Document Document Title
US08269180B2 Method and apparatus for the measurement of signals from radiation sensors
The preferred embodiments of the present invention include a device for measuring an ionizing event in a radiation sensor. The device can include a charge amplifier and a timing shaper. The charge amplifier receives a cathode signal and is configured to output an amplified cathode signal. The timing shaper is operatively connected to the charge amplifier to receive the amplified cathode signal. The timing shaper is configured to generate a first pulse in response to a beginning of the ionizing event and a second pulse in response to an end of the ionizing event. The first and second pulses are associated with a depth of interaction of the ionizing event and are generated in response to a slope of the amplified cathode signal changing.
US08269176B2 Detector head proximity sensing and collision avoidance apparatuses and methods
A gamma camera (8, 180) includes at least one radiation detector head (10, 12, 210, 212). At least one such radiation detector head (10, 12, 210, 212) includes a plurality of capacitive elements (60, 260, 76, 276) disposed over at least a radiation sensitive portion (50) of the radiation detector head. A proximity sensor monitor (62) is coupled with the plurality of capacitive elements to detect proximity of a subject to the radiation detector head based on a measured electrical characteristic of the capacitive elements. A collision sensor monitor (64) is coupled with the plurality of capacitive elements to detect conductive electric current flowing between spaced apart parallel conductive plates (66, 67) of the capacitive element responsive to mechanical deformation of the spacing between the plates.
US08269174B2 Method and apparatus for compact spectrometer for multipoint sampling of an object
A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.
US08269169B1 Nanotube based polarimetric electromagnetic sensor and focal plane array
A polarimetric sensor includes a substrate and a plurality of aligned nanotube film patches arranged on the substrate. Each of the plurality of aligned nanotube film patches is oriented on the substrate to sense a different orientational component of electromagnetic radiation. For each of the plurality of aligned nanotube film patches, at least two contacts are arranged in electrical communication with the respective aligned nanotube film patch. The at least two electrodes are configured to conduct to an external circuit an electric signal generated in the respective aligned nanotube film patch when exposed to a respective orientational component of electromagnetic radiation.
US08269168B1 Meta materials integration, detection and spectral analysis
A detector and modulator of electromagnetic radiation is 3-dimensional structure made of substantially 2 dimensional high impedance metamaterial surfaces stacked one above the other with a dielectric layer in between and located above a conducting ground plane. Each 2 dimension surface may be formed by an open continuous conductive trace, such as metallic wire or a printed circuit line, which is cast or plated on or into a 2-D periodic arrangement of an element that belongs to the Hilbert space filling curves.
US08269166B2 MS/MS mass spectrometer
A mass analysis of a standard sample having a known mass-to-charge ratio is carried out by performing a mass scan at a first-stage quadrupole (13) over a predetermined mass range, under the condition that a collision induced dissociation (CID) gas is introduced into a collision cell (14) and a voltage applied to a third-stage quadrupole (17) is set so that no substantial mass separation occurs in this quadrupole. Various kinds of product ions originating from a precursor ion selected by the first-stage quadrupole (13) arrive at and are detected by a detector (18) without being mass separated. Accordingly, based on the detection data, a data processor (25) can obtain a relationship between the voltage applied to the first-stage quadrupole (13) and the mass-to-charge ratio of the selected ions, with a time delay in the collision cell (14) reflected in that relationship. This relationship is stored in a calibration data memory (26), to be utilized in a neutral loss scan measurement or the like. By using this relationship, a mass shift due to the time delay in the collision cell (14) can be cancelled, so that the product ions can be detected with high sensitivity over the entire mass range. Furthermore, a mass spectrum having an accurate mass axis can be created.
US08269164B2 Mass spectrometer system
This invention describes a vacuum interface for a mass spectrometer system formed from a diverging nozzle. The vacuum interface may be used to transfer a beam of ions from an atmospheric pressure ionization source into a vacuum chamber for analysis by a mass analyser.
US08269162B2 Azimuthal elemental imaging
Measurements made by a wireline-conveyed pulsed neutron tool with two or more gamma ray detectors are used to provide a mineralogical and/or elemental image of the formation. This may be used in reservoir navigation and in furthering the understanding of the geology of the prospect.
US08269159B2 Modular panoramic night vision goggles having configurable attachments
A night vision goggle system is shown, including optical modules, a heads-up display (HUD) module, and a camera module. Each module may be added to and removed from the system without structural, electrical, or optical damage to itself or the remaining modules. Each optical module takes input light at one end and provides an intensified image at the other. A heads-up display module (HUD) can provide an informational display in any of at least two of the optical modules or both. A camera module is capable of recording both the intensified image produced by a particular optical module, as well as the HUD information shown through that module with substantially no offset from the original display. Both the camera module and the HUD module are installable onto the same optical module at the same time, and can be installed on either (or in some embodiments, any) optical module.
US08269158B2 Sensing system and method for obtaining position of pointer thereof
In a sensing system and a method for obtaining a position of a pointer, the sensing system includes a sensing area, a reflective mirror, an image sensor and a processing circuit. The reflective mirror is configured for generating a mirror image of a pointer when the pointer approaches the sensing area. The image sensor is configured for sensing the pointer and the mirror image thereof when the pointer approaches the sensing area. When the pointer approaches the sensing area, the processing circuit calculates a coordinate value of the pointer according to an image sensed by the image sensor and a predetermined size of the pointer. The pointer forms an imaginary orthographic projection in the sensing area, the processing circuit regards the imaginary orthographic projection as a round projection, and a radius of the round projection is the predetermined size.
US08269153B2 Energy-saving water boiler utilizing high-frequency induction coil heating
A water boiler includes a water storage tank, a heater, and a heat pipe unit. The water storage tank includes a heating room, an outer water storage room, and an inner water storage room between the heating room and the outer water storage room in a radial direction. Outside water flows from an inlet pipe to the outer water storage room, and water in the outer water storage room flows into the inner water storage room and the heating room for storage. The heater includes an induction coil. The heat pipe unit includes a plurality of heat-transfer pipes. An upper segment of each heat-transfer pipe is arranged in the heating room, while a lower segment of each heat-transfer pipe is received in the induction coil. When the induction coil turns ON, the heat-transfer pipes are heated to heat the water in the heating room.
US08269151B2 Method for displaying, particularly a heating or cooling curve, and cooking appliance for carrying out such a method
The invention relates to a method for displaying the curve when a desired climate has been reached in a cooking compartment of a cooking appliance by taking into account at least one actual value of the first variable that changes over time and is characteristic of the climate in the cooking compartment. Said method is characterized in that the actual value of the first variable is detected at least once during an interval t0 to t1 and is compared with a desired value of the first variable, said desired value characterizing the desired climate, a point in time t2 when a second interval is to begin and/or the point in time t3 when the desired climate has been reached is/are estimated in accordance with said comparison, and the course of the first variable over time is taken into account at least once when estimating the point in time t3 during a second interval t2 to t3, wherein t2≧t1. The invention also relates to a cooking appliance for carrying out such a method.
US08269148B2 Cooktop with forced convection cooling
A ventilation system for cooling a cooking appliance that can be placed within a kitchen countertop is described. The cooking appliance includes one or more air inlets within the sides of the cooktop, and an air mover that draws air in through the air inlets and over control circuits provided within the frame of the cooking appliance.
US08269138B2 Method for separating a sheet of brittle material
A method for separating sheet of brittle material having a thickness equal to or less than about 1 mm is disclosed. Once an initial flaw or crack is produced, a full body crack can be propagated across a dimension of the brittle material with a laser beam that is substantially absorbed proximate the surface of the sheet to produce sub-sheets. In some embodiments, only a single pass of the laser beam over a surface of the sheet is necessary to separate the sheet. In other embodiments a plurality of passes may be used. Sub-sheets can be further processed into electronic devices by depositing thin film materials on the sub-piece.
US08269137B2 Link processing with high speed beam deflection
The present invention relates to the field of laser processing methods and systems, and specifically, to laser processing methods and systems for laser processing multi-material devices. Systems and methods may utilize high speed deflectors to improve processing energy window and/or improve processing speed. In some embodiments, a deflector is used for non-orthogonal scanning of beam spots. In some embodiment, a deflector is used to implement non-synchronous processing of target structures.
US08269135B2 Color sensing for laser decoating
A coating removal apparatus utilizing a common optics path to provide laser pulses to a coated surface and to direct a light illumination reflected from the coated surface to a photosensitive detector and analyzer. The apparatus is an integrated device including a laser source, a beam splitter, scanning optics, a waste removal apparatus, one or more light illuminators, a photosensitive detector, a comparator, and a control logic circuit. Alternatively, the laser source is external to the integrated device and a fiber optic cable is used to connect the laser source to the integrated device.
US08269132B2 Method for electrical discharge machining of electrically non-conductive material
The invention relates to a method for electrical discharge machining of electrically non-conductive material in which a layer of an electrically conductive substance is applied as an auxiliary electrode on the electrically non-conductive material. Said method is characterized in that the electrically conductive substance is chemically converted by oxidative heat treatment after electrical discharge machining.
US08269127B2 Tulip contacting device for vacuum circuit breaker
Disclosed is a tulip contacting device for a vacuum circuit breaker employed to quickly break off an electric power system, in which contact fingers are bidirectionally rotatable in a state of being restricted at an outer diameter portion of a mover holder, such that the flexibility of the contact fingers can be increased, whereby it is possible, upon connecting the vacuum circuit breaker to a case, to flexibly deal with the variation of axial angles of terminals inserted in both sides of the tulip contacting device, and also springs may be coupled to the contact fingers, respectively, so as to effectively prevent separation and overall destroy of the contact fingers from the mover holder during installation.
US08269125B2 Mixed product delivery point sequencer and method of use
A device and method for device for sequencing disparate products includes at least a first feeder mechanism feeding a stream of a first product type in a pre-sequenced order. At least a second feeder mechanism feeds a stream of second product type though a sequencing process. A reading device reads product information of the first product type and the second product type. A pausing device pauses the first stream of the first product type or the second stream of the second product type in a first pass sort order of the sequencing process based on the information read from the reading device. The first product type and the second product type are intermixed into a stream forming a merged stream of sequenced first and second product type. A separation item may be placed between groupings of the intermixed product.
US08269119B2 Apparatus for mutually locking two switches, in particular circuit breakers
An apparatus is disclosed for mutually locking two switches, in particular circuit breakers, with two plungers which move in opposition to one another via a forced mechanical coupling. When one switch opens, one plunger is shifted into its opening position and the other plunger is shifted into its locking position. In order to achieve a maintenance-free apparatus, at least one embodiment of the invention proposes that each plunger has a toothed rack, which meshes with a gearwheel, on which in each case one radial lever is arranged. The levers are connected in articulated fashion to one another via a connecting rod and a stop lever is mounted in rotary fashion on each gearwheel and, when the plungers are located in the zero position, bears in each case against a fixing stop. Furthermore, a driver is located on each gearwheel and bears in each case against a stop face formed on the stop lever, wherein, when a plunger is shifted, in particular when a switch opens, one driver pivots the stop lever towards a spring, while the other driver is removed from the stop face of the stop lever.
US08269117B2 Housing for an electric or electronic device
A housing for an electric or electronic device has at least one receiving part for accommodating electric and/or electronic components, parts, component groups and parts groups in an interior thereof has at least one locking part for closing the receiving part, and having a bayonet connector for connecting the at least one locking part with the at least one receiving part. The bayonet connector has a first connector part on the locking part and a second connector part on the receiving part which engage each other in a connected position. One of the first and second connector parts has a base and head in respective planes running perpendicular to a direction of insertion of the connector parts and a diagonal surface running diagonally from the base toward a head, the base, diagonal surface and head being distributed alternately around the entirety periphery of the first connector part.
US08269116B2 Circuit board case with electric connector and electronic unit provided with the same
A circuit board case with an electrical connector comprises a case member having formed thereon a connector mating portion, and a connection member accommodated in the case member and mounted on the connector mating portion to electrically connect the counterpart connector and the circuit board. The connection member comprises a terminal provided with a first bar portion and a second bar portion, and a first fixing member which holds the first bar portion of the terminal and is mounted on the connector mating portion of the case member to fix the terminal, and a second fixing member which holds the second bar portion and is mounted on the case member to regulate movement of the terminal in a direction in which the first bar portion extends into the case member.
US08269103B2 Electrical junction box
An electrical junction box is fixed via at least one mounting foot to a component-fixation section in a crushable zone of a vehicle. The mounting foot includes a breakage-inducing portion. The breakage-inducing portion is provided between an insertion hole into which a fastening bolt is inserted for fixation of the electrical junction box, and an outer edge of the mounting foot. The breakage-inducing portion is provided such that a body of the box is displaced in a displacement direction in a vehicle collision, and the breakage-inducing portion resides on a displacement trajectory that the fastening bolt may describe. The breakage-inducing portion provided on the displacement trajectory of the fastening bolt includes a throughhole and a notch.
US08269095B1 Magnetic pickup response measurement and presentation
The magnetic pickup response measurement and presentation system quickly measures frequency responses of magnetic pickups under various loading conditions, and the data is presented graphically and aurally to the user to aid user comparison and selection of magnetic pickups for use in musical instruments.
US08269094B2 System and method to generate and manipulate string-instrument chord grids in a digital audio workstation
A system and method that enables a user to generate and manipulate string-instrument chord grids in a digital audio workstation. The system and method for generating a string-instrument chord grid includes receiving first data input and second data input. The first data input can include a chord root note and/or a position for one or more fingering dots. The second data input can include an instrument type and our tuning for one or more strings. Using the received data input, a processor generates an entered string-instrument chord based and displays the entered string-instrument chord on a grid. The processor can also generate and display the musical name of the entered string-instrument chord.
US08269087B1 Mute
A mute for a horn-type musical instrument is disclosed. The mute having a freely resonating body including an opening therein to permit air flow into the body, the body having n number of first facets wherein n is an integer from 3 to 99 and having o number of second facets wherein o is an integer from 1 to 99. The mute changes the timbre of the sound generated by the instrument, yet maintains the majority of the volume of sound prior to placement of the mute into the bell.
US08269079B2 Plants and seeds of hybrid corn variety CH354755
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH354755. The invention thus relates to the plants, seeds and tissue cultures of the variety CH354755, and to methods for producing a corn plant produced by crossing a corn plant of variety CH354755 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH354755.
US08269077B2 Plants and seeds of hybrid corn variety CH522191
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH522191. The invention thus relates to the plants, seeds and tissue cultures of the variety CH522191, and to methods for producing a corn plant produced by crossing a corn plant of variety CH522191 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH522191.
US08269076B2 Compositions and methods for altering tocotrienol content
The invention provides isolated nucleic acids and their encoded polypeptides that alter tocol content in seeds. The invention further provides expression cassettes, host cells and transformed plants containing the nucleic acids. The present invention further provides methods for altering tocol content in seeds.
US08269075B2 Cotton variety 09R999B2R2
The invention relates to the novel cotton variety designated 09R999B2R2. Provided by the invention are the seeds, plants, plant parts and derivatives of the cotton variety 09R999B2R2. Also provided by the invention are tissue cultures of the cotton variety 09R999B2R2 and the plants regenerated therefrom. Still further provided by the invention are methods for producing cotton plants by crossing the cotton variety 09R999B2R2 with itself or another cotton variety and plants produced by such method.
US08269071B2 Soybean variety A1015669
The invention relates to the soybean variety designated A1015669. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1015669. Also provided by the invention are tissue cultures of the soybean variety A1015669 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1015669 with itself or another soybean variety and plants produced by such methods.
US08269068B2 Mutant hydroxyphenylpyruvate dioxygenase polypeptides and methods of use
Compositions and methods for conferring hydroxyphenyl pyruvate dioxygenase (HPPD) herbicide resistance or tolerance to plants are provided. Compositions include amino acid sequences, and variants and fragments thereof, for mutant HPPD polypeptides. Nucleic acids that encode the mutant HPPD polypeptides are also provided. Methods for conferring herbicide resistance or tolerance, particularly resistance or tolerance to certain classes of herbicides that inhibit HPPD, in plants are further provided. Methods are also provided for selectively controlling weeds in a field at a crop locus and for the assay, characterization, identification and selection of the mutant HPPDs of the current invention that provide herbicide tolerance.
US08269067B2 Slow-maturing, determinate peas
A determinate pea plant, where peas of the pea plant have a wrinkled-seed phenotype, and where the pea plant is slow-maturing.
US08269066B2 Nitrate reductases from red algae, compositions and methods of use thereof
The NR enzymes described herein were discovered in the red algae of Porphyra perforata (PpNR) and Porphyra yezoensis (PyNR). The present invention provides methods and compositions relating to altering NR activity, nitrogen utilization and/or uptake in plants. The invention relates to a method for the production of plants with maintained or increased yield under low nitrogen fertility. The invention provides isolated nitrate reductase (NR) nucleic acids and their encoded proteins. The invention further provides recombinant expression cassettes, host cells, and transgenic plants. Plants transformed with nucleotide sequences encoding the NR enzyme show improved properties, for example, increased yield and growth.
US08269059B2 Protective dressing and methods of use thereof
A protective device having a substantially rigid casing for placement on a patient's skin, wherein the casing has a hollow interior facing the patient's skin and a lip. The casing can be spanned across its hollow interior by a membrane. The casing can have a first adhesive seal attached to a bottom surface of the lip of the casing, and a second adhesive seal attached to the top surface of the lip of the casing.
US08269055B2 Method for deactivation of an organometallic catalyst and reactor system therefor
The present invention relates to a method for the deactivation of an organometallic catalyst in the product stream from an oligomerization reactor for the production of linear alpha-olefin, characterized in that the catalyst-containing product stream of the reactor is subjected to a temperature of at least 160° C. in a heating device. A reactor system for the method of the invention is also disclosed.
US08269054B2 Process for producing tetra-hydro alkyl substituted indanes
The present invention relates to an improved process for producing tetra-hydro alkyl substituted indanes which are used in the synthesis of fragrance ingredients for perfumery applications.
US08269051B2 Wickerol and method for producing the same
The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained.
US08269042B2 Crystallized diacetylenic indicator compounds and methods of preparing the compounds
Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.
US08269041B2 Ionic liquids having uronium or thiouronium cations
The present invention relates to salts having thiouronium or uronium cations, to processes for the preparation thereof, and to the use thereof as ionic liquids.
US08269039B2 Amino acids and catalytic preparatory methods
The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ2-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers.
US08269038B2 Process for production of sulfonic acid ester
The present invention provides a method for producing a sulfonate ester efficiently and in high yield.The present invention is an invention of a method for producing a sulfonate ester compound, which comprising reacting: (a) a compound having a sulfo group (—SO3H); and (b) a compound having a group represented by the general formula [1]: —OR1  [1] [wherein, R1 represents a sulfonyl group represented by the general formula [2]: —SO2—R2  [2] (wherein, R2 represents a halogen atom, a haloalkyl group, an alkoxy group, or an optionally substituted alkyl group or an optionally substituted aryl group) or an acyl group represented by the general formula [3]: (wherein, R3 represents an optionally substituted alkyl group or an optionally substituted aryl group)]; in the presence of an organic base which is capable of forming a salt with said sulfo group.
US08269030B2 Polyarylacetylenes containing siloxane, silane, and carborane moieties
Disclosed herein are the compounds shown below. Each R is an organic group, Cb is a carborane group, and —C6H4— is phenylene. The value of each m is a nonnegative integer, q is 0 or 1, with the proviso that if q is 0 then m is 0 or 1, p is a positive integer, r is a positive integer, and n is an integer greater than or equal to 10. Also disclosed are methods of making and crosslinking the compounds —{SiR2—([O]q—SiR2)m-[Cb-SiR2—([O]q—SiR2)m]p—C≡C—C6H4—C≡C}— —{SiR2—(O—SiR2)m—C≡C—C6H4—C≡C}n—; —{SiR2—([O]q—SiR2)m—[C≡C—C6H4—SiR2—([O]q—SiR2)m]p-Cb-[SiR2—([O]q—SiR2)m-Cb]r}-.
US08269028B2 Method and apparatus for refining biodiesel
Method and apparatus for producing biodiesel fuel, i.e., alkyl ester, from vegetable and/or animal oil. A transesterification catalyst is prepared in a base catalyst tank by spraying alkyl alcohol under pressure through jets at metal hydroxide pellets until the pellets have fully reacted with the alcohol. The oil is heated and transesterified in the presence of alkyl alcohol and the transesterification catalyst in a closed, recirculating transesterification flow system under slight cavitation to yield product alkyl ester and product glycerol. Cavitation is achieved by permitting air to enter the transesterification flow system through an adjustable air inlet valve. When permitted to stand, product alkyl ester forms an upper layer that is decanted and subjected to purification steps, to remove particulates and alkyl alcohol from the product alkyl ester, and a lower layer of product glycerol is drained away. Purification of the product alkyl ester preferably includes subjecting the product alkyl ester to an overhead water mist in a wash tank with simultaneous infusion of a stream of air bubbles. Alcohol vapor is reclaimed as liquid alcohol within an alcohol condenser and stored for reuse. If the oil contains free fatty acids, prior to transesterification, the oil is heated and the free fatty acids are esterified in the presence of an esterification catalyst and alkyl alcohol. For safety, baffles and explosion damper/flame arrestors are provided in locations where flammable vapors pose a risk.
US08269025B2 Purification of p-dioxanone
The present disclosure provides methods for purifying p-dioxanone. In embodiments, crude p-dioxanone may be contacted with at least one isocyanate-functionalized scavenger. The at least one isocyanate-functionalized scavenger may react with hydroxyl compounds present with the crude p-dioxanone to form reaction products, in embodiments polyurethanes and/or polyureas, which may then be removed. The p-dioxanone thus obtained is of greater purity than the starting crude p-dioxanone.
US08269020B2 Processes for the preparation of pyrazoles
The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal′ are independently selected from Cl and F, and R1 is selected from Cl, F and H.
US08269018B2 Pyrazolotriazole compound and electrophotographic toner
A compound represented by Formula (X-1) is disclosed. in the formula, Rx1 and Rx2 each independently represents an alkyl group, Lx is a hydrogen atom or an alkyl group, Gx1 is an alkyl group having 2 or more carbon atoms, Gx2 is an alkyl group or an aromatic hydrocarbon group, Gx3 is a hydrogen atom, a halogen atom, a Gx4-CO—NH— group or a Gx5-N(Gx6)-CO—group, Gx5 and Gx6 each independently represents a hydrogen atom or a substituent, and Qx1, Qx2, Qx3, Qx4 and Qx5 each independently represents a hydrogen atom or a substituent. An electrophotographic toner containing the compound is also disclosed.
US08269017B2 Compounds for the treatment of proliferative disorders
The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
US08269016B2 Insecticidal N-substituted (6-halooalkylpyridin-3-yl)-alkyl sulfoximines
N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects.
US08269015B2 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of CCR2
The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
US08269012B2 Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase
The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
US08269006B2 Processes for the selective amination of ketomorphinans
The present invention is generally directed to a process for the preparation of a ketomorphinan comprising maintaining a ketone group as unprotected and performing reductive amination using a hydrogen source and a catalyst.
US08269004B2 Heterocyclical anti-aromatic chromophore architectures
NLO chromophores of the form of Formula (I): and the acceptable salts, solvates and hydrates thereof, wherein Z1-4, X1-4, π1-2, D, A and R have the definitions provided herein.
US08269003B2 Stable crystal form of imatinib mesylate and process for the preparation thereof
The invention relates to imatinib for use in tumor therapy. This invention describes a stable, non hygroscopic alpha crystalline form of methane sulfonic acid addition salt of 4-(4-methyl piperazin-1-yl methyl)-N-[4-methyl-3-(4-pyridin-3-yl)-pyrimidin-2-yl amino) phenyl]-benzamide (imatinib mesylate) having the general structural formula A process for the preparation of the crystalline form is also described.
US08268998B2 Pyrrolotriazine kinase inhibitors
The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of Trk receptors such as TrkA, TrkB, TrkC or Flt-3 thereby making them useful as anticancer agents.
US08268995B2 Processes for preparing amines and catalysts for use therein
Processes for preparing an amine, which processes comprise: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 0.2 to 40% by weight of an oxygen compound of cobalt, calculated as CoO, 0.1 to 5% by weight of an oxygen compound of iron, calculated as Fe2O3, and 0.1 to 5% by weight of at least one oxygen compound of lead, tin, bismuth or antimony, calculated as PbO, SnO, Bi2O3 and Sb2O3 respectively.
US08268988B2 Process for preparing an A2A-adenosine receptor agonist and its polymorphs
Disclosed is a synthesis suitable for large scale manufacture of an A2A-adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph.
US08268983B2 Primers for amplifying and detecting the beta 2 adrenergic receptor gene
Present invention relates to a method for predicting an individual's bronchodilatory response to a β agonist. Present invention particularly relates to the detection of specific allelic variants of the β2AR gene and their use as pharmacogenetic markers towards response to β agonist.
US08268982B2 Primers and probes for the detection of HIV
Provided herein are primer/probe sets useful for detecting HIV (HIV-1) in a test sample. The primer/probe sets can be employed according to nucleic acid amplification procedures including PCR, real-time quantitative PCR, or RT-PCR. The primer/probe sets can also be provided in the form of a kit with other reagents for performing a nucleic acid amplification reaction.
US08268978B2 Modified oligonucleotides and applications thereof
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.
US08268976B2 Flea GABA receptor subunit nucleic acid molecules
The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and inhibitory compounds, particularly those that specifically inhibit flea GABA receptor subunit activity, as well as the use of such therapeutic compositions to treat animals.
US08268973B2 Anti-amyloid antibodies
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
US08268967B2 Glycopegylated interferon α
The present invention provides IFN-α conjugates including IFN-α peptides and modifying groups such as PEG moieties. The IFN-α peptide and modifying group are linked via an intact glycosyl linking group interposed between and covalently attached to the IFN-α peptide and the modifying group. The IFN-α conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar onto an amino acid or a glycosyl residue on the IFN-α peptide. Also provided are methods for preparing the IFN-α conjugates, methods for treating various disease conditions with the IFN-α conjugates, and pharmaceutical formulations including the IFN-α conjugates.
US08268964B2 MHC peptide complexes and uses thereof in infectious diseases
Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.
US08268962B2 Molecules for targeting compounds to various selected organs or tissues
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.
US08268961B2 Antibacterial peptides and analogues thereof
Antibacterial peptides and their multimeric analogues, with a wide range of action and low haemolytic activity are described. In particular, the peptide molecules exhibit a high antimicrobial activity against numerous bacterial species, with reduced cytotoxicity and a low haemolysis rate. The molecules of the invention are advantageously usable as therapeutic agents and coadjutants against infections caused by strains that are resistant to common antibiotics.
US08268960B2 Process for the synthesis of 3-hydroxyglutaronitrile
A high yield and high productivity processes for preparing 3-hydroxyglutaronitrile by reacting an epihalohydrin or a 4-halo-3-hydroxy-butanenitrile, or analogous compound containing a different leaving group, with cyanide (CN—) in the presence of water and an ionic liquid. The use of an ionic liquid as a cosolvent with water results in increased productivity and selectivity.
US08268957B2 Polyethylene imine based pigment dispersants
This invention refers to a novel process for the synthesis of polyethylene imine (PEI)-based pigment dispersants characterized by a “grafting from” approach, allowing the manufacture of solvent based dispersant systems. The polyethylene imine (PEI)-based pigment dispersant can be presented by the formula (I) X-(T)m-P-(T)n-H wherein P is a polyethyleneimine (PEI) back-bone; T is a residue —CO-A-O— wherein A is C2-C12 alkylene optionally substituted with C1-C6 alkyl with the proviso that each linkage between P and T is an amide bond and each linkage between X and T is an ester bond, X is a modifier or terminator residue R—CO— wherein R is a linear or branched, saturated or unsaturated alkanecarboxylic acids having from 1 to 22 carbon atoms or an unsaturated fatty acid residue or a hydroxycarboxylic residue or a polyester residue obtained from polycondensation of hydroxycarboxylic acids, or an acid terminated polyether; n, m independently are a number from 1 to 100.
US08268956B2 Transparent mold made of a polyamide molding material
The invention is directed to a transparent mold made of a polyamide molding material containing at least one polyamide formed from at least one diamine selected from the group of hexamethylene diamine (HMDA), bis-(4-amino-3-methylcyclohexyl)methane (MACM) and/or bis-(4-amino-cyclohexyl)methane (PACM) as well as from at least one dicarboxylic acid selected from the group of isophthalic acid (IPS), terephthalic acid (TPS) and/or dodecanedioic acid (DDS) or from the aforementioned diamines and dicarboxylic acids in combination with lactams and/or α-/ω-amino acids.
US08268951B2 Composition comprising a fluorine-containing organopolysiloxane and a process for preparing the same
Present invention provides a fluorine-containing organopolysiloxane composition comprising a fluorine-containing silicone polymer having a three-dimensional, cross-linked structure, prepared by addition polymerizing the following (A), (B) and (C) and containing 10 to 30 mass % of the fluorine atoms, relative to a total mass of (A) to (C), (A) a vinyl group-containing organopolysiloxane represented by the following formula (1): (B) an organohydrogenpolysiloxane represented by the following formula (2): and (C) an organopolysiloxane having a reactive group on one end alone and represented by the following formula (3), and further comprising (D) a low viscosity silicone oil with a dynamic viscosity of 50 mm2/s or less at 25 degrees C.
US08268949B2 Borohydride metallocene complex of a lanthanide, catalytic system including the said complex, polymerisation method using same and ethylene/butadiene copolymer obtained using said method
Borohydride metallocene complex of lanthanide, preparation process, catalytic system incorporating it, copolymerization of olefins employing catalytic system and ethylene/butadiene copolymer, the butadiene units comprise 1,2-cyclohexane or 1,2- and 1,4-cyclohexane links. The complex corresponds to of formulae A and/or B: where, in A two ligands Cp1 and Cp2, each of a fluorenyl group, are connected to the lanthanide Ln, where, in B, a ligand molecule, composed of two fluorenyl groups Cp1 and Cp2 are connected via bridge P of formula MR1R2, is an element from group IVa, R1 and R2, which are identical or different, represent an alkyl group comprising from 1 to 20 carbon atoms, connected to lanthanide Ln, L is alkali metal, N is molecule of a complexing solvent, x is integral or non-integral number ≧0 and p is integer ≧1.
US08268948B2 Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
US08268946B2 Clay activation of PD(II) and NI(II) complexes
A clay-supported complex that includes a metal complex containing a phosphinobenzenesulfonate ligand coordinated to Pd(II) or Ni(II), and a clay combined with the metal complex. The metal complex can be neutral or charged. The clay-supported complex is active in the homopolymerization and copolymerization of olefins, including polarized and non-polarized alpha-olefins.
US08268944B2 Dual metallocene catalysts for polymerization of bimodal polymers
This invention relates to catalyst compositions, methods, and polymers encompassing at least one first Group 4 metallocene compound comprising bridging η5-cyclopentadienyl-type ligands, in combination with at least one second Group 4 metallocene with non-bridging η5-cyclopentadienyl-type ligands, typically in combination with at least one cocatalyst, and at least one activator. The compositions and methods disclosed herein provide ethylene polymers with a bimodal molecular weight distribution.
US08268943B2 Preparation of supported chromium catalyst and polymerization process
A process for the preparation of a chromium-type supported olefin polymerization catalyst. A fluidized bed of support particles in an inert carrier gas is established. A chromium (III) compound is added to the fluidized support particles to provide a supported catalyst component. The supported catalyst component is activated to convert at least a portion of the chromium (III) to Chromium (VI). The chromium (III) containing particles may be recovered from the fluidized bed and then activated or they may be activated in the fluidized bed. Also the support particles can be treated in the fluidized bed with other treatment agents. The support particles may be pretreated with a solution of a boron treating agent prior to incorporation of the support in the fluidized bed.
US08268935B2 Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.
US08268934B2 Methods of making polymer blend compositions
Methods of making miscible and compatible immiscible polymer blends are disclosed. The polymer blends have a polyimide as a component. The miscible polymer blends have a single glass transition temperature. The compatible polymer blends have two glass transition temperatures.
US08268930B2 EPDM production and reformation process for rubber products
The invention constituting the subject matter of this application is related to the production method and process regarding any and all products created by forming the EPDM rubber including a mixture of ethylene, propylene and diene by using heat and particularly the seal of the door gasket, which is a part of the washing machines.
US08268922B2 Pressure-sensitive adhesive from a resin-modified polyurethene
Pressure-sensitive adhesive based on a mixture of chemically crosslinked polyurethane and at least one hydrocarbon resin, the chemically crosslinked polyurethane being a reaction product of at least one aliphatic or alicyclic polyisocyanate and a combination of at least one polypropylene glycol diol and one polypropylene glycol triol, reacted with one another catalytically in the presence of the at least one hydrocarbon resin, the at least one hydrocarbon resin being a monomer resin of the styrene/α-methylstyrene type.
US08268921B2 Elastomeric composition comprising functionalized butadienic elastomers and high dispersible aluminium-based silica
The instant invention relates to elastomeric compositions especially useful for manufacturing articles for tires which comprise: (1) at least one butadienic elastomer E, containing a functionalized butadienic elastomer prepared in solution, and modified by a polyfunctional alkoxy silane coupling agent; and (2) a specific precipitated silica having high dispersibility properties and containing aluminum, as at least one reinforcing filler in said butadienic elastomer.
US08268919B2 Polymer for detecting fingerprint, method of producing the same, composition for detecting fingerprint and method of detecting fingerprint using the same
It is intended to provide a polymer for detecting a fingerprint, which can be easily handled in a scene of the fingerprint detection as a substitute for conventionally employed 2-cyanoacrylate (a monomer), and a composition for detecting a fingerprint. It is also intended to provide a method of detecting a fingerprint whereby a fingerprint can be detected at a high sensitivity regardless of the color or conditions of a specimen and wherein the specimen can be well restored. The present polymer and composition for detecting a fingerprint and method of detecting a fingerprint using the same make it possible to definitely detect a fingerprint by using fluorescence even from an almost white specimen such as a shopping bag or an aluminum foil from which a fingerprint can be hardly detected by the existing methods.
US08268915B2 Polymer two phase system and use thereof
The present invention relates to a liquid mixture comprising a first polymer, which is a poly(acid), a second polymer, which is a poly(ether), and at least one salt, wherein the molecular weight of the poly(acid) is in the range of 1000-100,000 Da. The second polymer is selected to be capable of forming immiscible aqueous phases in the presence of the poly(acid) and salt. The poly(acid) may be selected from the group consisting of poly(acrylic acid) and poly(methacrylic acid), and the second synthetic polymer may comprise ethylene oxide. The invention may be used for separation of biomolecules, cells or particles.
US08268914B2 Water-soluble film
A film-forming composition made from a mixture of PVOH, chitosan, an alkali metal or ammonium bisulfite or metabi sulfite, and optional ingredients such as plasticizers, antioxidants, UV stabilizers, surfactants, crosslinking agents, lubricants, and extenders, is disclosed. Also disclosed are a method of making a film from the composition, a resulting film, and a packet made from the film and containing a cleaning composition such as a rinse additive. The composition can be formulated to yield an article such as a film which is soluble only below a predetermined pH threshold.
US08268911B2 Bimodal filler systems for enhanced flame retardancy
Use of a bimodal filler system allows masterbatches with higher filler levels to be processable. When used with moisture curable resins, the use of a masterbatch having a bimodal filler allows the preparation of a composition having a higher percentage of moisture curable resin than if a unimodal filler was used and also provides enhanced flame retardant properties.
US08268906B2 Process for producing flexible polyurethane foam, process for producing hot press molded product, and hot press molded product
To provide a process for producing a flexible polyurethane foam which is excellent in low resiliency, air flow and hot moldability, and a process for producing a hot press molded product by using such a flexible polyurethane foam. Further, the present invention provides a hot press molded product which has a low resiliency and air flow.
US08268900B2 Electrolyte membrane, process for its production and membrane-electrode assembly for polymer electrolyte fuel cells
Provided is an electrolyte membrane containing: a reinforced inner layer; and an unreinforced outer layer on one or each side of the reinforced inner layer, wherein the reinforced inner layer includes an inner ion exchange resin reinforced with a non-woven fabric composed of a melt moldable fluororesin in the form of a continuous fiber, wherein a number of intersecting points of the continuous fiber are fused and/or bonded, and wherein the unreinforced outer layer includes an outer ion exchange resin, which may be the same as or different from the inner ion exchange resin. Also provided is a membrane electrode assembly for a polymer electrolyte fuel cell, wherein the membrane electrode assembly contains the above-mentioned polymer electrolyte membrane.
US08268895B2 Perfuming ingredients of the floral and/or anis type
The present invention concerns the use as perfuming ingredient, for instance to impart odor notes of the floral and/or green type, of a compound of formula 5 wherein R is an ortho, meta or para substituent of the phenyl, and represents a hydrogen atom or a C 1-2 alkyl or alkoxyl group; R 1 represents a hydrogen atom or a methyl or ethyl group; 10 R 2 represents a hydrogen atom or a C 1-3 alkyl group; and X represents a CHO, COOR 3, CH(OR 4) 2 or CN group, R 3 being a methyl or ethyl group, and R 4, taken seperately, being a methyl or ethyl group, or said R 4, taken together, a C 2-5 alkanediyl group; and at least one of said R, R 1 or R 2 represents a group containing at least one carbon atom.
US08268894B2 Compositions and methods for the treatment of infectious diseases
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
US08268893B2 Use of dapsone as a neuroprotector in cerebral infarction
The use of dapsone is the first effective treatment against the disabling consequences associated with cerebral infarction in patients. Dapsone was evaluated as a neuroprotector in the cerebral infarction model produced by the occlusion of the middle cerebral artery in rats and in patients suffering from acute cerebral infarction caused by thromboembolism. In both studies, dapsone displayed a reduction of between 70 and 90% in the adverse effects which occur as a consequence of the infarction.
US08268891B1 Autotaxin inhibitors
Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include thioureas, diphenyldiazerenes, xanthenes, and isoindoles and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.
US08268890B2 Method of treating ischemia/reperfusion injury with nitroxyl donors
Nitroxyl donating compounds are administered prior to the onset of ischemia for the prevention and/or reduction of ischemia/reperfusion injury in subjects at risk for ischemia. Nitroxyl donors also are administered to organs to be transplanted for the prevention and/or reduction of ischemia/reperfusion injury upon reperfusion in a recipient. Nitroxyl donors include any nitroxyl donating compound. In particular cases the nitroxyl donor is a nitroxyl-donating diazeniumdiolate, such as Angeli's salt or IPA/NO.
US08268885B2 Entry inhibitors of the HIV virus
The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
US08268883B2 Organo-arsenoxide compounds and use thereof
The present invention relates to organo-arsenoxide compounds and to methods for their synthesis. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in the treatment of diseases and disorders, in particular proliferative diseases and disorders, including treatment of solid tumors and leukaemia.
US08268875B2 Use of anti-cytokine agents for treating carpal and tarsal tunnel syndrome
Methods for treating carpal tunnel syndrome and tarsal tunnel syndrome in a subject involve providing an effective amount of an anti-cytokine agent at or near inflammation in the carpal or tarsal tunnel. Anti-cytokine agents, such as, TNF-a inhibitors, NF-κB inhibitors, IL-1 inhibitors, IL-6 inhibitors, IL-8 inhibitors, IL-12 inhibitors, IL-15 inhibitors, IL-10, Interferon-gamma (IFN-gamma) act to prevent further inflammation initiated by cytokine factors. One embodiment includes, adding with the anti-cytokine agent one or more of an antibiotic or analgesic. Delivery of the anti-cytokine agent may be provided to the inflamed tissue of the carpal or tarsal tunnel by injection, implantation, or a transdermal patch. These agents, individually or in combination, directly address the underlying inflammation that causes the discomfort, pain, and restricted movement associated with carpal and tarsal tunnel syndrome.
US08268870B2 Aminotetrahydroindazoloacetic acids
The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
US08268869B2 Vinyl indazolyl compounds
The present invention provides vinyl indazolyl compounds useful in the treatment of cancer.
US08268862B2 Sirtuin modulating compounds
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
US08268861B2 P2X7R antagonists and their use
The present application is directed to novel P2X7R antagonists that are N-indol-3-yl-acetamide and N-azaindol-3-yl-acetamide compounds, pharmaceutical compositions comprising the same and their use for the prophylactic or therapeutic treatment of diseases mediated by P2X7R activity.
US08268858B2 Compounds and methods for kinase modulation, and indications therefor
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
US08268857B2 Compositions and methods for inhibiting TGF-β
This invention provides compounds that are useful for treating patients having a TGF-β-mediated disease, particularly an ALK5-mediated disease. The compounds are represented by formula I: wherein: a-b is CH2CH2, CH2CH2CH2, CH═CH, CH═N, or N═CH; Z is N or C—F; and G is C1-6 aliphatic or a phenyl, naphthyl, or 5-6 membered heteroaryl ring.
US08268853B2 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 positive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
US08268845B2 Tetrahydro- and dihydroquinazolinones
The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula I as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the manufacture of a pharmaceutical composition and new tetrahydro- and dihydroquinazolinones.
US08268844B2 Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-l-phenylalanine hydrochloride, production method thereof and use thereof
Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride: are useful as α4 integrin inhibitors.
US08268841B2 Phosphonoxy quinazoline derivatives and their pharmaceutical use
Quinazoline derivatives of formula (I): wherein A is 5-membered heteroaryl containing a nitrogen atom and one or two further nitrogen atoms; compositions containing them, processes for their preparation and their use in therapy.
US08268835B2 Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
US08268833B2 Inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
US08268829B2 Substituted pyrimidines useful as protein kinase inhibitors
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
US08268823B2 Medical use of triazine derivatives
Compounds of formula (I) especially where R1 is an optionally substituted alkyl, aralkyl or heterocyclyl-alkyl group, are shown to have activity as sodium channel blockers or as antifolates. Some novel compounds where R1 is an aralkyl or heterocyclyl-alkyl are disclosed.
US08268822B2 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
A heterocyclic inhibitor having the formula I, with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role:
US08268818B2 Inhibitors of C-MET and uses thereof
The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
US08268816B2 Compounds for modulating integrin CD11b/CD18
The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. For example, one such compound useful as an agonist of integrin CD11b/CD18 is the compound of Formula (I): Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.
US08268813B2 Zilpaterol enantiomer compositions and methods of making and using such compositions
This invention is directed generally to zilpaterol enantiomer compositions, and, in particular, to compositions comprising the 6R,7R zilpaterol enantiomer. This invention is also directed to processes for making such compositions; methods for using such compositions to, for example, increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and/or fish; and uses of such compositions to make medicaments. This invention is further directed to methods for determining the absolute configurations of zilpaterol enantiomers.
US08268810B2 Lipophilic chelates and their use in imaging
The invention relates to chelate compounds which can be used in MRI, the chelates being intended to be conveyed by lipophilic transporters, such as lipid nanoparticles or liposomes. The invention also relates to compounds comprising, in association, these chelates and these transporters, if appropriate connected via chemical bonding groups, and to their use in diagnostic imaging, it being possible for this association additionally to comprise biological targeting markers, denoted biovectors.
US08268808B2 Carrageenan and carrageenan-containing products
The present invention discloses a carrageenan composition comprising: sodium in the range of about 5.410 to about 8.230%, preferably about 6.300 to about 8.230%, and more preferably about 7.380 to about 8.230%; potassium in the range of about 0.023% to about 0.248%, preferably about 0.023 to about 0.238%, and more preferably about 0.023 to about 0.078%; calcium in the range of 0.046-0.553%, preferably 0.046-0.446%, and more preferably 0.046-0.325%; and magnesium in the range of about 0.051 to about 0.338%, preferably about 0.051 to about 0.244% and more preferably about 0.051 to about 0.127%; wherein the carrageenan product has a gelling temperature of 7-30° C., preferably 7-18° C., more preferably 7-12° C.; and a melting temperature in the range 16-38° C., preferably 16-28° C., more preferably 16-24° C.
US08268805B2 Use of ceramides for depigmenting the skin
The invention relates to the use, as agent for depigmenting and/or whitening the skin, in particular for eliminating pigmentary spots and/or senescence spots, and/or as anti-browning agents, of a compound of formula (I): R1—CHOH—CH(NH—COR2)(CH2OH)  (I) in which R1 denotes a C11 to C21 alkyl radical, and R2 denotes a linear, optionally hydroxylated C11-C19 hydrocarbon-based radical, with the hydroxyl group being in the alpha-position with respect to the carbonyl, which may comprise one or more ethylenic unsaturations, in particular one or two ethylenic unsaturations. The invention also relates to a cosmetic process for depigmenting and/or lightening skin exhibiting pigmentation spots, comprising the application to the skin of a composition comprising, in a physiologically acceptable medium, a compound of formula (I).
US08268803B2 5, 6-ring annulated indole derivatives and use thereof
The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
US08268801B2 Sulfoglycolipid antigens, their process of preparation, and their use against tuberculosis
The present invention relates to compounds of the following general formula (I) their process of preparation and their use in the treatment or the prophylaxis of tuberculosis.
US08268800B2 Certain compounds, compositions and methods
The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
US08268796B2 Lipophilic nucleic acid delivery vehicle and methods of use thereof
Provided herein are compositions and methods for delivery of nucleic acids to individuals and to cells, including nucleic acid delivery particles that comprising a lipid-binding polypeptide, a lipid bilayer comprising one or more cationic lipids, and a nucleic acid.
US08268795B2 Emergence of a R-type CA2+ channel (CAV 2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage
The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.
US08268788B2 Combination cancer immunotherapy with co-stimulatory molecules
Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective amount of a soluble form of a co-stimulatory molecule from an antigen presenting cell and by reducing the activity of immunoregulatory T cells in the individual. Methods of reduction in the activity of immunoregulatory T cells involve removing them ex vivo or depleting or inactivating them in vivo. Also provided are cancer therapeutic compositions comprising a soluble form of a co-stimulatory molecule from an antigen presenting cell and an antibody specific for an intracellular antigen.
US08268787B2 Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
US08268783B2 Antidotes for factor Xa inhibitors and methods of using the same
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
US08268781B2 Peptide derivatives of exendin-4
In the current invention peptides, which are derived from GLP-1 (glucagon-like peptide-1) and exendin-3 and/or exendin-4, are provided which bond to the GLP-receptor and can be used, labeled or unlabeled, for the production of an agent for diagnostic and therapy of benign and malignant diseases, in which GLP-1 receptor expression plays a role.
US08268778B2 Flavivirus NS5A proteins for the treatment of HIV
GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a -GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections.
US08268777B2 Oximyl macrocyclic derivatives
The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
US08268773B2 Methods of treating multiple sclerosis (MS) using an IL-17A and IL-17F antagonist
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.
US08268772B2 Depot preparations
The present invention relates to depot preparations for the targeted release of an aldehyde together with two carboxylic acids, where the released aldehydes are organoleptic substances, specifically fragrances or flavorings, and these depot preparations are prepared by reacting aldehydes with carboxylic anhydrides.
US08268768B2 Automatic dishwashing agent
The invention relates to a phosphate- and bleach-free automatic dishwashing agent containing: a) 5 to 60 wt % citrate, b) (hydrogen) carbonate, c) 2 to 40 wt % ethylenediamine disuccinic acid, wherein the weight ratio of the components b) and c) is between 1:5 and 10:1, and wherein said automatic dishwashing agent is characterized by good cleaning performance, particularly improved cleaning of tea.
US08268763B2 Enzymatic degradation of colorant in lens care solutions
The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention comprises a colored lens care solution including a colored protein and a proteolytic enzyme. The kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention relies upon a color change to indicate the completion of disinfection and cleaning of contact lenses.
US08268760B2 Method for reducing friction/wear of formulated lubricating oils by use of ionic liquids as anti-friction/anti-wear additives
The anti-wear and anti-friction performance of a lubricating oil is improved by the addition thereto of an additive amount of ionic liquids.
US08268759B2 Titanium compounds and complexes as additives in lubricants
A lubricating composition comprising an oil of lubricating viscosity, 1 to 1000 parts per million by weight of titanium in the form of an oil-soluble titanium-containing material, and at least one additional lubricant additive provides beneficial effects on properties such as deposit control, oxidation, and filterability in engine oils.
US08268757B2 Methods and compositions for enhancing guar hydration rates and performing guar derivitization reactions
Methods are provided that include, but are not limited to, methods of treating guar splits comprising: exposing guar splits to a treatment chemical to create treated guar splits, wherein the treatment chemical comprises at least one treatment chemical selected from the group consisting of: an aqueous salt solution; a caustic solution, and a derivatizing agent; and grinding the treated guar splits to create ground, treated guar splits.
US08268750B2 Combination of active substances with insecticidal properties
The invention relates to novel insecticidal active compound combinations comprising, firstly, compounds which act as insecticides on nicotinergic acetylcholine receptors as agonists and antagonists, and at least one active compound from the group of the anthranilamides, which combinations are suitable for protecting plants against attack by pests.
US08268749B2 Fast symptom glyphosate formulations
Aqueous herbicidal glyphosate compositions are provided, particularly sprayable, ready-to-use (RTU) formulations that are capable of inducing early visually apparent phytotoxic effects while minimizing antagonism to the glyphosate component of the composition and preserving the equally desirable attribute of prolonged control of the treated plants. The compositions combine a glyphosate component and a fatty acid component as a fast symptomology active ingredient and, in one embodiment, are enhanced by the concentration of the fatty acid component utilized and the inclusion of an agronomically acceptable inorganic ammonium salt, preferably ammonium sulfate. In another embodiment, the compositions of the present invention include a nonionic surfactant component comprising certain water-soluble, alkoxylated alcohols.
US08268745B2 Silicate-resistant desulfurization sorbent
A silicate-resistant sorbent composition, as well as a method of making and using the same, is provided. The sorbent composition generally comprises a support component comprising one or more silicate-resistant silica-containing components that have been treated one or more silicate-inhibiting metals. The inventors have discovered that sorbent compositions made and used according to embodiments the present invention exhibit a surprisingly low in situ silicate generation rate when exposed to oxidative regeneration conditions.
US08268744B2 High shear method for manufacturing a synthetic smectite mineral
A method of preparing a mercury sorbent material comprising making a copper/clay mixture by admixing a dry clay and a dry copper source; making a sulfur/clay mixture by admixing a dry clay and a dry sulfur source; admixing the copper/clay mixture and the sulfur/clay mixture, to form a mercury sorbent pre-mixture; and shearing the mercury sorbent pre-mixture to form the mercury sorbent material. The mercury sorbent material has an interlayer d(001)-spacing of less than 12 Å when the mercury sorbent material contains less than 4 wt % water, and a powder X-ray diffraction pattern of the mercury sorbent material is substantially free of a diffraction peak at 2.73±0.01 Å, and the ζ-potential of the mercury sorbent material is greater than the ζ-potential of the dry clay.
US08268741B2 Low solar absorbing blue glass, solar reflecting coated blue glass, and insulating unit having a low solar heat gain
An insulating unit having a neutral grey color and a solar heat gain coefficient less than 0.40 includes a clear glass sheet spaced from a coated glass sheet. The coated glass sheet includes a colored glass substrate having a solar infrared reflective coating. The composition of the coated substrate includes a base glass portion and a glass colorant portion, the glass colorant portion including total iron in the range of 0.04 to less than 0.28 weight percent; CoO in the range of 32 to 90 parts per million, and Se in the range of greater than 0 to less than 5.5 parts per million. In one non-limiting embodiment of the invention the glass substrate at a thickness of 0.223 inches has a* chromaticity coordinates of −3.5 to +2.5 and b* chromaticity coordinates of −1 to −15, and a visible light transmittance of 40 to 80%.
US08268737B1 Facer and construction materials made therewith
Electron beam curable resins or ultraviolet light curable resins can be used in combination with filler and other additives to make coated facers that can be used on insulation boards. Also disclosed are facers made of such composition, the process for making said facers and their use in insulation, building and construction boards. More specifically a flexible facer can be made by a process that comprises (1) applying a monomeric composition to a fiber mat, wherein the fiber mat is a non-asphaltic, non-cellulosic fiber mat, and wherein the monomeric composition is comprised of at least one monomer and/or at least one oligomer, and a filler, (2) initiating polymerization of the monomer within the monomeric composition by exposing the monomeric composition to ultraviolet light or an electron beam, and (3) allowing the monomer to polymerized to produce the flexible facer.
US08268735B2 Semiconductor device manufacturing method and method for reducing microroughness of semiconductor surface
Surface treatment is performed with a liquid, while shielding a semiconductor surface from light. When the method is employed for surface treatment in wet processes such as cleaning, etching and development of the semiconductor surface, increase of surface microroughness can be reduced. Thus, electrical characteristics and yield of the semiconductor device are improved.
US08268732B2 Methods of utilizing block copolymers to form patterns
Some embodiments include methods of forming patterns utilizing copolymer. A copolymer composition is formed across a substrate. The composition includes subunits A and B, and will be self-assembled to form core structures spaced center-to-center by a distance of L0. The core structures are contained within a repeating pattern of polygonal unit cells. Distances from the core structures to various locations of the unit cells are calculated to determine desired distributions of subunit lengths.
US08268729B2 Smooth and vertical semiconductor fin structure
A method for processing a semiconductor fin structure is disclosed. The method includes thermal annealing a fin structure in an ambient containing an isotope of hydrogen. Following the thermal annealing step, the fin structure is etched in a crystal-orientation dependent, self-limiting, manner. The crystal-orientation dependent etch may be selected to be an aqueous solution containing ammonium hydroxide (NH4OH). The completed fin structure has smooth sidewalls and a uniform thickness profile. The fin structure sidewalls are {110} planes.
US08268727B2 Methods for fabricating FinFET semiconductor devices using planarized spacers
Methods of fabricating a semiconductor device on and in a semiconductor substrate are provided. In accordance with an exemplary embodiment of the invention, one method comprises forming a sacrificial mandrel overlying the substrate, wherein the sacrificial mandrel has sidewalls. Sidewall spacers are formed adjacent the sidewalls of the sacrificial mandrel, the sidewall spacers having an upper portion and a lower portion. The upper portion of the sidewall spacers is removed. The sacrificial mandrel is removed and the semiconductor substrate is etched using the lower portion of the sidewall spacers as an etch mask.
US08268726B2 Method for fabricating semiconductor device
A method for fabricating a semiconductor device includes forming a plurality of plugs over a die region and an edge bead removal (EBR) region of a wafer, forming metal lines coupled to the plugs, removing the metal lines in the EBR region, forming an inter-layer dielectric layer over the wafer, and forming a plurality of contact holes that expose the metal lines by selectively etching the inter-layer dielectric layer through a dry etch process using a plasma etch device.
US08268724B2 Alternative to desmear for build-up roughening and copper adhesion promotion
In some embodiments, an alternative to desmear for build-up roughening and copper adhesion promotion is presented. In this regard, a substrate in introduced having a dielectric layer, a plurality of polyelectrolyte multilayers on the dielectric layer, and a copper plating layer on the polyelectrolyte multilayers. Other embodiments are also disclosed and claimed.
US08268721B2 Semiconductor device and semiconductor device manufacturing method
There are provided a semiconductor device and a semiconductor device manufacturing method capable of preventing electrical leakage while suppressing increase of wiring resistance and deterioration of productivity. The semiconductor device manufacturing method for forming on a substrate a semiconductor device having a porous low-k film serving as an interlayer insulating film. Further, the semiconductor device manufacturing method includes forming the low-k film on the substrate; etching the low-k film to form a trench or a hole therein; reforming a surface of the low-k film exposed by etching the low-k film by allowing plasma of a nitro compound to act on the exposed surface within the trench or the hole; and filling the trench or the hole with a conductor.
US08268717B2 Manufacturing method of bump structure with annular support
A manufacturing method of a bump structure with an annular support includes the following steps. A substrate including pads and a passivation layer is provided. The passivation has first openings exposing a portion of the pads. An UBM material layer is formed to cover the passivation layer and the pads. A patterned photoresist layer, having second openings respectively exposing the UBM material layer over the pads, is formed on the UBM material layer. A diameter of each second opening located on a lower surface of the patterned photoresist layer is less than that located on an upper surface of the patterned photoresist layer. Bumps are formed in the second openings. A portion of the patterned photoresist layer is removed to form an annular support at a periphery of each bump. The UBM material layer is patterned using the annular supports and the bumps as masks to form UBM layers.
US08268708B2 Epitaxially coated silicon wafer and method for producing epitaxially coated silicon wafers
Silicon wafers polished on their front sides are individually placed on a susceptor in an epitaxy reactor and firstly pretreated under a hydrogen atmosphere, and secondly with addition of an etching medium with a flow rate of 1.5-5 slm to the hydrogen atmosphere, the hydrogen flow rate being 1-100 slm in both steps, and subsequently epitaxially coated on the polished front side, and then removed from the reactor. In a second method, gas flows introduced into the reactor by injectors are distributed into outer and inner zones of the chamber, such that the inner zone gas flow acts on a wafer central region and the outer zone gas flow acts on a wafer edge region, the inner/outer distribution of the etching medium I/O=0-0.75. Silicon wafers having an epitaxial layer having global flatness value GBIR of 0.02-0.06 μm, relative to an edge exclusion of 2 mm are produced.
US08268701B2 Manufacturing of semiconductor device
Instead of forming a semiconductor film by bonding a bond substrate (semiconductor substrate) to a base substrate (supporting substrate) and then separating or cleaving the bond substrate, a bond substrate is separated or cleaved at a plurality of positions to form a plurality of first semiconductor films (mother islands), and then the plurality of first semiconductor films are bonded to a base substrate. Subsequently, the plurality of first semiconductor films each are partially etched, whereby one or more second semiconductor films (islands) are formed using one of the first semiconductor films and a semiconductor element is manufactured using the second semiconductor films. The plurality of first semiconductor films are bonded to the base substrate based on a layout of the second semiconductor films so as to cover at least a region in which the second semiconductor films of the semiconductor element are to be formed.
US08268699B2 Wafer structures and wafer bonding methods
Wafer structures and wafer bonding methods are provided. In some embodiments, a wafer bonding method includes providing a conductive wafer and a plurality of insulating wafers, the conductive wafer being larger than the insulating wafers; performing a pre-treatment operation on the conductive wafer, the insulating wafers, or both; and directly bonding the insulating wafers to the conductive wafer.
US08268697B2 Silicon-on-insulator devices with buried depletion shield layer
A silicon-on-insulator device with a with buried depletion shield layer.
US08268694B2 Method of manufacturing a transistor and method of manufacturing a semiconductor device
In a method of manufacturing a transistor, a gate structure is formed on a substrate. First impurities are implanted into the substrate to form an impurity region at an upper portion of the substrate adjacent to the gate structure. An epitaxial layer is formed on the impurity region. An insulation layer having an opening partially exposing the epitaxial layer is formed on the substrate. Second impurities are implanted into a portion of the epitaxial layer exposed by the opening.
US08268693B2 Method for fabricating a radiation hardened device
A “tabbed” MOS device provides radiation hardness while supporting reduced gate width requirements. The “tabbed” MOS device also utilizes a body tie ring, which reduces field threshold leakage. In one implementation the “tabbed” MOS device is designed such that a width of the tab is based on at least a channel length of the MOS device such that a radiation-induced parasitic conduction path between the source and drain region of the device has a resistance that is higher than the device channel resistance.
US08268690B2 Methods of forming semiconductor devices having recessed channels
A semiconductor device includes a substrate, a gate insulation layer, a gate structure, a gate spacer, and first and second impurity regions. The substrate has an active region defined by an isolation layer. The active region has a gate trench thereon. The gate insulation layer is formed on an inner wall of the gate trench. The gate structure is formed on the gate insulation layer to fill the gate trench. The gate structure has a width smaller than that of the gate trench, and has a recess at a first portion thereof. The gate spacer is formed on sidewalls of the gate structure. The first and second impurity regions are formed at upper portions of the active region adjacent to the gate structure. The first impurity region is closer to the recess than the second impurity region. Related methods are also provided.
US08268689B2 Multiple threshold voltages in field effect transistor devices
A method for fabricating a field effect transistor device includes forming a first conducting channel and a second conducting channel, forming a first gate stack on the first conducting channel to partially define a first device, forming second gate stack on the second conducting channel to partially define a second device, implanting ions to form a source region and a drain region connected to the first conducting channel and the second conducting channel, forming a masking layer over second device, a portion of the source region and a portion of the drain region, performing a first annealing process operative to change a threshold voltage of the first device, removing a portion of the masking layer to expose the second device, and performing a second annealing process operative to change the threshold voltage of the first device and a threshold voltage of the second device.
US08268686B2 Nonvolatile semiconductor memory device with twin-well
A nonvolatile semiconductor memory device includes a first well of a first conductivity type, which is formed in a semiconductor substrate of the first conductivity type, a plurality of memory cell transistors that are formed in the first well, a second well of a second conductivity type, which includes a first part that surrounds a side region of the first well and a second part that surrounds a lower region of the first well, and electrically isolates the first well from the semiconductor substrate, and a third well of the second conductivity type, which is formed in the semiconductor substrate. The third well has a less depth than the second part of the second well.
US08268685B2 NAND flash memory device and method of manufacturing the same
A NAND flash memory device and method of manufacturing the same is disclosed. Source and drain select transistor gates are recessed lower than an active region of a semiconductor substrate. A valid channel length of the source and drain select transistor gates is longer than a channel length of memory cell gates. Accordingly, an electric field between a source region and a drain region of the select transistor can be reduced. It is thus possible to prevent program disturbance from occurring in edge memory cells adjacent to the source and drain select transistors in non-selected cell strings.
US08268684B2 Method and apparatus for trench and via profile modification
Embodiments of the present invention generally relates to an apparatus and a method for processing semiconductor substrates. Particularly, embodiments of the present invention relates to methods and apparatus for profile modification prior to filling a structure, such as a trench or a via. One embodiment of the present invention comprises forming a sacrifice layer to pinch off a top opening of a structure by exposing the structure to an etchant. In one embodiment, the etchant is configured to remove the first material by reacting with the first material and generating a by-product, which forms the sacrifice layer.
US08268680B2 Transistor of semiconductor device and method of fabricating the same
A method of fabricating a transistor of a semiconductor device comprises: forming a gate in a NMOS region and a PMOS region of a semiconductor substrate; forming a gate spacer on a sidewall of the gate; performing an ion implantation process on the NMOS region to form a junction region in the NMOS region; depositing an oxide film on the entire surface of the semiconductor substrate including the gate; removing hydrogen (H) existing in the oxide film and the gate spacer; and removing the oxide film in the PMOS region and performing a ion implantation process on the PMOS region to form a junction region in the PMOS region.
US08268677B1 Semiconductor device and method of forming shielding layer over semiconductor die mounted to TSV interposer
A semiconductor device has a plurality of conductive vias formed partially through a substrate. A conductive layer is formed over the substrate and electrically connected to the conductive vias. A semiconductor die is mounted over the substrate. An encapsulant is deposited over the semiconductor die and substrate. A trench is formed through the encapsulant around the semiconductor die. A shielding layer is formed over the encapsulant. The trench is formed partially through the substrate and the shielding layer is formed in the trench partially through the substrate. An insulating layer can be formed in the trench prior to forming the shielding layer. A portion of the substrate is removed to expose the conductive vias. An interconnect structure is formed over the substrate opposite the semiconductor die. The interconnect structure is electrically connected to the conductive vias. The shielding layer is electrically connected to the interconnect structure.
US08268674B2 Semiconductor device and method for manufacturing the same
A semiconductor device includes a semiconductor constituent provided with a semiconductor substrate and a plurality of electrodes for external connection provided under the semiconductor substrate. A lower-layer insulating film is provided under and around the semiconductor constituent. A plurality of lower-layer wirings are electrically connected to the electrodes for external connection of the semiconductor constituent, and provided under the lower-layer insulating film. An insulation layer is provided on the lower-layer insulating film in the periphery of the semiconductor constituent. An upper-layer insulating film is provided on the semiconductor constituent and the Insulation layer. A plurality of upper-layer wirings are provided on the upper-layer insulating film. A base plate on which the semiconductor constituent and the insulation layer are mounted is removed.
US08268672B2 Method of assembly and assembly thus made
An assembly (100) is provided comprising a first chip (20) and a second chip (30) which are interconnected through solder connections. These comprise, at the first chip, an underbump metallization and a solder bump, and, at the second chip, a metallization. In this case the solder bump is provided as a fluid layer with a contact angle of less than 90° C., and an intermetallic compound is formed on the basis of the metallization at the second chip, and at least one element of the composition is applied as the solder bump.
US08268670B2 Method of semiconductor device protection
A method for protecting a semiconductor device is disclosed that can improve reliability of a performance test for the semiconductor device and prevent damage to the semiconductor device during transportation or packaging for shipment. An IC cover is attached to the semiconductor device, which has height unevenness because it includes semiconductor chips and electric parts having different heights. The IC cover includes projecting portions and a base portion. After being attached to the semiconductor device, the projecting portions stand in a free area in the semiconductor device, and the base portion is supported by the projections to be separated from the semiconductor chips and electric parts in the semiconductor device. The IC cover is detachably attached to the semiconductor device.
US08268668B1 Destructor integrated circuit chip, interposer electronic device and methods
A method of fabricating an electronic circuit including forming a first depression on a first surface of a first wafer and forming a second depression on the first surface of the first wafer. The second depression is adjacent the first depression and separated from the first depression by a wall. The method further includes locating an actuator on the wall and attaching a first surface of a second wafer to the first surface of the first wafer to cover the first and second depressions. A first portion of the second wafer and the first depression define a first reservoir to contain a first chemical, and a second portion of the second wafer and the second depression define a second reservoir to contain a second chemical.
US08268666B2 Field-effect transistor and method for fabricating field-effect transistor
A method for fabricating a field-effect transistor having a gate electrode, a source electrode, a drain electrode, and an active layer forming a channel region, the active layer having an oxide semiconductor mainly containing magnesium and indium is disclosed. The method includes a deposition step of depositing an oxide film, a patterning step of patterning the oxide film by processes including etching to obtain the active layer, and a heat-treatment step of heat-treating the obtained active layer subsequent to the patterning step.
US08268662B2 Fabricating method of complementary metal-oxide-semiconductor (CMOS) image sensor
A method of fabricating a complementary metal-oxide-semiconductor (CMOS) image sensor is provided. First, an isolation structure is formed in a substrate with a photo-sensitive region and a transistor device region in the substrate. The transistor device region includes at least a region for forming a transfer transistor. A dielectric layer and a conductive layer are sequentially formed on the substrate. An ion implantation process is performed to implant a dopant into the substrate below the position for forming a gate of the transfer transistor and in the photo-sensitive region through the conductive layer and the dielectric layer. The conductive layer and the dielectric layer are patterned to at least form the gate structure of the transfer transistor on the transistor device region. Thereafter, a photo diode is formed in the substrate in the photo-sensitive region.
US08268661B2 Sealing laminated sheet for electronic device and electronic device production method using same
The present invention is a sealing laminated sheet for an electronic device in which a first sheet and a second sheet 5 are laminated, wherein the first sheet contains an acid-modified polyolefin-based thermoplastic resin, the second sheet 5 has a melting point higher than that of the first sheet, and a peel strength at 25° C. of the second sheet 5 relative to the first sheet is 0.5 to 10.0 N/15 mm. According to the present invention, the production yield of an electronic device can be improved.
US08268648B2 Silicon based solid state lighting
A semiconductor device includes a substrate comprising a first surface having a [111] orientation and a second surface having a second orientation and a plurality of III-V compound layers on the substrate, wherein the plurality of III-V compound layers are configured to emit light when an electric current is produced in one or more of the plurality of III-V compound layers.
US08268644B2 Light emitting device, and method and apparatus for manufacturing same
A method for manufacturing a light emitting device includes: measuring at least one of each wavelength of the emitted light of the light emitting element, each optical output of the emitted light of the light emitting element, and each chromaticity of the mixed light emitted through the mixed resin in a manufacturing process of the light emitting device; and adjusting chromaticity for each light emitting device by performing a prescribed chromaticity adjustment with regard to the mixed resin, on basis of a result obtained in the measuring, so that the chromaticity of the mixed light falls within a preset prescribed range.
US08268643B2 Substrate, epitaxial layer provided substrate, method for producing substrate, and method for producing epitaxial layer provided substrate
The present invention provides a substrate formed at a low cost and having a controlled plate shape, an epitaxial layer provided substrate obtained by forming an epitaxial layer on the substrate, and methods for producing them. The method for producing the substrate according to the present invention includes an ingot growing step serving as a step of preparing an ingot formed of gallium nitride (GaN); and a slicing step serving as a step of obtaining a substrate formed of gallium nitride, by slicing the ingot. In the slicing step, the substrate thus obtained by the slicing has a main surface with an arithmetic mean roughness Ra of not less than 0.05 μm and not more than 1 μm on a line of 10 mm.
US08268642B2 Method for removing electricity and method for manufacturing semiconductor device
An object is to suppress a significant change in electrical characteristics of thin film transistors and a deviation thereof from the designed range due to static electricity, and to improve the yield in manufacturing semiconductor devices. In order to prevent a substrate from being charged with static electricity by heat treatment or to favorably reduce static electricity with which a substrate is charged in a manufacturing process of a semiconductor device, heat treatment is performed with a substrate provided with a thin film transistor stored in a conductive container. In addition, a heating apparatus for performing the heat treatment is electrically connected to a ground potential, and the container and the substrate are also electrically connected to the ground potential.
US08268639B2 Diagnostic kit for detecting urinary protein of a cat after cauxin removal
A method for diagnosing a kidney disease in a cat by detecting a cat urinary protein without being affected by cauxin, and a diagnostic agent therefor are provided. A method of detecting a urinary protein derived from renal dysfunction in a cat according to claim 1, wherein cauxin is removed from cat urine by bringing the cat urine into contact with a lectin or an anti-cauxin antibody that specifically binds to cauxin.
US08268630B2 Differential preconcentrator-based chemical sensor stabilization
Sensor devices and sensing methods are provided. A sensor device is provided two flow channels, each comprising a sensor, and analyte flow is alternated between the two channels such that the sensors alternately serve as a sensor and a reference, thereby increasing accuracy of the sensors. The device is useful, for example, in chemical sensing using a variety of sensor types including without limitation: chemiresistors, gravimetric sensors, optical sensors, among others. Related sensing methods also are provided.
US08268628B1 Method for determination of protein, peptide or peptoid aggregation, stability, and viability and system using the same
The invention describes a method for determining aggregation in protein, peptide or peptoid formulation, without the use of probes or additives. The method uses FTIR spectroscopy combined with the two-dimensional correlation analysis (2DCOS) which allows for the determination of the presence of aggregates, the determination of the mechanism of aggregation, allowing for correction in the pipeline manufacturing process of the protein to once again generate viable protein. In addition, the thermal transition of the protein can also be determined and a 2DCOS plot generated to compare with the established viable protein, allowing for quality control, stability and viability of the desired protein product. The ease of sample preparation and data analysis allows for the automation of this method.
US08268626B2 Method for analyzing of lipoproteins
A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.
US08268623B2 Method of marking a product, marked product resulting thereof, and method of identifying same
A method and means for identifying the authenticity and the genuine nature of a solid or liquid bulk material, by incorporating a marking composition containing at least one trace ion into the said bulk material, whereby the total concentration of the incorporated trace ions in the market bulk material is chosen to be lower than the corresponding concentration of the same ions in standard sea water. The authenticity and the genuine nature or the adulteration level of the marked bulk material can be tested in-the-field using electrochemical sensors, and confirmed in the laboratory using a method such as atomic absorption spectroscopy, ion chromatography or mass spectrometry.
US08268621B2 Methods of deriving definitive endoderm cells from pluripotent parthenogenetic stem cells
The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.
US08268620B2 OCT4 and SOX2 with SV40 T antigen produce pluripotent stem cells from primate somatic cells
Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed.
US08268618B2 Repressing endogenous CCR5 gene expression in cells using engineered zinc finger proteins
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
US08268616B2 Method for tracing gram-negative bacteria inside animal model using stable and bioluminescence-based expression system therefor
A method of creating a biotechnological product and an efficient and stable bio-luminescence vector which could be used for tracking Gram-negative bacteria when distributing inside animal body are provided. Through conjugation, this auto-luminescence vector can be easily transmitted from bacteria to bacteria among Gram-negative bacteria, and may facilitate bacteria to be luminescence-labeled for subsequently analyzing the dynamic change of bio-luminescent bacteria within animal body in vivo. This system includes a lacZ promoter-driven luxABCDE, a high copy number of ColE1 replicon, and a high plasmid stability of the conjugative and broad host-ranged plasmid pSE34 from Salmonella enterica serovar Enteritidis Sal550. This resulting construct pSE-Lux1 can not only conjugatively transmit among bacteria with broad host range, but also stably maintain in bacteria to efficiently express the bio-luminescent luxABCDE without supplementing the subtract for luciferases and the antibiotics for plasmid selection.
US08268612B2 Apparatus and method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
US08268607B2 Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
A non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway includes at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme or protein expressed in a sufficient amount to produce 1,3-BDO. A method for producing 1,3-BDO that includes culturing the this non-naturally occurring microbial organism under conditions and for a sufficient period of time to produce 1,3-BDO.
US08268603B2 Apparatus and method for cell disruption
An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
US08268596B2 Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
The present invention is directed to nucleic acids encoding glycosyltransferases, the proteins encoded thereby, and to methods for synthesizing oligosaccharides using the glycosyltransferases of the invention. In particular, the present application is directed to identification a glycosyltransferase locus of Neisseria gonorrhoeae containing five open reading frames for five different glycosyltransferases. The functionally active glycosyltransferases of the invention are characterized by catalyzing reactions such as adding Gal β1→4 to GlcNAc or Glc; adding GalNAc or GlcNAc β1→3 to Gal; and adding Gal αl→4 to Gal. The glycosyltransferases of the invention are particularly suited to the synthesis of the oligosaccharides Galβ1→4GlcNAcβ1→3Galβ1→4Glc (a mimic of lacto-N-neotetraose), GalNAcβ1→3Galβ1→4GlcNAcβ1→3Galβ1→4Glcβ1→4 (a mimic ganglioside), and Galα1→4Galβ1→4Glcβ1→4Hep→R (a mimic of the saccharide portion of globo-glycolipids).
US08268591B2 Compositions and methods for producing inhibitors of vascular endothelial growth factor activity
The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
US08268588B2 Methods and compositions for the prevention and treatment of anemia
Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
US08268586B2 Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells
The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to a polynucleotide sequence encoding the polypeptide and a modified mRNA processing/stabilizing sequence located downstream of the promoter region and upstream of the ribosome binding site of the polynucleotide sequence encoding the polypeptide, wherein the modified mRNA processing/stabilizing sequence promotes higher expression of the polynucleotide sequence compared to an unmodified mRNA processing/stabilizing sequence; and (b) isolating the polypeptide having biological activity from the cultivation medium. The present invention also relates to such modified mRNA processing/stabilizing sequences, nucleic acid constructs, and bacterial host cells and to methods of obtaining such bacterial host cells.
US08268585B2 Transformation system in the field of filamentous fungal hosts
A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.
US08268583B2 Cell with improved secretion mediated by MrgA protein or homologue
A progeny cell derived from a parent cell, wherein the progeny cell comprises at least one gene encoding MrgA protein or a functional homologue thereof and/or a DNA segment operably linked with the encoding gene, wherein said gene and/or DNA segment is manipulated with respect to the parent cell; the progeny cell comprises two or more copies of a gene encoding MrgA protein or a functional homologue thereof; or the progeny cell is mutated with respect to the parent cell; whereby the progeny cell produces greater amounts of MrgA protein or a functional homologue thereof than the parent cell.
US08268581B2 Carboxy terminal residues as predictors and regulators of protein stability
Compositions and methods are provided that are useful for predicting and controlling the stability of expressed polypeptides. The compositions and methods may be used to predict and as desired, increase or decrease the stability of proteins recombinantly expressed in mycobacteria, for example DesA3 expressed in Mycobacterium smegmatis. At the C terminus and the penultimate position, substitution to residues with charged side chains, large non-polar side chains, or no side chains can be used to reduce or inhibit the protein degradation. At the antepenultimate position from the C terminus, residues with no side chain or acidic side chains can increase the stability, i.e. reduce or inhibit the protein degradation. The combinational substitution of only the last three residues of polypeptides can make the polypeptides more stable during heterologous expression in mycobacterial hosts.
US08268580B2 Medium for detecting the presence or absence of pathogenic staphylococci
A test mixture for detecting the presence or absence of pathogenic staphylococci (“p.staphylococci”) directly in a first generation specimen test sample, the test mixture comprising: an effective amount of amino acids, an effective amount of nitrogen sources, an effective amount of salts, an effective amount of vitamins, an effective amount of calcium, and an effective amount of coagulase substrates, which coagulase substrates include fibrinogen, which will create a clot within a liquid medium containing the test mixture and the first generational specimen test sample at temperatures in the range of about 20° C. to about 42° C. in the presence of p.staphylococci in the first generation specimen test sample.
US08268570B2 Restricted access media and methods for making restricted access media
The present invention is directed to restricted access media (RAM), methods for preparing restricted access media, and kits for preparing restricted access media that contain protected ligand binding agents or protected enzymes. Certain RAM provided contain a plurality of protected regions of the support that contain ligand binding agents that are protected by blocking agents. Certain RAM provided contain a plurality of protected regions of the support that contain unbound ligand binding agents or enzymes that are retained in the protected regions by a capping agent. Methods of making the RAM of the invention and associated kits are also provided.
US08268569B2 Recombinant 15-kDa polypeptide and use of same in detecting human infection with Bartonella henselae
Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
US08268568B2 Methods and compositions for categorizing patients
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.
US08268567B2 Reaction sensing in living cells
Chemical reactions occurring within a living cell are measured in a manner that does not affect the viability of the cell or the reaction under study. In one embodiment, one or more sensors are introduced into the cell and/or covalently associated with the exterior cell membrane. The sensor(s) emit an observable signal indicating a value of a parameter associated with the chemical reaction, e.g., the concentration of a reaction product. Because cell viability is not compromised, the cell may be stimulated (e.g., by subjection to an agonist or antagonist, a pathogen, a pharmaceutical compound, or a potential toxin) so as to affect the reaction under study.
US08268565B2 Methods for identifying bioagents
The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
US08268561B2 Methods for screening for genetic predisposition to type I diabetes
A method of genetically screening large numbers of individuals to identify those individuals requiring follow-up testing for active Type I diabetes (T1D) is provided. The method includes obtaining a nucleic-acid containing biological sample from each individual and testing for the presence of specific combinations of HLA II alleles in the sample.
US08268557B2 Method of detecting equine polysaccharide storage myopathy
The present invention relates to diagnosing Polysaccharide Storage Myopathy (PSSM) disease in equines.
US08268551B2 Sensitive sensing based on optical nonlinear wave mixing
Techniques and systems for using nonlinear four wave mixing to optically measure microarrays with sample cells of biological or chemical materials. Examples of suitable microarrays include but are not limited to DNA microchips and capillary electrophoresis microarrays.
US08268544B2 Stamp for patterning, method for manufacturing such stamp and method for manufacturing an object using the stamp
A stamp for patterning onto a receiving surface of an object (101) according to a defined pattern (P) comprises a stamping surface (21) of a resilient diaphragm (20). The stamping surface is planar at rest. The pattern is reproduced on the stamping surface and the diaphragm is affixed to a rigid body (13) along a peripheral edge, so that a middle part of the diaphragm can move along a direction perpendicular to the stamping surface. The diaphragm (20) is more flexible near the peripheral edge than in the middle part. Then, the pattern (P) printed on a pseudo-spherical receiving surface (103) using the stamp exhibits few distortion.
US08268541B2 Mask and blank storage inner gas
The present disclosure provides a lithography apparatus. The lithography apparatus includes a radiation source providing a radiation energy with a wavelength selected from the group consisting of 193 nm, 248 nm, and 365 nm; a lens system configured approximate to the radiation source; a mask chamber proximate to the lens system, configured to hold a mask and operable to provide a single atom gas to the mask chamber; and a substrate stage configured to hold a substrate and receive the radiation energy through the lens system and the mask during an exposing process.
US08268540B2 Method of manufacturing light receiving device
A method of manufacturing a light receiving device 1 includes: providing a resin layer 14 containing a photo curing resin on a transparent substrate 13 where a plurality of transparent substrate portions 13A are integrated so that the resin layer covers the transparent substrate 13; selectively irradiating the resin layer 14 with light, followed by a developing process, so that the resin layer 14 remains in regions of the transparent substrate 13 which surround portions corresponding to regions facing light receiving portions 11 in the transparent substrate portions 13A; dividing the transparent substrate 13 into units of transparent substrate portions 13A so that a plurality of transparent substrate portions 13A are obtained; dividing the base substrate 12 into units of base substrate portions 12A so that a plurality of base substrate portions 12A are obtained; and joining the base substrate portions 12A and the transparent substrate portions 13A via the resin layer 14.
US08268539B2 Method of manufacturing liquid ejection head
A method of manufacturing a liquid ejection head includes: exposing a negative organic resin layer to be a flow path forming member except for regions in which an ejection orifice and a fluid resistance portion are to be formed, respectively, and heating the negative organic resin layer and a flow path pattern to move a portion of the negative organic resin layer which corresponds to the fluid resistance portion toward a substrate; and exposing and developing the region of the negative organic resin layer in which the fluid resistance portion is to be formed.
US08268537B2 Method for manufacturing printed circuit board
A printed circuit board substrate includes a metal-clad substrate and a number of N spaced circuit substrates arranged on the metal-clad substrate along an imaginary circle, N is a natural number greater than 2. The circuit substrates are equiangularly arranged about the center of the circle, and each of the circuit substrates is oriented 360/N degrees with respect to a neighboring printed circuit board.
US08268536B2 Electrode formation based on photo-induced reduction of metal ions in the presence of metal nanomaterials
Systems and methods of forming an electrode on a substrate are disclosed. The methods can include applying a solution including metal ions and metal nanomaterials to a surface of a substrate. The methods further can include exposing a selected portion of the solution with light having a wavelength capable of inducing reduction of the metal ions, wherein the selected portion corresponds to at least a portion of the electrode.
US08268533B2 Flexographic printing forme precursor for laser engraving
A method of making a flexographic printing form precursor for laser engraving including the steps of (i) providing at least one layer of a curable composition on a substrate; (ii) curing the at least one layer; wherein the curable composition defining an outermost layer includes at least 0.5% by weight relative to the total weight of the composition of an organo-silicon compound including at least one polymerizable group; and a urethane (meth)acrylate oligomer having three or less polymerizable groups.
US08268532B2 Method for forming microscopic structures on a substrate
The invention relates to a method for forming microscopic structures. By scanning a focused particle beam over a substrate in the presence of a precursor fluid, a patterned seed layer is formed. By now growing this layer with Atomic Layer Deposition or Chemical Vapor Deposition, a high quality layer can be grown.An advantage of this method is that forming the seed layer takes relatively little time, as only a very thin layer needs to be deposited.
US08268528B2 Resist composition and patterning process
A resist composition is provided comprising (A) an additive polymer of acyl-protected hexafluoroalcohol structure, (B) a base polymer having a structure derived from lactone ring, hydroxyl group and/or maleic anhydride, the base polymer becoming soluble in alkaline developer under the action of acid, (C) a photoacid generator, and (D) an organic solvent. The additive polymer is transparent to radiation of wavelength up to 200 nm, and its properties can be tailored by a choice of the polymer structure.
US08268526B2 Toner, developer and image forming apparatus
The present invention relates to toner compositions containing: toner particles made of: binder resin; colorant; and a wax which is dispersed in the toner particles, where the toner composition satisfies relationship (2): B≦394−400A′ when 0.950
US08268524B2 Black toner and image forming method
A black toner includes: toner mother particles containing carbon black as a colorant and a binder resin, the toner mother particles being surface-modified with a polyalkyleneimine.
US08268523B2 Black color material and toner
A black color material includes a squarylium compound represented by the following formula (1); and a blue color material:
US08268517B2 Photolithographic method and mask devices utilized for multiple exposures in the field of a feature
A photolithographic mask set for creating a plurality of characters on a device includes a plurality of photolithographic masks, wherein each mask includes at least one mask character area and at least one mask character field area that surrounds said mask character area; wherein each said mask character field area has a radiation energy density transmission factor Tf that is greater than zero, and wherein each mask character area has a radiation energy density transmission factor Tc that is greater than zero, such that each mask character field area and each mask character area of each mask is not opaque.
US08268509B2 Hydrogen-permeable structure, method of manufacturing thereof and fuel cell using the same
A hydrogen-permeable structure is disclosed, which includes a hydrogen-permeable base in which a fluctuation range of a d value by X-ray analysis measurement is at most 0.05% in a region within 2 μm deep from a surface, and an oxide proton conductive film formed on a surface thereof. The disclosure also relates to a method of manufacturing the hydrogen-permeable structure and a fuel cell using the hydrogen-permeable structure.
US08268505B2 Fuel cell system
A fuel cell stack includes a stack body formed by stacking a plurality of power generation cells. At opposite ends of the stack body in a stacking direction, end plates are provided. A second power collecting terminal protrudes outwardly from the end plate. One end of a bus bar is electrically connected to the second power collecting terminal such that the bus bar extends along an end plate surface intersecting the second power collecting terminal. A high voltage cable is connected to the other end of the bus bar. The high voltage cable is drawn toward the end plate.
US08268501B2 Fuel cell system, control method therefor, and movable body
A fuel cell system has produced water amount detection means that detects the amount of water produced in the fuel cell during low-efficiency operation of the system and gas supply limitation means that limits the amount of gas to be supplied to the fuel cell, based on the detected amount of water. The produced water amount detection means allows the amount of produced water to be correctly determined during low-efficiency operation of the fuel cell, thereby enabling the appropriate warm-up, and inhibits a condition, in which the amount of produced water is too large and warm up operation is hindered, to be generated. As a result, the amount of water produced during low-efficiency operation of the fuel cell is correctly determined and the appropriate warm-up is enabled.
US08268497B2 Fuel cell with fuel-stoichiometric ratio control portion
A fuel cell system includes: a fuel cell stack including a plurality of fuel cells connected in series; a fuel supply portion supplying a fuel to each fuel cell; a current regulation portion regulating an electric current flowing from the fuel cell stack in such a way that an output voltage of the fuel cell stack is a predetermined set voltage; a voltage detection portion detecting an output voltage of each fuel cell; a fuel-supply control portion regulating a fuel supply to each fuel cell by the fuel supply portion in such a way that the difference decreases between an output voltage of each fuel cell detected by the voltage detection portion; a fuel-stoichiometric ratio detection portion detecting a fuel stoichiometric ratio of the fuel cell stack; and a fuel-stoichiometric ratio control portion regulating the set voltage in such a way that a fuel stoichiometric ratio detected by the fuel-stoichiometric ratio detection portion is a target fuel stoichiometric ratio set in advance.
US08268496B2 Fuel cell system and control method thereof
An object of the present invention is to provide a fuel cell system capable of starting below freezing point without increasing the size of the diluter. The fuel cell system 1 comprises an OCV purge execution unit 42 replacing gas retained in a fuel cell 10 by supplying additional anode gas from a supply device 20 to the fuel cell 10 when starting up the fuel cell. In addition, the fuel cell system 1 comprises a low temperature startup determination unit 41 determining whether to perform low temperature startup or normal startup on the fuel cell 10. The OCV purge execution unit 42 decreases the pressure of additional anode gas supplied from the supply device 20 and increases the total replacing amount of gas retained in the fuel cell 10 in a case of performing low temperature startup, as compared with a case of performing normal startup.
US08268492B2 Fuel cell stack features for improved water management
An electric insulator for a fuel cell stack with a plurality of fuel cell plates is provided. The electric insulator includes an insulation layer having a water management feature adapted to militate against liquid water contacting the fuel cell plates. Fuel cell stacks having the water management feature are also described.
US08268491B1 Thermally integrated fuel cell system
A thermally integrated fuel cell system includes a stack zone, a burner zone and a low temperature zone. The fuel is combined with steam and passed sequentially through a primary reformer and a secondary reformer or a radiative fuel heat exchanger. Air may be passed sequentially through an afterburner heat exchanger and a radiative air heat exchanger such that the radiative heat exchanger may be used to heat the stack zone. The stack exhaust is combusted in an afterburner. Afterburner exhaust heats the primary reformer, the high temperature air heat exchanger, the low temperature air heat exchanger and steam generator. The stack zone includes the stacks, the secondary reformer and the radiative heat exchanger. The burner zone includes the afterburner which includes a start burner, the primary reformer and the high temperature air heat exchanger. The low temperature zone includes the low temperature air heat exchanger and a steam generator.
US08268489B2 Non-aqueous electrolyte solution for lithium secondary battery and lithium secondary battery comprising the same
Disclosed are a non-aqueous electrolyte solution for a lithium secondary battery and a lithium secondary battery comprising the same. The non-aqueous electrolyte solution for a lithium secondary battery comprises a silicon-based compound represented by a specific chemical formula and having both a hydroxyl group and a hydrocarbon group having a carbon-carbon double bond. When it is applied to a lithium secondary battery, the non-aqueous electrolyte solution improves deterioration of cycle life characteristics occurring after repeated charge/discharge cycles and prevents swelling phenomena by suppressing a decomposition reaction of an electrolyte solution even when a battery in a fully charged state is stored at high temperature or is charged/discharged, thereby enhancing the life characteristics at high temperature.
US08268485B2 Nonaqueous electrolyte secondary battery
A nonaqueous electrolyte secondary battery which has a positive electrode containing lithium cobalt oxide as a positive active material, a negative electrode containing a graphite material and a nonaqueous electrolyte solution containing ethylene carbonate as a solvent and which is charged with an end-of-charge voltage of at least 4.3 V. Characteristically, the battery uses, as the positive active material, lithium cobalt oxide obtained by firing a mixture of a lithium salt, tricobalt tetraoxide (Co3O4) and a zirconium compound and having particle surfaces onto which the zirconium compound adheres.
US08268484B2 Electrode for nonaqueous electrolyte secondary battery, method for producing same, and nonaqueous electrolyte secondary battery comprising such electrode for nonaqueous electrolyte secondary battery
An electrode for a non-aqueous electrolyte secondary battery 6 according to the present invention includes: a current collector 3; a first active material layer 2 formed on the current collector 3; and a second active material layer 5 provided on the first active material layer 2, the second active material layer 5 including a plurality of active material particles 4. The plurality of active material particles 4 is mainly of a chemical composition represented as SiOx (0≦x<1.2). The first active material layer 2 is mainly of a chemical composition represented as SiOy (1.0≦y<2.0, y>x). The area in which the first active material layer 2 is in contact with the plurality of active material particles 4 is smaller than the area in which the current collector 3 is in contact with the first active material layer 2.
US08268482B2 Nonaqueous electrolyte secondary battery and battery module
A nonaqueous electrolyte secondary battery, having an internal resistance of 10 mΩ or less as an alternating-current impedance value of 1 kHz, comprises a metal outer container, a nonaqueous electrolyte contained in the container, a positive electrode contained in the container, a negative electrode contained in the container, a separator interposed between the negative electrode and the positive electrode, a negative electrode lead having one end connected to the negative electrode, and a negative electrode terminal attached to the outer container so as to be connected electrically to the other end of the negative electrode lead, at least the surface of the negative electrode terminal which is connected to the negative electrode lead being formed of aluminum alloy with an aluminum purity of less than 99 wt. % containing at least one metal selected from the group consisting of Mg, Cr, Mn, Cu, Si, Fe and Ni.
US08268479B2 Battery spacer, protection assembly for electric core, and power battery
A battery spacer, a protection assembly for electric core, and a power battery are provided. The battery spacer comprises a spacer body. The spacer body comprises: a tab passing area located in a middle portion of the spacer body, the tab passing area being adapted to receive an end of an electric core of a battery; and receiving areas adjacent to ends of the tab passing area along the spacer body. The spacer body and the tab passing area provide an end wall, two side walls, and a top wall configured to surround each of the receiving area. At least one tab aperture is formed in the tab passing area and penetrates the spacer body.
US08268476B2 Battery including opening closure member with case contact part and case inside part
A battery includes a power generation element, a case member that accommodates the power generation element, and an opening closure member that closes the case member. The opening closure member includes a case contact part for contacting an elongated opening edge of the case member around an entire periphery thereof, and a case inside part projecting toward an inside of the case member from a portion of a surface of the opening closure member on the case member side internally of the case contact part. The case inside part has two narrower portions positioned at both ends of the case inside part in a longitudinal direction of the elongated opening edge of the case member and spaced from an inner surface of the side of the case member, and a wider portion positioned between the two narrower portions and contacting an inner surface of the side of the case member.
US08268475B2 Thin printable electrochemical cell and methods of making the same
A thin printed flexible electrochemical cell, and its method of manufacture, using a “picture frame” structure sealed, for example, with a high moisture and oxygen barrier polymer film and featuring, for example, a printed cathode deposited on an optional, highly conductive carbon printed cathode collector with a printed or a foil strip anode placed adjacent to the cathode. A viscous or gelled electrolyte is dispensed and/or printed in the cell, and a top laminate can then be sealed onto the picture frame. Such a construction could allow the entire cell to be made on a printing press, for example, as well as gives the opportunity to integrate the battery directly with an electronic application, for example.
US08268474B2 Battery module with cell barrier between unit cells and having bending element
A battery module, including a plurality of unit cells and a cell barrier interposed between the unit cells, is provided. The cell barrier includes a body member extending in a direction and at least partially covering a first outer surface of an adjacent unit cell, the body member having an opening extending in the direction, and a bending element extending from a side of the body member in another direction and at least partially enclosing a second outer surface of the adjacent unit cell, the bending element having an opening extending in the another direction.
US08268471B2 High-amperage energy storage device with liquid metal negative electrode and methods
An electrochemical method and apparatus for high-amperage electrical energy storage features a high-temperature, all-liquid chemistry. The reaction products created during charging remain part of the electrodes during storage for discharge on demand. In a simultaneous ambipolar electrodeposition cell, a reaction compound is electrolyzed to effect transfer from an external power source; the electrode elements are electrodissolved during discharge.
US08268468B2 Battery can having off-center vent
An electrochemical cell is provided with an enhanced pressure relief vent formed in a closed end of the cell container that allows for effective venting of gas from the closed end of the container. The cell includes a container having a first end, a second end, a side wall extending between the first and second ends, and an end wall extending across the first end. The cell has a positive electrode, a negative electrode, and an aqueous alkaline electrolyte, all disposed in the container. The cell further includes a pressure relief vent mechanism having an offset C-shaped reduced thickness groove formed in the end wall of the container. A cover can be welded to the closed end wall of the container over the pressure relief vent mechanism.
US08268467B2 Battery safety features
The invention broadly provides improved safety features for batteries utilized in electronic devices. The invention provides an improved CID design that allows for more reliable disconnection (breaking the electrical circuit) during abnormal pressure or temperature events inside the cell. The invention provides a multi-layered CID configured to force electric current through a thin, fragile element such that the thin, fragile element is broken upon any abnormal pressure and temperature event.
US08268466B2 Method for coating noble metals on titanium current collectors for use in nonaqueous Li/CFx cells
A lithium/fluorinated carbon electrochemical cell having the CFx material supported on a titanium current collector screen sputter coated with a noble metal is described. The gold, iridium, palladium, platinum, rhodium and ruthenium-coated titanium current collector provides the cell with higher rate capability, even after exposure to high temperatures, in comparison to cells of a similar chemistry having the CFx contacted to a titanium current collector painted with a carbon coating.
US08268465B2 Battery, electrical equipment, and a powering method implementing means for short-circuiting the battery
The present invention relates to a method of supplying electrical power to an equipment by means of a battery, said method including the step of short-circuiting the battery until it has a temperature greater than a predetermined threshold, characterized in that the battery is short-circuited with a temporal duty ratio determined to keep the equipment functioning and to maintain the temperature of the battery above the predetermined threshold. The invention also relates to a battery and an electrical equipment for implementing that method.
US08268464B2 CCM composite
CCM formed of a membrane having on one of the two surfaces a first electrocatalytic layer containing a catalyst and on the other one a second electrocatalytic layer containing a catalyst, said electrocatalytic layers and said membrane containing (per)fluorinated ionomers, said CCM having the following characteristics: size variations, for both the orthogonal directions of the plane xy, lower than 15%, by dipping the CCM, after drying at 105° C. under vacuum for one hour in demineralized water at 100° C. for 30 minutes; the CCM remains substantially unchanged after having been subjected to treatments of 60 cycles by dipping in water at 80° C. for 8 hours and then in water at the temperature of 25° C. for 16 hours.
US08268462B2 Hybrid grain boundary additives
Magnetic layers are described that include the use of magnetic grains and non-magnetic grain boundaries with hybrid additives. Hybrid additives include the use of at least two different additives in the composition of the grain boundaries of a magnetic layer in magnetic recording media. The use of hybrid additives in the grain boundaries results in improved recording media. Methods for forming magnetic layers and magnetic recording media with the hybrid additive grain boundaries are also described.
US08268460B2 High heat resistant masterbatch, heat ray shielding transparent molded resin, and heat-ray shielding transparent lamination body
To provide a transparent resin molded product with less yellowing due to thermal deterioration of a dispersant by melting and kneading during molding process, and having excellent visible light transmittance and excellent heat ray shielding function. Then, a high heat resistant masterbatch is provided, which is used for manufacturing a heat ray shielding transparent molded resin, comprising: a thermoplastic resin; composite tungsten oxide particles expressed by a general formula WOX (satisfying 2.45≦X≦2.999) and/or composite tungsten oxide particles expressed by a general formula MYWOZ (satisfying 0.1≦Y≦0.5, 2.2≦Z 3.0) and having a crystal structure of hexagonal crystal; and a high heat resistant dispersant having a thermal decomposition temperature of 230° C. or more, satisfying a range of 10≧[weight of the high heat resistant dispersant/(weights of tungsten oxide particles and/or composite tungsten oxide particles)]≧0.5.
US08268459B2 Benzanthracene compound and organic electroluminescence device using the same
A compound having the following structure as at least a part thereof: wherein FA and FA′ are independently a substituted or unsubstituted hydrocarbon aromatic ring or hetero atom-containing aromatic ring, and at least one of FA and FA′ is the hetero atom-containing aromatic ring.
US08268458B2 Carbazole compounds and organo-electroluminescent devices using the same
A carbazole compound represented by Formula 1: wherein X1, X2 and X3 are each independently selected from the group consisting of a hydrogen atom, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C1-C20 alkoxy group, a substituted or unsubstituted C6-C30 aryl group, a substituted or unsubstituted C6-C30 arylalkyl group, a substituted or unsubstituted C2-C30 heteroaryl group, a substituted or unsubstituted C3-C20 cycloalkyl group and a substituted or unsubstituted C5-C30 heterocycloalkyl group; and l, m and n are each independently an integer from 0 to 5.
US08268453B2 Steel based composite material
The present document describes a composite material adapted to resist degradation by an erosive agent. The composite material comprises a steel base and crystals embedded in the steel base. At least 50% of the crystals have an elongated portion. Optionally, the composite material comprises an external surface for exposure to the erosive agent. At least 50% of the elongated portions are transverse to the external surface. A filler material is also described for forming the composite material on a ferrous surface by welding. The filler material comprises iron, carbon, boron, molybdenum and silicon. Methods are also described form forming the composite material.
US08268449B2 Thermal- and chemical-resistant acid protection coating material and spin-on thermoplastic adhesive
New compositions for use as protective coatings and/or adhesives are provided. The compositions comprise a hydrocarbon resin (e.g., terpene rosin) and a rubber (e.g., EPDM) dispersed or dissolved in a solvent system. The solvent system is preferably a single-solvent system, and the compositions are preferably free of surfactants, dyes, and chromophores. The compositions can be cured or dried to form layers or films that are chemically and thermally resistant, but that can be readily dissolved and removed at the appropriate stage in the fabrication process.
US08268446B2 Photocurable perfluoropolyethers for use as novel materials in microfluidic devices
The use of a photocurable perfluoropolyether (PFPE) material for fabricating a solvent-resistant PFPE-based microfluidic device, methods of flowing a material and performing a chemical reaction in a solvent-resistant PFPE-based microfluidic device, and the solvent-resistant PFPE-based microfluidic devices themselves are described. In an embodiment, a method is described for preparing a patterned layer of a photocured perfluoropolyether, the method comprising: (a) providing a substrate, wherein the substrate comprises a patterned surface; (b) contacting a perfluoropolvether precursor with the patterned surface of the substrate; and (c) photocuring the perfluoropolyether precursor to form a patterned layer of a photocured perfluoropolyether.
US08268442B2 Adhesive tape and its use
Adhesive tape suitable for flying splice of flat web material having non-polar surfaces which has been wound to form rolls, the adhesive tape comprising an upper self-adhesive composition (1, 11), a splittable carrier (2, 12) and a lower self-adhesive composition (3, 13) on the bottom face of the splittable carrier (2, 12), wherein as upper self-adhesive composition (1, 11) a silicone-free self-adhesive composition is used which has a bond strength to a polyethylene substrate of 1.5 N/cm or more (measurement method tesa test A) and an initial tack corresponding to a rolling distance of 200 mm or less (measurement method tesa test D), and as lower self-adhesive composition (3, 13) a self-adhesive composition is used which has a bond strength to a polyethylene substrate of 1.5 N/cm or more (measurement method tesa test A) and a complex viscosity of 10,000 Pa·s or more at 1 rad/s and 40° C. (measurement method tesa test F).
US08268441B2 Light diffusion member, back light assembly including the same and display device including the same
The light diffusion member includes a light diffusing body and a light diffusing layer. The light diffusing body includes a polymer mixture obtained by uniformly blending a first polymer having a first glass transition temperature and a second polymer having a second transition temperature higher than the first transition temperature. Alternatively, the light diffusing body includes a copolymer prepared from the first and the second polymer. The light diffusing body diffuses an incident light through a light exiting surface. The light diffusing layer is formed on the light exiting surface of the light diffusing body and includes a binder resin having beads. A back light assembly including the light diffusion member and a liquid crystal display device including the light diffusion member exhibit an improved luminance and an improved light diffusing efficiency.
US08268439B2 Process for fabricating polymeric articles
A process for the production of a polymeric article comprises the steps of: (a) forming a ply having successive layers, namely (ii) a first layer made up of strands of an oriented polymeric material; (ii) a second layer of a polymeric material; (iii) a third layer made up of strands of an oriented polymeric material, wherein the second layer has a lower peak melting temperature than that of the first and third layers; (b) subjecting the ply to conditions of time, temperature and pressure sufficient to melt a proportion of the first layer, to melt the second layer entirely, and to melt a proportion of the third layer; and to compact the ply; and (c) cooling the compacted ply. The resultant articles have good mechanical properties yet may be made at lower compaction temperatures than articles not employing the second layer, leading to a more controllable manufacturing process.
US08268433B2 Information recording medium and method for producing same, and sputtering target
An information recording medium (1) of the present invention is an information recording medium allowing information to be recorded thereon by irradiation with a laser beam or by application of electrical energy. The information recording medium (1) includes a recording layer (15) capable of undergoing a phase change by the irradiation with the laser beam or by the application of the electrical energy. The recording layer (15) contains Sb, Te, Ge, and C, and a content of Te in the recording layer (15) is at least 8 atom % but not more than 25 atom %.
US08268432B2 Co-molded elements in reinforced resin composites
A composite structure such as a carbon-fiber surgical table width extender includes a fiber-resin composite body and outer surface protective elements. The protective elements are adhered to the body during curing of the body's thermosetting binding matrix at a given temperature and pressure. The protective elements can include stainless steel elements and thermosetting elements which can be deformably thermoplastic and non-liquid, and simultaneously thermoset at this same temperature and pressure.
US08268428B2 Adhesive articles and release liners
The present application is directed to adhesive articles and release liners. Namely, the present application is directed to an article comprising an adhesive layer with a structured surface. The structured surface comprises a first groove and a second groove recessed into the adhesive layer from a reference plane defined by the adhesive surface on either rim of the groove. In some embodiments, the second groove is contained within the first groove, and in other embodiments the grooves are separate. The first groove and the second groove have walls. The wall angle of the first groove with respect to the reference plane is non-zero and is smaller than the wall angle of the second groove with respect to the reference plane. The application is also directed to release liners for the adhesive article, wherein the surface of the release liner is the inverse of the adhesive surface.
US08268421B2 Packaging bag and drying agent with moisture absorption indicator function
A packaging bag and a drying agent with a moisture absorption indicator function are provided without using a heavy metal harmful to the human body. The packaging bag includes a first packaging material (10) and a second packaging material (20). The first packaging material (10) is provided on an outermost side thereof with a transparent barrier film (12) having a barrier property against water vapor. The second packaging material (20) has a light-reflective or light-absorbing film (24) and a pattern printed layer (23) overlaid on a bag interior side thereof, the pattern printed layer (23) having a printed moisture-absorbing indicator pattern (30). A desiccant-containing resin film (11, 21) which becomes transparent due to moisture absorption is overlaid on a bag interior side of at least one of the first packaging material (10) and the second packaging material (20). The drying agent with a moisture absorption indicator function includes an indicator film layer (70) having a barrier film (75), a pattern printed layer (73) for a moisture absorption indicator, and a moisture-absorbing film (71) containing zeolite, the pattern printed layer (73) and moisture-absorbing film (71) being laminated in this order on the barrier film (75). The drying agent further includes a main desiccant layer (61) and a moisture permeable film (64) that are overlaid on the moisture-absorbing film (71).
US08268416B2 Thermal transfer sheet
A thermal transfer sheet includes a base material sheet, a thermal transfer dye layer, which is disposed on one surface of the base material sheet and which contains a dye, and a heat-resistant lubricating layer disposed on the other surface of the base material sheet, wherein the heat-resistant lubricating layer is formed from a binder, in which a specific amount of at least one of a polyvinyl acetal having a softening point of 262° C. or higher and a glass transition temperature of 106° C. or higher and cellulose acetate propionate and a specific amount of polyamide imide silicone are mixed.
US08268415B2 Melt thermal transfer recording paper
A melt thermal transfer recording paper suitable for melt thermal transfer recording comprising a stretched resin film, wherein stretched resin film contains from 30 to 75% by weight of an inorganic fine powder and/or an organic filler and from 25 to 70% by weight in total of a thermoplastic resin having a Vicat softening point of not higher than 140° C. and a polyolefin-based resin having a Vicat softening point of higher than 140° C.; the stretched resin film contains more than 75 parts by weight and at most 900 parts by weight of the thermoplastic resin relative to 100 parts by weight of the polyolefin-based resin.
US08268413B2 Liquid crystal display device
A liquid crystal display device comprises a color filter substrate and an array substrate. An optical compensation film is disposed on the color filter substrate and/or the array substrate, wherein the optical compensation film comprises a polyimide, comprising the following formula: wherein n is an integer greater than 1, and wherein when A is cyclo-aliphatic compound, B is aromatic compound or cyclo-aliphatic compound, and when A is aromatic compound, B is cyclo-aliphatic compound.
US08268403B2 Method for forming organic silica film, organic silica film, wiring structure, semiconductor device, and composition for film formation
A method of forming an organic silica film includes forming a coating including a silicon compound having an —Si—O—Si— structure and an —Si—CH2—Si— structure on a substrate, heating the coating, and curing the coating by applying ultraviolet radiation.
US08268402B2 Fullerene film and fullerene polymer both produced from fullerene derivative and processes for producing these
Disclosed is a fullerene film which can be easily formed by a wet process without deteriorating the intrinsic properties of a fullerene by using a fullerene derivative as a raw material. Also disclosed are a fullerene polymer, a method for producing a fullerene film, and a method for producing a fullerene polymer. A fullerene film or a fullerene polymer maintaining the intrinsic properties of the fullerene is obtained by coating a base with a solution of a fullerene derivative and then heating the thus-obtained coating film at a temperature higher than the thermal decomposition temperature of the fullerene derivative but lower than the thermal decomposition temperature of the fullerene.
US08268389B2 Precast thermal interface adhesive for easy and repeated, separation and remating
Precast curable thermal interface adhesives facilitating the easy and repeatable separation and remaining of electronic components at thermal interfaces thereof, and a method for implementing the foregoing repeatable separation and remating at the thermal interfaces of components through the use of such adhesives.
US08268385B2 Optical monitor with computed compensation
A method is provided for the determination a thickness error in a previously deposited layer using the reflection monitor signal of the currently-depositing layer. This thickness error is then used to compute corrections to the thickness of the currently-depositing layer and the next layer which corrects for the thickness error in the previous layer. The method is stable with respect to noise in the optical monitor signal. The technique is applicable for optical coating designs which are not necessarily quarter wave. The approach avoids the buildup of thickness errors from layer to layer and thus is applicable for very thick designs with many layers. Near the end of a currently depositing layer the monitor signal is used to fit the admittance of the base stack under the current layer. This establishes the parameters in an exact reflectance model used for the thickness monitoring of the current layer.
US08268382B2 Method of making a stent with hollow struts
A stent including hollow struts is formed on a cylindrical substrate. The struts of the stent are formed by electroforming metal layers of the strut in openings formed in a patterned photoresist material. A first metal layer forming the inner strut material is formed in openings in a first photoresist material. A sacrificial material to form the cavity to make the struts hollow is formed in openings in a second photoresist material. A second metal layer forming the side walls and outer wall of the struts is formed in openings in a third photoresist material and around the sacrificial material. The photoresist materials are removed. The substrate and cavity sacrificial material are removed, leaving hollow struts formed into a stent pattern. The hollow struts may be filled with a therapeutic substance for elution. Openings through the struts to the cavity may be formed during the forming process.
US08268375B2 Method for imprinting patterns on an extruded product
A method for spraying a food product is disclosed herein. The method includes the step of disposing a first sprayer along an axis defining, at least in part, a path of movement for a food product. The method also includes the step of disposing a second sprayer along the axis axially and radially spaced from the first sprayer. The method also includes the step of directly communicating with the first and second sprayers disposed along the axis with a cavity operable to receive edible ink such that the first and second sprayers concurrently spray the edible ink to the axis.
US08268374B2 Pet food and process of manufacture
A method for manufacturing pet food with an ultrasonic horn and an anvil, using human grade ingredients without the use of additives, including but not limited to preservatives, plasticizers, binders and fluidizers.
US08268369B2 Compositions and methods for treating hypercholesterolemia using Ortanique peel extract
The invention relates to compositions and methods for treating hypercholesterolemia, including methods for increasing HDL cholesterol levels, using a composition comprising an extract from the Ortanique peel. The invention also relates to compositions and methods for treating hypercholesterolemia, including methods for increasing HDL cholesterol levels, using a composition comprising substantially similar amounts of tetramethylscutellarein and nobiletin by weight and/or a composition comprising substantially similar amounts of tetramethylscutellarein, nobiletin, and tangeretin by weight.
US08268364B1 Water based pain relieving composition
Disclosed is a water based topical pain relieving composition that is substantially odorless and does not leave a greasy or oily residue behind. The water based topical pain relieving composition may be particularly useful in treating areas near the eyes or mucous membranes. In some embodiments the topical pain relieving composition may comprise a water based emulsion comprising an effective amount of an analgesic composition comprising trolamine salicylate and an inflammation reducing composition comprising effective amounts of Anthemis Nobilis (roman chamomile) extract, Arnica Montana flower extract, Calendula Officinalis (marygold) extract, Centaurea Cyanus (blue bottle) extract, inflammation reducing oil, Hypericum Perforatum (St. John's Wort) extract, Matricaria Chamomilla (Wild Chamomile) extract, methylsulfonylmethane (MSM), Salix Alba (willow) bark extract, sorbitol, Tilia Sylvestris (limetree) extract, and aloe vera concentrate.
US08268361B2 Acellular bioabsorbable tissue regeneration matrices
The present invention provides methods and compositions useful in the regeneration of damaged, lost and/or degenerated tissue in humans and animals. In certain embodiments, the present invention provides an acellular bioabsorbable tissue regeneration matrix, methods of making such a matrix, and methods of using such a matrix for the regeneration of damaged, lost and/or degenerated tissue. In certain embodiments, methods and compositions of the present invention are useful in the treatment of damaged, lost and/or degenerated nerve tissue.
US08268359B2 Organic polymer-inorganic fine particle antimicrobial composites and uses thereof
An embodiment relates to a composition comprising a noble-metal containing nanoparticle and a polymer located on a surface of the nanoparticle, wherein the polymer is a polycondensation product of a halogenated monomer. Other embodiments relate to the method of making a composition and providing antimicrobial treatment using the composition.
US08268357B2 Processes for the preparation of lipophilic drug delivery vehicles
The invention provides compositions and methods for delivery of a bioactive agent to an individual. Delivery vehicles are provided that include a bioactive agent in disc shaped particles that include one or more lipid binding polypeptides circumscribing the perimeter of a lipid bilayer in which the bioactive agent is localized. Chimeric lipid binding polypeptides are also provided and may be used to add additional functional properties to the delivery particles.
US08268355B2 Silica particle comprising an organolanthanide compound, preparation process therefor and uses thereof
The present invention relates to a silica particle comprising at least one complex of at least one lanthanide and of at least one ligand of formula (A) in which Z1, Z2 and Z3, which may be identical or different, each represent a group bearing an atom bearing a lone pair and/or a negative charge; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12, which may be identical or different, each represent a hydrogen, an optionally substituted alkyl radical, an optionally substituted aryl radical, a halogen, a group —OR13 or a group —SR13, with R13 representing H, an optionally substituted alkyl group or an optionally substituted aryl group.
US08268354B2 Sonic low pressure spray drying
This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.
US08268353B2 Polymer latex compound
A polymer latex composition has an acrylonitrile component, a polychloroprene component, and a natural latex component. When these components are blended together and formed into a film, the film exhibits a resistance to ozone that is greater than a resistance to ozone of materials in which acrylonitrile is not included. Furthermore, the combination of acrylonitrile and chloroprene imparts a synergistic effect to the composition with regard to ozone resistance. The film can be formed into a glove having a resistance to ozone that is improved over the resistance to ozone of gloves not including acrylonitrile. The glove may include an antimicrobial agent.
US08268352B2 Modified release composition for highly soluble drugs
A novel modified release dosage form comprising of a high solubility active ingredient, which utilizes dual retard technique to effectively reduce the quantity of release controlling agents. Present invention can optionally comprise additionally another active ingredient as an immediate release form or modified release form. Present invention also relates to a process for preparing the said formulation.
US08268351B2 Matrix film tablet with controlled release of a natural mixture of conjugated estrogens
A pharmaceutical matrix film tablet with controlled release of natural mixtures of conjugated estrogens which have been obtained from the urine of pregnant mares.
US08268350B2 Binders for tablets with high strength based on finely divided vinyllactam polymers, the production and use thereof
Finely divided binders in powder form composed of vinyllactam polymers, where the binders have an average particle size of up to 35 μm and an apparent density of less than 0.2 g/ml.
US08268349B2 Solid pharmaceutical dosage form
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
US08268347B1 Dual action, inhaled formulations providing both an immediate and sustained release profile
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
US08268345B2 Multipurpose hydrogel compositions and products
Disclosed are sterile hydrogel compositions comprising polyvinyl alcohol (“PVA”), polyvinyl pyrrolidone (“PVP”), and a polysaccharide, wherein the combined amount of PVA and PVP present in the hydrogel compositions is from about 2% to about 12% weight by volume, based on the total volume of the composition, and wherein the hydrogel compositions has a gel fraction greater than or equal to 97%. Sterile hydrogel products including such sterile hydrogel compositions, and methods of making such sterile hydrogel compositions and sterile hydrogel products.
US08268344B2 Particle-containing complex porous materials
Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
US08268343B2 Non-hormonal vaginal contraceptive
The present invention relates to a non-hormonal, biocompatible, and biodegradable intravaginal device for the delivery of spermiostatic, spermicidal and anti-infectious agents. The present invention also relates to methods of contraception using such a device, as well as the prevention and treatment of sexually transmitted diseases and vaginal infections through the application of the device.
US08268337B2 Nontoxic killer of E. coli and other problem microorganisms
The present invention provide a composition of non-toxic low-cost ingredients that effectively kill pathologic bacteria and methods for use of the composition. The present invention comprises novel compositions and methods for controlling enteric pathogens and spoilage organisms such as Salmonella, Escherichia, Campylobacter, Listeria, Pseudomonas and Enterobacteracae on the surface of meat products and food preparation surfaces.
US08268336B2 Compositions containing aromatic aldehydes and their use in treatments
Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
US08268334B2 Aqueous acidic hard surface cleaning and disinfecting compositions
A highly aqueous liquid acidic hard surface treatment composition having a pH of about 3.5 or less which necessarily comprises: 0.001-3.5% wt. of an acid constituent which comprises one or more organic acids, but which preferably comprises lactic acid and one or more further organic acids acids, and especially preferably wherein the acid constituent consists solely of lactic acid; an organic solvent constituent, desirably selected from a monohydric alcohol and/or a glycol ether; an anionic surfactant constituent, desirably a sulfur atom containing anionic surfactant constituent, such as of the sulfate or sulfonate types; a nonionic surfactant constituent; optionally a cosurfactant constituent, including one or more nonionic, cationic, amphoteric or zwitterionic surfactants; optionally one or more further constituents selected coloring agents, fragrances and fragrance solubilizers, viscosity modifying agents including one or more thickeners, pH adjusting agents and pH buffers including organic and inorganic salts, optical brighteners, opacifying agents, hydrotropes, abrasives, and preservatives, as well as other optional constituents known to the art; and the balance, water, wherein water comprises at least 80% wt. of the composition. The highly aqueous liquid acidic hard surface treatment composition may be used as such, or may be used to impregnate absorbent substrates to form wipe articles.Methods for the use of said highly aqueous liquid acidic hard surface treatment compositions, in cleaning and/or disinfection of hard surfaces are also disclosed.
US08268329B2 Modified Vaccinia ankara virus variant
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus, wherein the MVA-BN virus, or a derivative thereof, induces at least substantially the same level of immunity in vaccinia virus prime/vaccina virus boost regimes when compared to DNA prime/vaccinia virus boost regimes. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised, receiving antiviral therapy, or have a pre-existing immunity to the vaccine virus.
US08268328B2 Immediate protection against pathogens via MVA
The invention relates to methods and kits comprising poxviruses including, but not limited to modified vaccinia virus Ankara (MVA) and uses thereof to provide immediate protection against pathogens. Poxviruses including, but not limited to MVA can be delivered to a host animal just prior to or after exposure to a pathogen and provide protection against the pathogen.
US08268324B2 Modified galectin 9 proteins and use thereof
It is suggested that recombinant galectin 9 (rGal 9), produced in host Escherichia coli, exhibits an immune system-mediated action and a direct action on tumor cells (i.e., activity of inducing the intercellular adhesion and apoptosis of the tumor cells), thereby potent in inducing the inhibition of cancer metastasis and reduction. Moreover, the rGal 9 exerts no efficacy on non-activated lymphocytes but can induce apoptosis in activated T cells, in particular, CD4-positive T cells causing an excessive immune response. The rGal 9 has a further potent apoptosis-inducing property on synovial cells participating in joint deformation in rheumatism, etc. In the rGal 9, however, a link domain linking two CRDs is highly susceptible to protease and, therefore, is very easily digestible with the enzyme, thereby losing the above activities. Thus, there is a need for a more stabilized molecule in view of further studies. Modification of the link domain linking two CRDs in galectin 9 provides a modified molecule having an elevated activity without any undesirable effects on the above activities.
US08268319B2 Immunoconjugates with an intracellularly-cleavable linkage
The invention relates to therapeutic conjugates with improved ability to target various cancer cells containing a targeting moiety and a therapeutic moiety. The targeting and therapeutic moieties are linked via an acid cleavable linkage that increases therapeutic efficacy of the immunoconjugate.
US08268316B2 Monoclonal antibody specific to anthrax toxin
Disclosed is a monoclonal antibody having very high affinity to anthrax toxin and potent toxin-neutralizing activity. Also disclosed are a composition for neutralizing anthrax toxin comprising the antibody and a kit for detecting anthrax toxin.
US08268311B2 Human GM-CSF antigen binding proteins
Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit GM-CSF-induced activation of human monocytes.
US08268304B2 Use of the long pentraxin PTX3 for the prevention or treatment of viral diseases
It is described the use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
US08268301B2 Cationic betaine precursors to zwitterionic betaines having controlled biological properties
Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.
US08268293B2 UV protection
The present invention relates to the use of compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, for the development of UV-A or UV-B protection during use, to corresponding novel compounds and compositions, and to corresponding processes for the preparation of compounds and compositions.
US08268292B2 Obovatol having anti-anxiety activity
The present invention relates to obovatol compound isolated from Magnolia obovata Thunb. for the prevention and treatment of anxiety disorders involved with CNS. The obovatol compound isolated from Magnolia obovata Thunb. have potent anti-anxiety activity, verified by an increased percentage of time on the open arms, an increased number of entries into, time spent on, the distal portion of the open arms, and a decreased activity of locomotor. Therefore it can be used as the therapeutics or health care food for treating and preventing anxiety disorders.
US08268290B2 UZM-29 family of crystalline zeolitic compositions and a method of preparing the compositions
This invention relates to a new family of crystalline microporous zeolite designated the UZM-29 family. These zeolites are represented by the empirical formula: Mmn+R+rAl1-xExSiyOz UZM-29 has the PHI structure type topology but is thermally stable up to a temperature of at least 350° C. The UZM-29 family of zeolite can be used in various hydrocarbon conversion processes such as, isomerization of butane.
US08268284B2 System and method for producing iodine compound
A system (100) of the present invention for producing an iodine compound includes: a raw material adjusting unit (1) for supplying hydrogen-containing gas to at least one of liquid iodine in an iodine melting pot (4) and gaseous iodine obtained by evaporating liquid iodine so as to obtain a mixture gas; a hydrogen iodide producing unit (10) including a hydrogen iodide producing tower (12) having a catalyst layer (12a) for converting the introduced mixture gas into crude hydrogen iodide gas; a hydrogen iodide refining unit for removing unreacted iodine from the introduced crude hydrogen iodide gas so as to obtain hydrogen iodide gas; and an iodine compound producing unit (30) for producing a target iodine compound from the obtained hydrogen iodide gas and a reaction material. This allows producing an iodine compound with high purity easily, efficiently, and with low cost.
US08268281B2 Dry powder injector for industrial production of carbon single walled nanotubes (SWNTs)
Methods, processes, and apparatuses for the continuous synthesis of carbon nanostructures are provided. Metal catalysts having small diameter and narrow distribution of particle sizes are prepared and continuously injected as aerosols into a reactor. The metal catalysts are supported on supports that are substantially free of carbon. The metal catalyst, in the form of a powder, is placed on a fluidized bed and aerosolized using an inert gas. The powder entrailed in the gas is injected near the top of a vertical reactor for the synthesis of SWNTs.
US08268279B2 Pastillation of ammonium sulfate nitrate
Processes are presented for the production of ammonium sulfate nitrate. The processes provide for producing a highly uniform product and having a substantially uniform size. The processes include reacting ammonium sulfate and ammonium nitrate to form an FASN slurry melt. The slurry melt is continuously stirred and heated to keep the slurry melt under a shear thinned condition and at a uniform temperature until the slurry melt is extruded, cooled and solidified.
US08268278B2 Phosphorus-calcium-strontium compound and uses thereof in endodontic cements
Phosphorus-calcium-strontium compound of formula (I); method for preparing same; composition for the extemporaneous preparation of a cement comprising a solid phase (SP) and a liquid phase (LP), wherein the solid phase comprises a mixture of inorganic compounds of formula (II); use as an endodontic cement.
US08268276B2 Method and system for reducing lime consumption in dry flue gas desulfurization systems
In a method for reducing lime consumption in DFGD systems, a slaker is provided wherein lime and water is introduced to produce a slaked lime slurry. The slurry is introduced into a spray dryer wherein the slurry is atomized. A flue gas stream is also introduced into the spray dryer and reacts with the atomized slurry, causing calcium sulfate and sulfite, as well as unreacted lime particulate to form. A portion of the particulate is filtered and sent back in a substantially dry form to the slaker to form part of the slurry.
US08268275B2 Method and device for controlling the supply of a reducing agent to an SCR system
A selective catalytic reduction reactor (8), which comprises at least one catalyst layer (14), is operative for removing NOx from a flow of process gas of a process plant, such as a combustion plant or an incineration plant. A device for controlling the feeding of a reducing agent, such as urea or ammonia, to said at least one catalyst layer (14), which has an attack area (A) facing the flow (P) of process gas, comprises at least one supply nozzle (32) which is operative for supplying reducing agent in at least one supply area (34) which corresponds to a part of the attack area (A), and a moving device (36) which is operative for moving said supply area (34) over the attack area (A).
US08268274B2 Catalyst combinations and methods and systems for oxidizing nitric oxide in a gas stream
One embodiment of the invention may include a product comprising a catalyst combination comprising a perovskite catalyst and a second catalyst that is not a perovskite catalyst.
US08268269B2 Manufacture of water chemistries
As population density increases, the transportation of hazardous chemicals, including acids and disinfectants, lead to an increased incidence of spills while the consequences of spills become more serious. While solutions of halide acids, hypohalites and halites are safer disinfectants for transportation, handling, storage and use than traditional gaseous chlorine, the manufacturing cost of these disinfectants has here-to-fore limited their use. Economical processes are presented for the manufacture of O2, halogen oxides, halide acids, hypohalites, and halates; as well as polynucleate metal compounds, metal hydroxides and calcium sulfate hydrate (gypsum). The instant invention presents methods and processes that incorporate the use of sulfur. This is while environmental regulators, such as the US EPA, require an increased removal of sulfur from hydrocarbon fuels, thereby creating an abundance of sulfur, such that the refining industry is in need of a way to dispose of said abundance of sulfur.
US08268265B2 Apparatus and method for picking up, transporting, and depositing microscopic samples
An apparatus and method for picking up, transporting and depositing microscopic samples. Such an apparatus includes at least one interchangeable adhesive body and a gripping tool for picking up, transporting and depositing the adhesive body, the adhesive body having at least one outwardly curved surface which is at least partially adhesive with respect to the sample. In this method, a gripping tool picks up an adhesive body having an at least partially outwardly curved surface which is at least partially adhesive with respect to the sample. The gripping tool then guides the adhesive body to above the sample. The at least partially curved surface of the adhesive body is then brought into contact with the sample, the sample adheres to the surface of the adhesive body when this is being removed from the sample location, and is finally deposited at the depositing location.
US08268264B2 Devices, systems and methods for separating magnetic particles
A method and device for separating from samples magnetic particles that contain capture compounds on their surfaces. The device includes a sheath including a magnet and including orienting pin adapted to concentrate or direct a magnetic field of the magnet; and a magnetizable plate with lid holes for receiving a vessel lid of a vessel, the magnetizable plate configured to receive the sheath and position the orienting pin over the vessel lid. In one method, magnetic beads with attached molecules are collected in the lids of the reaction vessel by the magnetic separator device provided herein and the separated magnetic particles, which carry the molecules of interest through affinity-based attachment chemistry and are held in the lid by the magnet of the device, are released into a new vessel containing a solution by removal of the separator device without the need for pipettes or liquid handling devices.
US08268263B2 Reagent cartridge
A self dispensing reagent cartridge includes a vessel with a movable piston at one end and a puncturable self sealing septum at an opposite end. A hollow needle is located in alignment with the septum. The vessel is moved toward the needle to enable the needle to puncture the septum. The piston is then moved toward the septum to enable a predetermined amount of liquid in the vessel to be transferred outwardly of the vessel through the needle in an amount corresponding to the piston stroke.
US08268262B2 Retaining microfluidic microcavity and other microfluidic structures
A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).
US08268261B2 Pipette core member, pipette, and pipette device
A pipette core member is used in a pipette for sampling a sample. This pipette core member includes: a pump body including a reservoir communicated with one suction/discharge port of an electroosmotic flow pump, the electroosmotic flow pump and the reservoir being integrally formed; and a capillary connected to the electroosmotic flow pump and communicated with the other suction/discharge port of the electroosmotic flow pump. The capillary is secured to the pump body.
US08268260B2 Capillary stop
A microfluidics system comprising a channel having an inlet (32) and an outlet (38); a first membrane (31) positioned between the inlet (32) and outlet (38) and comprising an aperture having a radius within the range 0.1 to 50 μm, the inlet (32) and the outlet (38) being in hydraulic communication with one another, such that a fluid can move along the channel from the inlet to the outlet.
US08268259B2 Blood glucose monitoring kit
A blood glucose monitoring kit includes a case constructed in the form of a bi-fold wallet which comprises an upper flap and a lower flap that are connected together through a fold. The case includes an outer layer constructed out of a water resistant and soft fabric and an inner layer constructed out of a water resistant material, the outer and inner layers being sewn together about their peripheries. A layer of cushioned material is preferably disposed between the inner and outer layers to provide the case with a soft feel. Blood glucose monitoring electronics are preferably integrated directly into the upper flap of the case, the electronics including a printed circuit board (PCB), a test port mounted on the PCB and a display mounted on the PCB. Preferably, the upper flap is provided with an opening through which the test port is externally accessible. Additionally, the upper flap is provided with a window through which the display is externally visible. A pouch is secured onto the inner surface of the lower flap and is sized and shaped to retain a plurality of disposable test components.
US08268257B2 Process and a device for treating objects
Described is a process and an arrangement for the treatment of objects, in particular for sterilization, comprising at least one chamber for the joint take-up of at least two objects to be treated. A closing element is arranged to the opening of the chamber, which closing element is arranged in a moveable way in the arrangement for the purposes of opening and closing the opening. The chamber can be closed by means of the closing element in a vacuum-tight way, whereby no relative movement takes place between the closing element and the chamber in the closed state. It is provided that the minimum of two objects to be treated are inserted one after the other, and that the closing of the opening by means of the minimum one closing element takes place essentially on a continuous basis.
US08268256B2 Holding sealing material, method for manufacturing holding sealing material, and exhaust gas purifying apparatus
A holding sealing material includes mats which have a longitudinal direction and first and second longer side faces along the longitudinal direction and which include a lower mat and an upper mat laminated on the lower mat. A length of the lower mat in the longitudinal direction is longer than a length of the upper mat in the longitudinal direction. Each of the mats is connected to each other at a fixed portion which extends substantially along a width direction perpendicular to the longitudinal direction. The fixed portion has first and second end portions in the width direction. The first end portion is on a side of the first longer side face. The second end portion is on a side of the second longer side face. The first and second end portions are spaced apart from the first and second longer side face, respectively.
US08268255B2 Holding sealing material, method for manufacturing holding sealing material, and exhaust gas purifying apparatus
A holding sealing material includes a plurality of mats. The plurality of mats have a longitudinal direction and include a lower mat and an upper mat laminated on the lower mat. Each of the plurality of mats includes inorganic fibers and has a substantially rectangular shape. A length of the lower mat in the longitudinal direction is longer than a length of the upper mat in the longitudinal direction. Each of the plurality of mats is connected to each other at at least two fixed portions. The at least two fixed portions are positioned at different positions in the longitudinal direction.
US08268254B2 Method and apparatus for the fluorination of plastics
The gas-phase fluorination of plastic articles is effected in a reaction chamber 1 into which the plastic articles to be fluorinated are introduced. The gas-phase fluorination is effected at normal or atmospheric ambient pressure of about 1 kPa in the reaction chamber. The gas-phase fluorination can be carried out statically or dynamically. The flushing carried out before the gas-phase fluorination for complete or partial removal of atmospheric oxygen from the reaction chamber 1 can also be effected at atmospheric pressure in the reaction chamber. The reaction chamber 1 is equipped with a cover 2 and metering valves V0, V1, V2 for air, inert gas and gas mixture comprising fluorine and one or more inert gases are present on the entrance side of the reaction chamber, which is not vacuum-tight and hence also cannot be evacuated. The metering valves are connected to the reaction chamber 1 via a flow meter 4. A release valve V3 and a flow-through/shut-off valve V4 are arranged in an exhaust gas line 8 of the reaction chamber 1.
US08268253B2 Air purifier
An air sterilizer that operates by electro-kinetic conversion of energy is provided. The sterilizer can have an electro-kinetic converter, rows of needles fastened along support plates, and neutralizing electrodes. The converter can have a rectangular frame with two armatures joined by electrically insulating transverse plates. The armatures can be provided on one of the margins with a row of rectangular notches, equally-spaced with a constant pitch. In the notches, the ion-generating electrodes can be introduced. On their opposed margin, the plates can be interleaved at the same pitch and with V-shaped openings where the neutralizing electrodes can be introduced. The electrodes can be affixed by insulating covers, in the shape of the letter U. Each cover can be elastically deformable. The power supply can derive from an impulse generator with sufficient voltage to form an intense electric field which can ionize surrounding air and create a plasma zone.
US08268251B2 Early warning sulfur detection based on change in fluorescence intensity of polymer-bound phosphine compound
An early warning sulfur detection system for detecting the presence of corrosive gases, especially elemental sulfur (S8), in air employs a substrate that includes a polymer-bound phosphine compound having sulfur-getting functionality. The phosphine compound in the polymer reacts with any airborne elemental sulfur. This reaction is accompanied by a decrease in the fluorescence intensity (If) of the substrate. The If of the substrate is monitored in real time by a spectrofluorometer to detect a change in fluorescence intensity (ΔIf). In an embodiment sited in a data center, an alarm is triggered if the ΔIf is above a predetermined threshold, thereby providing a real-time, early warning to IT professionals that corrective action is required to protect metal conductors from corrosion. Preferably, the phosphine compound in the polymer does not react with other components in the air (e.g., carbon dioxide).
US08268249B2 Analytical device with lightguide illumination of capillary and microgroove arrays
An analytical cell including a lightguide with a plurality of conduits filled with a migration medium. The medium, the lightguide and a surrounding medium have refractive indices selected such that light entering the lightguide is internally reflected within the lightguide to provide substantially uniform illumination of the conduits.
US08268247B2 Electrophoresis extraction device
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.
US08268246B2 PCB droplet actuator fabrication
Alternative approaches to fabricating printed circuit boards for use in droplet actuator operations are provided. In one embodiment, a method of manufacturing a droplet actuator for conducting droplet operations includes positioning a dielectric material between a first metal layer configured to include an electrode and a second metal layer configured to include an interconnect pad. The method additionally includes forming a connection between the first and second metal layers. Droplet actuators and methods of fabricating and supporting printed circuit boards of droplet actuators are also provided.
US08268242B2 Hydrogen sensor
A hydrogen sensor includes a substrate, a hydrogen absorbing member, a power source, an ammeter, and a processing unit. The hydrogen absorbing member is positioned on the substrate, and includes a carbon nanotube yarn and a hydrogen absorbing film coated on the carbon nanotube yarn. The ammeter measures an electric current. The hydrogen absorbing member and the ammeter are connected in series to the power source. The processing unit is electrically coupled to the ammeter to obtain a hydrogen concentration according to the electric current.
US08268240B2 Ciclesonide-containing sterile aqueous suspension
The present invention provides methods of manufacturing a sterile ciclesonide-containing aqueous suspension comprising the step of sterilization by autoclaving a ciclesonide-containing aqueous suspension.
US08268238B2 System and method for recycling sterilant gas
A system for recovery of a sterilant gas mixture from a sterilizer chamber is disclosed. The system includes a gas recovery tank, a sterilizer chamber in gaseous communication with the gas recovery tank and a gas recovery assembly coupled to the gas recovery tank and the sterilizer chamber. The gas recovery assembly is configured to transfer a sterilant gas mixture including at least one sterilant gas between the sterilizer chamber and the gas recovery tank. The system further includes an analyzer assembly coupled to the sterilizer chamber, the analyzer assembly including at least one sterilant gas sensor configured to detect density of the sterilant gas and a control module coupled to the analyzer assembly and to the gas recovery assembly. The control module includes at least one control module configured to determine at least one of a transfer pressure and flammability of the sterilant gas mixture as a function of the density of the sterilant gas.
US08268237B2 Method of coating with cryo-milled nano-grained particles
A method of coating a substrate with cryo-milled, nano-grained particles includes forming a face-centered-cubic gamma matrix comprising nickel, cobalt, chromium, tungsten and molybdenum, adding a dispersion strengthening material to the gamma matrix to form a first mixture, cryo-milling the first mixture to form a second mixture to form a nano-grained structure, and cold spraying the second mixture onto a substrate to form a coating having a nano-grained structure.
US08268234B2 Cermets from molten metal infiltration processing
New cermets with improved properties and applications are provided. These new cermets have lower density and/or higher hardness than B4C cermet. By incorporating other new ceramics into B4C powders or as a substitute for B4C, lower densities and/or higher hardness cermets result. The ceramic powders have much finer particle size than those previously used which significantly reduces grain size of the cermet microstructure and improves the cermet properties.
US08268233B2 Eddy-free high velocity cooler
A cooling system comprises serpentine cooling fluid passages cast into a work piece with carefully controlled turning radii and profiles. Individual interdigitated baffles are contoured in the plane of coolant flow to have walls that thicken and then round off at their distal ends. The outside radii at these turns is similarly rounded and controlled such that the coolant flow will not be swirled into eddies.
US08268231B2 Treatment method for high-temperature exhaust gas
This invention is intended to lower a temperature of a high-temperature exhaust gas to a desired temperature, while effectively suppressing adhesion of melting components and dusts in the high-temperature exhaust gas onto an inner wall of a cooling tower. For this purpose, a method of the present invention comprises an introduction step of introducing a high-temperature exhaust gas into a cooling tower through a gas duct, and a cooling step of sparging cooling water to the high-temperature exhaust gas in the cooling tower to cool the high-temperature exhaust gas. During the introduction step, the high-temperature exhaust gas is introduced into the cooling tower through the gas duct comprising two gas duct lines, in such a manner that respective portions of the high-temperature exhaust gas from the two gas duct lines become equal to each other in flow velocity and flow volume. Further, respective axes of the two gas duct lines are arranged so as to extend in directions opposed to each other and approximately orthogonal to an axis of the cooling tower, when viewed from a direction along the axis of the cooling tower.
US08268227B2 Method for forming optical compensating films, optical compensating films formed thereby, structure of optical compensating films, and polarizing plates
The invention provides a method for forming optical compensating films, including: (a) providing a suspension containing clay; (b) adding a mono-functional acrylic oligomer of formula (I) in the suspension, wherein n1 is 2-25, R1 is C1-10 alkyl or H and R2 is H or CH3; (c) adding a water-soluble polymer in the suspension; (d) adding a bi-functional acrylic oligomer of formula (II) in the suspension, wherein n2 is 3-50, and R3 and R4 independently are H or CH3; (e) after the step (d), drying the suspension to form a film; (f) exposing the film under UV light to cure the film; and (g) stretching the film, wherein the film has only a negative C-plate property before the stretching and has both negative C-plate and positive A-plate properties after the stretching.
US08268223B2 Form and process for casting concrete blocks
A form and process for casting concrete blocks, each having at least one side textured. The blocks are cast in cavities which have a resilient insert on at least one side for imparting texture to the blocks. After the cast blocks are cured, the form is inverted and placed on a support surface. At least the side having the resilient insert is moved laterally away from the block and the form is lifted to leave the block on the support surface. The textured side can release from the form despite deep grooves and crevices simulating natural stones.
US08268222B2 Methods of making electrical motor components from conductive loaded resin-based materials
Electric motor components are formed of a conductive loaded resin-based material. The conductive loaded resin-based material comprises micron conductive powder(s), conductive fiber(s), or a combination of conductive powder and conductive fibers in a base resin host. The percentage by weight of the conductive powder(s), conductive fiber(s), or a combination thereof is between about 20% and 50% of the weight of the conductive loaded resin-based material. The micron conductive powders are metals or conductive non-metals or metal plated non-metals. The micron conductive fibers may be metal fiber or metal plated fiber. Further, the metal plated fiber may be formed by plating metal onto a metal fiber or by plating metal onto a non-metal fiber. Any platable fiber may be used as the core for a non-metal fiber. Superconductor metals may also be used as micron conductive fibers and/or as metal plating onto fibers in the present invention.
US08268219B2 Method of resin sealing permanent magnets in laminated rotor core
A laminated rotor core (36) wherein permanent magnets (47) are inserted in respective magnet insertion holes (46) is disposed between and pressed by an upper die (37) and a lower die (29). The upper die (37) has resin reservoir pots (50) provided above the laminated rotor core (36) and at positions corresponding to the respective magnet insertion holes (46). Raw resin material put in the resin reservoir pots (50) is heated by the upper die (37). Subsequently, the resin material in a liquefied state is ejected from the resin reservoir pots (50) by plungers (52) that are inserted and moves vertically in the resin reservoir pots (50) and is directly filled in the magnet insertion holes (46). Consequently, the respective magnet insertion holes (46) are filled with the resin material more evenly and highly reliable products can be supplied at low cost.
US08268218B2 Release film for semiconductor resin molds
A process of sealing a semiconductor substrate by contacting the semiconductor substrate with a surface of a release layer (I) of a gas barrier release film that is in the form of a mold, which includes vacuum suction; injecting a sealing resin between the semiconductor substrate and the mold; and releasing said mold from said semiconductor substrate having said sealing resin present thereon, where the gas barrier release film has a release layer (I), which has excellent releasability; a plastic support layer (II) supporting the release layer; and a metal or a metal oxide gas restraint layer (III), present between the release layer and the support layer, where the gas barrier release film exhibits a xylene gas permeability of at most 5×10−15 (kmol m/(s·m2·kPa)) at 170° C., and a surface of said release layer (I) has an arithmetic surface roughness of from 0.15 to 3.5 μm, exhibiting a satin-finish.
US08268212B2 Process for manufacturing a plastic hollow body from a parison and die for extruding a parison
Process for manufacturing a plastic hollow body, said process comprising the following steps: a) a molten plastic parison is extruded, in an extruder, through a die; b) at least one longitudinal cut is made in the parison; c) the parison is introduced into a mold comprising two cavities; and d) the hollow body is molded by conforming the parison to the mold cavities, said die being equipped with a passage for the molten plastic which gradually modifies the shape of the parison so that it is substantially flattened on exiting. Die suitable for implementing this process.
US08268211B2 Method and apparatus for making bodily fluid absorbent pad
In making bodily fluid absorbent pads quantity of scrapped material is reduced. A bodily fluid absorbent pad (liner) 10 has a shape symmetric in a longitudinal direction P as well as in a transverse direction Q. A dimension of the pad 10 in the transverse direction Q is larger in opposite end regions 31, 32 than in an intermediate region 33. The pad 10 is formed along opposite side edges 11a, 11b with first and second compressed lines 21, 22. Paired compression rolls 302 are used to form the first and second compressed lines 21, 22, and at least one roll constituting the paired compression rolls 302 is formed on a peripheral surface thereof with compressing units projecting from the peripheral surface. The compressing units are arranged in a circumferential direction to form one row and at least one additional row, which is adjacent to the one row in an axial direction of the roll. In each pair of the adjacent rows, there is an offset between the compressing unit in the one row and the compressing units in the other row in the circumferential direction.
US08268210B2 Method and apparatus for the injection molding of a molded part
The moulded part has at least two different sections with different outer diameter and a void inside the moulded part. To make the void, a projectile is passed through the still molten injection mouldable material in a direction of flow. A pressurized fluid is exerted in the void in the direction of flow behind the projectile to move the projectile. To obtain constant wall thicknesses, the projectile has at least one elastic or plastic section, which is delimited by a space in which the pressurized fluid can enter. The volume of the space and the effective outer diameter of the projectile can be changed by the fluid pressure and is controlled in such a manner that the space and the effective outer diameter of the projectile is enlarged and/or reduced to make the moulded part with different diameters.
US08268205B2 Method for fabricating injection-molded product
A method for fabricating an injection-molded product for a mold in which a pattern carved therein is prepared. An interim injection-molded product with a pattern arranged on an inner face thereof is fabricated using the mold having the carved pattern. Paint or a coloring agent is deposited on the inner face of the molded interim injection-molded product. The pattern on the injection-molded product finished by depositing paint is visible from an exterior of the finished product.
US08268202B2 Potassium cesium tungsten bronze particles
Disclosed are potassium cesium tungsten bronze solid solution particles of the formula KxCsyWOz, where x+y≦1 and 2≦z≦3. The particles are for instance micron or nano scaled particles. Also disclosed are organic or inorganic compositions comprising an organic or inorganic substrate and incorporated therein the present potassium cesium tungsten bronze solid solution particles. The substrates are for instance plastics, coatings, inks, adhesives, ceramics or glass. Also disclosed is a method for the preparation of the present potassium cesium tungsten bronze solid solution particles, which method comprises mixing a suitable tungsten source with a salt of potassium and a salt of cesium to form a powder mixture and exposing the powder mixture to a plasma torch under a reducing atmosphere. The present tungsten bronze particles are suitable NIR absorbers and heat shielding additives.
US08268201B2 Color composition for color filter, color filter using the composition and liquid crystal display device
A color filter and a liquid crystal display device with the color filter that includes a substrate; and a color layer formed on the substrate and constituting color pixels of a plurality of colors, wherein the color layer is formed through a curing of a color composition comprising at least acrylic resin and a coloring agent, wherein the acrylic resin contains a copolymer formed of a first vinyl monomer having a benzyl group and a second vinyl monomer having a carboxyl group, the first vinyl monomer having a function of regulating a retardation of a color layer, the copolymer having a weight average molecular weight of 3000 to 11000 and an acid value of solid matter falling within the range of 30 to 85.
US08268200B2 Pigment dispersing composition for color filter
Provided is a pigment dispersing composition for a color filter including a color material, a resin, and an organic solvent which may dissolve the resin, wherein a modified pigment (D) is contained as the color material which includes, on the surface of a pigment (A), a polymer (P) obtained by polymerizing a polymer (B) containing a polymerizable unsaturated group soluble in a non-aqueous solvent and at least one type of polymerizable unsaturated monomer (C) which is soluble in the non-aqueous solvent and becomes either insoluble or poorly soluble following polymerization, alternatively wherein a modified pigment (D) is contained as the color material which is obtained, under the presence of a pigment (A), a non-aqueous solvent, and a polymer (B) containing a polymerizable unsaturated group soluble in the non-aqueous solvent, by polymerizing at least one type of polymerizable unsaturated monomer (C).
US08268198B2 Precursor for preparation of lithium transition metal oxide
Provided is a precursor for the preparation of a lithium transition metal oxide that is used for the preparation of a lithium transition metal oxide as a cathode active material for a lithium secondary battery, through a reaction with a lithium-containing compound, wherein the precursor contains two or more transition metals, and sulfate ion (SO4)-containing salt ions derived from a transition metal salt for the preparation of the precursor have a content of 0.1 to 0.7% by weight, based on the total weight of the precursor.
US08268197B2 Solid electrolyte material manufacturable by polymer processing methods
The present invention relates generally to electrolyte materials. According to an embodiment, the present invention provides for a solid polymer electrolyte material that is ionically conductive, mechanically robust, and can be formed into desirable shapes using conventional polymer processing methods. An exemplary polymer electrolyte material has an elastic modulus in excess of 1×106 Pa at 90 degrees C. and is characterized by an ionic conductivity of at least 1×10−5 Scm-1 at 90 degrees C. An exemplary material can be characterized by a two domain or three domain material system. An exemplary material can include material components made of diblock polymers or triblock polymers. Many uses are contemplated for the solid polymer electrolyte materials. For example, the present invention can be applied to improve Li-based batteries by means of enabling higher energy density, better thermal and environmental stability, lower rates of self-discharge, enhanced safety, lower manufacturing costs, and novel form factors.
US08268195B2 Electrically conductive films formed from dispersions comprising polythiophenes and ether containing polymers
An aqueous dispersion and a method for making an aqueous dispersion. The dispersion including at least one conductive polymer such as a polythienothiophene, at least one ether containing polymer and optionally at least one colloid-forming polymeric acid and one non-fluorinated polymeric acid. Devices utilizing layers formed of the inventive dispersions are also disclosed.
US08268193B2 Polymer composition for organic electroluminescence
A polymer material as light emitter or charge transport material, and a polymer composition for organic electroluminescence containing a crosslinking agent characterized in that the crosslinking agent has no aromatic ring.
US08268191B2 Liquid-crystalline medium and liquid-crystal display
The present invention relates to dielectrically positive liquid-crystalline media comprising one or more compounds of the formula I in which the parameters have the meaning indicated in the specification, and optionally one or more compounds selected from the group of the compounds of the formulae II and III in which the parameters have the meaning indicated in the specification, and optionally one or more compounds of the formula IV in which the parameters have the meaning indicated in the specification, and to liquid-crystal displays containing these media, especially to active-matrix displays and in particular to TN, IPS and FFS displays.
US08268190B2 Liquid crystal composition for use in liquid crystal display
A liquid crystal composition is disclosed, which includes a liquid crystal material having a negative dielectric constant anisotropy and at least two different kinds of reactive monomers. A proportion The amount of the at least two different kinds of the reactive monomers in the total weight of the liquid crystal composition is ranges from 0.05% to 10% by weight. Additionally, a liquid crystal display using the liquid crystal composition as well as methods and uses thereof are further provided.
US08268182B2 Product having through-hole and laser processing method
A processing method of forming a through-hole in a workpiece by means of a pulsed laser beam includes the steps of providing a removable sacrifice layer on the workpiece, forming a through-hole in the workpiece by the laser beam in a state where the sacrifice layer is provided, and removing the sacrifice layer from the workpiece after the step of forming the through-hole.
US08268179B2 Liquid vacuuming and filtering device and method
A liquid vacuuming and filtering device may include a container having a sealed interior, a vacuum pump connected to the interior, a two-way valve connected to the interior, a flexible hose connected to the valve, a filter positioned within the interior and connected to the valve and a standpipe positioned within the interior and connected to the valve. The pump may be adjusted to a filling configuration, in which the pump evacuates the container interior to a pressure below ambient, causing fluid to be drawn through the hose, valve, and filter, which collects suspended particulates; or to a discharge configuration, in which the pump pressurizes the interior to a pressure above ambient, wherein the valve is adjusted to allow filtered fluid within the container to flow through the standpipe, valve and out through the hose.
US08268178B1 Fluid conditioning system and process of conditioning fluid
A process of conditioning a fluid includes passing the fluid through a magnetic field. A fluid conditioning system includes a conduit through which fluid passes, and a magnet assembly including at least one magnet disposed such that the produced magnetic field penetrates the conduit. The conduit is formed from a material that allows the magnetic field to have a magnetic effect on molecules of the fluid as it passes through the conduit. The conduit has a cross-sectional area designed to maintain a flow rate of the fluid through the conditioning volume within a pre-determined range. The magnetic field produced by the magnet has a field strength within the conduit, and the predetermined range is predetermined as a factor in combination with the field strength to precipitate an ion from the fluid in the conditioning volume.
US08268177B2 Microfluidic separation system
A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.
US08268176B2 Backwash
A method of backwashing a membrane filtration module (4), said module (4) including one or more membranes (5) located in a feed-containing vessel (3), the membranes (5) having a permeable wall which is subjected to a filtration operation wherein feed containing contaminant matter is applied to one side of the membrane wall and filtrate is withdrawn from the other side of the membrane wall, the method including: removing liquid from the feed-containing vessel (3) until the level of liquid in the feed-containing vessel (3) falls to a first level (L2) below an upper level of the membranes; suspending the filtration operation; performing a liquid backwash of the membrane wall until liquid level within the feed-containing vessel (3) rises to a second predetermined level (L1) above said first level; aerating the membrane surface with gas bubbles to dislodge fouling materials therefrom; performing a sweep or drain down of the feed-containing vessel (3) to remove the liquid containing the dislodged contaminant matter; and recommencing the filtration operation.
US08268174B2 Wastewater treatment method and system with ozonation for microconstituent removal
In a sewage treatment system, microconstituents, including personal care products and pharmaceutical materials, often difficult to degrade biologically, are removed by supersaturating the untreated wastewater feed with ozone. This breaks down refractory microconstituents into more readily biodegradable materials, subsequently treated preferably in an activated sludge membrane bioreactor process. The oxygen byproduct of ozonation is utilized by feeding the oxygen into an aerobic part of the plant to meet a portion of the biological demand, thereby increasing efficiency of ozone use in the process.
US08268173B2 Controlled aeration of integrated fixed-film activated sludge bioreactor systems for the treatment of wastewater
A method of biologically treating wastewater with an integrated fixed film activated sludge process. The integrated fixed film activated sludge process includes biomass suspended in mixed liquor and biomass disposed on carriers. Under certain conditions the dissolved oxygen concentration in a reactor that includes the mixed liquor, biomass suspended in the mixed liquor, and the biomass on the carriers, biological treatment is performed primarily by the biomass in the mixed liquor. This is achieved by controlling or maintaining the dissolved oxygen concentration in the reactor at a relatively low concentration. When the biomass suspended in the mixed liquor is unable to adequately biologically treat the mixed liquor, the dissolved oxygen concentration in the reactor is controlled or maintained at a relatively high concentration. This enables biomass on the carriers to contribute more to the biological treatment of the mixed liquor than when the dissolved oxygen concentration was maintained relatively low.
US08268172B2 Waste fluid treating apparatus
A waste fluid treating apparatus including a pure water generating unit including an ion exchanger for purifying a fresh water sent by a fresh water pump to obtain a pure water. The ion exchanger includes a housing, an anion exchange resin layer accommodated in the housing, and a mixed resin layer accommodated in the housing. The anion exchange resin layer is composed of only anion exchange resin, and the mixed resin layer is composed of a mixture of anion exchange resin and cation exchange resin. The housing is provided with a fresh water inlet for introducing the fresh water into the anion exchange resin layer and a pure water outlet for discharging the pure water from the mixed resin layer.
US08268170B2 Filter
A filter including a filter bowl (4), filer head (48) and filter element (2). The filter element (2) comprises a locking ring (12), a first end cap (6) coupled to the locking ring (12), a filter media (10) coupled to the first end cap (6), and a locking rib (30) extending outwardly from the locking ring (12). The locking rib (30) comprises a first portion (34) which extends radially from the locking ring (12) and a second portion (38) which extends from the first portion (34) around the periphery of the locking ring (12). At least part of the second portion (38) of the locking rib (30) is arranged to flex relative to the first portion (34) of the locking rib (30). The locking rib (30) forms part of a bayonet connection.
US08268169B2 Membrane bioreactor (MBR) and moving bed bioreactor (MBBR) configurations for wastewater treatment
The water treatment system and method incorporating the use of a hydrodynamic separator to remove most of the total suspended solids (TSS) in source water being treated to thereby lighten the load on membrane filtration in the water treatment system and lower energy costs.
US08268168B2 Filter unit for shower system
A filter unit for a shower system includes a filtering housing and a filter core. The filtering housing includes a main body having a water inlet and a plurality of water outlets, wherein the water inlet is arranged to connect with the water supply tube so as to allow water to flow into the filtering housing through the water inlet, wherein one of the water outlets is connected with the second end of an extension tube of a shower head. The filter core is received in the filtering housing, and is capable of filtering unwanted substances in the water flowing from the water supply tube, wherein the filtered water is guided to flow out of the filtering housing through one of the corresponding water outlet to the extension tube and the shower head.
US08268162B2 Voltammetric device having sample degassing system
A system and method for voltammetric analysis of a liquid sample solution.
US08268161B2 Electrochemical sensor having a mediator compound with a solid
An electrochemical sensor is provided especially for gases. The electrochemical sensor has a mediator compound, which is both dissolved in an electrolyte (9) in a saturated form and is present as an excess solid (10) in the electrolyte (9).
US08268160B2 Corrosion testing of fuel-cell separator plate materials
In one example, a specimen is immersed in an electrolyte, and a plurality of potentials of the specimen are experimentally related to a plurality of currents by applying the potentials to the specimen while measuring the currents, or, by drawing the currents through the specimen while measuring the potentials. The potentials are referenced to a hydrogen reference electrode. Hydrogen is supplied to the hydrogen reference electrode via an electrolysis cathode distinct from the hydrogen reference electrode. In another example, an electrochemical cell confines a head gas disposed over the electrolyte. A partial pressure of water vapor in the head gas is adjusted so that the concentration of water in the electrolyte, when equilibrated with the head gas, falls within a predetermined concentration range. The head gas and electrolyte are then equilibrated, thereby controlling the concentration of water in the electrolyte, and an electrochemical property of the specimen is measured.
US08268155B1 Copper electroplating solutions with halides
Methods, electroplating solution, and apparatuses for electroplating copper into a surface of a partially fabricated semiconductor substrate are provided. Electroplating solutions include copper ions, suppressor additives, chloride ions, and alternative halide ions, which include bromide ions and/or iodide ions. The concentration of the alternative halide ions in the solution may be between about 0.25 ppm and 20 ppm. Addition of the alternative halide ions at certain concentrations improves suppression properties of the solution over a range of feature sizes without a need to change suppressors.
US08268153B2 Substrate and method for fabricating the same
A single crystal of zinc oxide which is c-axis oriented with use of electrolytic deposition method is formed on an amorphous carbon layer, after the amorphous carbon layer is provided on an inexpensive graphite substrate. The amorphous carbon layer is provided by oxidizing the surface of the graphite substrate.
US08268152B2 Microfluidic system and method for assembling and for subsequently cultivating, and subsequent analysis of complex cell arrangements
A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26). A cell arrangement is assembled in this microstructure (11) by supplying medium (21, 22) with cells (23, 24) for assembling the cell culture in the microstructure (11), with the inhomogeneous electric field (28) determined by the microstructure (11) bringing about the assembling of the cell arrangement from the supplied cells (23, 24).
US08268151B2 Method and device for the manipulation of particles by overlapping fields of force
Methods and relative devices are illustrated for generating time-variable electric fields suitable for determining the creation of closed dielectrophoretic cages able to trap inside even single particles without the cages being necessarily positioned at relative minimum points of the electric field.
US08268148B2 Reference electrode, manufacturing method and battery comprising same
A reference electrode having a casing with an inner cavity successively filled with a paste constituting an active material and a porous material impregnated with an electrolyte solution. The projecting end of a silver wire is embedded in the paste at the bottom of the inner cavity. The paste is constituted of a powder of a silver compound and of the alkaline electrolyte solution. The silver compound is any insoluble silver salt or oxide containing the negative ion of the electrolyte solution. The impregnated porous material is preferably constituted by a plurality of mat separator pieces mechanically and compressed by a closing plug, closing the inner cavity and forming a porous liquid junction.
US08268147B2 Gas sensor control device and method
A control device for a gas sensor is configured to: receive a mode command to specify one of a plurality of sensor energization modes including at least a gas concentration detection mode, a protection mode and a pre-energization mode; switch a sensor element of the gas sensor into the one of the plurality of sensor energization modes according to the mode command; judge satisfaction of a certain condition where the mode command is to specify the gas concentration detection mode and the sensor element is in any of the plurality of sensor energization modes other than the pre-energization mode at the time of receipt of the mode command; and prohibit the sensor element from switching over to the gas concentration detection mode when the certain condition is satisfied.
US08268139B2 Hydrogen generation apparatus
The present invention relates to a hydrogen generation apparatus using chemical hydride. The present invention features an electrolyte including chemical hydride and a catalyst that is inserted between metal electrodes, wherein the hydrogen is generated in a unit cell by hydrolysis of the hydride.
US08268135B2 Method and apparatus for electrochemical planarization of a workpiece
An electrochemical planarization apparatus for planarizing a metallized surface on a workpiece includes a polishing pad and a platen. The platen is formed of conductive material, is disposed proximate to the polishing pad and is configured to have a negative charge during at least a portion of a planarization process. At least one electrical conductor is positioned within the platen. The electrical conductor has a first end connected to a power source. A workpiece carrier is configured to carry a workpiece and press the workpiece against the polishing pad. The power source applies a positive charge to the workpiece via the electrical conductor so that an electric potential difference between the metallized surface of the workpiece and the platen is created to remove at least a portion of the metallized surface from the workpiece.
US08268134B2 System for protecting turbine engine surfaces from corrosion
According to various embodiments, a system includes a turbine engine component that includes a first material having a surface exposed to a fluid flow path and a sacrificial anode layer disposed on the surface. The sacrificial anode layer includes a second material that is electrochemically more active than the first material and the second material is configured to preferentially corrode to protect the first material from corrosion.
US08268133B2 Method and apparatus for microwave reduction of organic compounds
The invention described herein generally pertains to utilization of high power density microwave energy to reduce organic compounds to carbon and their constituents, primarily in a gaseous state. The process includes, but is not limited to, scrap tires, plastics, asphalt roofing shingles, computer waste, medical waste, municipal solid waste, construction waste, shale oil, and PCB/PAH/HCB-laden materials. The process includes the steps of feeding organic material into a microwave applicator and exposing the material to microwave energy fed from at least two linear polarized sources in non-parallel alignment to each other, and collecting the material. The at least two sources of microwave energy are from a bifurcated waveguide assembly, whose outputs are perpendicular to each other and fed through waveguide of proper impedance, such that the microwave sources are physically and electrically 90° out of phase to each other. The microwave frequency is between 894 and 1000 MHz, preferably approximately 915 MHz.
US08268128B2 Security substrates
The invention is directed toward improvements in security substrates, such as paper, used for making security documents, such as bank notes, having anti-counterfeit able features and in particular to security substrates incorporating an elongate security element and methods of making the substrate. The invention comprises a security substrate for making security documents and the like comprising a fibrous base substrate and an elongate security element at least partially embedded therein. At one surface of the security substrate one portion of the security element is exposed to provide a continuous track along the length of the security element. A plurality of other portions along at least one edge of the security element are partially covered by overlapping regions of the fibrous substrate. The invention further comprises a method of manufacturing such a security substrate.
US08268127B2 Method of degumming jute fibres with complex enzyme
A method of degumming jute fibers with complex enzyme, wherein said complex enzyme comprises pectinase and laccase, comprises the steps of: a. soaking the jute fibers in the water solution of said complex enzyme made from pectinase and laccase and adjusting the weight proportion of said complex enzyme water solution and said jute fibers; b. adjusting the PH value of said complex enzyme water solution, and adjusting the temperature of said complex enzyme water solution to a first temperature, then keeping said complex enzyme water solution with the first temperature for a certain period of time; c. adjusting the PH value of said complex enzyme water solution, and adjusting the temperature of said complex enzyme water solution to a second temperature; then, keeping said complex enzyme water solution with the second temperature for another period of time; d. conducting enzyme deactivation of the jute fibers processed with said complex enzyme.
US08268125B2 Method for vapor phase pulping with alcohol and sulfur dioxide
A method for the fractionation of lignocellulosic materials into cellulose, hemicelluloses and lignin in a batch or continuous process in a treatment with vaporous mixture of aliphatic alcohol, sulfur dioxide and water. Cooking conditions are varied to get different proportions of cellulose, hemicelluloses and lignin. Chemical recovery through pressure release is described.
US08268123B2 Process for producing bleached pulp
Provided are a method for producing bleached pulp, comprising processing unbleached pulp obtained by cooking a lignocellulose substance, for alkali-oxygen bleaching followed by treatment with peroxomonosulfuric acid and thereafter by multistage chlorine-free bleaching treatment starting from chlorine dioxide treatment; a method for producing bleached pulp, comprising processing the unbleached pulp for alkali-oxygen bleaching followed by chlorine-free bleaching treatment or totally chlorine-free bleaching treatment to bleach it to a degree of brightness of from 70 to 89%, and further followed by treatment with peroxomonosulfuric acid; and paper produced by the use of the bleached pulp produced according to these production methods, at a papermaking pH of at most 6. Provided are the efficient production methods for bleached pulp in which the color reversion resistance is enhanced in chlorine-free bleaching and the bleaching cost increase is prevented, and the paper produced by the use of the bleached pulp according to an acid papermaking process.
US08268122B2 Process of producing high-yield pulp
The present invention relates to a process for preparing a high-yield pulp comprising a) treating a lignocellulose containing material chemically by means of an oxidizing system comprising at least one non-enzymatic oxidant substantially free from ozone and chlorine dioxide and an activator at a pH from about 2 to about 6.5; and b) treating the lignocellulose containing material mechanically for a time sufficient to produce a high-yield pulp, wherein the lignocellulose containing material is chemically treated prior to and/or during any mechanical treatment stage, and wherein the lignocellulose containing material is not chemically treated at a pH from about 11.5 to about 14 between stages a) and b).
US08268114B2 Workpiece holder for polishing, workpiece polishing apparatus and polishing method
A workpiece holder for polishing includes a workpiece holder body having multiple perforated holes to hold a workpiece by vacuum suction. A holding surface of the workpiece holder body may be coated with resin. A coefficient of thermal expansion of the resin coating on the holding surface may be 1×10−5/K or less. The resin coating on the holding surface may be epoxy resin filled with silica particles.
US08268113B2 Apparatus and method for fabricating bonded substrate
A bonded-substrate fabricating apparatus capable of reducing defective bonded substrates fabricated. A transfer robot sucks the outer edge area of the bottom surface of a substrate and spouts gas toward the bottom surface of the substrate to carry the substrate into a vacuum process chamber of a press machine while keeping the substrate horizontally. A press plate holds the substrate, which is held by the transfer robot, by suction.
US08268111B2 Method and apparatus for forming a continuous oriented structure of a polymer
A method and an apparatus for easily making a continuous oriented structure of a polymer are provided. In making a polymer assembly, single crystals are bonded to each other, an external force, such as an electrical field or a magnetic field, is applied to the single crystals, or a solution of the polymer is applied on a substrate such that the applied solution is linear in shape.
US08268102B2 Formaldehyde-free lignocellulosic adhesives and composites made from the adhesives
Method for making lignocellulosic composites by adhering lignocellulosic substrates together. A first variant of the method involves using an adhesive composition that comprises a reaction product of (i) first ingredient selected from a soy protein or lignin and (ii) at least one substantially formaldehyde-free curing agent that includes at least one amine, amide, imine, imide, or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the soy protein. A second variant of the method involves using an adhesive composition that comprises a reaction product of (i) a protein or lignin, (ii) a first compound that includes at least one amine, amide, imine, imide or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the protein and (iii) a curing agent.
US08268100B2 Laser-produced porous surface
A method of fabricating a porous or partially porous three-dimensional metal article for use as a tissue ingrowth surface on a prosthesis. The porous article is formed using direct laser remelting in a cross section of a layer of metallic powder on a build platform without fusing thereto. The power, speed, spot size and beam overlap of the scanning laser is coordinated so that a predetermined porosity of the metallic powder can be achieved. Laser factors also vary depending from the thickness of the powder layer, type of metallic powder and size and size distribution of the powder particles. Successive depositing and remelting of individual layers are repeated until the article is fully formed by a layer-by-layer fashion. In an additional embodiment, a first layer of metallic powder may be deposited on a solid base or core and fused thereto.
US08268095B2 Method of manufacturing hot dip galvannealed steel sheet and hot dip galvannealed steel sheet
A method of manufacturing a hot dip galvannealed steel sheet, including the steps of: subjecting a steel sheet to hot dip galvanizing to manufacture a hot dip galvanized steel sheet; heating the hot dip galvanized steel sheet for alloying; subjecting the hot dip galvanized steel sheet to temper rolling; bringing the temper-rolled hot dip galvanized steel sheet into contact with an acid solution containing at least one ion selected from the group consisting of Zr ions, Ti ions, and Sn ions to thereby form an acid solution film on the surface of the steel sheet; after completion of the contact, a state where the acid solution film is formed on the surface of the steel sheet is held for at least 1 second; and washing with water the hot dip galvanized steel sheet after holding, to thereby form a Zn oxide layer having a thickness of 10 nm or more on the surface of the galvanized steel sheet. The hot dip galvannealed steel sheet has an oxide layer having an average thickness of 10 nm or more on the surface of the plated steel sheet.
US08268094B2 Furnace atmosphere activation method and apparatus
A gas injector including in which a gas is passed through high-voltage/low-current electrical discharges before being discharged into the chamber of a thermal treatment furnace. The electrical activation of the gas accelerates desirable reactions between the gas, gases in the furnace chamber, and the chamber workload. Preferably, a hot electrode is electrically charged and the other parts of the gas injector and the furnace are grounded. Also provided is a method for activating an atmosphere within the reaction chamber of a controlled-atmosphere reactor.
US08268093B2 R-Fe-B porous magnet and method for producing the same
An R—Fe—B based porous magnet according to the present invention has an aggregate structure of Nd2Fe14B type crystalline phases with an average grain size of 0.1 μm to 1 μm. At least a portion of the magnet is porous and has micropores with a major axis of 1 μm to 20 μm.
US08268091B2 Dish washing machine comprising a device for storing washing liquid
A dish washing machine configured to consume the smallest possible amount of water has a device for storing the washing liquid, in which at least one storage reservoir is provided that is made of a flexible material for holding at least a portion of the washing liquid located inside the dish washing machine. The dish washing machine offers the possibility of removing, at any time during the washing program, at least a portion of the washing bath from the washing circuit, of storing it in the storage reservoir and, when needed, of supplying it once again to the washing circuit. Thus, for example, after completing the last clear rinsing cycle, the washing bath is at least partially retained in the storage reservoir until use of the bath in a subsequent washing cycle, whereby by and large reducing the consumption of water of the dish washing machine.
US08268087B2 Liquid processing apparatus, liquid processing method, and storage medium
A liquid processing apparatus includes: a hollow holding plate configured to hold an object to be processed; a hollow outer rotational shaft fixedly connected to the holding plate; a rotary drive part configured to rotate the outer rotational shaft; and a lift pin plate disposed in a hollow space of the holding plate, and having a lift pin configured to support the object to be processed. Inside the lift pin plate, a cleaning-liquid supply part configured to supply a cleaning liquid is extended. Connected to the lift pin plate is a lifting member configured to locate the lift pin plate on an upper position and a lower position. When located on the lower position, the lift pin plate receives a force of the rotary drive part for rotating the outer rotational shaft so that the lift pin plate is rotated.
US08268086B2 Method for processing a photomask for semiconductor devices
A method for processing a photomask for semiconductor devices. The method includes providing a partially completed mask structure, which has a backside and a face. The face includes a substrate material, a light blocking layer overlying the substrate material, and an overlying patterned photoresist layer overlying the light blocking layer. The method includes supporting the backside of the mask structure to maintain the mask structure in place and maintaining the face of the patterned photoresist layer in a direction parallel to a gravitational force and toward the gravitational force. The method includes rotating the mask structure in an annular manner as the patterned photoresist layer of the mask structure is being maintained in the direction parallel to the gravitational force and toward the gravitational force. Additionally, the method includes applying cleaning fluid on the patterned photoresist layer as the patterned photoresist layer of the mask structure is being maintained in the direction parallel to gravity, is facing the gravitational force, and is being rotated to remove one or more particles from the patterned surface. Preferably, the method includes accelerating the one or more particles away from the surface of the patterned photoresist layer, whereupon the one or more particles are prevented from attaching themselves back to the patterned photoresist layer via the gravitational force.
US08268085B2 Methods for forming metal gate transistors
A method for cleaning a diffusion barrier over a gate dielectric of a metal-gate transistor over a substrate is provided. The method includes cleaning the diffusion barrier with a first solution including at least one surfactant. The amount of the surfactant of the first solution is about a critical micelle concentration (CMC) or more. The diffusion barrier is cleaned with a second solution. The second solution has a physical force to remove particles over the diffusion barrier. The second solution is substantially free from interacting with the diffusion barrier.
US08268080B2 Apparatus and method for preparing composite particulates using vapor deposition
Disclosed herein is an apparatus for preparing composite particulates, including a rotary body having a bottom surface and a side wall and operative to contain particulates to which an adhering material is to be made to adhere; a centrifugal machine for rotating the rotary body so as to apply centrifugal forces to the particulates in the rotary body; and an inclination varying device operative to vary the inclination of the rotary body to an arbitrary inclination angle in the range from an angle at which the bottom surface of the rotary body forms a horizontal surface perpendicular to the direction of gravity to an angle at which the bottom surface forms a vertical surface parallel to the direction of gravity, and operative to support the rotary body at the arbitrary inclination angle.
US08268078B2 Method and apparatus for reducing particle contamination in a deposition system
A method and system is described for reducing particle contamination of a substrate in a deposition system. The deposition system comprises one or more particle diffusers disposed therein and configured to prevent or partially prevent the passage of film precursor particles, or break-up or partially break-up film precursor particles. The particle diffuser may be installed in the film precursor evaporation system, or the vapor delivery system, or the vapor distribution system, or two or more thereof.
US08268074B2 Method and device for producing oriented solidified blocks made of semi-conductor material
A method and a device for producing oriented solidified blocks made of semi-conductor material are provided. The device includes a crucible, in which melt is received, and has an insulation which surrounds the crucible at least from the top and from the side and which is arranged at a distance therefrom at least above the crucible, and at least one heating device which is arranged above the crucible. The region inside the insulation above the crucible is divided by an intermediate cover in a process chamber and a heating chamber is arranged thereabove, where at least one heating element is arranged.
US08268068B2 Metal-polymer coordination complex incorporating phosphorus atoms and applications using such a complex
The invention relates to a compound comprising at least one polymeric chain incorporating phosphorus atoms and consisting, in all or in part, of identical or different repeated units, each of said units being represented by the following formula: wherein X3 represents —[Si(O2)]—; or —O—[Si(R1R2)O]— with R1 and R2 being, independently of each other, a C1-C30 alkyl or alkoxy group, a C5-C30 aryl group; or a mono- or polyorganosilicate derived radical; or —N(R3)— with R3 being —H, a C1-C30 alkyl group or a C5-C30 aryl group, optionally substituted with —OH or —NH2, or at least one unit of general formula (I), and ═X4 represents an electron pair, ═O, ═S, ═NR4 with R4 representing a C1-C30 alkyl group or a C5-C30 aryl group, ═Se or ═Te, and its use for complexing metal atoms.
US08268065B2 X-ray opaque barium-free glasses and uses thereof
Zirconium-containing BaO- and PbO-free X-ray opaque glasses having a refractive index nd of about 1.518 to about 1.533 and a high X-ray opacity with an aluminum equivalent thickness of at least about 180% are provided. Such glasses are based on a SiO2—Al2O3—B2O3 system with additions of K2O, ZrO2, and one or both of La2O3 and Cs2O. Such glasses may be used, in particular, as dental glasses or as optical glasses.
US08268064B2 Ink-jet inks and ink sets exhibiting reduced bleed, wicking, and/or halo effect and associated methods
Compositions, systems, and methods for ink-jet printing having improved black to color bleed control, reduced wicking, and/or reduced halo are described. The composition can include a functionalized carbon pigment dispersed in an ink vehicle. The carbon pigment includes functional groups chemically attached thereto. Suitable functional groups includes an aromatic ring structure having multiple carboxyl groups (or salts thereof) attached to the aromatic ring structure, wherein at least two of the multiple carboxyl groups are positioned on adjacent carbon atoms of the aromatic ring structure.
US08268060B2 Dehumidifier system
A dehumidifier system having a dehumidifier section within which liquid desiccant absorbs moisture from air flowing therethrough and a dehumidifier section within which the desiccant is regenerated employs a heat exchanger for maintaining a relatively high temperature differential between the desiccant contained within the dehumidifier and regenerator sections. The desiccant which is conducted to either the dehumidifier section or the regenerator section is separated into multiple streams, and the multiple streams are treated differently from one another before being discharged into preselected segments of the air flow moving through the corresponding one of the dehumidifier section and the regenerator section. A control scheme in the system is capable of altering, and thereby improving, the concentration level of desiccant utilized in the system.
US08268056B2 Method for manufacturing separator, separator manufactured by the method and method for manufacturing electrochemical device including the separator
Disclosed is a method for manufacturing a separator. The method includes (S1) preparing a porous planar substrate having a plurality of pores, (S2) preparing a slurry containing inorganic particles dispersed therein and a polymer solution including a first binder polymer and a second binder polymer in a solvent, and sequentially coating the slurry on the porous substrate through a first discharge hole and a non-solvent incapable of dissolving the second binder polymer on the slurry through a second discharge hole adjacent to the first discharge hole, and (S3) simultaneously removing the solvent and the non-solvent by drying. According to the method, a separator with good bindability to electrodes can be manufactured in an easy manner. In addition, problems associated with the separation of inorganic particles in the course of manufacturing an electrochemical device can be avoided.
US08268054B2 Hood air scoop
An apparatus and a system is provided that may be utilized to provide stability to air flow through a hood scoop. The present invention may also be utilized to straighten and smooth out air flow through a hood scoop and accompanying air filter media. The present invention utilizes an air filtration media which may be inserted into at least a portion of a vehicle hood scoop and may filter out particulate and may also slow air flow down temporarily in order to straighten and/or smooth turbulent air flow through the air filtration media. Additionally, the present invention may provide an apparatus that may facilitate more uniform pressure inside the hood scoop of the vehicle.
US08268052B2 Wall assembly
A wall assembly for mixing polluted air with less polluted air to provide moderately polluted air. The wall assembly includes means for dividing air from a roadway region into a lower part and an upper part, and means for permitting at least a portion of the upper part to flow substantially in one or more flow directions toward a leeward region. The wall assembly also includes means for directing the lower part substantially upwardly in a direction substantially transverse to the flow direction to intersect with the upper part and to mix the polluted air with the less polluted air, to provide the moderately polluted air proximal to the leeward area.
US08268050B2 CO2 separation apparatus and process for oxy-combustion coal power plants
An improved process for the separation of carbon dioxide from the flue gas of an oxy-combustion power plant is provided. The flue gas is compressed, cleaned, cooled and dried. This clean, compressed dry flue gas is then further cooled, partially condensed and separated into liquid and vapor streams. The liquid streams, which contain a high concentration of carbon dioxide, are vaporized, compressed and exported to an end user. The vapor streams are heated and expanded, in order to extract useable energy. At least two expanders are used to extract this energy, with an intermediate warming step.
US08268048B2 Oxygen binding of nanoparticulate metal complexes
Solid nanoparticulate transition metal complexes of Co(II) salen exhibit reversible oxygen absorption in a near stoichiometric manner. In contrast, no measurable oxygen binding was observed with unprocessed Co(II) salen.
US08268044B2 Separation of a sour syngas stream
A feed stream, comprising hydrogen sulphide (H2S), carbon dioxide (CO2), hydrogen (H2) and, optionally, carbon monoxide (CO), is separated into at least a CO2 product stream and an H2 or H2 and CO product stream. The stream is separated using a pressure swing adsorption system, an H2S removal system and a further separation system, which systems are used in series to separate the stream. The method has particular application in the separation of a sour (i.e. sulphur containing) syngas, as for example produced from the gasification of solid or heavy liquid carbonaceous feedstock.
US08268042B2 Polymer inorganic clay composites
The instant invention generally provides polymer inorganic clay composite comprising a molecularly self-assembling material and an inorganic clay, and a process of making and an article comprising the polymer inorganic clay composite.
US08268041B2 Hollow organic/inorganic composite fibers, sintered fibers, methods of making such fibers, gas separation modules incorporating such fibers, and methods of using such modules
A suspension of inorganic particles, a copolymer comprising soft segments and hard segments, and a solvent may be extruded through a spinnerette to produce inorganic/organic composite hollow precursor fibers. The precursor fibers may be sintered. The fibers may be utilized in a gas separation module for separation of a gas mixture or production of syngas. The fibers may be installed in the gas separation module after sintering or they may be sintered after installation.
US08268038B2 High temperature leaching process
A method of conducting a bioleaching process including the steps of forming a main heap, culturing at least one microorganism which exhibits bioleaching activity in a predetermined temperature range, monitoring the temperature in the main heap, which is a result, at least, of microbial leaching activity and inoculating the heap with the cultured microorganism at least before the temperature reaches the predetermined range.
US08268033B2 Filter medium and structure
Thermoplastic bicomponent binder fiber can be combined with other media, fibers and other filtration components to form a thermally bonded filtration media. The filtration media can be used in filter units, such as breather caps. Such filter units can be placed in the stream of a mobile fluid and can remove a particulate and/or fluid mist load from the mobile stream. The unique combination of media fiber, bicomponent binder fiber and other filtration additives and components provide a filtration media having unique properties in filtration applications.
US08268028B2 Compositions, devices and methods for hydrogen generation
Methods and systems for hydrogen generation from solid hydrogen storage compositions which generate hydrogen in an exothermic reaction wherein the heat released can be absorbed by solid endothermic compositions are disclosed. The solid hydrogen storage compositions comprise mixtures of chemical hydrides and water surrogate compounds. Fuel cartridges suitable for use with compositions which generate hydrogen upon the application of thermal initiation and methods for operating the fuel cartridges are also disclosed.
US08268013B2 Hair treatment composition and methods
In one embodiment, the invention provides a method of removing color from dyed hair, the method comprising applying to the hair a color removal composition comprising a sulfur-containing nucleophile or a precursor thereof.
US08268010B2 System and method for forming bone filling materials with microparticles
A method for treating a vertebral bone comprises providing a plurality of hollow microparticles and providing a flowable and settable bone filling material. The method further comprises mixing the plurality of hollow microparticles with the bone filling material to form a bone augmentation material. The method further comprises inserting an injection device into the vertebral bone and injecting the bone augmentation material from the injection device and into the vertebral bone.
US08268006B2 Constrained prosthetic knee with rotating bearing
A constrained prosthetic knee having a modular hinge post and a rotating bearing. A cannulated hinge post is rotatably connected to the femoral component of the knee prosthesis so that a hinge post extension may be anteriorly positioned through the hinge post and into the tibial component of the knee prosthesis, after positioning of the femoral component in the femur and the tibial component in the tibia. The hinge post is preassembled to the femoral component so that such assembly is not required during the implantation procedure. A meniscal component forming the rotating bearing of the knee prosthesis is packaged together with the hinge post extension so that the appropriate hinge post extension is readily available. The meniscal component includes a mechanism for preventing lift off of the meniscal component from the tibial component, while allowing rotation of the meniscal component relative to the tibial component.
US08268005B2 Porous titanium modular revision patella system
A patellar implant includes a posterior portion and an anterior portion. The posterior portion can have a first radial sidewall that extends between an outboard face and an inboard face. The outboard face can include an articulating surface. The inboard face can include one of a stem and a recess, and one of an annular central hub and an annular radial pocket. The anterior portion can have a second radial sidewall that extends between a tissue engaging surface and a posterior portion engaging surface.
US08268004B2 Stabilized, adjustable expandable implant and method
Embodiments of the invention include expandable, implantable devices and methods. Devices expand linearly to provide secure fixation between or among anatomical structures. In some embodiments, an implant replaces one or more vertebral bodies of the spine.
US08267996B2 Intraocular lens
An intraocularlens of novel structure by which the outer circumferential part of an optical portion can be pressed stably against a posterior capsule under worn state and crisis of secondary cataract can be suppressed more advantageously. A pair of coupling portions (14, 14) are formed to hold an optical portion (12) between them in one direction perpendicular to the optical axis, wherein the outer fringe parts of the coupling portions (14, 14) are made thicker than the outer fringe part of the optical portion (12), a pair of supporting portions (16, 16) are formed to project from the outer fringe parts of the coupling portions (14, 14) and a edge contour part (32) is formed continuously on the outer fringe parts of the optical portion (12) and respective posterior surfaces (20, 24) of the coupling portions (14, 14) so as to extend smoothly along the entire circumference thereof.
US08267993B2 Expandable annuloplasty ring and associated ring holder
Devices and methods are provided for surgical repair of dilated aortic root to restore aortic valve competence while preserving native leaflets. In one aspect of the invention an expandable annuloplasty ring is provided for external placement at the base of a dilated aortic root. The expandable ring is capable of elastically expanding between a first diastolic diameter and a larger second systolic diameter to provide a physiologically representative surgical repair of the aortic root. In a further aspect of the invention, is provided a holder assembly for aortic annuloplasty ring and suitable for other cardiac valve prosthesis. The holder assembly consists of a holder body pivotingly coupled to a handle member through a ball-and-socket arrangement.
US08267987B2 Medical appliance delivery apparatus and method of use
The present invention, in an exemplary embodiment, provides a stent deployment apparatus comprising safety and stent placement and deployment features. An exemplary stent deployment apparatus includes a longitudinally extending outer tubular member and a safety mechanism coupled thereto, wherein the safety mechanism includes a diverted channel. The apparatus also includes a longitudinally extending inner tubular member being longitudinally and axially displaceable relative to the outer tubular member, wherein the inner tubular member further comprises at least one detent along the longitudinal expanse thereof for operative interaction with the diverted channel. The extent of displaceability of the outer tubular member and inner tubular member relative to the other is limited to a predetermined threshold corresponding to engagement of the detent with the diverted channel absent intervention by the user of the device such that the degree of stent deployment is limited absent the user intervention.
US08267986B2 Vascular stenting for aneurysms
Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.
US08267983B2 Medical devices incorporating thermoelectric transducer and controller
A temperature control system may include a thermoelectric device, a controller electrically coupled to the thermoelectric device, a heat transfer structure thermally coupled to the thermoelectric device, and a temperature controlled medium thermally coupled to the thermoelectric device. The controller may be configured to sense a first value of an electrical characteristic of the thermoelectric device and to generate a first electrical control signal to pump heat through the thermoelectric device in response to sensing the first value of the electrical characteristic of the thermoelectric device. The controller may be further configured to sense a second value of the electrical characteristic of the thermoelectric device and to generate a second electrical control signal to pump heat through the thermoelectric device in response to sensing the second value of the electrical characteristic of the thermoelectric device.
US08267978B2 Hybrid bone fixation apparatus
An orthopedic bone fixation device including an anchor member having a cavity and an insert member. The anchor member retains the insert member at least partially or entirely in the cavity. The insert member has an insert aperture for accommodating part of a screwdriver or other device.
US08267976B2 Bone screw and bone screw with holding element
A bone screw is provided, with a thread section (2) of tubular construction having a tip (3) at its first end and a second end opposite the latter. The tubular thread section (2) comprises a bone thread (22) on its outer wall, and the wall of the thread section (2) comprises a plurality of recesses (21). The bone screw further includes a holding element (4, 6) with a first section (41, 61) for connection to the thread section (2) and with a rod-like second section (43, 63) which in the inserted state of the holding element (4, 6) protrudes beyond the second end of the thread section (2). A stop is provided for limiting the distance of insertion of the holding element (4, 6) in the thread section (2). The holding element (4, 6) comprises an element (44, 64) at its free end for engagement with a screw-in tool.
US08267975B2 Bone screw system
A set of screws sized and configured for fixing a Jones fracture in a fifth metatarsal bone of a patient by preserving a bone thread path. Each screw has a low profile head on a trailing end, a thread portion on a leading portion, and a smooth shank portion between the head portion and the thread portion. A first screw has a thread major diameter of between about 4.4-4.6 mm, a second screw a thread major diameter of between about 5.4-5.6 mm, and a third screw a thread major diameter of between about 6.4-6.6 mm. The thread portion of all the screws in the set has a set of identical thread profile characteristics comprising a pitch, a leading edge angle, a trailing edge angle, a leading edge radius, a trailing edge radius, and a land. Each screw size is provided in various preferred lengths.
US08267973B2 Fixable suture anchor plate and method for tendon-to-bone repair
A fixable suture anchor plate including an anchor plate having a tunnel aperture that aligns with one or more bone tunnels formed in the bone. The anchor plate also includes one or more suture passages that align with one or more grooves formed along an edge of the anchor plate to permit passing a suture through the anchor plate after the anchor plate is fixed to the bone. The anchor plate also includes a screw hole that allows the anchor plate to be fixed to a bone with a screw. A method for tendon-to-bone repair includes sewing a medial row of stitches proximate to a medial line of tendon-to-bone attachment and securing the suture to the anchor plate through a bone tunnel and sewing a lateral row of stitches along a lateral line of tendon-to-bone attachment and securing the second suture to the anchor plate.
US08267967B2 Methods and apparatus for modular and variable spinal fixation
A system and method for the stabilization of the human spine using rods or plates having variable shapes and mechanical properties over their length. The rods or plates may be made up of various segments, each having different properties such as different flexibilities.
US08267963B2 Suture anchor loading device
A suture anchor member manual loading device may include a body comprising first and second portions preventing operator contact with a tip of a needle. An anchor receiving portion shaped to receive and restrain a suture anchor member is disposed in the first portion of the body. A suture receiving portion has a first end connected to the anchor receiving portion and a second end disposed on an outer surface of the body such that the suture receiving portion extends away from the anchor receiving portion at a non-parallel angle. When the suture is tensioned the anchor member is translationally and rotationally restrained against the anchor receiving portion. A needle receiving portion disposed in the second portion of the body is shaped to receive the needle such that the suture anchor member is received into a lumen of the needle when the needle is advanced through the needle receiving portion.
US08267962B2 Device for repositioning cartilage and method of use
A device comprising a plate with attached suture including a portal and possibly including a fastener for the suture which can be used to dynamically reposition nasal cartilage to repair upper lateral cartilage, to splint septal cartilage, or to aid in scar inhibition in wound closure.
US08267959B2 Technique for securing a suture
A device to seal an incision in a blood vessel includes an inner member and an outer member. A suture connects the inner member and the outer member. A first portion of the suture is embedded within a second portion of the suture such that as tension in the suture increases the first and second portions are held together.
US08267956B2 Vascular embolic filter exchange devices and methods of use thereof
Vascular embolic filtering systems, as well as methods for using the same, are provided. In general, the subject invention includes a system comprised of a delivery and retrieval sheath adapted for delivering and retrieving multiple embolic filters, wherein the embolic filters are each operatively coupled to a distal region of a filter wire segment and are deployable within a target vessel.
US08267951B2 Dissecting cannula and methods of use thereof
Methods and devices described herein facilitate improved access of locations within the body by providing a variety of dissection modes on a single access device.
US08267949B2 Flexible device for introducing a medical apparatus into a body
An introducing device for introduction of a medical device into a body is described which has a distal region with a tip region for generating an opening in the skin, and a segment region which comprises at least two sections which, in a rigid state, are essentially rigidly connected at least to one another and to the distal region and which are movable relative to one another in a flexible state. Furthermore, a system is described in which a sensor is integrated into the device for introduction into a body.
US08267947B2 Vascular suturing device
A surgical device of suturing vascular vessels is described, as well as methods for suturing tissue employing the surgical device. In one form the device includes a distal member for insertion into a vascular vessel puncture wound. The distal member contains a suture and needle engaging fitting. At least one needle is advanced through tissue adjacent the puncture wound and into the needle engaging fitting to draw lengths of suture material which can then be used to close the puncture wound. In another form the device includes at least one needle advanceable through tissue and into a needle capture element within a distal end of the surgical device to draw lengths of suture material which can then be used to close various puncture wounds, particularly in vascular tissue. In still another form the device includes at least one needle advanceable through tissue to drawn lengths of suture material which can then be used to close various puncture wounds, particularly in vascular tissue. A foot is pivotal between a non-deployed position and a deployed position where it engages vascular tissue on a distal side of the vessel.
US08267946B2 Endoscopic surgical clip applier
An apparatus for application of surgical clips to body tissue includes an actuator at least partially disposed within a body and longitudinally movable in response to actuation of a handle portion. The apparatus includes a jaw closure member positioned adjacent the first and second jaw portions to move the jaw portions to the approximated position and a rack having ratchet teeth connected to the actuator. The apparatus includes a pawl engaging a series of ratchet teeth and capable of preventing an inadvertent return of the actuator before full actuation of the apparatus. A clip pusher incrementally moves distally each time a clip is released from the apparatus. When the clip pusher reaches a predetermined distal point in a clip carrying channel, a feed bar is deflected to a second position to prevent retraction but not advancement of the actuator and thereby manipulates the pawl to engage the ratchet teeth.
US08267945B2 Clip advancer with lockout mechanism
A surgical clip applier and methods for applying surgical clips to a vessel, duct, shunt, etc., during a surgical procedure are provided. In one embodiment, a surgical clip applier is provided and can include a housing having a trigger movably coupled thereto and an elongate shaft extending therefrom with opposed jaws formed on a distal end thereof. The clip applier can include an advancer assembly disposed within the elongate shaft and configured to advance one of a plurality of clips disposed within the elongate shaft into the opposed jaws. A feeder shoe can be disposed within the elongate shaft and can be configured to engage and prevent the advancer assembly from moving to a proximal position after the advancer assembly has moved to a distal position to advance a proximal-most clip into the opposed jaws. This can indicate to a user that a clip supply of the surgical clip applier is depleted.
US08267944B2 Endoscopic surgical clip applier with lock out
An apparatus for application of surgical clips to body tissue is provided and includes a handle assembly; a shaft assembly including a housing extending distally from the handle assembly and defining a longitudinal axis; a plurality of surgical clips disposed within the shaft assembly; a jaw mounted adjacent a distal end portion of the shaft assembly, the jaw being movable between an open spaced-apart condition and a closed approximated condition; and a pusher bar reciprocally disposed within the housing of the shaft assembly and being detachably connectable to the housing of the shaft assembly, the pusher bar being configured to load a distal-most surgical clip into the jaws during distal movement and remain connected to the housing of the shaft assembly and in a distally advanced position during an approximation of the jaws.
US08267942B2 Systems and methods for closing a vessel wound
Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from prior interventional procedures. A sealing member is deployed intravascularly into the target vessel, and an anchor member is deployed extravascularly of the target vessel. The sealing member and the anchor member are connected by a suture that may be drawn to tighten the sealing member and the anchor member relative to one another in order to effect the seal of the puncture wound. After tightening, the suture is secured to maintain the sealing member and the anchor member relative to one another in order to maintain the seal. Preferably, the anchor member, the suture and the sealing member are comprised of biocompatible, bioresorbable materials that are absorbed into the body after the sealing of the puncture wound has been achieved. The sealing member, suture and the anchor member are delivered by a delivery rod or other components over a guidewire or through an introducer already in place from the preceding interventional procedure.
US08267940B2 Systems, methods and devices for removing obstructions from a blood vessel
Devices and methods for removing an obstruction from a blood vessel are described. The devices are deployed in a collapsed condition and are then expanded within the body. The devices are then manipulated to engage and remove the obstruction.
US08267937B2 Method for determining a tooth period length of a bone milling cutter
A method for manufacturing bone milling cutters, wherein a milling cutter toothing (12) is created at a distal face of a tubular milling cutter shaft (10) of a bone milling cutter at a given outer diameter (D) of the milling cutter shaft (10). The following steps are carried out: determining the tube circumference (U) of the milling cutter shaft (10); ascertaining an average desired tooth height (Hgew) of the milling cutter toothing (12); ascertaining the desired tooth period length (LZ′) of the milling cutter toothing from the desired tooth height (Hgew) at given parameters of a tooth period pattern; dividing the tube circumference (U) by the desired tooth period length (LZ); rounding the results to an even number value (Qz); and dividing the tube circumference (U) by the value (Qz) in order to obtain the tooth period length (LZ).
US08267924B2 Powered surgical instrument
A surgical instrument including a housing, an endoscopic portion, a shaft portion and an end effector is disclosed. The endoscopic portion extends distally from the housing and defines a longitudinal axis. The shaft portion is selectively connectable to a distal end of the endoscopic portion. The end effector is selectively connectable to a distal end of the shaft portion.
US08267921B2 Manually operable portable infusion device
A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.
US08267918B2 System and method for percutaneously administering reduced pressure treatment using a flowable manifold
A reduced pressure delivery system for applying a reduced pressure to a tissue site includes a manifold delivery tube having a passageway and a distal end, the distal end configured to be percutaneously inserted and placed adjacent the tissue site. A flowable material is provided and is percutaneously deliverable through the manifold delivery tube to the tissue site. The flowable material is capable of filling a void adjacent the tissue site to create a manifold having a plurality of flow channels in fluid communication with the tissue site. A reduced pressure delivery tube is provided that is capable of fluid communication with the flow channels of the manifold.
US08267906B2 Transdermal delivery apparatus and method
An apparatus and method for applying a beneficial agent to the skin is disclosed in one embodiment of the invention as including first and second chemical reactants, each being compatible with the skin. The first and second chemical reactants react with one another to generate a beneficial agent and enhance the permeability of the skin (e.g., by generating heat). The beneficial agent may then be applied to the skin while the permeability of the skin is enhanced. In selected embodiments, the first chemical reactant includes one or more metals, or alloys thereof, that are compatible (i.e., not harmful) with the skin. Similarly, in selected embodiments, the second chemical reactant may include water. In certain embodiments, the beneficial agent generated by the first and second chemical reactants includes an antioxidant such as hydrogen.
US08267905B2 Apparatus and method for delivery of therapeutic and other types of agents
Implantable drug delivery systems target delivery of small volumes of drugs to specific tissues. In some cases, a drug delivery system includes an implantable osmotic pump connected to a drug-containing housing, with that housing connected to a needle, cochlear implant or other type of component for ultimate delivery to the target tissue. In some implementations, a subcutaneous port receives a fluid from an external pump. The port is connected to a needle or other component for delivery of one or more drugs to the target tissue. Both solid and liquid drug formulations can be used. In embodiments using solid drugs, a separate drug vehicle (such as saline) can be used to dissolve a portion of the solid drug, with the drug-loaded vehicle then delivered to the target tissue.
US08267904B2 Medicinal delivery device
A medicinal delivery device is provided. The device includes a clip defining an ala inner surface-engaging portion about a first end thereof. The clip also defines an ala outer surface-engaging portion about a second end thereof. The ala outer surface-engaging portion is in spaced-apart and generally inward facing arrangement relative to the first end of the clip. This forms a gap between the ala inner surface-engaging portion and the ala outer surface-engaging portion for receiving a patient's ala. A medicine chamber is carried about the first end of the clip for dispensing medicine into the patient's nasal cavity.
US08267903B2 Casing
A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively moveable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.
US08267902B2 Syringe, capsule device therefore, and syringe device
A syringe including a front end and a rear end. A front portion of the syringe having an axially extending hollow needle that projects from the front end. The rear end of the needle is in fluid communication with a space that extends substantially to the rear end of the syringe. A plunger extends axially and is movable to and fro in the space and is designed such that, when drawn out, it sucks liquid through the needle and, when pressed in, discharges liquid through the needle. A radially projecting flange element in the front portion of the syringe is designed in such a way that it can be gripped between the thumb and middle finger of a user's hand. The syringe is dimensioned so as to permit injection using the index finger of the same hand. A capsule device for at least partially accommodating a syringe. A syringe device.
US08267897B2 Center twist hemostatic valve
The invention comprises a hemostatic valve apparatus used in medical procedures that provides a valve that is always sealed. The valve apparatus incorporates a double twist and a rotation member placed between the ends of the valve. Because the valve is never fully opened, either no fluids or an insignificant amount of fluids will flow when used in surgical or interventional procedures. The invention also comprises a valve conduit with first and second fixed ends and a rotatable member positioned between the first and second ends.
US08267896B2 Surgical instrument cleaning arrangement
The instrument cleaning apparatus of the present disclosure facilitates the cleaning of a scope inserted through a sealed portal during a surgical procedure by providing a cleaning solution within the operating cavity so that the surgical instrument doesn't have to be removed therefrom. In an embodiment, a surgical access device is provided with a housing, a sleeve extending distally from the housing, and a conduit disposed in mechanical cooperation with the sleeve. The sleeve defines a longitudinal axis and is dimensioned for passage through a tissue tract. The sleeve also defines a longitudinal bore for reception and passage of a surgical instrument. The conduit has a first portion configured to receive a fluid and a second portion configured to discharge the fluid. In another embodiment, an instrument cleaning apparatus includes a base portion and a fluid retention portion. The base portion includes a substantially tubular wall having a proximal end and a distal end and a longitudinal passageway extending therethrough. The fluid retention portion is in mechanical cooperation with the base portion and is adapted to retain a cleaning fluid therein.
US08267893B2 Method and apparatus for detecting occlusions in an ambulatory infusion pump
An improved pump, reservoir and reservoir piston are provided for controlled delivery of fluids. A motor is operably coupled to a drive member, such as a drive screw, which is adapted to advance a plunger slide in response to operation of the motor. The plunger slide is removably coupled to the piston. A method, system, and an article of manufacture for automatically detecting an occlusion in a medication infusion pump is provided. The electrical current to an infusion pump is measured. Based on a series of measurements of one or more variables, the infusion pump detects whether there is an occlusion in the system.
US08267882B2 Methods and apparatus for treating glaucoma
An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.
US08267881B2 Method and apparatus for blood withdrawal and infusion using a pressure controller
A method and apparatus for controlling blood withdrawal and infusion flow rate with the use of a pressure controller. The pressure controller uses pressure targets based upon occlusion limits that are calculated as a function of flow. The controller has the ability to switch from controlling withdrawal pressure to controlling infusion pressure based upon the detection of an occlusion. The controller distinguishes between partial and total occlusions of the withdrawal vein providing blood access. Depending on the nature of occlusion, the controller limits or temporarily reverses blood flow and, thus, prevents withdrawal vessel collapse or reverses blood flow to quickly infuse blood into the vessel without participation from operator.
US08267878B2 Arterial cooling elements for use with a cervical immobilization collar
A kit for cooling the blood in the carotid arteries includes a cervical immobilization collar and a cooling element. The cooling element may include a body-facing panel attached on a body-facing surface to a lining layer, an outward-facing panel, and cooling material disposed between the body-facing panel and the outward facing panel. The cooling material comprises urea and Carbamakool™ in an amount sufficient to produce a temperature of 20° F. to 35° F. within a minute of activation when measured on the body-facing surface of the body-facing panel.
US08267868B2 Single-insertion, multiple sample biopsy device with integrated markers
The present invention provides for exemplary embodiments of a single-insertion, multiple sample biopsy device. Exemplary embodiments of a single-insertion, multiple sampling device with integrated marker release.
US08267867B2 Ultrasound image diagnosis apparatus and drive voltage setting method for ultrasound probe thereof
An ultrasound image diagnosis apparatus and a method for setting an ultrasound drive voltage by which appropriate probe motion parameters are established by individually estimating temperature changes which occur due to a plurality of heat sources existing within the probe. By individually storing or correcting relative temperature change data associated with motion parameters due to a plurality of heat source elements, an optimum driving voltage for the ultrasound transducers is set. Since a transmission drive voltage is larger than the conventional drive voltage can be set under a permissible probe temperature, image diagnosis can be improved.
US08267865B2 Sonoelastographic shear velocity imaging using crawling wave excitation
Vibration sources are applied to a body or other object to image a region of interest. The mechanical vibrations introduced by the sources interfere in the region of interest to produce a crawling wave, which is detected by an ultrasound probe A relationship between crawling wave phase derivatives and local shear wave velocity is derived with phase derivatives estimated using either one-dimensional (1D) or two-dimensional (2D) autocorrelation-based techniques to image the region of interest.
US08267856B2 Laryngoscope spatula
The invention relates to a laryngoscope spatula with a spatula blade. The spatula blade, in cross section, has two side walls, which are spaced apart from each other along at least part of the length of the spatula blade, and two limbs. A first limb extends from the first side wall to beyond the second side wall, and a second limb extends from the second side wall to beyond the first side wall. The side walls and the limbs thus form a cavity. The spatula blade is composed of an upper shell and a lower shell which, in cross section, each have a first portion and two mutually oppositely directed second and third portions. The second portions of the upper shell and lower shell, lying flat on each other, form the first limb, and the third portions, lying flat on each other, form the second limb, while the first portions form the side walls. The invention further relates to a method for producing a spatula blade of such a laryngoscope spatula.
US08267850B2 Transcranial magnet stimulation of deep brain targets
The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed.
US08267849B2 Radioactive therapeutic fastening instrument
An instrument used for brachytherapy delivery in the treatment of cancer by radiation therapy including a handle having first and second handle actuators; an end effector; and an instrument shaft that connects the handle with the end effector. The end effector has first and second adjacent disposed staple mechanisms that each retain a set of staples. The first mechanism is for holding standard staples in a first array, and dispensing the standard staples under control of the corresponding first handle actuator. The second mechanism is for holding radioactive source staples in a second array, and dispensing said radioactive source staples under control of the corresponding second handle actuator. A holder is for receiving the first and second mechanisms in a substantially parallel array so that the standard staples close the incision at a surgical margin while the source staples are secured adjacent thereto.
US08267847B2 Method and apparatus for a rules-based utilization of a minimum-slit-head configuration plunger slitter
A method and apparatus for performing an order change in a corrugator uses a minimum slit head configuration with all slit heads carried on two sides of a single tool support structure. A single robot is operable on the support structure to independently reset the positions of slit heads during a running order to prepare for subsequent order change in a most efficient manner, utilizing order scheduling that eliminates order changes that cannot be formed with the minimum slit head configuration.
US08267844B2 Gripping device
The present invention relates to a gripping device that removably attaches onto a user's wrist to enable the user to grip onto a handle. The gripping device comprises a wrist-wrapping, elongated belt portion having opposite ends, and a gripping structure that extends outward from the plane of the belt portion.
US08267843B2 Gluteus weight training machine
Some embodiments provide a gluteus weight training machine for progressive overload resistance training of the gluteus muscles. The gluteus weight training machine includes a frame, a support member linked to the frame, and two resistance members that provide resistance against a downward arcing rotation of the resistance member. Each resistance member includes a pad against which a user's leg applies force in order to perform the downward arcing rotation of the resistance member. Each resistance member further includes a weight assembly that adjusts the amount of weight used as resistance.
US08267834B2 Self-propelled vehicle for conveyance and method of controlling stop thereof
A self-propelled vehicle for conveyance that can be safely stopped without deviating from a predetermined route when an obstacle is detected during running, and a method of controlling a stop of the self-propelled vehicle for conveyance are provided. The method of controlling the stop of the self-propelled vehicle for conveyance includes a second detection step in which an obstacle located at a set distance is detected during the running of the self-propelled vehicle for conveyance, and a stop step in which a leftward or rightward positional deviation of the self-propelled vehicle for conveyance from the predetermined route is correctively controlled in the state where brake means for a pair of left and right driving wheels are released and the self-propelled vehicle for conveyance is stopped, when the positional deviation turns out to be present on the basis of detection of the obstacle in the second detection step. Therefore, when the obstacle is detected during the running of the self-propelled vehicle for conveyance, the self-propelled vehicle for conveyance is safely stopped without deviating from the predetermined route.
US08267833B2 High efficiency transfer case
A multi-speed power transmission device includes an input shaft, first and second output shafts and a planetary gearset. An axially moveable sleeve fixes the first output shaft and the input shaft for rotation when in a first position and the sleeve fixes the sun gear and the input shaft for rotation when in a second position. A hub is axially moveable and free to rotate relative to the first output shaft when in the first position. The hub is fixed for rotation with the first output shaft when in the second position. A cam plate is continuously fixed for rotation with the carrier and urges the hub toward its second position when in a second axial position. The input shaft drives the first output shaft at a reduced speed via the planetary gearset when the sleeve, hub and cam plate are at their second positions.
US08267826B2 Uninterruptible oil supply in planetary system
A planetary carrier includes a journal bearing for supporting a planetary gear. The journal bearing receives lubricant to produce a lubricant film to support gear loads. A torque frame is attached to the carrier housing to transmit torque and to prevent twisting of the carrier housing. The torque frame includes several lubricant communication passages to provide lubricant to each of the separate journal bearings. Each of the lubricant communication passages includes an accumulator for storing lubricant during normal operation. The accumulator stores a desired amount of lubricant to provide lubricant to the adjacent journal bearing for the interim period between primary system stoppage and reestablishment of lubricant flow by a secondary system.
US08267825B2 Track car drive system, and track car using the system
Provided is a track car drive system, which is assisted by a generator motor so that it may attain a gear array for equalizing the number of speed range and the gear ratios at the individual gears as a transmission for the forward speed and the backward speed and which can be combined with the generator motor. A transmission (15) for receiving the output of an engine (14) at an input shaft (30) is constituted by combining a forward range (31) and a backward range (32) with two intermediate shafts (41 and 42) having different speed ranges (51 to 54) between themselves and an output shaft (45). By shifting/fastening a first clutch (43) or a second clutch (44) selectively, the rotation of either the forward range (31) or the backward range (32) is transmitted to either of the intermediate shafts (41 and 42). When one of the speed ranges (51 to 54) is selected, the same gear number and gear ratio are taken no matter whether the track car might run forward or backward. The assist force by the generator motor (18) is applied from a differential mechanism (55) through the two intermediate shafts (41 and 42) to the output shaft (45).
US08267823B2 Device for activating a cogged flexible transmission organ
A drive transmission system for activating a cogged flexible transmission organ includes a support pulley borne idle on a drive shaft which contacts tops of the organ cogs at a calibrated circumference thereof which defines a predetermined winding radius of the flexible transmission organ. A cogged drawing pulley is mounted on the drive shaft and has cogs for enmeshing with recesses in the cogged flexible transmission organ for advancing the flexible transmission organ. The drawing pulley has cogs sized for enmeshing with the recesses of the cogged flexible transmission organ, such that tops of the drawing pulley cogs are displaced from bottoms of the flexible transmission organ recesses and tops of the flexible transmission organ cogs are displaced from bottoms of the drawing pulley recesses. The drawing pulley therefore cannot drag on the flexible transmission organ when the support pulley is not subject to drive torque.
US08267820B2 Bicycle chain tensioner
A bicycle chain tensioner is provided with a bracket, a tensioner arm, a securing position adjustment mechanism and a chain engaging member. The bracket has a bicycle axle mounting portion and an arm attachment portion. The tensioner arm is adjustably secured to the arm attachment portion of the bracket. The securing position adjustment mechanism selectively fixes the tensioner arm with respect to the bracket in one of a plurality of the securing positions. The chain engaging member is attached to the tensioner arm.
US08267816B1 Mechanical arrow nocks
An arrow nock having a telescoping impeller and housing with resilient means for enhancing the acceleration of launch. In various embodiments, effective together or independently, the housing and impeller are configured and coupled to: create arrow rotation during launch; grip the bowstring during notching and release it during launch; and generate tracking signals.
US08267810B2 Low lift golf ball
A golf ball having a plurality of dimples formed on its outer surface, the outer surface of the golf ball being divided into plural areas, a first group of areas containing a plurality of first dimples and a second group of areas containing a plurality of second dimples, each area of the second group abutting one or more areas of the first group, the first and second groups of areas and dimple shapes and dimensions being configured such that the golf ball is spherically symmetrical as defined by the United States Golf Association (USGA) Symmetry Rules, the plural areas configured such that the golf ball has a Drag Coefficient (CD) and a Lift Coefficient (CL) of less than about 0.330 and 0.270, respectively, at a Reynolds Number (Re) of about 80,000 and a spin rate of between about 2,900 rpm and about 3,000 rpm and a CD and CL of less than about 0.260 and 0.155, respectively, at a Re of about 170,000 and a spin rate between about 3,420 rpm and 3,520 rpm, and the first dimples being of different dimensions from the second dimples.
US08267808B2 Golf club with optimum moments of inertia in the vertical and hosel axes
A hollow golf club is provided having an outer shell and an inner frame. The outer shell comprises one or more lightweight members, such as the crown or the skirt, and preferably fits within an envelope of about 5 inches×5 inches×2.8 inches. The inner frame fits within a smaller envelope and sits on the sole of the club head. One or more weights are located either on or within the inner frame to optimize the moment of inertia of the club head about both the vertical axis running through the center of gravity or geometric center of the club head, hereinafter referred to as the “y-axis,” and the axis running through the center of the shaft of the golf club, hereinafter referred to as the “hosel axis.” The weights can be attached to the inner frame or can be distributed within the inner frame. In another embodiment, the hitting face and a portion of the skirt proximate the toe form a curved blade in the shape of a sickle or battle ax and an inner support bridges the toe end of the curved blade to the hosel for structural support. The ratio of moment of inertia of the club head about the y-axis to moment of inertia of the club head about the hosel axis is preferably 0.55. More preferably, this ratio is 0.75.
US08267796B2 Game machine, game machine control method, and information storage medium
To provide a game machine capable of reducing a sense of discomfort which the user feels due to unmatched image display timing and image-related sound output timing. An image reproduction unit (highlight scene image reproduction control unit (72)) reproduces an image. An image-related sound reproduction unit (comment sound reproduction control unit (78)) reproduces an image-related sound corresponding to the image. A reproduction state determination unit (76) determines whether or not the reproduction state of the image and that of the image-related sound corresponding to the image satisfy a predetermined condition. Based on a result of a determination by the reproduction state determination unit (76), a reproduction state describing sound reproduction control unit (80) reproduces a reproduction state describing sound which describes the reproduction state of the image and/or image-related sound.
US08267795B2 Information storage medium and game-providing system
A server includes an acquisition section that provides a user with information about a virtual event area selected based on acquired current position information and position information linked to the virtual event area, the virtual event area being linked to position information that indicates a position within a predetermined range from an acquired current position, and stores the virtual event area as acquisition information about the user when an acquisition request for the virtual event area has been received, the virtual event area being linked to user identification information, a visit processing section that provides the user with information about the virtual event area having position information that indicates a position within a predetermined range from the acquired current position, based on the acquired current position information and the position information linked to the virtual event area, and receives a visit request, and a parameter calculation section that changes a result value or a predetermined game parameter of the user when a visit request for the virtual event area stored as the acquisition information about the user has been received from another user.
US08267794B2 Profit sharing in video game environments
Video game methods and systems allow players to acquire ownership of video game environments. Methods and systems additionally include methods for buying and selling ownership or fractions of ownership in a particular game environment.
US08267790B2 Interactive games on a television via internet protocol
Particular embodiments of the disclosed subject matter provide methods and systems to support interactive games on a television via internet protocol. An example embodiment includes receiving a game selection from a remote user through a set-top box via a network, activating the selected game on a games server, and communicating game rendering information to the set-top box via the network thereby enabling remotely playing the selected game via a television monitor and a remote control device.
US08267789B2 Method and apparatus for machine location
A method and apparatus for tracking and determining a location of a gaming machine or other item within a casino or hotel is disclosed. In one embodiment the method and apparatus utilizes a transmitter or emitter to provide a tracking signal that may be tracked by one or more receivers or detectors. It is contemplated that the transmitter or emitter connect to a gaming machine. As the gaming machine is relocated within the casino its location is monitored. The one or more receivers may communicate with a host computer or other data processing system to generate location data regarding the gaming machine in relation to other aspects of the casino. Based on the location information generated by the location monitoring and tracking system, other aspects of machine operation may be controlled and additional features dependant on the machine location information may be enabled.
US08267787B2 Controller and portable electronic apparatus
A controller (portable electronic apparatus) includes a housing and a key provided for protruding and retreating movement on the housing. The housing has a front face, a rear face, and a side face for connecting the front face and the rear face to each other. The key has a body having one end inserted in an opening formed in the side face and the other end exposed to the outside of the housing, and an extension extending along the side face from the other end of the body to the outside farther than an end edge of the opening. With the controller (portable electronic apparatus), the area of the face of the key which is exposed to the outside of the housing, that is, the area of the face which opposes to a finger of a user, can be increased. Therefore, at whichever position the face is depressed, the key can be inputted and the contact area with the finger can be increased.
US08267786B2 Game controller and game system
A first control unit includes a first operation data generation section for generating first operation data in accordance with a motion of a first control unit body included in the first control unit. A second control unit includes a second operation data generation section for generating second operation data in accordance with a direction input operation performed by a player or a motion of a second control unit body included in the second control unit. Further, one of the first control unit and the second control unit includes a transmission section for transmitting the first operation data and the second operation data to a computer at a predetermined timing.
US08267782B2 Game device, game control method, and game control program
A game device includes a shape data storage which stores data of an object disposed in a three-dimensional space, a first rendering unit which sets a point of view and a line of sight and renders the object by referencing data stored in the shape data storage, a viewpoint changing unit which receives a change instruction indicating a change of the point of view or line of sight and changes the point of view or line of sight. The viewpoint changing unit changes the point of view or line of sight to outside a predetermined range when the point of view or line of sight enters within the predetermined range.
US08267781B2 Visual target tracking
A method of tracking a target includes receiving an observed depth image of the target from a source and obtaining a posed model of the target. The model is rasterized into a synthesized depth image, and the pose of the model is adjusted based, at least in part, on differences between the observed depth image and the synthesized depth image.
US08267780B2 Game console and memory card
A portable, handheld game console includes a main body incorporating a first display screen, and a cover body incorporating a second display screen. The main body is hingedly connected to the cover body along adjacent forward and rearward edges, respectively, such that the cover body is movable between a closed and open positions. The main body is provided with a plurality of control buttons and a pair of game card slots for receiving game cards of different dimensions. One of the game cards is substantially square and comprises a substantially flat card body having a plurality of electrically conductive terminal strips adjacent the forward edge. One of the side edges of the card has a single continuous step configuration along substantially the entire length dimension of the card. A first notch is formed in a first forward corner of the card where the forward edge meets the other of the pair of side edges and a second notch is formed along the other of the pair of side edges, between the forward and rearward edges.
US08267776B2 Gaming machine including terminals and playing method thereof
A gaming machine includes: a base game; gaming terminals; a bonus game configured to award a bonus payout more rewarding than the payout in the base game; a bonus payout indicator that displays the bonus payout; and paths, respectively corresponding to the gaming terminals, including light emitting portions arranged to form a channel extending from a position corresponding to each gaming terminal to the bonus payout indicator. In each gaming terminal, the base game is run independently from the other gaming terminals. The bonus game is run. A random number of the light emitting portions are activated toward the bonus payout indicator in a path corresponding to a gaming terminal in which a predetermined winning is met, every time the predetermined winning is met in the gaming terminals. The bonus payout is awarded in a gaming terminal corresponding to a path in which the light emitting portions turned active up to the bonus payout indicator.
US08267773B2 Wagering system with improved expected value during a special event
A method and system for conducting a wagering game with a changed expected value for a special event based on the achievement of a wagering-game enhancement parameter award. The wagering game includes a base game and a special event. The wagering game has a first expected value attributable to the base game and a second expected value attributable to the special event. The special event occurs in response to a triggering event. The first expected value attributable to the base game is decreased. The second expected value attributable to the special event is subsequently increased to compensate for decreasing the first expected value attributable to the base game.
US08267772B2 Gaming machines having rhythmic reels
A gaming machine and methods for independently controlling the movement of each mechanical reel are disclosed. The gaming machine includes a plurality of mechanical reels each having indicia provided on an outer surface of each of the reels. A game controller generates a game outcome and determines a spin duration for each of the plurality of reels. One or more stepper motors are operatively coupled to the mechanical reels to independently spin each reel. A reel control unit is in communication with one or more stepper motors and the game controller. The reel control unit determines an appropriate spin profile for each reel based upon the game outcome and the spin duration to cause the reels to spin and stop in a rhythmic manner.
US08267771B2 Gaming system having outcomes interactive with playing fields
A gaming system comprises a wager input device and at least one display for displaying a primary wagering game and a secondary wagering game. The secondary wagering game comprises a playing field, the playing field having a set of field attributes associated therewith. The system further comprises a controller operative to (i) determine and display a first outcome of the primary wagering game, (ii) determine if a first set of game attributes associated with first outcome is eligible for play in the secondary wagering game, (iii) if the first outcome is eligible, determine a second outcome of the secondary wagering game by resolving the first set of game attributes with the set of field attributes in accordance with a first rule set, and (iv) if the second outcome is a winning outcome, award a first award.
US08267769B2 Gaming system having a plurality of slot machines and control method of the gaming system
A gaming system of the present invention includes a plurality of slot machines. Each of the slot machines includes a display that displays a symbol and a controller that rearranges a symbol arranged on the display. The respective displays provided to the plurality of slot machines display symbols that are located on the displays respectively when a plurality of symbols are scrolled on one continuous display band obtained by virtually connecting the displays.
US08267768B2 Gaming device with perimeter bonusing
A gaming machine is described wherein one or more moving indicators travel around or among slot machine reels granting awards, bonuses or special characteristics to associated symbols on the reels.
US08267767B2 3-D reels and 3-D wheels in a gaming machine
A disclosed gaming machine provides method and apparatus for presenting a plurality of game outcome presentations derived from one or more virtual 3-D gaming environments stored on the gaming machine. While a game of chance is being played on the gaming machine, two-dimensional images derived from a 3-D object in the 3-D gaming environment may be rendered to a display screen on the gaming machine in real-time as part of a game outcome presentation. Apparatus and methods are described for generating and displaying a sequence of symbols from a virtual reel strip in the 3-D gaming environment. In particular, the sequence of symbols may be mapped to one or more to flat reels, rounded reels or sequences of moving objects in the 3-D gaming environment. The flat reels, round reels or sequences of moving objects may be moved in the 3-D gaming environment through a motion that allow the sequence of symbols from the virtual reel strip to displayed as part of game outcome presentation for a game of chance played on the gaming machine.
US08267765B2 Gaming device and method having a first interactive game which determines a function of a second wagering game
A gaming device including a first player interactive game requiring one or more player inputs which result in an outcome. The outcome does not result in an award provided to the player. In one embodiment, the gaming device determines a paytable employed in the wagering game based on an outcome of the interactive game. In another embodiment, the gaming device includes a plurality of different wagering games. The gaming device determines which wagering game to provide to the player based, at least in part, on the outcome of the interactive game. Other suitable functions can be employed in the wagering game based on the outcome of the interactive game in accordance with the present invention. In any embodiment, the gaming device provides an outcome to the player for the wagering game which can result in an award.
US08267755B2 Elastic drive disk for a coin handling machine
An elastic coin moving disk assembly (23) for moving coins across a coin sorting and coin collection member (13) in a coin handling machine (10), in which the coin sorting and coin collection member (13) has openings (28) of varying size to receive coins (14) of respective denominations, the coin moving disk assembly (23) having an annular disk body with a groove (32) and an outer rim (35) having a cavity (33) in a bottom surface; and a fin ring (39) molded into the cavity (33) in the bottom surface, the fin ring (39) comprising planar fingers (42) extending downward and substantially perpendicular to the bottom surface of the rim (35) when first manufactured, and later taking on an angular “set” after an initial break-in period, which is compensated for by a user-removable shim (43).
US08267744B2 Drive for a cutting or grinding machine
The present invention provides a drive for a grinding or cutting machine. The drive comprises a body having a drive coupling for receiving at least one drive shaft in a manner so that the or each drive shaft is drivable by the drive. The drive also comprises a mount for mounting the body to a portion of the machine such as to a linkage arm of an earth grinding or cutting vehicle. The drive coupling is arranged to inter-fit with a portion of the or each drive shaft.
US08267740B1 Asymmetrical bosom corrective brassiere
An anomaly-correcting brassiere of assumed positions of asymmetrical bosoms using interconnecting patches of Velcro loops and hooks for shoulder straps constituted as closed loops and non-elastic construction material to maintain symmetrical and obviate asymmetrical bosom conditions.
US08267739B2 Automobile toy
Disclosed is an automobile toy, including: a first chassis to support an axle of a front wheel; and a second chassis to support an axle of a rear wheel, wherein the first and second chassis are rotatably connected with each other by a rotating shaft that lies along a width direction of the automobile toy, and a spring for biasing the first and second chassis is arranged between the first and second chassis, so as to bias the front wheel and the rear wheel to an approaching direction to the ground.
US08267735B2 Pattern formation method for electroluminescent element
There is provided a pattern formed object having an electroluminescent layer coating. The pattern formed object comprising a substrate, partition walls provided on the substrate, and a coating stacked on the substrate in its part between the partition walls, wherein the partition walls have a sloped liquid non-repellent surface and have a section form that, at least in the lower part of the partition wall, as the distance from the substrate increases, the size of the partition wall in a direction parallel to the substrate decreases, and in the coating, the ratio of the maximum thickness (Tmax) to the minimum thickness (Tmin), Tmax/Tmin, is not more than 130% as measured in the coating in its part between the lower ends of the partition walls adjacent to each other.
US08267729B2 Socket contact
A socket contact is configured to receive a part of a mating contact. The socket contact comprises a spring portion, a spring support portion and a lance. The spring portion is brought into contact with the mating contact when the socket contact receives the part of the mating contact. The spring support portion supports the spring portion. The lance is provided on the spring support portion.
US08267728B2 Receptacle, printed wiring board, and electronic device
A receptacle includes a signal terminal, a ground terminal, and a signal terminal. A second portion of the ground terminal is distanced from a first portion of the signal terminal in an extension direction. A third portion of the signal terminal is distanced from the first portion of the signal terminal in the extension direction.
US08267725B2 Electrical connector with high intensity contacts
An electrical connector includes an insulative housing defining a mating surface, a mounting surface and a plurality of passageways running through the mating surface and the mounting surface and a plurality of contacts upwardly assembled into the corresponding passageways. Each of the contacts defines an upright retention portion interfered with the passageway, a pair of elastic arms extending from the retention portion and spaced apart with each other and a lying V-shaped contacting portion formed by a distal end of each elastic arms bending and extending beyond the mating surface of the housing. Each contact defines a connecting portion connecting with the pair of elastic arms and received in the passageway.
US08267721B2 Electrical connector having ground plates and ground coupling bar
An electrical connector includes a plurality of leadframe assemblies having discrete signal contacts extending through a leadframe housing and defining opposed mating ends and mounting ends. The leadframes lack discrete ground contacts, and instead includes a ground plate having a plurality of mating ends, such that the mating end of at least one signal contact is disposed between a pair of the mating ends of the ground plate. The ground plate further includes a ground coupling bar connected between the pair of mating ends of the ground plate.
US08267719B1 Plug tail lighting switch and control system
The present invention is directed to an electrical wiring system for use in an AC electrical power distribution circuit including at least one first AC power conductor disposed between an upstream AC power element and a device box and at least one second AC power conductor disposed between the device box and a downstream AC power element. The at least one first AC power conductor and the at least one second AC power conductor are routed into an interior portion of the device box and accessible via a front open face of the device box. The system includes a connector device including a connector housing having a plurality of connector contacts disposed therein. The plurality of connector contacts are coupled to termination structures configured to couple the at least one first AC power conductor and the at least one second AC power conductor to corresponding contacts of the plurality of connector contacts. An electrical wiring device includes a device housing having a front portion and a rear portion. The front portion includes at least one user-accessible control element disposed thereon. The at least one user-accessible control element is coupled to an electrical switch mechanism disposed in the device housing and coupled to a plurality of device contacts. The plurality of device contacts are accessible by way of a device connection arrangement formed in the rear portion of the device housing. The plurality of device contacts are configured to mate with the plurality of connector contacts when the connector device is coupled to the device connection arrangement.
US08267714B2 Modular connector with reduced termination variability and improved performance
A telecommunications connector including a connector housing; a plurality of connector contacts in the connector housing; a substrate having first plated through holes for receiving termination ends of the connector contacts, the first plated through holes arranged in an area on the substrate; a plurality of termination contacts, the plurality of termination contacts positioned in second plated through holes in the substrate; the second plated through holes intersecting the area on the substrate.
US08267710B2 Connection apparatus
A connection apparatus includes a male plug which may be mated into bayonet-type engagement with a female socket. The plug has at least one radially projecting lug and the socket has at least one axially extending insertion channel and at least one adjoining locking channel within which the lug may be received. The locking channel includes at least one depression which is located radially angularly offset from the insertion channel. Engagement between the lug with the depression resists unintentional detachment of the connection.
US08267697B2 Educational equipment with multiple configurations
The invention relates to educational equipment comprising a plurality of information support means (1) having identical dimensions but bearing at least partly different information. According to the invention, each support means (1) takes the form of a board comprising an outer frame (2) into which are inserted, removably and with friction, at least two inner frames (3), into each of which are inserted, removably and with friction, at least two labels (4) bearing the information.
US08267692B2 Method for creating an artistic work incorporating a basic symbol form set based on a circular object and movements thereof
A method of using a collection of symbols based on the movement of a circular object in space on three-dimensional and two-dimensional art works. The method relates to orienting a circular object at different angles and to trace the path of the circular object to create basic symbols. The basic objects are incorporated in a three-dimensional sculpture including surfaces and circular objects suspended at relative heights and orientations according to the collection of symbols.
US08267691B1 Threat fire simulation and training system
A firearm training simulation system for simulating the impact of one or more projectiles impacting a user includes an electrical impulse element configured for physical contact with the user. A controller is in communication with the electrical impulse element. The controller enables receipt of a signal for activating the electrical impulse element to deliver one or more electrical pulses to the user. Each electrical pulse simulates an impact of a projectile on the user.
US08267690B2 Simulating device
A device for simulating fire effects in military or civilian combat training. The device includes a light source configured to produce light beams and a light source control adapted to control a light lobe formed by the light beams from the light source. The light source control includes a two-dimensional array of elements electronically controllable to assume a selected state among at least a first state of letting through light incident thereupon in a main direction of the light lobe or a second state of not letting through the light incident thereupon in the main direction, and a unit adapted to control the elements for designing the spatial propagation of the light lobe.
US08267686B2 Orthodontic bracket with brazed archwire slot liner
An orthodontic article and method of making the orthodontic article, where the orthodontic article includes a fine-grain ceramic bracket and a metal liner secured in an archwire slot of the bracket with a brazing alloy comprising silver, copper, and at least about 1.5% by weight titanium.
US08267682B2 Alternate polymer extrusion system with accumulator
An extrusion system and method uses an accumulator to control and use excess plastic melt. The accumulator is situated between an extruder and a gear pump. The accumulator includes an accumulator housing to store excess plastic melt from the extruder and an accumulator spring connected to an accumulator piston to subsequently send the excess plastic melt to the gear pump. In another embodiment, the accumulator includes an accumulator housing to store excess plastic melt from the extruder and a hydraulics system to send the excess plastic melt to the gear pump. The accumulator can be a first in first out (FIFO) device having a melt passage through the accumulator piston. The system and method are used particularly advantageously in Alternate Polymer extrusion installation in which gear pumps regularly increase and decrease their speed but in which the melt-supplying extruder cannot accommodate such rapid speed changes.
US08267679B2 Mold device for forming grooves in tire shoulder
A mold device is described for use in a mold having a plurality of tread molding segments. Each tread molding segment has an end face for mating with an adjoining segment. The mold device includes a piston located on the segment and is actuated by the opening and closing of the mold. The piston is positioned within a first chamber and has a plunger end in communication with a working material and a spring. Each of the mold segments further includes a retractable blade assembly having a distal end in fluid communication with a second chamber. The first chamber is in fluid communication with the second chamber. Closing of the mold compresses the piston, forcing the working fluid to transfer from the first chamber to the second chamber, actuating the blade assembly.
US08267673B1 Brushless cooling fan
A fan assembly with an impeller and shroud for application in a vehicle cooling system. The fan is powered by an external rotor brushless direct current (BLDC) motor having an electronic controller positioned away from the BLDC on an outer shroud wall with a plurality of ducts drawing an airflow from a static lower pressure created by the impeller, the airflow streaming over a heat sink disposed on the controller, exiting through a shroud. The static lower pressure air is pulled by a centrifugal fan and skewed magnets inside the motor through a plurality of ducts in a shroud hub, cooling the BLDC, maintaining low resistance for high efficiency. The BLDC is integrated into the assembly, having a stator fixed in the shroud hub and a rotor directly fused to the impeller, the shroud and impeller forming the BLDC motor without a housing, allowing the motor to easily dissipate heat.
US08267671B2 Variable displacement pump
A variable displacement pump includes: a pump body; a rotor; a cam ring; inlet and outlet ports; first and second fluid pressure chambers; a metering orifice provided in a discharge passage connected with the outlet port; a pressure regulating section arranged to regulate the pressure introduced into the first or second fluid pressure chamber, and including a high pressure chamber, a middle pressure chamber, and a low pressure chamber; a relief valve; a pilot orifice provided in a passage connecting the metering orifice and the middle pressure chamber, and having a circular section with a diameter of a mm; and a damper orifice provided in a passage connecting the outlet port and the high pressure chamber, and having a circular section with a diameter of b mm. The pilot orifice and the damper orifice satisfy the following relationships: a+2b−2.1≧0, −4a+b−16.3≦0, and a≦1.8.
US08267670B2 Pistonless compressor
A compressor for the compressing of gaseous medium with at least one compressor cylinder which is connected with an inlet duct and with an outlet duct for the medium, an operating fluid, in particular an ionic operating fluid, being arranged in the compressor cylinder, which fluid is connected with a displacement machine, the displacement machine being constructed as a piston machine with at least one cylinder chamber and each cylinder chamber being connected with a compressor cylinder. To solve the problem of providing a compressor which guarantees a reliable operation with low structural expenditure, it is proposed that a separation device for the operating fluid is associated with the outlet duct of the compressor, the separation device being connected with the inlet duct of the compressor for the return of the operating fluid.
US08267669B2 Magnetic induction pump
A magnetic induction pump for pumping molten metal. The pump includes a motor and a shaft operatively connected to the motor. The pump further includes at least one bipolar permanent magnet operatively connected to the shaft and a conduit for the passage of molten metal. The motor rotates the shaft and magnet about the conduit inducing eddy currents in the molten metal in the conduit which react with the moving magnetic field to produce force to pump the metal through the conduit with the metal coming into contact with only an interior surface of the conduit.
US08267668B2 Fuel pump motor using carbon commutator having reduced filming
A fuel pump system for pumping fuel to an engine in a vehicle includes a pump motor having a carbon-based commutator and brushes in a position exposed to fuel, resulting in a tendency to form a film between the commutator and brushes that can reduce pump performance by increasing the electrical resistance of the brush-commutator interface. The pump motor has a nominal voltage rating. A power circuit is coupled to the pump motor for selectably providing an operating voltage and a boost voltage, wherein the boost voltage is greater than the nominal voltage rating. A controller selecting the operating voltage during an ordinary run cycle and selects the boost voltage during a clean-up cycle. The controller selects the clean-up cycle for a limited time that is sufficiently short to avoid damage to the pump motor from exceeding the nominal voltage rating and sufficiently long to create arcing between the commutator and brushes that reverses formation of the film.
US08267663B2 Multi-cast turbine airfoils and method for making same
A gas turbine engine airfoil is made from separate cast sections having different cast alloy structures. The cast alloy structures are selected on the basis of the local operating conditions of each section. Friction welding can be used to join the sections together.
US08267662B2 Monolithic and bi-metallic turbine blade dampers and method of manufacture
A method for manufacturing a turbine damper by a metal injection molding process is disclosed. The damper includes a base section and a wire section, and is formed of a nickel-base or cobalt base superalloy.
US08267659B2 Turbine blade
A turbine blade is provided. The turbine blade includes a support structure and a shell which surrounds the support structure and which is connected to and at a distance from the support structure by at least one spacing element. For example the spacing element can be a solder globule in order to form a space through which a cooling medium can flow between the support structure and the shell. A method for the production of a turbine blade having a support structure and a shell which surrounds the support structure and which is connected to and at a distance from the support structure is also provided. The shell is soldered to the support structure in at least at one place of the support structure in order to connect the shell to and at a distance from the support structure.