of the first electrostatic precipitator is maintained slightly higher than the first predetermined temperature. The sequential steps of coolant injection and collection are repeated at progressively cooler temperatures in order to selectively collect one or more fractions of the hot mixture.
US08992734B2 Process for the preparation of surface-treated calcium carbonate material and use of same in the control of organic material in an aqueous medium
The present invention relates to a process for the production of a surface-treated calcium carbonate, the use of this surface-treated calcium carbonate in a process for the control of organic material in an aqueous medium, as well as to a composite of surface-treated calcium carbonate and organic material, such as a composite of surface-treated calcium carbonate and to the use of such a composite.
US08992732B2 System and process for improving paper and paper board
The invention relates to a process for making paper or paper board comprising forming a cellulosic suspension, flocculating the suspension, draining the suspension on a device to form a sheet and then drying the sheet, wherein the suspension is flocculated using a formation improving 3-component flocculation system comprising a) a linear cationic or ampoteric co-polymer of: i) acrylamide, and ii) a substance with formula (I) with a halide as counter-ion; b) at least one water soluble component chosen from the group of anionic polyacrylamide, non-ionic polyacrylamide and polyethyleneoxide; and c) inorganic microparticles, whereby the flocculation system does not contain a wafer-dispersible or branched anionic organic polymer. The invention also relates to use of the flocculation/retention system in the manufacture of paper or paper board, and to paper and paper board thus produced.
US08992730B2 Method and apparatus for manufacturing coated paper
A method of manufacturing coated paper by applying a coating liquid to a strip-shaped web of paper to form a plurality of bands extending in the width direction of the web and spaced from each other in the longitudinal direction of the web includes: a coating step (S1) of applying the coating liquid to the web to form the bands with a coating band pitch narrower than a design band pitch defined as a standard for the coated paper; an aftertreatment step (S2), executed after the coating step, of drying the web; and a tension applying step (S3), executed after the aftertreatment step, of expanding the band pitch of the web by applying tension to the web to cause the band pitch of the web to approach the design band pitch.
US08992729B2 Method and arrangement for separating contaminants from liquids or vapors
A method and assembly for separating contaminants from liquids, such as condensates, or vapors at an evaporation plant. The contaminants are separated from liquids by stripping when bringing a contaminant-enriched liquid into direct contact with a vapor by spraying or distributing the liquid into the vapor flowing in a vapor duct or onto wall surfaces in the vapor duct thus reducing the contaminant-content of the sprayed liquid and producing a cleaner liquid. The contaminants are enriched in the vapor. From vapors contaminants are separated by absorption when bringing a contaminant-enriched vapor into direct contact with a cleaner liquid by spraying or distributing the liquid into the vapor flowing in a vapor duct or onto wall surfaces in the vapor duct thus increasing the contaminant-content of the liquid, but producing a cleaned vapor.
US08992727B2 Device for removing a protective film off a sheet
A device for removing a protective film off a sheet such as tickets or the like is described. The device has at least one removal or scraping roll of the protective film and at least one drawing or pulling roll of the sheet opposite the scraping roll and between which the sheet passes. The device also has a base and a roll unit mobile or removable with respect to the base and including the scraping roll and the drawing roll.
US08992726B2 Method and device for peeling off silicon wafers
A device for peeling off silicon wafers, including: a supporting member that is configured to support a board-shaped member to which plural silicon wafers are bonded via an adhesive; a heating unit for heating the board-shaped member; a shifting mechanism that is configured to shift, in a horizontal direction, the supporting member relatively with respect to the heating unit; a peeling-off mechanism that is configured to peel off the silicon wafers one by one; and a container for allowing the silicon wafers, the board-shaped member and the supporting member to soak in a liquid.
US08992725B2 Plasma reactor with inductie excitation of plasma and efficient removal of heat from the excitation coil
The plasma reactor of the invention is intended for treating the surfaces of objects such as semiconductor wafers and large display panels, or the like, with plasma. The main part of the plasma reactor is an array of RF antenna cells, which are deeply immersed into the interior of the working chamber. Each antenna cell has a ferromagnetic core with a heat conductor and a coil wound onto the core. The core and coil are sealed in the protective cap. Deep immersion of the antenna cells having the structure of the invention provides high efficiency of plasma excitation, while the arrangement of the plasma cells and possibility of their individual adjustment provide high uniformity of plasma distribution and possibility of adjusting plasma parameters, such as plasma density, in a wide range.
US08992724B2 Plasma processing apparatus and plasma processing method
A plasma processing apparatus includes a processing chamber which plasma-processes a sample, a first high-frequency power supply which supplies first high-frequency power for plasma generation to the processing chamber, a second high-frequency power supply which supplies second high-frequency power to a sample stage on which the sample is placed and a pulse generation device which generate first pulses for time-modulating the first high-frequency power and second pulses for time-modulating the second high-frequency power. The pulse generation device includes a control device which controls the first and second pulses so that frequency of the first pulses is higher than frequency of the second pulses and the on-period of the second pulse is contained in the on-period of the first pulse.
US08992722B2 Direct drive arrangement to control confinement rings positioning and methods thereof
A direct drive arrangement for controlling pressure volume within a confinement region of a processing chamber of a plasma processing system during substrate processing is provided. The confinement region is a chamber volume surrounded by confinement rings is provided. The arrangement includes plunger assemblies configured for changing the pressure of motor assemblies configured for vertically moving the plunger assemblies, and recording set point position values for the plunger assemblies. The arrangement further includes a set of circuits configured for driving the motor assemblies to move the plunger assemblies to change the pressure volume within the confinement region. The set of circuits is also configured for providing power to the motor assemblies. The set of circuits is further configured for receiving the set point position values from the motor assemblies.
US08992720B2 Pressure sensitive adhesive comprising functionalized polyisobutylene hydrogen bonded to acylic polymer
A pressure sensitive adhesive composition is described comprising a polyisobutylene polymer having a first functional group and an acrylic polymer having a second functional group present in the acrylic polymer backbone. The first and second functional groups form a hydrogen bond. In some embodiments, the adhesive composition further comprises a crosslinker that covalently crosslinks the second functional group(s) present in the polymer backbone of the acrylic polymer. Also described are adhesive articles, such as a tape, methods of adhesively bonding, and methods of making a pressure sensitive adhesive.
US08992717B2 Catheter with helical drive shaft and methods of manufacture
Drive shafts having helical blades and methods of making are disclosed. In one method a helical auger blade is formed by twisting or sculpting a heated polymer tube which has been placed over a cylindrical drive shaft. In another method a drive shaft is placed within a helical winding and heat is applied to melt polymer which has been coated over one or both of the drive shaft and helical winding.
US08992715B2 System and method for the rapid, automated creation of advanced composite tailored blanks
An embodiment of the present invention provides a method for manufacturing a composite preform from tape material, including feeding a tape section into a tape section guide that suspends the tape across a tooling surface, moving at least one of the tape section guide and the tooling surface relative to each other to position the tape section at a desired location and orientation relative to the tooling surface, moving the tape section toward a pre-existing tape section disposed on the tooling surface, and tacking the tape section to the pre-existing tape section. A corresponding apparatus for manufacturing composite preforms is also disclosed.
US08992713B2 Process for producing multilayer printed wiring board
Multi-layer printed wiring boards may be produced by: (1) conveying an adhesive sheet from an adhesive sheet roll wherein an adhesive sheet having a prepreg formed on a support film is wound in a roll and placing the adhesive sheet such that a prepreg surface contacts one or both of the surfaces of a circuit board, (2) partially adhering the adhesive sheet to the circuit board by heating and pressing a part of the adhesive sheet from the support film side, and cutting the adhesive sheet according to the size of the circuit board with a cutter, (3) heating and pressing the temporarily fitted adhesive sheet under reduced pressure to laminate the adhesive sheet on the circuit board, (4) forming an insulating layer by thermally curing the prepreg, and (5) detaching the support film after the thermal curing step.
US08992712B2 Method for manufacturing electronic devices and electronic devices thereof
In some embodiments, a method of manufacturing electronic devices including providing a carrier substrate having a first side, a second side, and a first adhesive at the first side; providing a first flexible substrate; and bonding the first flexible substrate to the first side of the carrier substrate. The first adhesive bonds the first flexible substrate to the first side of the carrier substrate. The carrier substrate comprises a mechanism configured to compensate for a deformation of the carrier substrate. Other embodiments are disclosed.
US08992710B2 Inverted balloon system and inflation management system
At least one exemplary embodiment is directed to a pressure management system for an earpiece comprising: a first valve, where the first valve allows air to pass from a first side of the valve to a second side more readily than from the second side to the first side an inflation channel, where the inflation channel has an outer diameter less than 5 mm; a pressure release mechanism; a pump; a stent, where the inflation channel is embedded; and a balloon, where the first valve, the inflation channel, the pressure release mechanism, the pump, and the balloon are operatively connected, where the first valve is positioned so that air from the pump passes through the first valve to inflate the balloon and where the leak rate of the air from the balloon back to the pump is less than 1% by volume per minute and where the pressure release mechanism is configured to release pressure from the balloon to the environment upon actuation, and where the pressure management system is configured to manage the inflation pressure of the balloon in an orifice.
US08992709B2 Sandwich structure having arrestment feature and method of making the same
A composite sandwich structure comprises a core sandwiched between composite laminate facesheets. The core includes a plurality of core sections spliced together at joints that incorporate integral features for arresting the propagation of irregularities in the facesheets.
US08992706B2 Copper alloy sheet, and method of producing copper alloy sheet
One aspect of this method of producing a copper alloy sheet includes: a hot rolling process; a cold rolling process; a recrystallization heat treatment process; and a finish cold rolling process in this order, wherein a hot rolling initiation temperature is 800° C. to 940° C., a cooling rate from a temperature after final rolling or 650° C. to 350° C. is 1° C./second or more, and a cold working rate is 55% or more. In the recrystallization heat treatment process, 550≦Tmax≦790, 0.04≦tm≦2, and 460≦{Tmax−40×tm−1/2−50×(1−RE/100)1/2}≦580 are fulfilled, in which Tmax is the highest arrival temperature, tm (min) is a retention time in a temperature range from a temperature lower than the highest arrival temperature by 50° C. to the highest arrival temperature, and RE (%) is a cold working rate.
US08992703B2 Laser-produced porous surface
The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.
US08992702B2 Copper alloy sheet, manufacturing method of copper alloy sheet, and electric/electronic component
There is provided a copper alloy sheet including 1.0 to 3.5 mass % Ni, 0.5 to 2.0 mass % Co, and 0.3 to 1.5 mass % Si, a Co/Ni mass ratio being 0.15 to 1.5, an (Ni+Co)/Si mass ratio being 4 to 7, and a balance being composed of Cu and an unavoidable impurity, wherein in observation results of a crystal grain boundary property and crystal orientation by EBSP measurement, a density of twin boundaries among all crystal grain boundaries is 40% or more and an area ratio of crystal grains with Cube orientation is 20% or more, on a rolled surface.
US08992698B2 Welding metal having excellent low-temperature toughness and drop-weight characteristics
Provided is a welding metal in which the chemical component composition thereof is appropriately controlled; an A value that is specified by a predetermined relational expression satisfies the requirement of being 3.8% to 9.0%; an X value that is specified by a predetermined relational expression satisfies the requirement of being 0.5% or greater; the area percentage of carbide particles having a circle-equivalent diameter of 0.20 μm or greater in the welding metal is 4.0% or less; and the number of carbide particles having a circle-equivalent diameter of 1.0 μm or greater is 1000 particles/mm2 or less. This welding metal, which can exhibit not only high strength but also good low-temperature toughness and good drop-weight characteristics, is useful as a material for a pressure vessel in a nuclear power plant.
US08992697B2 High strength press-formed member and method for manufacturing the same
A high strength press-formed member includes a steel sheet constituting the member including a composition including by mass %, C: 0.12% to 0.69%, Si: 3.0% or less, Mn: 0.5% to 3.0%, P: 0.1% or less, S: 0.07% or less, Al: 3.0% or less, N: 0.010% or less, Si+Al: at least 0.7%, and remainder as Fe and incidental impurities, wherein a microstructure of the steel sheet includes martensite, retained martensite, and bainite containing bainitic ferrite, an area ratio of said martensite with respect to the entire microstructure of the steel sheet is 10% to 85%, at least 25% of said martensite is tempered martensite, content of retained austenite is 5% to 40%, area ratio of said bainitic ferrite in said bainite with respect to the entire microstructure of the steel sheet is at least 5%, total of area ratios of said martensite, said retained austenite, and said bainitic ferrite in said bainite with respect to the entire microstructure of the steel sheet is at least 65%, and average carbon concentration in the retained austenite is at least 0.65 mass %.
US08992692B2 Adjustable brush cleaning apparatus for semiconductor wafers and associated methods
A cleaning apparatus for cleaning a semiconductor wafer includes a rotary brush to be positioned to clean the semiconductor wafer, and an optical sensing device associated with the rotary brush to sense a separation distance between a reference position thereon and the semiconductor wafer. An actuator is coupled to the optical sensing device to position the rotary brush based upon the sensed separation distance.
US08992690B1 Flat belt treadmill-like rotation toothbrush
In an embodiment of the disclosed technology, a toothbrush head formed of a bristled tread is rotatable about at least one vertically disposed sprocket. The toothbrush head has an elongated neck with sprockets extending axially therefrom. Bristles are wrapped around either or both sprockets. The bristles may be on a single belt wrapped around both sprockets. Alternatively, the bristles may extend from two spindles, each fitted around a sprocket. The sprockets rotate circumferentially within an upper head portion of the device. The bristles spin 360 degrees (full rotation) around the sprockets and within the stationary head. The head portion itself is replaceable or changeable, such that a handle portion may be used by multiple users or replaced.
US08992679B2 Cementitious material, dry construction pellets comprising uncured cement powder and binder, and method of making thereof
Dry construction pellets that may be made by mixing predetermined portions of two or more components of cementitious materials without ingredients that would allow the mixture to cure, and separating the un-curable mixture of the two or more components into a plurality of pellets, each having substantially the predetermined portions of the two or more components. An extrusion system may include a transport line configured to transport the dry pellets in a gaseous transport stream.
US08992676B2 Ink set and ink jet recording method
An ink set for an aqueous ink jet includes a first ink and a second ink, in which the first ink satisfies requirement 1 and requirement 2 described below: requirement 1: the first ink contains a coloring material, a fluorinated surfactant, and a specific salt, and requirement 2: the difference between the dynamic surface tensions of the first ink at lifetimes of 50 msec and 5000 msec measured by a maximum bubble pressure method at 25° C. is 17 mN/m or more, and the dynamic surface tension of the first ink at a lifetime of 5000 msec is 32 mN/m or less.
US08992672B2 Housing and housing assembly for substance removing an undesired respiratory gas component of a respiratory gas flow and an arrangement for ventilating lungs of a subject
A housing for a substance removing an undesired component of a respiratory gas is disclosed herein. The housing includes a first space for the substance and a first wall surrounding part of the first space. The housing also includes a first end, surrounding part of the first space, comprising a first opening for the gas communication with the first space, and a second end, surrounding part of the first space, comprising a second opening for the gas communication with the first space. The housing further includes a first channel between the first and the second end for the gas flow, the first channel comprising a first orifice at the first end and a second orifice at the second end. The first orifice, the first opening, the second orifice and the second opening are in flow communication with outside the housing.
US08992669B2 Hydrogen separation membrane module and hydrogen separation method using same
The hydrogen separation membrane module according to the present invention is used for separating hydrogen from a gas to be treated containing hydrogen, and is provided with a tubular hydrogen separation membrane being selectively permeable to hydrogen, a casing for the hydrogen separation membrane, an insertion member being arranged on the inside of the hydrogen separation membrane and having an outer surface that defines a flow path of the gas to be treated together with an inner surface of the hydrogen separation membrane, a gas supply port for supplying the gas to be treated to the inside of the hydrogen separation membrane, a gas discharge port for discharging a non-permeating gas that does not permeate the hydrogen separation membrane, from a downstream side of the flow path, and a hydrogen discharge port provided in the casing, for discharging hydrogen having permeated the hydrogen separation membrane.
US08992667B2 Systems and methods for closed crankcase ventilation and air filtration
A system for providing air to an internal combustion engine comprises a crankcase ventilation unit that receives unrefined blowby gas from a crankcase, separates oil from the unrefined blowby gas, and discharges refined blowby gas. A conduit delivers the refined blowby gas to an air cleaner housing. The air cleaner housing comprises a first chamber that receives intake air through a first port, a second chamber that receives intake air from the first chamber and refined blowby gas from the conduit through a second port, and a third chamber that receives a mixture of intake air and refined blowby gas from the second chamber and discharges the mixture through a third port. A primary filter element filters the intake air as it passes from the first chamber to the second chamber. A secondary filter element filters the mixture as it passes from the second chamber to the third chamber.
US08992664B2 Blast furnace top gas recycling process and corresponding recycling equipment
A process for recycling blast furnace gas is provided. At least one portion of the gases resulting from the blast furnace undergo a CO2 purification step to create a CO-rich gas which is reinjected at a first top injection point at a temperature between 700° C. and 1000° C. through a top injection line, and at a second bottom injection point at a temperature between 1000° C. and 1300° C. through a bottom injection line. The gases from the bottom and top injection lines are heated at a temperature between 1000° C. and 1300° C. A portion of the CO-rich gas exiting the purification step is directly introduced into the top injection line via a cold gas injection line to obtain a temperature between 700° C. and 1000° C. at the first top injection point. The gas that flows through the bottom and top injection points controlled upstream of the system of the heaters. A device is also provided.
US08992663B2 Method for the simultaneous production of iron and a crude syngas containing CO and H2
The invention relates to a method for simultaneously producing iron and a crude syngas containing CO and H2 by means of a blast furnace that is charged with iron ore and carbon-containing reducing agents. The amount of carbon-containing reducing agents fed to the blast furnace is greater than the amount of fuel required for producing the iron. Technically pure oxygen is fed into the blast furnace for the blast furnace process and for producing the crude syngas. In addition, CO2 and/or steam are fed to the blast furnace in order to control the ratio between CO and H2 in the crude syngas discharged from the blast furnace as top gas and/or moderate the temperature at which the oxygen is injected.
US08992661B2 Production of specialty aluminum alloys using partition of feed impurities
A series of inventions leading to the production of specific aluminum alloys (especially aluminum beverage can sheet product) through novel approach of introducing, selectively partitioning and managing alloying elements. This invention also enables manufacturing practices to enhance the performance characteristics of aluminum alloys produced. The selected elements can be derived from carbon anodes made from calcined petroleum coke with high metallic contents (such as nickel and vanadium). Alloying elements can also be introduced and managed from other raw material such as alumina and bath constituents added during aluminum smelting process. Additionally, cell operating parameters, such as cell temperature, off gas flow rate, aluminum tapping rate and impurity partition characteristics can also be manipulated to produce low cost aluminum alloys and facilitate utilization of high metallic content calcined petroleum coke.
US08992659B2 Metal powder composition
A metal powder composition including: an iron or iron-based powder composition, and a lubricating combination including a substance A, a substance B, and a substance C; wherein: substance A is a polyolefin, substance B is chosen from a group of saturated and unsaturated fatty acid amides, saturated and unsaturated fatty acid bisamides, saturated fatty alcohols and fatty acid glycerols, and substance C is an amide oligomer having a molecular weight between 500 g/mol and 30 000 g/mol; and wherein the amounts of respective substances A, B and C in weight percent of the iron or iron-based powder composition are: 0.05≦A+B<0.4 wt %, C≧0.3 wt %, A+B+C≦2.0 wt %, and the relation between substances A and B is: B/A>0.5. Also, a method of producing a metal powder composition and a method for producing a green component.
US08992658B2 Sintered metallic bearing and fluid dynamic bearing device equipped with the bearing
A sintered metal bearing is obtained by compression-molding of a raw-material powder containing at least a Cu powder, an SUS powder, and a pure Fe powder and thereafter sintering a compression-molded body at a predetermined temperature.
US08992657B2 Material for decorative parts
A lightweight material for decorative parts having a silver metallic color tone is provided. The material includes a sintered body including a main hard phase composed of a solid solution formed of titanium carbonitride and titanium carbide; a main binder phase composed of nickel; a first additive material composed of at least one selected from the group consisting of molybdenum carbide, niobium carbide, tungsten carbide, and tantalum carbide; a second additive material composed of at least one of chromium and chromium carbide; and the balance being incidental impurities. The N content in the sintered body is 2.0% to 6.0% by mass. The color tone of the sintered body satisfies L*=9 to 14, a*=−2 to 3, and b*=−6 to 0, which are values of the L*a*b* color system measured with a spectrophotometric colorimeter.
US08992655B2 Methods for improving bud break
Methods of inducing bud break of deciduous fruit vines, trees, or shrubs following dormancy by the application of bud breaker compositions that do not contain hydrogen cyanamide.
US08992653B2 Seed treatment methods and compositions
Disclosed are methods of enhancing plant growth, comprising treating seed at least one month prior to planting with an effective amount of a plant signal molecule, wherein upon harvesting the plant exhibits at least one of increased plant yield measured in terms of bushels/acre, increased root number, increased root length, increased root mass, increased root volume and increased leaf area, compared to plants harvested from untreated seed, or compared to plants harvested from seed treated with the signal molecule just prior to or within a week or less of planting.